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Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli

Mirenowicz, Jacques, Schultz, Wolfram·1996·Nature

DOI 10.1038/379449a0

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Abstract

Midbrain dopamine systems are crucially involved in motivational processes underlying the learning and execution of goal-directed behaviour. Dopamine neurons in monkeys are uniformly activated by unpredicted appetitive stimuli such as food and liquid rewards and conditioned, reward-predicting stimuli. By contrast, fully predicted stimuli are ineffective, and the omission of predicted reward depresses their activity. These characteristics follow associative-learning rules, suggesting that dopamine responses report an error in reward prediction. Accordingly, neural network models are efficiently trained using a dopamine-like reinforcement signal. However, it is unknown whether the responses to environmental stimuli concern specific motivational attributes or reflect more general stimulus salience. To resolve this, we have compared dopamine impulse responses to motivationally opposing appetitive and aversive stimuli. In contrast to appetitive events, primary and conditioned non-noxious aversive stimuli either failed to activate dopamine neurons or, in cases of close resemblance with appetitive stimuli, induced weaker responses than appetitive stimuli. Thus, dopamine neurons preferentially report environmental stimuli with appetitive rather than aversive motivational value.

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The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Classical conditioning II: Current research and theory.
Black, A. H., & Prokasy, W. F. (1972) · Appleton-Century-Crofts eBooks · Cited by 4,449
Brain Dopamine and Reward
Wise, R. A., & Rompre, P.-P. (1989) · Annual Review of Psychology · doi:10.1146/annurev.ps.40.020189.001203 · Cited by 1,968
Toward a modern theory of adaptive networks: Expectation and prediction.
Sutton, R. S., & Barto, A. G. (1981) · Psychological Review · doi:10.1037/0033-295x.88.2.135 · Cited by 1,450
Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning a delayed response task
Schultz, W., Apicella, P., & Ljungberg, T. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-03-00900.1993 · Cited by 1,291
Self-citation
Models of Information Processing in the Basal Ganglia
(1994) · doi:10.7551/mitpress/4708.001.0001 · Cited by 1,190
Differential effect of stress on in vivo dopamine release in striatum, nucleus accumbens, and medial frontal cortex
Abercrombie, E. D., Keefe, K. A., DiFrischia, D. S., & Zigmond, M. J. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09224.x · Cited by 1,106
Responses of monkey dopamine neurons during learning of behavioral reactions
Ljungberg, T., Apicella, P., & Schultz, W. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.67.1.145 · Cited by 987
Self-citation
Contemporary Animal Learning Theory.
Abrahamson, D. (1981) · Europe PMC (PubMed Central) · Cited by 945
Contemporary Animal Learning Theory
LoLordo, V. M., & Dickinson, A. (1982) · The American Journal of Psychology · doi:10.2307/1422669 · Cited by 890

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Fibiger, H. C. & Phillips, A. G. in Handbook of Physiology—The Nervous System IV, (ed. Bloom,F. E.) 647–675 (Williams and Wilkins, Baltimore, 1986).
Gaffan, D. & Harrison, S. J. Neurosci. 7, 2285–2292 (1987).

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Authors: Mirenowicz, J., & Schultz, W.
Affiliations: University of Fribourg (CH)
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1996-02
Volume: 379
Issue: 6564
Pages: 449-451
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/379449a0
OpenAlex: W1979640215
Cited by: 829
References: 33
Citations by year: 2026: 8 · 2025: 16 · 2024: 23 · 2023: 14 · 2022: 22 · 2021: 15 · 2020: 17 · 2019: 19 · 2018: 33 · 2017: 23 · 2016: 34 · 2015: 39 · 2014: 40 · 2013: 46 · 2012: 45
FWCI: 11.74
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: midbrain dopaminergic neurons, appetitive stimuli, aversive stimuli, reward prediction error, motivational value, stimulus salience, reinforcement learning, goal-directed behavior
MeSH terms: Animals, Haplorhini, Appetitive Behavior, Avoidance Learning, Dopamine, Mesencephalon, Neurons

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Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli

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