The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer
Abstract
An abundant cDNA enriched in Spemann's organizer, cerberus, was isolated by differential screening. It encodes a secreted protein that is expressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo.
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“In the extra-cellular matrix, a number of secreted proteins that bind to Wnts and prevent their interaction with either Fz or LRP5/6 to antagonize Wnt signaling have been identified. These include Dickkopf (Dkk) proteins,16 Wnt-inhibitor protein (WIF),17 soluble Frizzled-related proteins (SFRP),18 Cerebrus,19 Frzb20 and the context dependent Wnt inhibitor Wise.21”
From Wnt signal transduction pathways (2008) · cites this paper as [19]
Citations
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Kofron, M. J., Xanthos, J. B., & Heasman, J. (2004) · Springer eBooks · doi:10.1007/978-3-662-10416-3_1
“Some genes, such as goosecoid and cerberus, are expressed almost exclusively on the dorsal side (Steinbeisser and de Robertis 1993; Bouwmeester et al. 1996), while others, including the Xnrs 1, 2 and 4, Xlim 1 and Xhex, have a temporal wave of expression, starting on the dorsal side before the…”
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Minnema, S. E. (2006) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/10915
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Zhao, H. (2002) · DuEPublico (University of Duisburg-Essen)
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Catala, M. (1999) · Rivista di Neuroradiologia · doi:10.1177/19714009990120s302
Dickkopf-1 ou un candidat têtu à l'induction de la tête.
Ott, M. (1998) · médecine/sciences · doi:10.4267/10608/929
“X-cerberus est un autre inducteur de tête, décrit chez le xénope par le groupe de De Robertis (Los Angeles, CA, USA) ; l’injection de son ARN messager dans les embryons de xénope induit la formation de têtes ectopiques [5].”
BackgroundNifuji, A., Ideno, H., Takanabe, R., & Noda, M. (2010)
Spemann's organizer and self- regulation in amphibian embryos
Oversold, L. (2006)
Izzi, L. (2008) · TSpace (University of Toronto)
Xmc, a novel Xenopus laevis organiser : gene regulating gastrulation movements.
Frazzetto, G. (2002) · OpenGrey (Institut de l'Information Scientifique et Technique)
Cooper, B. R. D. (2016) · UCL Discovery (University College London)
Functional analysis of Prdm14 during Xenopus embryogenesis
Berndt, R. P. (2016) · doi:10.53846/goediss-5704
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Westmoreland, J. (2007) · Europe PMC (PubMed Central)
Dawid, I. B. (1999) · Elsevier eBooks · doi:10.1016/b978-012505255-9/50020-1
Wardle, F. C., & Sive, H. L. (2004) · Springer eBooks · doi:10.1007/978-3-662-10416-3_20
Krishnapati, L. S., Khade, S., Trimbake, D., Patwardhan, R., Nadimpalli, S. K., & Ghaskadbi, S. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/510602
“Similarly, Cerberus and Connective tissue growth factor bind to Wnt and BMP, affecting both pathways (Bouwmeester et al., 1996).”
BackgroundLee, J. H. (2018) · TSpace (University of Toronto)
Kiecker, C. M. (2005) · Wiley eBooks · doi:10.1002/9783527619689.ch5
Bene, F. D., & Wittbrodt, J. (2005) · doi:10.1002/9783527619689.ch13
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Signaling Components in Dorsal-Ventral Patterning and the Organizer in Xenopus
Robertis, E. M. D., & Tejeda‐Muñoz, N. (2022) · CRC Press eBooks · doi:10.1201/9781003050230-5
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Shen, M. M. (2007) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1071911.524854
Bovolenta, P. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.725544970.793553991
Positionsinformation, Musterbildung und embryonale Induktion
(2006) · Springer eBooks · doi:10.1007/3-540-29472-4_12
Sakiyama, S. (2002) · Elsevier eBooks · doi:10.1016/b978-012476249-7/50012-6
Hongo, I., Yamaguchi, C., & Okamoto, H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.23.563695
“In particular, cerberus expression does not extend to the dorsal lip of the blastopore (Bouwmeester et al., 1996), whereas chordin expression does (Fig.”
BackgroundInfluentialL’embryologie: d’un vertige l’autre
Nicolas, J.-F. (2023) · Histoire de la recherche contemporaine · doi:10.4000/12e6a
Du, S., Rizou, E. A., & Warmflash, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.07.658391
“Meanwhile, Wnt antagonists are found in the anterior region and are critical for head induction (Bouwmeester et al., 1996; Glinka et al., 1998; Leyns et al., 1997; Shibata et al., 2005; Wang et al., 1997; Yamamoto et al., 2005).”
Molecular mechanisms and clinical implications of Wnt pathway inhibition
Wang, R., & Wang, P. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152806
Type IIA procollagen NH2-propeptide functions as an antagonist of bone morphogenetic proteins
McAlinden, A., Fukui, N., & Sandell, L. J. (2002) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8133-3_1
Embryonic Induction Mechanisms in Vertebrates: Conserved Principles and Flexible Details
Bayramov, A. V., Ermakova, G. V., Kucheryavyy, A. V., & Zaraisky, A. G. (2025) · Paleontological Journal · doi:10.1134/s0031030125600751
“The Cerberus and Dickkopf genes were described as inducers of the anterior (head) region (Bouwmeester et al., 1996; Glinka et al., 1998).”
Lapébie, P. (2010) · theses.fr (ABES) · doi:10.70675/29fb5e58z95e7z4353z8498zaa306e8a2449
Loreti, M. (2017) · theses.fr (ABES) · doi:10.70675/57e0f3d3z704dz4113z974bz4e76939b1c8c
Pan, R., Zou, J., Chen, Y., Yan, Q., Zhong, Y., Qu, Q., & Li, G. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2531024123
An Extra-Embryonic Wnt Signaling Event Controls Gastrulation in Mice: A Dissertation
Tortelote, G. G. (2012) · eScholarship@UMassChan · doi:10.13028/5xx4-8047
“The mouse orthologue of Cerberus (Cerl-1) does not seem to have a high degree of conservation and it is debatable whether it indeed plays a role for Wnt inhibition (Belo et al. 2000; Bouwmeester et al. 1996).”
In Vitro Control of Organogenesis by ActivinA Treatment of Amphibian and Mouse Stem Cells
Asashima, M., Kurisaki, A., & Michiue, T. (2008) · Springer eBooks · doi:10.1007/978-1-4020-8274-0_7
“Subsequent molecular analyses clarified that formation of the head organizer requires several secreted factors including Cerberus, frzb and dickkopf ( Bouwmeester et al., 1996; Wang et al., 1997; Leyns et al., 1997; Glinka et al., 1998).”
BackgroundControl of Development and Homeostasis Via Regulation of BMP, Wnt, and Hedgehog Signaling
Hackenmiller, R., Degnin, C., & Christian, J. L. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-736-9_8
Role for the Axin-RGS domain during embryonic development
Schneider, P. N. (2010) · doi:10.17077/etd.1lixw2of
“These genes are important during D-V axis and notochord formation (Bouwmeester et al., 1996; Piccolo et al., 1996; Smith and Harland, 1992).”
BackgroundDelaspre, F. (2011) · Repositori digital de la UPF (Universitat Pompeu Fabra)
Metadata
- Authors
- Bouwmeester, T., Kim, S.-H., Sasai, Y., Lu, B., & Robertis, E. M. D.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Nature
- Published
- 1996-08
- Volume
- 382
- Issue
- 6592
- Pages
- 595-601
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2081939122
- Cited by
- 759
- References
- 44
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 15 · 2023: 11 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 6 · 2018: 10 · 2017: 13 · 2016: 14 · 2015: 14 · 2014: 10 · 2013: 21 · 2012: 23
- FWCI
- 23.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- Cerberus, Spemann's organizer, anterior endoderm, secreted proteins, head induction, Xenopus embryo, gene expression, embryonic induction
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Blastomeres, Digestive System, Embryonic Induction, Endoderm, Gastrula, Head, Mesoderm, Molecular Sequence Data, Proteins, RNA, Messenger, Tail, Ultraviolet Rays, Xenopus, Cell Polarity, In Situ Hybridization, DNA Primers, DNA, Complementary, Xenopus Proteins, Intercellular Signaling Peptides and Proteins
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