Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

Bouwmeester, Tewis, Kim, Sung-Hyun, Sasai, Yoshiki, Lu, Bin, Robertis, Eddy M. De·1996·Nature
DOI 10.1038/382595a0

Cited by (754)

Items 101–200 of 754

  1. Spemann’s organizer and the self-regulation of embryonic fields
    Edward M. De Robertis · 2009 · Mechanisms of Development
  2. Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo
    Caroline Erter Burns, Thomas P. Wilm, Nathan Basler, Christopher V.E. Wright, Lilianna Solnica‐Krezel · 2001 · Development
  3. Mixer , a Homeobox Gene Required for Endoderm Development
    Gilbert Lee Henry, Douglas A. Melton · 1998 · Science
  4. TheXenopusreceptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling
    Hiroki Hikasa, Mikihito Shibata, Ichiro Hiratani, Masanori Taira · 2002 · Development
  5. Global expression analysis of gene regulatory pathways during endocrine pancreatic development
    Gu, Guoqiang, Wells, James M., Dombkowski, David, Preffer, Fred, Aronow, Bruce, Melton, Douglas A. · 2004 · Development
  6. Head in the WNT: the molecular nature of Spemann’s head organizer
    Christof Niehrs · 1999 · Trends in Genetics
  7. Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning
    Volker Gawantka, Nicolas Pollet, Hajo Delius, Martin Vingron, Ralf Pfister, Rebecca Nitsch, Claudia Blumenstock, Christof Niehrs · 1998 · Mechanisms of Development
  8. The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo
    Marc Hild, Alexander Dick, Gerd-Jörg Rauch, Andrea Meier, Tewis Bouwmeester, Pascal Haffter, Matthias Hammerschmidt · 1999 · Development
  9. Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex
    Foley, Ann C., Mercola, Mark · 2005 · Genes & Development
  10. Xenopus research: metamorphosed by genetics and genomics
    Richard M. Harland, Robert M. Grainger · 2011 · Trends in Genetics
  11. Making Senses
    Gerhard Schlosser · 2010 · International review of cytology
  12. Neural Induction in Xenopus: Requirement for Ectodermal and Endomesodermal Signals via Chordin, Noggin, β-Catenin, and Cerberus
    Hiroki Kuroda, Oliver Wessely, Edward M. De Robertis · 2004 · PLoS Biology
  13. BMP-2 induces ectopic expression of cardiac lineage markers and interferes with somite formation in chicken embryos
    Birgit Andrée, Delphine Duprez, Britta Vorbusch, Hans-Henning Arnold, Thomas Brand · 1998 · Mechanisms of Development
  14. Dickkopf genes are co-ordinately expressed in mesodermal lineages
    Ann Paula Monaghan, Petra Kioschis, Wei Wu, Aimée Zúñiga, Dagmar Bock, Annemarie Poustka, Hajo Delius, Christof Niehrs · 1999 · Mechanisms of Development
  15. FGF signaling is necessary for establishing gut tube domains alongthe anterior–posterior axis in vivo
    Jessica Sordet‐Dessimoz, Robert J. Opoka, Jennifer J. Kordich, Anne Grapin‐Botton, James M. Wells · 2005 · Mechanisms of Development
  16. Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis
    Shin‐Ichi Osada, Christopher V.E. Wright · 1999 · Development
  17. Zebrafish Dkk1 Functions in Forebrain Specification and Axial Mesendoderm Formation
    Hisashi Hashimoto, Motoyuki Itoh, Yojiro Yamanaka, Susumu Yamashita, Takashi Shimizu, Lilianna Solnica-Krezel, Masahiko Hibi, Toshio Hirano · 2000 · Developmental Biology
  18. Transient depletion of xDnmt1 leads to premature gene activation in Xenopus embryos
    Irina Stancheva, Richard R. Meehan · 2000 · Genes & Development · Retracted
  19. Murine Cerberus Homologue mCer-1: A Candidate Anterior Patterning Molecule
    Christine Biben, Edouard G. Stanley, Louis Fabri, Surendra Kotecha, Muriel Rhinn, Catherine C. Drinkwater, Myoung Soo Lah, C-C. Wang, Andrew D. Nash, Douglas J. Hilton et al. · 1998 · Developmental Biology
  20. Shisa Promotes Head Formation through the Inhibition of Receptor Protein Maturation for the Caudalizing Factors, Wnt and FGF
    Akihito Yamamoto, Takashi Nagano, Shoko Takehara, Masahiko Hibi, Shinichi Aizawa · 2005 · Cell
  21. Wnt Signaling in Vertebrate Axis Specification
    Hiroki Hikasa, Sergei Y. Sokol · 2012 · Cold Spring Harbor Perspectives in Biology
  22. Distinct roles for visceral endoderm during embryonic mouse development
    Małgorzata Bielińska, Naoko Narita, David Brown Wilson · 1999 · The International Journal of Developmental Biology
  23. The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
    Sara Marques, Ana Cristina Borges, Ana Cristina Silva, Sandra Freitas, Michelangelo Cordenonsi, José António Belo · 2004 · Genes & Development
  24. Parsing the prosencephalon
    Murielle Rallu, Joshua G. Corbin, Gord Fishell · 2002 · Nature reviews. Neuroscience
  25. Antagonistic Signaling by Caronte , a Novel Cerberus -Related Gene, Establishes Left–Right Asymmetric Gene Expression
    Yuji Yokouchi, Kyle J. Vogan, Richard V. Pearse, Clifford James Tabin · 1999 · Cell
  26. Regulation of vertebrate eye development by Rx genes
    Travis J. Bailey, Heithem M. El‐Hodiri, Li Zhang, Rina Shah, Eter H. Mathers, Milan Jamrich · 2004 · The International Journal of Developmental Biology
  27. Bix1, a direct target of Xenopus T-box genes, causes formation of ventral mesoderm and endoderm
    Masazumi Tada, Elena Silva Casey, Lucy C. Fairclough, James C. Smith · 1998 · Development
  28. Asymmetric expression of the BMP antagonists chordin and gremlin in the sea anemone Nematostella vectensis: Implications for the evolution of axial patterning
    Fabian Rentzsch, Roman Anton, Michael Saina, Matthias Hammerschmidt, Thomas W. Holstein, Ulrich Technau · 2006 · Developmental Biology
  29. Anterior Endomesoderm Specification inXenopusby Wnt/β-catenin and TGF-β Signalling Pathways
    Aaron M. Zorn, Karen Butler, John Bertrand Gurdon · 1999 · Developmental Biology
  30. Neural Induction
    Daniel C. Weinstein, Ali Hemmati‐Brivanlou · 1999 · Annual Review of Cell and Developmental Biology
  31. Zebrafish nodal-related 2Encodes an Early Mesendodermal Inducer Signaling from the Extraembryonic Yolk Syncytial Layer
    Caroline Erter Burns, Lilianna Solnica-Krezel, Christopher V.E. Wright · 1998 · Developmental Biology
  32. Inhibin Is an Antagonist of Bone Morphogenetic Protein Signaling
    Ezra Wiater, Wylie Vale · 2003 · Journal of Biological Chemistry
  33. Xenopus Cdc42 Regulates Convergent Extension Movements during Gastrulation through Wnt/Ca2+ Signaling Pathway
    Sun‐Cheol Choi, Jin‐Kwan Han · 2002 · Developmental Biology
  34. Axis determination by inhibition of Wnt signaling in Xenopus
    Ken Itoh, Sergei Y. Sokol · 1999 · Genes & Development
  35. BMP antagonists: Their roles in development and involvement in pathophysiology
    Motoko Yanagita · 2005 · Cytokine & Growth Factor Reviews
  36. Crosstalk between Wnt and bone morphogenic protein signaling: A turbulent relationship
    Nobue Itasaki, Stefan Hoppler · 2009 · Developmental Dynamics
  37. Tissues and signals involved in the induction of placodal Six1 expression in Xenopus laevis
    Katja Ahrens, Gerhard Schlosser · 2005 · Developmental Biology
  38. Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation in the mouse
    William Shawlot, Maki Wakamiya, Kin Ming Kwan, Artur Kania, Thomas M. Jessell, Richard R. Behringer · 1999 · Development
  39. Early induction of neural crest cells: lessons learned from frog, fish and chick
    Manuel Javier Aybar, Roberto Mayor · 2002 · Current Opinion in Genetics & Development
  40. TGF-β Family Signaling in Early Vertebrate Development
    Joseph M. Zinski, Benjamin J. Tajer, Mary C. Mullins · 2017 · Cold Spring Harbor Perspectives in Biology
  41. Anterior specification of embryonic ectoderm: the role of the Xenopus cement gland-specific gene XAG-2
    Fritz Aberger, Gilbert Weidinger, Horst Grunz, Klaus Richter · 1998 · Mechanisms of Development
  42. Biosynthesis, Post-translation Modification, and Functional Characterization of Drm/Gremlin
    Lilia Z. Topol, Boris Bardot, Qingyun Zhang, James Resau, Emmanuelle Huillard, Maria Marx, Georges Calothy, Donald G. Blair · 2000 · Journal of Biological Chemistry
  43. Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation
    Dario Acampora, Virginia Avantaggiato, Francesca Tuorto, Paola Briata, Giorgio Corte, Antonio Simeone · 1998 · Development
  44. The molecular and morphogenetic basis of pancreas organogenesis
    Hjalte List Larsen, Anne Grapin‐Botton · 2017 · Seminars in Cell and Developmental Biology
  45. Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning
    Gary R. Davidson, Bingyu Mao, Iván del Barco Barrantes, Christof Niehrs · 2002 · Development
  46. Cell fate specification and competence by Coco, a maternal BMP, TGFβand Wnt inhibitor
    Esther J. de H. Bell, Ignacio Muñoz-Sanjuán, Curtis R. Altmann, Alin Vonica, Ali H. Brivanlou · 2003 · Development
  47. Misexpression of Cwnt8C in the mouse induces an ectopic embryonic axis and causes a truncation of the anterior neuroectoderm
    Heike Pöpperl, Christel Schmidt, Valerie A. Wilson, R.C. Hume, Jane Dodd, Robb K. Krumlauf, Rosa S. P. Beddington · 1997 · Development
  48. Chordin Is Required for the Spemann Organizer Transplantation Phenomenon in Xenopus Embryos
    Michael Oelgeschläger, Hiroki Kuroda, Bruno Reversade, Edward M. De Robertis · 2003 · Developmental Cell
  49. FGF Signaling and the Anterior Neural Induction in Xenopus
    Ikuko Hongo, Mineko Kengaku, Harumasa Okamoto · 1999 · Developmental Biology
  50. Pre-bilaterian origin of the blastoporal axial organizer
    Kraus, Yulia, Aman, Andy, Technau, Ulrich, Genikhovich, Grigory · 2016 · Nature Communications
  51. IN VIVO SOMATIC CELL GENE TRANSFER OF AN ENGINEERED NOGGIN MUTEIN PREVENTS BMP4-INDUCED HETEROTOPIC OSSIFICATION
    David L. Glaser, Aris N. Economides, Lili Wang, Xia Liu, ROBERT D. KIMBLE, James P. Fandl, James M. Wilson, Neil Stahl, Frederick S. Kaplan, Eileen Malko Shore · 2003 · Journal of Bone and Joint Surgery
  52. The GAL4 system : a versatile system for the expression of genes.
    D. Elliott, Andrea H. Brand · 2008 · Methods in molecular biology
  53. USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney
    Motoko Yanagita, Masako Oka, Tetsuro Watabe, Haruhisa Iguchi, Atsushi Niida, Satoru Takahashi, Tetsu Akiyama, Kohei Miyazono, Masashi Yanagisawa, Takeshi Sakurai · 2004 · Biochemical and Biophysical Research Communications
  54. The XHex homeobox gene is expressed during development of the vascular endothelium: overexpression leads to an increase in vascular endothelial cell number
    Craig S. Newman, Frank Chia, Paul A. Krieg · 1997 · Mechanisms of Development
  55. The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning
    Olga Kazanskaya, Andrei Glinka, Christof Niehrs · 2000 · Development
  56. The TINS Lecture. Understanding the roles of Otx1 and Otx2 in the control of brain morphogenesis.
    D. Acampora, A. Simeone · 1999 · Trends in Neurosciences
  57. Otx1 and Otx2 in the development and evolution of the mammalian brain
    Antonio Simeone · 1998 · The EMBO Journal
  58. Siamois is required for formation of Spemann’s organizer
    Daniel S. Kessler · 1997 · Proceedings of the National Academy of Sciences
  59. Anterior patterning by synergistic activity of the early gastrula organizer and the anterior germ layer tissues of the mouse embryo
    Patrick Tam, Kirsten A. Steiner · 1999 · Development
  60. BMP Signaling and Skeletogenesis
    Xuelin Li, Xu Cao · 2006 · Annals of the New York Academy of Sciences
  61. Molecular Mechanisms of Holoprosencephaly
    DEEANN E. WALLIS, Maximilian Muenke · 1999 · Molecular Genetics and Metabolism
  62. HNF3β and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo
    Aitana Perea-Gómez, William Shawlot, Hiroshi Sasaki, Richard R. Behringer, Siew‐Lan Ang · 1999 · Development
  63. Vertebrate Neural Induction: Inducers, Inhibitors, and a New Synthesis
    Paul A. Wilson, Ali Hemmati‐Brivanlou · 1997 · Neuron
  64. FGF2 Specifies hESC‐Derived Definitive Endoderm into Foregut/Midgut Cell Lineages in a Concentration‐Dependent Manner
    Jacqueline Ameri, A. Ståhlberg, J. Pedersen, J. Johansson, M. Johannesson, I. Artner, H. Semb · 2009 · Stem Cells
  65. Vegetal rotation, a new gastrulation movement involved in the internalization of the mesoderm and endoderm in Xenopus
    Rudolf Winklbauer, Matthias Schürfeld · 1999 · Development
  66. The roles of three signaling pathways in the formation and function of the Spemann Organizer
    Jennifer B. Xanthos, Matthew J. Kofron, Qinghua Tao, Kyle Schaible, Christopher C. Wylie, Janet Heasman · 2002 · Development
  67. Endogenous Gradients of Resting Potential Instructively Pattern Embryonic Neural Tissue via Notch Signaling and Regulation of Proliferation
    Vaibhav P. Pai, Joan M. Lemire, Jean‐François Paré, Gufa Lin, Ying Chen, Michael G. Levin · 2015 · Journal of Neuroscience
  68. Expression of the mouse cerberus -related gene, Cerr1 , suggests a role in anterior neural induction and somitogenesis
    William Shawlot, Jian Min Deng, Richard R. Behringer · 1998 · Proceedings of the National Academy of Sciences
  69. Cerberus regulates left–right asymmetry of the embryonic head and heart
    Lei Zhu, Martha J. Marvin, Aaron Gardiner, Andrew B. Lassar, Mark A. Mercola, Claudio D. Stern, Michael G. Levin · 1999 · Current Biology
  70. Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies
    Yasuko Onuma, Shuji Takahashi, Makoto Asashima, Shoichiro Kurata, Walter J. Gehring · 2002 · Proceedings of the National Academy of Sciences
  71. The lefty-related factor Xatv acts as a feedback inhibitor of Nodal signaling in mesoderm induction and L-R axis development in Xenopus
    Abby M. S. Cheng, Bernard Thisse, Christine Thisse, Christopher V.E. Wright · 2000 · Development
  72. Determination of the zebrafish forebrain: induction and patterning
    Yevgenya Grinblat, Joshua T. Gamse, Mukesh Patel, Hazel L. Sive · 1998 · Development
  73. A role for the vegetally expressed Xenopus gene Mix.1 in endoderm formation and in the restriction of mesoderm to the marginal zone
    Patrick Lemaire, Sébastien Darras, Danielle H. Caillol, Laurent Kodjabachian · 1998 · Development
  74. Cellular strategies for retinal repair by photoreceptor replacement
    Sujatha A. Jayakody, Anai Gonzalez-Cordero, Robin R. Ali, Rachael A. Pearson · 2015 · Progress in Retinal and Eye Research
  75. Increased XRALDH2 activity has a posteriorizing effect on the central nervous system of Xenopus embryos
    Yonglong Chen, Nicolas Pollet, Christof Niehrs, Tomas Pieler · 2001 · Mechanisms of Development
  76. Active repression of RAR signaling is required for head formation
    Tetsuya Koide, Michael Downes, Roshantha A.S. Chandraratna, Bruce Blumberg, Kazuhiko Umesono · 2001 · Genes & Development
  77. An eye on eye development
    Rebecca Sinn, Joachim Wittbrodt · 2013 · Mechanisms of Development
  78. Signaling Specificity by Frizzled Receptors in Drosophila
    Michael Boutros, József Mihály, Tewis Bouwmeester, Marek Mlodzik · 2000 · Science
  79. The Xenopus tadpole gut: fate maps and morphogenetic movements
    Andrew D. Chalmers, Jonathan M.W. Slack · 2000 · Development
  80. Neural Induction in the Absence of Mesoderm: β-Catenin-Dependent Expression of Secreted BMP Antagonists at the Blastula Stage in Xenopus
    Oliver Wessely, Eric Agius, Michael Oelgeschläger, Edgar M. Pera, Edward M. De Robertis · 2001 · Developmental Biology
  81. A role for GATA5 in Xenopus endoderm specification
    Heike Weber, Carole E. Symes, Maggie E. Walmsley, Adam Rodaway, Roger K. Patient · 2000 · Development
  82. Rearranging gastrulation in the name of yolk: evolution of gastrulation in yolk-rich amniote eggs
    Detlev Arendt, Katharina Nübler‐Jung · 1999 · Mechanisms of Development
  83. Lefty-Dependent Inhibition of Nodal- and Wnt-Responsive Organizer Gene Expression Is Essential for Normal Gastrulation
    William W. Branford, H. Joseph Yost · 2002 · Current Biology
  84. Molecular specification of germ layers in vertebrate embryos
    Clemens Martin Kiecker, Thomas J. D. Bates, Esther J. de H. Bell · 2015 · Cellular and Molecular Life Sciences
  85. Zebrafish Dkk1, induced by the pre-MBT Wnt signaling, is secreted from the prechordal plate and patterns the anterior neural plate
    Minori Shinya, Cathrin Eschbach, Matthew D. Clark, Hans Rudolf Lehrach, Makoto Furutani‐Seiki · 2000 · Mechanisms of Development
  86. Molecular mechanisms controlling brain development: an overview of neuroepithelial secondary organizers
    Claudia Vieira, Ana Pombero, Raquel García‐López, Lourdes Gimeno, Diego Echevarrı́a, Salvador Martı́nez · 2009 · The International Journal of Developmental Biology
  87. Involvement of the small GTPases XRhoA and XRnd1 in cell adhesion and head formation in early Xenopus development
    Katrin Wünnenberg-Stapleton, Ira L. Blitz, Chikara Hashimoto, Ken W.Y. Cho · 1999 · Development
  88. Vg1 is an essential signaling molecule in Xenopus development
    Bilge Birsoy, Matthew J. Kofron, Kyle Schaible, Chris Wylie, Janet Heasman · 2005 · Development
  89. A direct screen for secreted proteins in Xenopus embryos identifies distinct activities for the Wnt antagonists Crescent and Frzb-1
    Edgar M. Pera, Edward M. De Robertis · 2000 · Mechanisms of Development
  90. Identification of drm , a Novel Gene Whose Expression Is Suppressed in Transformed Cells and Which Can Inhibit Growth of Normal but Not Transformed Cells in Culture
    Lilia Z. Topol, Maria Marx, Danielle Laugier, Natalia N. Bogdanova, Nikolai V. Boubnov, Peter A. Clausen, Georges Calothy, Donald G. Blair · 1997 · Molecular and Cellular Biology
  91. The Wnt/β-Catenin Pathway Posteriorizes Neural Tissue in Xenopus by an Indirect Mechanism Requiring FGF Signalling
    Pedro Manuel Dias Neto Domingos, Nobue Itasaki, C. Michael Jones, Sara Mercurio, Michael G. Sargent, James C. Smith, Robb K. Krumlauf · 2001 · Developmental Biology
  92. Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain
    Marc E. R. Hallonet, Thomas Hollemann, Roland Wehr, Nancy A. Jenkins, Neal G. Copeland, Tomas Pieler, Peter Gruß · 1998 · Development
  93. Timing of endogenous activin-like signals and regional specification of theXenopusembryo
    Michelle A. Lee, Janet Heasman, Malcolm Whitman · 2001 · Development
  94. FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo
    Minoru Watanabe, Malcolm Whitman · 1999 · Development
  95. Notochord Patterning of the Endoderm
    Cleaver, Ondine, Krieg, Paul A · 2001 · Developmental Biology
  96. Functional and biochemical interactions of Wnts with FrzA, a secreted Wnt antagonist
    Qihong Xu, Patrìcia A. D'Amore, Sergei Y. Sokol · 1998 · Development
  97. Closing the gaps among a web of DNA repair disorders
    Rhett J. Michelson, Ted A. Weinert · 2000 · BioEssays
  98. Differentiation of human embryonic stem cells into cone photoreceptors through simultaneous inhibition of BMP, TGFβ and Wnt signaling
    Shufeng Zhou, Anthony Flamier, Mohamed Abdouh, Nicolas Tétreault, Andrea Barabino, Shashi Wadhwa, Gilbert Bernier · 2015 · Development
  99. Extracellular modulation of BMP activity in patterning the dorsoventral axis
    Shawn C. Little, Mary C. Mullins · 2006 · Birth Defects Research Part C Embryo Today Reviews
  100. Bone Morphogenetic Proteins Induce Gremlin, a Protein That Limits Their Activity in Osteoblasts1
    Renata C. Pereira, Aris N. Economides, ERNESTO M. CANALIS · 2000 · Endocrinology