Cited by 1,736Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

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Synaptic tagging and long-term potentiation

Frey, Uwe, Morris, Richard G. M.·1997·Nature

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Abstract

Repeated stimulation of hippocampal neurons can induce an immediate and prolonged increase in synaptic strength that is called long-term potentiation (LTP)-the primary cellular model of memory in the mammalian brain. An early phase of LTP (lasting less than three hours) can be dissociated from late-phase LTP by using inhibitors of transcription and translation, Because protein synthesis occurs mainly in the cell body, whereas LTP is input-specific, the question arises of how the synapse specificity of late LTP is achieved without elaborate intracellular protein trafficking. We propose that LTP initiates the creation of a short-lasting protein-synthesis-independent 'synaptic tag' at the potentiated synapse which sequesters the relevant protein(s) to establish late LTP. In support of this idea, we now show that weak tetanic stimulation, which ordinarily leads only to early LTP, or repeated tetanization in the presence of protein-synthesis inhibitors, each results in protein-synthesis-dependent late LTP, provided repeated tetanization has already been applied at another input to the same population of neurons. The synaptic tag decays in less than three hours. These findings indicate that the persistence of LTP depends not only on local events during its induction, but also on the prior activity of the neuron.

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“To ensure that local protein synthesis is restricted to the relevant synapses, either through the local capture or translation of mRNAs only in speciﬁc synapses, a ’’synaptic tag’’ has been postulated (Frey and Morris, 1997; Martin et al., 1997).”
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“Such a mechanism, which has also been proposed for hippocampal synaptic plasticity (Frey and Morris, 1997), accounts for how cell-wide changes in gene expression can lead to long-term, synapse-specific plasticity (Frey and Morris, 1997; Martin et al., 1997b).”
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Authors: Frey, U., & Morris, R. G. M.
ORCID: Morris, Richard G. M.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1997-02
Volume: 385
Issue: 6616
Pages: 533-536
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/385533a0
OpenAlex: W2011882079
Cited by: 1,736
References: 25
Citations by year: 2026: 56 · 2025: 48 · 2024: 94 · 2023: 65 · 2022: 75 · 2021: 78 · 2020: 69 · 2019: 68 · 2018: 72 · 2017: 66 · 2016: 72 · 2015: 78 · 2014: 104 · 2013: 56 · 2012: 59
FWCI: 17.67
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: synaptic tagging, long-term potentiation, late-phase LTP, protein synthesis, hippocampal neurons, tetanic stimulation, synaptic specificity, memory, synaptic plasticity
MeSH terms: Animals, Anisomycin, Electric Stimulation, Evoked Potentials, Hippocampus, Male, Memory, Models, Neurological, Protein Synthesis Inhibitors, Synapses, Protein Biosynthesis, Rats, Wistar, Long-Term Potentiation, Rats, In Vitro Techniques

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Synaptic tagging and long-term potentiation

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