Long-Term Effects of Brief Acute Stress on Cellular Signaling and Hippocampal LTP
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In a previous study, we reported that a brief exposure to swim stress transforms an electrically induced, protein synthesis-independent early long-term potentiation (early LTP) into a protein synthesis-dependent late LTP [“reinforcement of LTP” in the hippocampal dentate gyrus (DG)] (Korz and Frey, 2003). This transformation depends on activation of mineralocorticoid receptors (MRs) by corticosterone, and on intact basolateral amygdala (BLA) function. Here, we demonstrate that a brief swim experience results in lasting changes in levels of hippocampal cellular signaling molecules that are known to be involved in the induction of late LTP. Within the DG, MRs were rapidly upregulated, whereas glucocorticoid receptor (GR) levels were elevated with a 3 h delay. Levels of phosphorylated mitogen-activated protein kinase 2 (pMAPK2) and p38 MAPK, as well as phosphorylated calcium/calmodulin-dependent protein kinase II (pCaMKII) were enhanced shortly after swim stress and remained elevated until 24 h, whereas levels of phosphorylated cAMP response element-binding protein (pCREB) remained unchanged. MR and GR were upregulated with a longer delay within the CA1 region, whereas levels of pMAPK2 and p38MAPK were rapidly increased, but the former returned to basal levels after 3 h. Levels of pCREB and pCaMKII were maintained in an enhanced state after swim stress. DG-LTP reinforcement requires a serotonergic but not dopaminergic heterosynaptic receptor activation that probably mediates the BLA-dependent modulation of LTP under stress. Thus, molecular alterations induced by specific stress resemble late LTP-related molecular changes. These changes, in interaction with stress-specific heterosynaptic processes, may support the transformation of early LTP into late LTP. The results contribute to the understanding of the rapid consolidation of cellular and possibly systemic memories triggered by stress.
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Brief stress transforms protein synthesis-independent LTP into a long-lasting protein synthesis-dependent form of LTP, via activation of mineralocorticoid (MR) receptors.
“Ahmed et al. [209] demonstrated that brief stress transforms protein synthesis-independent LTP into a long-lasting protein synthesis-dependent form of LTP, via activation of mineralocorticoid (MR) receptors.”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Ahmed et al. [209]
The onset of an emotional experience activates endogenous forms of neuroplasticity in the hippocampus for a period of seconds to minutes, which is revealed as an enhancement of LTP when tetanizing stimulation occurs in this narrow-time window.
“According to the temporal dynamics model, the onset of an emotional experience activates endogenous forms of neuroplasticity in the hippocampus for a period of seconds to minutes, which is revealed as an enhancement of LTP when tetanizing stimulation occurs in this narrow-time window (Ahmed et al. [209]; Reymann and Frey [242]).”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Ahmed et al. [209]
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- Authors
- Ahmed, T., Frey, J. U., & Korz, V.
- Affiliations
- Leibniz Institute for Neurobiology (DE)
- University of Bayreuth (DE)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-04-12
- Volume
- 26
- Issue
- 15
- Pages
- 3951-3958
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673904
- OpenAlex
- W2013192604
- Cited by
- 111
- References
- 71
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 5 · 2018: 2 · 2017: 8 · 2016: 7 · 2015: 1 · 2014: 4 · 2013: 6 · 2012: 8
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- acute stress, swim stress, long-term potentiation, dentate gyrus, hippocampus, mineralocorticoid receptor, glucocorticoid receptor, p38 MAPK, CaMKII, CREB, basolateral amygdala, memory consolidation, corticosterone
- MeSH terms
- Animals, Benzazepines, Disease Models, Animal, Electrophysiology, Hippocampus, Male, Stress, Psychological, Swimming, Time Factors, Signal Transduction, Rats, Wistar, Dopamine Antagonists, Rats
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