Cited by 136Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

A Functional Role for CREB as a Positive Regulator of Memory Formation and LTP

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Kida, Satoshi·2012·Experimental Neurobiology

Abstract

Short-term memory (STM) persists for several hours at most, while long-term memory (LTM) can last for up to a lifetime.The process underlying the formation of LTM is called memory consolidation [1].A clear biochemical feature of memory consolidation at the cellular level, which occurs immediately after learning (an episode), is the induction of gene expression.This gene expression is considered to induce plastic changes in neurons, thereby allowing the long-term retention of memory.For example, experiments in rodents using a Pavlovian fear conditioning task and other tasks showed that when gene expression in the brain was inhibited immediately after conditioning (learning), STM (up to 2-4 h) was intact, but LTM (approximately 24 h) was disrupted [2, 3].These findings indicate that memory consolidation is dependent on the activation of gene expression.In addition, long-term potentiation (LTP) is considered to be a cellular model that reflects one aspect of memory formation.Field recording analyses showed that long-lasting LTP (L-LTP) induced by tetanic stimulation of hippocampal CA1 neurons also requires gene expression; the inhibition of gene expression impairs L-LTP without affecting the induction or early phase of LTP [1,3]. CREB, MEMORY FORMATION, AND LTPCREB was cloned in 1988 as a transcription factor that binds to the cAMP-responsive element (CRE) [4].Subsequent studies showed that CREB belongs to the CREB/ATF family together A Functional Role for CREB as a Positive Regulator of Memory Formation and LTP

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Authors
Kida, S.
Affiliations
Tokyo University of Agriculture (JP)
Corresponding author
Kida, Satoshi
Venue
Experimental Neurobiology
Published
2012-12-30
Volume
21
Issue
4
Pages
136-140
ISSN
  • 1226-2560 (ISSN-L)
  • 2093-8144
OpenAlex
W2148920387
Cited by
136
References
25
Citations by year
2026: 9 · 2025: 13 · 2024: 10 · 2023: 8 · 2022: 10 · 2021: 11 · 2020: 12 · 2019: 7 · 2018: 9 · 2017: 11 · 2016: 10 · 2015: 6 · 2014: 13 · 2013: 7
FWCI
4.26
Type
journal article
Language
en
Open access
Locations
  • Experimental Neurobiology (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • Takeda Science Foundation (24116008 and 23115716)
  • Sumitomo Foundation
  • Japan Society for the Promotion of Science (18022038, 20380078, 18580129, 23300120)
  • Core Research for Evolutional Science and Technology
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
CREB, long-term memory, memory consolidation, long-term potentiation, gene expression, transcription factors, cAMP response element, synaptic plasticity, CA1 pyramidal neurons, fear conditioning

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