A Functional Role for CREB as a Positive Regulator of Memory Formation and LTP
Open accessAbstract
Short-term memory (STM) persists for several hours at most, while long-term memory (LTM) can last for up to a lifetime.The process underlying the formation of LTM is called memory consolidation [1].A clear biochemical feature of memory consolidation at the cellular level, which occurs immediately after learning (an episode), is the induction of gene expression.This gene expression is considered to induce plastic changes in neurons, thereby allowing the long-term retention of memory.For example, experiments in rodents using a Pavlovian fear conditioning task and other tasks showed that when gene expression in the brain was inhibited immediately after conditioning (learning), STM (up to 2-4 h) was intact, but LTM (approximately 24 h) was disrupted [2, 3].These findings indicate that memory consolidation is dependent on the activation of gene expression.In addition, long-term potentiation (LTP) is considered to be a cellular model that reflects one aspect of memory formation.Field recording analyses showed that long-lasting LTP (L-LTP) induced by tetanic stimulation of hippocampal CA1 neurons also requires gene expression; the inhibition of gene expression impairs L-LTP without affecting the induction or early phase of LTP [1,3]. CREB, MEMORY FORMATION, AND LTPCREB was cloned in 1988 as a transcription factor that binds to the cAMP-responsive element (CRE) [4].Subsequent studies showed that CREB belongs to the CREB/ATF family together A Functional Role for CREB as a Positive Regulator of Memory Formation and LTP
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
LTF and LTP both rely on cooperative gene induction by pCREB and CBP.
“and both rely on cooperative gene induction by pCREB and CBP53,96,99,100.”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [100]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
Gonzalez, G. A., & Montminy, M. (1989) · Cell · doi:10.1016/0092-8674(89)90013-5 · Cited by 2,464 · see citing works
Phosphorylated CREB binds specifically to the nuclear protein CBP
Chrivia, J. C., Kwok, R. P. S., Lamb, N., Hagiwara, M., Montminy, M. R., & Goodman, R. H. (1993) · Nature · doi:10.1038/365855a0 · Cited by 2,052 · see citing works
Bourtchuladze, R., Frenguelli, B., Blendy, J., Cioffi, D., Schutz, G., & Silva, A. J. (1994) · Cell · doi:10.1016/0092-8674(94)90400-6 · Cited by 1,800 · see citing works
Synaptic tagging and long-term potentiation
Frey, U., & Morris, R. G. M. (1997) · Nature · doi:10.1038/385533a0 · Cited by 1,736 · see citing works
CREB: a Ca 2+ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases
Sheng, M., Thompson, M. A., & Greenberg, M. E. (1991) · Science · doi:10.1126/science.1646483 · Cited by 1,498 · see citing works
Silva, A. J., Kogan, J. H., Frankland, P. W., & Kida, S. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.127 · Cited by 1,462 · see citing works
Self-citationGAL4-VP16 is an unusually potent transcriptional activator
Sadowski, I., Ma, J., Triezenberg, S., & Ptashne, M. (1988) · Nature · doi:10.1038/335563a0 · Cited by 1,298 · see citing works
CREB: A Major Mediator of Neuronal Neurotrophin Responses
Finkbeiner, S. M., Tavazoie, S. F., Maloratsky, A., Jacobs, K. M., Harris, K. M., & Greenberg, M. E. (1997) · Neuron · doi:10.1016/s0896-6273(00)80395-5 · Cited by 950 · see citing works
The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB
Kandel, E. R. (2012) · Molecular Brain · doi:10.1186/1756-6606-5-14 · Cited by 904 · see citing works
Gonzalez, G. A., Yamamoto, K. K., Fischer, W. H., Karr, D., Menzel, P., Biggs, W., Vale, W., & Montminy, M. (1989) · Nature · doi:10.1038/337749a0 · Cited by 893 · see citing works
Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP
Nguyen, P. V., Abel, T., & Kandel, E. R. (1994) · Science · doi:10.1126/science.8066450 · Cited by 888 · see citing works
Making memories last: the synaptic tagging and capture hypothesis
Redondo, R. L., & Morris, R. G. M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2963 · Cited by 792 · see citing works
Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA
Hoeffler, J. P., Meyer, T. E., Yun, Y., Jameson, J. L., & Habener, J. F. (1988) · Science · doi:10.1126/science.2974179 · Cited by 731 · see citing works
CREB required for the stability of new and reactivated fear memories
Kida, S., Josselyn, S. A., de Ortı́z, S. P., Kogan, J. H., Chévere-Torres, I., Masushige, S., & Silva, A. J. (2002) · Nature Neuroscience · doi:10.1038/nn819 · Cited by 624 · see citing works
Self-citationBarco, A., Alarcon, J. M., & Kandel, E. (2002) · Cell · doi:10.1016/s0092-8674(02)00657-8 · Cited by 595 · see citing works
Pittenger, C., Huang, Y. Y., Paletzki, R. F., Bourtchouladze, R., Scanlin, H., Vronskaya, S., & Kandel, E. R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00684-0 · Cited by 464 · see citing works
Barco, Á., Patterson, S., Alarcón, J. M., Gromova, P., Mata, M., Morozov, A., & Kandel, E. R. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.005 · Cited by 332 · see citing works
The CREB family of transcription activators
Brindle, P. K., & Montminy, M. (1992) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(05)80274-6 · Cited by 298 · see citing works
Kawashima, T., Okuno, H., Nonaka, M., Adachi-Morishima, A., Yagishita-Kyo, N., Okamura, M., Takemoto‐Kimura, S., Worley, P. F., & Bito, H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806518106 · Cited by 251 · see citing works
Upregulation of CREB-Mediated Transcription Enhances Both Short- and Long-Term Memory
Suzuki, A., Fukushima, H., Mukawa, T., Toyoda, H., Wu, L.-J., Zhao, M.-G., Xu, H., Shang, Y., Endoh, K., Iwamoto, T., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3257-10.2011 · Cited by 250 · see citing works
Self-citationRecruitment of CREB Binding Protein Is Sufficient for CREB-Mediated Gene Activation
Cardinaux, J.-R., Notis, J. C., Zhang, Q., Vo, N., Craig, J. C., Fass, D. M., Brennan, R. G., & Goodman, R. H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1546-1552.2000 · Cited by 162 · see citing works
Du, K., Asahara, H., Jhala, U. S., Wagner, B. L., & Montminy, M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4320-4327.2000 · Cited by 106 · see citing works
Transcriptional regulation of long-term memory in the marine snail Aplysia
Lee, Y., Bailey, C. H., Kandel, E. R., & Kaang, B. (2008) · Molecular Brain · doi:10.1186/1756-6606-1-3 · Cited by 84 · see citing works
Barco, Á., de Armentia, M. L., & Alarcón, J. M. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.01.002 · Cited by 77 · see citing works
Viosca, J., Malleret, G., Bourtchouladze, R., Benito, E., Vronskava, S., Kandel, E. R., & Barco, Á. (2009) · Learning & Memory · doi:10.1101/lm.1220309 · Cited by 77 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Regulation of Transcription in Memory Consolidation
Alberini, C. M., & Kandel, E. R. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021741 · Cited by 362 · see citing works
The right time to learn: Mechanisms and optimization of spaced learning
Smolen, P., Zhang, Y., & Byrne, J. H. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.18 · Cited by 326 · see citing works
Ortega-Martinez, S. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00046 · Cited by 263 · see citing works
Bergersen, L. H. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.206 · Cited by 255 · see citing works
Brain-derived estrogen and neural function
Brann, D., Lu, Y.-J., Wang, J., Zhang, Q.-G., Thakkar, R., Sareddy, G., Pratap, U. P., Tekmal, R., & Vadlamudi, R. (2021) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.11.014 · Cited by 140 · see citing works
Manipulating a “Cocaine Engram” in Mice
Hsiang, H.-L. (., Epp, J. R., van den Oever, M. C., Yan, C., Rashid, A. J., Insel, N., Ye, L., Niibori, Y., Deisseroth, K., Frankland, P. W., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-14.2014 · Cited by 131 · see citing works
A key role for TGF-β1 in hippocampal synaptic plasticity and memory
Caraci, F., Gulisano, W., Guida, C. A., Impellizzeri, A. A. R., Drago, F., Puzzo, D., & Palmeri, A. (2015) · Scientific Reports · doi:10.1038/srep11252 · Cited by 126 · see citing works
Sharma, V. K., Ounallah-Saad, H., Chakraborty, D., Hleihil, M., Sood, R., Barrera, I., Edry, E., Chandran, S. K., de Leon, S. B.-T., Kaphzan, H., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0628-17.2017 · Cited by 110 · see citing works
Li, H., Zhao, Y.-H., Zeng, M.-J., Fang, F., Li, M., Qin, T.-T., Ye, L., Li, H.-W., Qu, R., & Ma, S.-P. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4720-8 · Cited by 90 · see citing works
Datusalia, A. K., & Sharma, S. S. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8632-x · Cited by 79 · see citing works
Ricciarelli, R., Brullo, C., Prickaerts, J., Arancio, O., Villa, C., Rebosio, C., Calcagno, E., Balbi, M., van Hagen, B. T. J., Argyrousi, E. K., et al. (2017) · Scientific Reports · doi:10.1038/srep46320 · Cited by 78 · see citing works
Baby, N., Alagappan, N., Dheen, S. T., & Sajikumar, S. (2019) · Aging Cell · doi:10.1111/acel.13046 · Cited by 75 · see citing works
Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdala
Arendt, D. H., Hassell, J. E., Li, H., Achua, J. K., Guarnieri, D. J., Dileone, R., Ronan, P. J., & Summers, C. H. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.10.010 · Cited by 71 · see citing works
Koss, W. A., Haertel, J. M., Philippi, S. M., & Frick, K. M. (2018) · eNeuro · doi:10.1523/eneuro.0267-18.2018 · Cited by 66 · see citing works
Inhibition of glycogen synthase kinase 3 by lithium, a mechanism in search of specificity
Chatterjee, D., & Beaulieu, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1028963 · Cited by 65 · see citing works
Ding, X., Cai, J., Li, S., Liu, X., Wan, Y., & Xing, G. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.10.025 · Cited by 64 · see citing works
Paula-Lima, A. C., Adasme, T., & Hidalgo, C. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5796 · Cited by 58 · see citing works
Age-related metabolic and neurodegenerative changes in SAMP8 mice
Pačesová, A., Holubová, M., Hrubá, L., Strnadová, V., Neprašová, B., Pelantová, H., Kuzma, M., Železná, B., Kuneš, J., & Maletı́nská, L. (2022) · Aging · doi:10.18632/aging.204284 · Cited by 51 · see citing works
TGF-β/Smad3 Signalling Modulates GABA Neurotransmission: Implications in Parkinson’s Disease
Muñoz, M.-D., de la Fuente, N., & Sánchez‐Capelo, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020590 · Cited by 50 · see citing works
Wang, Y., Feng, L., Liu, S., Zhou, X.-Q., Yin, T., Liu, Z.-P., & Yang, Z. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00732-5 · Cited by 41 · see citing works
Sable, P., Kale, A. A., Joshi, A. A., & Joshi, S. (2014) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2014.01.003 · Cited by 47 · see citing works
Gümüşlü, E., Mutlu, O., Celikyurt, I. K., Ulak, G., Akar, F., Erden, F., & Ertan, M. (2016) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12192 · Cited by 44 · see citing works
Datusalia, A. K., & Sharma, S. S. (2016) · Current Neurovascular Research · doi:10.2174/1567202612666151030104810 · Cited by 44 · see citing works
The glia doctrine: Addressing the role of glial cells in healthy brain ageing
Nagelhus, E. A., Amiry-Moghaddam, M. R., Bergersen, L. H., Bjaalie, J. G., Eriksson, J., Gundersen, V., Leergaard, T. B., Morth, J. P., Storm‐Mathisen, J., Torp, R., et al. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.10.001 · Cited by 36 · see citing works
CDK5 downregulation enhances synaptic plasticity
Posada‐Duque, R., Ramírez, O. A., Härtel, S., Inestrosa, N. C., Bodaleo, F. J., González-Billault, C. E., Kirkwood, A., & Cardona‐Gómez, G. P. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2333-8 · Cited by 35 · see citing works
Regulation and function of elF2B in neurological and metabolic disorders
Hanson, F. M., Hodgson, R. E., de Oliveira, M. I. R., Allen, K. E., & Campbell, S. G. (2022) · Bioscience Reports · doi:10.1042/bsr20211699 · Cited by 34 · see citing works
Yanai, S., Toyohara, J., Ishiwata, K., Ito, H., & Endo, S. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.12.006 · Cited by 34 · see citing works
HIV-1 Tat protein promotes neuronal dysregulation by inhibiting E2F transcription factor 3 (E2F3)
Santerre, M., Bagashev, A., Gorecki, L., Lysek, K. Z., Wang, Y., Shrestha, J., Carpio‐Cano, F. D., Mukerjee, R., & Sawaya, B. E. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003744 · Cited by 32 · see citing works
Takahashi, K., Kurokawa, K., Miyagawa, K., Mochida-Saito, A., Nemoto, Y., Iwasa, H., Nakagawasai, O., Tadano, T., Takeda, H., & Tsuji, M. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.112997 · Cited by 32 · see citing works
Does Aerobic and Resistance Exercise Influence Episodic Memory through Unique Mechanisms?
Loprinzi, P. D., Moore, D., & Loenneke, J. P. (2020) · Brain Sciences · doi:10.3390/brainsci10120913 · Cited by 32 · see citing works
BDNF-TrkB signaling orchestrates the buildup process of local sleep
ElGrawani, W., Sun, G., Kliem, F. P., Sennhauser, S., Pierre-Ferrer, S., Rosi‐Andersen, A., Boccalaro, I. L., Bethge, P., Heo, W. D., Helmchen, F., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114500 · Cited by 31 · see citing works
Choi, W. Y., Kang, D. H., & Lee, H.-Y. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/7218504 · Cited by 30 · see citing works
Thapak, P., Bishnoi, M., & Sharma, S. S. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104783 · Cited by 30 · see citing works
Serotonergic neuromodulation of synaptic plasticity
Higa, G. S. V., Viana, F. J. C., Francis-Oliveira, J., Cruvinel, E., Franchin, T. S., Marcourakis, T., Ulrich, H., & De Pasquale, R. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110036 · Cited by 29 · see citing works
Qiu, Y., Wang, Y., Wang, X., Wang, C., & Xia, Z. (2018) · Journal of International Medical Research · doi:10.1177/0300060517744037 · Cited by 28 · see citing works
Cilostazol improves hippocampus-dependent long-term memory in mice
Yanai, S., Semba, Y., Ito, H., & Endo, S. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3442-4 · Cited by 27 · see citing works
Abuelezz, S. A., & Hendawy, N. (2023) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgad048 · Cited by 26 · see citing works
Nam, S. M., Kim, J. W., Yoo, D. Y., Yim, H. S., Kim, D. W., Choi, J. H., Kim, W., Jung, H. Y., Won, M., Hwang, I. K., et al. (2014) · BMC Neuroscience · doi:10.1186/s12868-014-0116-4 · Cited by 26 · see citing works
Lee, H.-Y., Weon, J. B., Jung, Y. S., Kim, N. Y., Kim, M. K., & Ma, C. J. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/6145926 · Cited by 25 · see citing works
Lin, J., Wang, S., Feng, Y., Zhao, W., Zhao, W., Luo, F., & Feng, N. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13524 · Cited by 25 · see citing works
Phosphodiesterase 4D: an enzyme to remember
Ricciarelli, R., & Fedele, E. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13257 · Cited by 25 · see citing works
PDE3 Inhibitors Repurposed as Treatments for Age-Related Cognitive Impairment
Yanai, S., & Endo, S. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1374-4 · Cited by 24 · see citing works
Akerele, O. A., & Cheema, S. K. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104778 · Cited by 23 · see citing works
Qu, L., Gao, Y., Sun, H., Wang, H., Liu, X., & Sun, D. (2015) · Biological Trace Element Research · doi:10.1007/s12011-015-0478-1 · Cited by 24 · see citing works
Nakagawasai, O., Lin, J.-R., Odaira, T., Takahashi, K., Nemoto, W., Moriguchi, S., Yabuki, Y., Kobayakawa, Y., Fukunaga, K., Nakada, M., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.583291 · Cited by 23 · see citing works
Ding, J., Xi, Y., Zhang, D.-D., Zhao, X., Liu, J.-M., Li, C., Han, J., & Xiao, R. (2013) · Synapse · doi:10.1002/syn.21692 · Cited by 22 · see citing works
Gongjin-Dan Enhances Hippocampal Memory in a Mouse Model of Scopolamine-Induced Amnesia
Lee, J., Hong, S.-S., Kim, H.-G., Lee, H.-W., Kim, W., Lee, S.-K., & Son, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159823 · Cited by 22 · see citing works
Sohn, E., Lim, H.-S., Kim, Y. J., Kim, B., Kim, J., & Jeong, S. (2019) · Nutrients · doi:10.3390/nu11061205 · Cited by 22 · see citing works
Meftahi, G. H., Bayat, M., Zarifkar, A. H., Akbari, S., Borhani‐Haghighi, A., Naseh, M., Nejad, A. Y., & Haghani, M. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.06.006 · Cited by 22 · see citing works
Croce, N., Mathé, A. A., Gelfo, F., Caltagirone, C., Bernardini, S., & Angelucci, F. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114529379 · Cited by 21 · see citing works
Oxiracetam can improve cognitive impairment after chronic cerebral hypoperfusion in rats
Yao, X.-L., Yao, Z., Li, L., Nie, L., & Zhang, S.-F. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.10.006 · Cited by 21 · see citing works
Bahdar, Z. I., Abu-El-Rub, E. M., Almazari, R., Alzu’bi, A., & Al‐Zoubi, R. M. (2025) · Neurogenetics · doi:10.1007/s10048-025-00803-0 · Cited by 20 · see citing works
The effects of Chinese medicines on cAMP/PKA signaling in central nervous system dysfunction
Li, L., Fan, X., Zhang, X.-T., Yue, S., Sun, Z.-Y., Zhu, J., Zhang, J., Gao, X., & Zhang, H. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.04.006 · Cited by 20 · see citing works
Weon, J. B., Yun, B.-R., Lee, J., Eom, M. R., Ko, H., Lee, H.-Y., Park, D., Chung, H., Chung, J. Y., & Ma, C. J. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/319436 · Cited by 20 · see citing works
Mehan, S., Kaur, G., Dudi, R., Rajput, M., & Kalra, S. (2017) · Open Journal of Parkinson s Disease and Treatment · doi:10.17352/ojpdt.000001 · Cited by 19 · see citing works
The BDNF mimetic R-13 attenuates TBI pathogenesis using TrkB-related pathways and bioenergetics
Thapak, P., Smith, G. S., Ying, Z., Paydar, A., Harris, N. G., & Gómez‐Pinilla, F. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166781 · Cited by 19 · see citing works
The ISR downstream target ATF4 represses long-term memory in a cell type–specific manner
Mahmood, N., Choi, J., Wu, P. Y., Dooling, S. W., Watkins, T. A., Huang, Z., Lipman, J., Zhao, H., Yang, A.-Q., Silversmith, J., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2407472121 · Cited by 18 · see citing works
Badrikoohi, M., Esmaeili‐bandboni, A., & Babaei, P. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.12.004 · Cited by 18 · see citing works
Yanai, S., Ito, H., & Endo, S. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.008 · Cited by 18 · see citing works
PML in the Brain: From Development to Degeneration
Korb, E., & Finkbeiner, S. M. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00242 · Cited by 18 · see citing works
Park, J., Seong, H., Jin, H.-B., & Kim, Y. (2016) · Biological Research For Nursing · doi:10.1177/1099800416686179 · Cited by 18 · see citing works
Inhibition of PDE2 and PDE4 synergistically improves memory consolidation processes
Paes, D., Xie, K., Wheeler, D. G., Zook, D. R., Prickaerts, J., & Peters, M. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108414 · Cited by 17 · see citing works
Receive, Retain and Retrieve: Psychological and Neurobiological Perspectives on Memory Retrieval
Savarimuthu, A., & Ponniah, R. J. (2023) · Integrative Psychological and Behavioral Science · doi:10.1007/s12124-023-09752-5 · Cited by 18 · see citing works
Genome-wide DNA methylation changes associated with olfactory learning and memory in Apis mellifera
Li, Y., Zhang, L.-Z., Yi, Y., Hu, W.-W., Guo, Y.-J., Zeng, Z., Huang, Z.-Y., & Wang, Z. (2017) · Scientific Reports · doi:10.1038/s41598-017-17046-1 · Cited by 15 · see citing works
Rivi, V., Batabyal, A., Benatti, C., Blom, J. M. C., Tascedda, F., & Lukowiak, K. (2021) · Journal of Comparative Physiology A · doi:10.1007/s00359-021-01522-1 · Cited by 15 · see citing works
Simulations suggest pharmacological methods for rescuing long-term potentiation
Smolen, P., Baxter, D. A., & Byrne, J. H. (2014) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2014.07.006 · Cited by 13 · see citing works
Weon, J. B., Eom, M. R., Jung, Y. S., Hong, E., Ko, H., Lee, H.-Y., Park, D., & Ma, C. J. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/1473801 · Cited by 14 · see citing works
CDK5 Targeting as a Therapy for Recovering Neurovascular Unit Integrity in Alzheimer’s Disease
Posada-Duque, R. A., & Cardona-Gómez, G. P. (2021) · Journal of Alzheimer's Disease · doi:10.3233/jad-200730 · Cited by 14 · see citing works
Lü, T., Chen, W.-G., Yin, C., Zhang, H., & Zhao, Q. (2019) · World Neurosurgery · doi:10.1016/j.wneu.2019.03.232 · Cited by 13 · see citing works
Okuyama, S., Furukawa, Y., Yoshimura, M., Amakura, Y., Nakajima, M., & Yoshida, T. (2021) · Plants · doi:10.3390/plants10051030 · Cited by 13 · see citing works
Emerging roles for integrated stress response signaling in homeostasis
Nandakumar, S., Grmai, L., & Vasudevan, D. (2025) · FEBS Journal · doi:10.1111/febs.70166 · Cited by 12 · see citing works
Petekkaya, E., Burakgazi, G., Kuş, B., Melek, İ., & Arpacı, A. (2020) · International Journal of Neuroscience · doi:10.1080/00207454.2020.1831490 · Cited by 12 · see citing works
Alkadhi, K. A., & Dao, A. T. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1425-x · Cited by 12 · see citing works
Improved object recognition memory using post-encoding repetitive transcranial magnetic stimulation
Heath, A. M., Brewer, M. A., Yesavage, J. A., & McNerney, M. W. (2021) · Brain stimulation · doi:10.1016/j.brs.2021.11.009 · Cited by 11 · see citing works
Niu, F., Sharma, A., Wang, Z., Feng, L.-Y., Muresanu, D., Sahib, S., Tian, Z., Lafuente, J., Buzoianu, A., Castellani, R., et al. (2021) · Progress in Brain Research · doi:10.1016/bs.pbr.2021.06.004 · Cited by 6 · see citing works
Luo, S., Shi, L., Liu, T., & Jin, Q. (2025) · BMC Neuroscience · doi:10.1186/s12868-025-00935-x · Cited by 10 · see citing works
Copper metabolism and cuproptosis in Alzheimer's disease: mechanisms and therapeutic potential
Meng, D., Luo, G., & Liu, P. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118354 · Cited by 10 · see citing works
The effects of doxorubicin on blood-brain barrier integrity in hCMEC/D3
Patel, C., Glytsou, C., Jang, M.-H., & Cole, P. D. (2025) · NeuroToxicology · doi:10.1016/j.neuro.2025.103355 · Cited by 10 · see citing works
The Involvement of NR2B and tau Protein in MG132-Induced CREB Dephosphorylation
Xie, M., Li, Y., Wang, S., Yu, Q., Meng, X., & Liao, X. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-0919-8 · Cited by 10 · see citing works
Zhang, C., Gai, J., Fan, X., Lei, J., & Tang, J. (2023) · Medicine · doi:10.1097/md.0000000000033625 · Cited by 9 · see citing works
Activity‐Dependent Induction of Younger Biological Phenotypes
Lissek, T. (2022) · Advanced Biology · doi:10.1002/adbi.202200119 · Cited by 9 · see citing works
The Route to ‘Chemobrain’ - Computational probing of neuronal LTP pathway
Fahim, A., Rehman, Z., Bhatti, M. F., Virk, N., Ali, A., Rashid, A., & Paracha, R. Z. (2019) · Scientific Reports · doi:10.1038/s41598-019-45883-9 · Cited by 9 · see citing works
Chen, F.-F., Wang, C., Chen, H., Wang, J., Han, Q.-Q., Cao, Y., Shen, T., Yang, Y., Hu, Z., Wang, F., et al. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147136 · Cited by 9 · see citing works
Wang, X., Chen, H., Tang, T., Zhan, X., Qin, S., Hang, T., & Song, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111634 · Cited by 8 · see citing works
Fat-1 expression enhance hippocampal memory in scopolamine-induced amnesia
Hwang, T. W., Kim, E., Kim, D., Jeong, J. Y., Kim, G., Lim, K., Moon, M., Yoon, K. A., Choi, D. E., & Kim, J.-J. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108394 · Cited by 8 · see citing works
Li, Y., Qing‐Xiu, L., Wang, J., Xiang, H., Zhang, R., & Huang, C.-Q. (2021) · International Journal of Neuroscience · doi:10.1080/00207454.2021.1928114 · Cited by 8 · see citing works
The epigenetic reader PHF21B modulates murine social memory and synaptic plasticity–related genes
Chin, E., Ma, Q., Ruan, H., Chin, C., Somasundaram, A., Zhang, C., Liu, C., Lewis, M. D., White, M., Smith, T. L., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.158081 · Cited by 9 · see citing works
Long‐term taurine supplementation regulates brain mitochondrial dynamics in mice
Rezaei, H., Wang, H., Tian, W., Zhao, J., Najibi, A., Retana‐Márquez, S., Rafiei, E., Rowhanirad, A., Sabouri, S., Kiafar, M., et al. (2024) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.14101 · Cited by 7 · see citing works
Kim, S., Kwon, Y., Seo, E., Lee, H., Sohn, J. O., Shin, H. M., Kim, S. J., & Ye, S.-K. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04252-3 · Cited by 7 · see citing works
Tran, T.-D. T., Park, J. W., Kim, D. Y., & Han, I. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00691.2023 · Cited by 7 · see citing works
UCH-L1 Inhibition Involved in CREB Dephosphorylation in Hippocampal Slices
Xie, M., Wang, S., Lu, Z., Pan, Y., Chen, Q.-C., & Liao, X. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0197-z · Cited by 7 · see citing works
Hamiti, Y., Liu, K., Wang, S., Yang, X. N., Kadier, X., & Yusufu, A. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1641476 · Cited by 6 · see citing works
Kunath, N., & Dresler, M. (2014) · The Receptors · doi:10.1007/978-1-4939-0823-3_10 · Cited by 6 · see citing works
Tan, B., Babür, E., Aşçıoğlu, M., & Süer, C. (2021) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10097 · Cited by 6 · see citing works
Kim, J.-E., Min, K.-S., Go, J., Park, H., Choi, Y., Lee, I.-B., Shin, J., Cho, H., Kim, H., Hwang, D. Y., et al. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13496 · Cited by 5 · see citing works
Shih, T.-W., Lee, L., Chang, H., Lin, H.-W., & Chang, M.-S. (2020) · Scientific Reports · doi:10.1038/s41598-020-67675-2 · Cited by 5 · see citing works
Protective Effect of Wheat Bran Extract against β-Amyloid-induced Cell Death and Memory Impairment
Lee, C., Park, G.-H., Lee, J.-W., & Jang, J. (2015) · The Korea Journal of Herbology · doi:10.6116/kjh.2015.30.1.67 · Cited by 5 · see citing works
Park, J.-K., Kim, H.-G., Lee, J.-S., Joo, J.-H., & Yoo, H.-R. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111644 · Cited by 4 · see citing works
Li, W., Yu, L., Yan, X., Cai, L., Wan, L., Teng, Q., Li, Y., Wang, Y., & Xu, H. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00337 · Cited by 4 · see citing works
Cardoso, S., & Moreira, P. I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413470 · Cited by 4 · see citing works
- Authors
- Kida, S.
- Affiliations
- Tokyo University of Agriculture (JP)
- Corresponding author
- Kida, Satoshi
- ORCID
- Kida, Satoshi
- Venue
- Experimental Neurobiology
- Published
- 2012-12-30
- Volume
- 21
- Issue
- 4
- Pages
- 136-140
- ISSN
- 1226-2560 (ISSN-L)
- 2093-8144
- PMC
- PMC3538177
- OpenAlex
- W2148920387
- Cited by
- 136
- References
- 25
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 10 · 2023: 8 · 2022: 10 · 2021: 11 · 2020: 12 · 2019: 7 · 2018: 9 · 2017: 11 · 2016: 10 · 2015: 6 · 2014: 13 · 2013: 7
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Experimental Neurobiology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Takeda Science Foundation (24116008 and 23115716)
- Sumitomo Foundation
- Japan Society for the Promotion of Science (18022038, 20380078, 18580129, 23300120)
- Core Research for Evolutional Science and Technology
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- CREB, long-term memory, memory consolidation, long-term potentiation, gene expression, transcription factors, cAMP response element, synaptic plasticity, CA1 pyramidal neurons, fear conditioning
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review