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Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

Chun, Tae-Wook, Carruth, Lucy, Finzi, Diana, Shen, Xuefei, DiGiuseppe, Joseph A., Taylor, Harry, Hermankova, Monika, Chadwick, Karen, Margolick, Joseph, Quinn, Thomas C., Kuo, Yen-Hong, Brookmeyer, Ronald, Zeiger, Martha A., Barditch-Crovo, Patricia, Siliciano, Robert F.·1997·Nature

DOI 10.1038/387183a0

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Abstract

The capacity of HIV-1 to establish latent infection of CD4+ T cells may allow viral persistence despite immune responses and antiretroviral therapy. Measurements of infectious virus and viral RNA in plasma and of infectious virus, viral DNA and viral messenger RNA species in infected cells all suggest that HIV-1 replication continues throughout the course of infection. Uncertainty remains over what fraction of CD4+ T cells are infected and whether there are latent reservoirs for the virus. We show here that during the asymptomatic phase of infection there is an extremely low total body load of latently infected resting CD4+ T cells with replication-competent integrated provirus (<10(7) cells). The most prevalent form of HIV-1 DNA in resting and activated CD4+ T cells is a full-length, linear, unintegrated form that is not replication competent. The infection progresses even though at any given time in the lymphoid tissues integrated HIV-1 DNA is present in only a minute fraction of the susceptible populations, including resting and activated CD4+ T cells and macrophages.

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Self-citation

Authors: Chun, T.-W., Carruth, L., Finzi, D., Shen, X., DiGiuseppe, J. A., Taylor, H., Hermankova, M., Chadwick, K., Margolick, J., Quinn, T. C., Kuo, Y.-H., Brookmeyer, R., Zeiger, M. A., Barditch-Crovo, P., & Siliciano, R. F.
Affiliations: Johns Hopkins University (US)
National Institutes of Health (US)
ORCID: Chun, Tae-Wook
DiGiuseppe, Joseph A.
Margolick, Joseph
Quinn, Thomas C.
Kuo, Yen-Hong
Zeiger, Martha A.
Siliciano, Robert F.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1997-05
Volume: 387
Issue: 6629
Pages: 183-188
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/387183a0
OpenAlex: W2030844138
Cited by: 2,050
References: 29
Citations by year: 2026: 29 · 2025: 47 · 2024: 48 · 2023: 59 · 2022: 54 · 2021: 56 · 2020: 80 · 2019: 79 · 2018: 102 · 2017: 81 · 2016: 98 · 2015: 79 · 2014: 86 · 2013: 87 · 2012: 74
FWCI: 25.32
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
Keywords: HIV-1, latent viral reservoir, CD4+ T cells, integrated provirus, viral persistence, asymptomatic HIV infection, activated T cells, macrophages, viral DNA, viral RNA, antiretroviral therapy
MeSH terms: Cells, Cultured, DNA, Viral, Humans, Immunologic Memory, Lymph Nodes, Lymphocyte Activation, Macrophages, Proviruses, Virus Replication, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Polymerase Chain Reaction, Virus Integration, Leukocyte Common Antigens, Virus Latency, Coculture Techniques, Anti-HIV Agents, Viral Load

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Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

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