The role of circadian rhythmicity in reproduction

Kennaway, David J.

doi:10.1093/humupd/dmh054

Cited by 120Circadian rhythm and melatoninHypothalamic control of reproductive hormonesReproductive Biology and Fertility

The role of circadian rhythmicity in reproduction

Kennaway, David J.·2005·Human Reproduction Update

DOI 10.1093/humupd/dmh054

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Abstract

Circadian rhythmicity is evident in a wide range of physiological systems including the reproductive axis. The recent discoveries of rhythmic clock gene expression in peripheral tissues, including reproductive tissue, suggests that they may play an important role in optimizing fertility. The evidence for rhythmic control of reproduction from studies in laboratory animals is reviewed and where possible this includes evidence from human studies. Clock genes are highly conserved across species including humans and there is no reason to suggest that they are functionless in humans. The challenge issued here is for researchers to probe their function and the consequences of their disruption in both animal and human reproduction.

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Circadian rhythms regulate many aspects of reproduction, including the timing of hormone release, ovulation, mating, and parturition.
“Circadian rhythms regulate many aspects of reproduction, including the timing of hormone release, ovulation, mating, and parturition [91, 190].”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [91]
Gonadal hormones can influence other circadian parameters including endogenous period, rhythm amplitude, range of entrainment, zeitgeber sensitivity, and oscillator coupling.
“Gonadal hormones can influence other circadian parameters as well, including endogenous period [7, 23, 47, 49, 91, 129, 212], rhythm amplitude [8, 17, 100], range of entrainment [49], zeitgeber sensitivity [23, 51, 79, 81], and oscillator coupling [126, 128, 187].”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [91]

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Authors: Kennaway, D. J.
Affiliations: The University of Adelaide (AU)
Corresponding author: Kennaway, David J.
ORCID: Kennaway, David J.
Venue: Human Reproduction Update
Publisher: Oxford University Press (OUP)
Published: 2005-01-01
Volume: 11
Issue: 1
Pages: 91-101
ISSN: 1355-4786 (ISSN-L)
1460-2369
DOI: 10.1093/humupd/dmh054
OpenAlex: W2130027734
Cited by: 120
References: 134
Citations by year: 2026: 5 · 2025: 4 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 10 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 11 · 2015: 5 · 2014: 4 · 2013: 10 · 2012: 5
FWCI: 0.49
Type: journal article
Language: en
Open access: closed
Locations: Human Reproduction Update (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords: circadian rhythm, clock genes, reproductive axis, fertility, reproductive tissues, human reproduction
MeSH terms: Animals, Circadian Rhythm, Female, Gene Expression Regulation, Humans, Male, Pregnancy, Pregnancy, Animal, Puberty, Reproduction, Suprachiasmatic Nucleus, Estrous Cycle

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The role of circadian rhythmicity in reproduction

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