Cardiac excitation–contraction coupling

Intracellular Ca 2+ Increases the Mitochondrial NADH Concentration During Elevated Work in Intact Cardiac Muscle

Brandes, R., & Bers, D. M. (1997) · Circulation Research · doi:10.1161/01.res.80.1.82 · Cited by 130

Voltage-Gated Calcium Channels

Catterall, W. A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003947 · Cited by 1,628

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

Ronaldson-Bouchard, K., Ma, S. P., Yeager, K., Chen, T., Song, L., Sirabella, D., Morikawa, K., Teles, D., Yazawa, M., & Vunjak-Novakovic, G. (2018) · Nature · doi:10.1038/s41586-018-0016-3 · Cited by 1,272

The machineries, regulation and cellular functions of mitochondrial calcium

Giorgi, C., Marchi, S., & Pinton, P. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0052-8 · Cited by 941

Adeno-associated virus as a delivery vector for gene therapy of human diseases

Wang, J.-H., Gessler, D. J., Zhan, W., Gallagher, T. L., & Gao, G. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01780-w · Cited by 904

Role of the Autonomic Nervous System in Modulating Cardiac Arrhythmias

Shen, M. J., & Zipes, D. P. (2014) · Circulation Research · doi:10.1161/circresaha.113.302549 · Cited by 867

Muscular Thin Films for Building Actuators and Powering Devices

Feinberg, A. W., Feigel, A., Shevkoplyas, S. S., Sheehy, S., Whitesides, G. M., & Parker, K. K. (2007) · Science · doi:10.1126/science.1146885 · Cited by 765

Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy

Sun, N., Yazawa, M., Liu, J., Han, L., Sanchez-Freire, V., Abilez, O. J., Navarrete, E. G., Hu, S., Wang, L., Lee, A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003552 · Cited by 696

Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans

Bailey, S. J., Fulford, J., Vanhatalo, A., Winyard, P. G., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., Benjamin, N., & Jones, A. M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00046.2010 · Cited by 607

S -Nitrosylation in Cardiovascular Signaling

Lima, B., Forrester, M. T., Hess, D. T., & Stamler, J. S. (2010) · Circulation Research · doi:10.1161/circresaha.109.207381 · Cited by 490

Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes: Insights Into Molecular, Cellular, and Functional Phenotypes

Karakikes, I., Ameen, M., Termglinchan, V., & Wu, J. C. (2015) · Circulation Research · doi:10.1161/circresaha.117.305365 · Cited by 478

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human

Haghighi, K., Kolokathis, F., Pater, L., Lynch, R. A., Asahi, M., Gramolini, A. O., Fan, G.-C., Tsiapras, D., Hahn, H. S., Adamopoulos, S., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17892 · Cited by 478

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo

Sala, L., van Meer, B. J., Tertoolen, L. G. J., Bakkers, J., Bellin, M., Davis, R. P., Denning, C., Dieben, M. A. E., Eschenhagen, T., Giacomelli, E., et al. (2018) · Circulation Research · doi:10.1161/circresaha.117.312067 · Cited by 416

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

Laverty, H., Benson, C., Cartwright, E., Cross, M., Garland, C., Hammond, T., Holloway, C., McMahon, N., Milligan, J., Park, B., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01255.x · Cited by 363

Heart–Brain Axis: Effects of Neurologic Injury on Cardiovascular Function

Tahsili-Fahadan, P., & Geocadin, R. G. (2017) · Circulation Research · doi:10.1161/circresaha.116.308446 · Cited by 291

Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues

Feric, N. T., & Radisic, M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.04.019 · Cited by 247

Force–frequency relationship in intact mammalian ventricular myocardium: physiological and pathophysiological relevance

Endoh, M. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.013 · Cited by 250

Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model

Pleger, S. T., Shan, C., Ksienzyk, J., Bekeredjian, R., Boekstegers, P., Hinkel, R., Schinkel, S., Leuchs, B., Ludwig, J., Qiu, G., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002097 · Cited by 234

Next-generation pacemakers: from small devices to biological pacemakers

Cingolani, E., Goldhaber, J. I., & Marbán, E. (2018) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.165 · Cited by 194

Functional sarcoplasmic reticulum for calcium handling of human embryonic stem cell-derived cardiomyocytes: insights for driven maturation

Liu, J., Fu, J. D., Siu, C. W., & Li, R. A. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0549 · Cited by 186

Mechanical surface waves accompany action potential propagation

El Hady, A., & Machta, B. B. (2015) · Nature Communications · doi:10.1038/ncomms7697 · Cited by 171

Absence of Transverse Tubules Contributes to Non-Uniform Ca 2+ Wavefronts in Mouse and Human Embryonic Stem Cell–Derived Cardiomyocytes

Lieu, D. K., Liu, J., Siu, C.-W., McNerney, G. P., Tse, H.-F., Abu-Khalil, A., Huser, T., & Li, R. A. (2009) · Stem Cells and Development · doi:10.1089/scd.2009.0052 · Cited by 160

Molecular characterization and functional properties of cardiomyocytes derived from human inducible pluripotent stem cells

Germanguz, I., Sedan, O., Zeevi‐Levin, N., Shtrichman, R., Barak, E., Ziskind, A., Eliyahu, S., Meiry, G., Amit, M., Itskovitz‐Eldor, J., et al. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00996.x · Cited by 160

High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis

Relling, D. P., Esberg, L. B., Fang, C. X., Johnson, W. T., Murphy, E. J., Carlson, E. C., Saari, J. T., & Ren, J. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000203846.34314.94 · Cited by 151

Cardiac adrenergic control and atrial fibrillation

Workman, A. J. (2010) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-009-0474-0 · Cited by 143

Biomechanics of Cardiac Electromechanical Coupling and Mechanoelectric Feedback

Pfeiffer, E. R., Tangney, J. R., Omens, J. H., & McCulloch, A. D. (2014) · Journal of Biomechanical Engineering · doi:10.1115/1.4026221 · Cited by 131

Myosin filament-based regulation of the dynamics of contraction in heart muscle

Brunello, E., Fusi, L., Ghisleni, A., Park-Holohan, S.-J., Ovejero, J. G., Narayanan, T., & Irving, M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920632117 · Cited by 129

Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function

van Dijk, S. J., Paalberends, E. R., Najafi, A., Michels, M., Sadayappan, S., Carrier, L., Boontje, N. M., Kuster, D. W. D., van Slegtenhorst, M., Dooijes, D., et al. (2012) · Circulation: Heart Failure · doi:10.1161/circheartfailure.111.963702 · Cited by 124

Facilitated maturation of Ca 2+ handling properties of human embryonic stem cell-derived cardiomyocytes by calsequestrin expression

Liu, J., Lieu, D. K., Siu, C. W., Fu, J.-D., Tse, H.-F., & Li, R. A. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00060.2009 · Cited by 109

Redox Dependent Modifications of Ryanodine Receptor: Basic Mechanisms and Implications in Heart Diseases

Nikolaienko, R., Bovo, E., & Zima, A. V. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01775 · Cited by 89

Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes

Keung, W., Boheler, K. R., & Li, R. A. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt406 · Cited by 87

Mechanisms of exercise‐induced improvements in the contractile apparatus of the mammalian myocardium

Kemi, O. J., & Wisløff, U. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02132.x · Cited by 85

Ca2+ microdomains organized by junctophilins

Takeshima, H., Hoshijima, M., & Song, L.-S. (2015) · Cell Calcium · doi:10.1016/j.ceca.2015.01.007 · Cited by 85

Automated analysis of contractile force and Ca2+transients in engineered heart tissue

Stoehr, A., Neuber, C., Baldauf, C., Vollert, I., Friedrich, F. W., Flenner, F., Carrier, L., Eder, A., Schaaf, S., Hirt, M. N., et al. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00705.2013 · Cited by 83

New Mass-Spectrometry-Compatible Degradable Surfactant for Tissue Proteomics

Chang, Y.-H., Gregorich, Z. R., Chen, A. J., Hwang, L., Guner, H., Yu, D., Zhang, J., & Ge, Y. (2015) · Journal of Proteome Research · doi:10.1021/pr5012679 · Cited by 80

Calcium signalling of human pluripotent stem cell-derived cardiomyocytes

Li, S., Chen, G., & Li, R. A. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.256495 · Cited by 76

The Young Mouse Heart Is Composed of Myocytes Heterogeneous in Age and Function

Rota, M., Hosoda, T., De Angelis, A., Arcarese, M. L., Esposito, G., Rizzi, R., Tillmanns, J., Tugal, D., Musso, E., Rimoldi, O., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.151449 · Cited by 75

Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy

Sanbe, A., James, J., Tuzcu, V., Nas, S., Martin, L., Gulick, J., Osinska, H., Sakthivel, S., Klevitsky, R., Ginsburg, K. S., et al. (2005) · Circulation · doi:10.1161/01.cir.0000164234.24957.75 · Cited by 74

Modulation of β-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5

Ho, D., Yan, L., Iwatsubo, K., Vatner, D. E., & Vatner, S. F. (2010) · Heart Failure Reviews · doi:10.1007/s10741-010-9183-5 · Cited by 68

Cardioprotection from stress conditions by weak magnetic fields in the Schumann Resonance band

Elhalel, G., Price, C., Fixler, D., & Shainberg, A. (2019) · Scientific Reports · doi:10.1038/s41598-018-36341-z · Cited by 64

Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes

Giacomelli, E., Mummery, C. L., & Bellin, M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2546-5 · Cited by 60

Leptin repletion restores depressed β‐adrenergic contractility in ob/ob mice independently of cardiac hypertrophy

Minhas, K. M., Khan, S. A., Raju, S. V. Y., Phan, A. C., Gonzalez, D. R., Skaf, M. W., Lee, K., Tejani, A. D., Saliaris, A. P., Barouch, L. A., et al. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.084566 · Cited by 59

Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transfer

Sakata, S., Lebeche, D., Sakata, Y., Sakata, N., Chemaly, E. R., Liang, L. F., Padmanabhan, P., Konishi, N., Takaki, M., del Monte, F., et al. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.01.002 · Cited by 57

Impact of site-specific phosphorylation of protein kinase A sites Ser23and Ser24of cardiac troponin I in human cardiomyocytes

Wijnker, P. J. M., Foster, D. B., Tsao, A. L., Frazier, A. H., dos Remedios, C. G., Murphy, A. M., Stienen, G. J. M., & van der Velden, J. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00498.2012 · Cited by 50

Antiarrhythmic therapy in atrial fibrillation

Ravens, U. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.06.004 · Cited by 48

Rapid frequency-dependent changes in free mitochondrial calcium concentration in rat cardiac myocytes

Wüst, R. C. I., Helmes, M., Martin, J. L., van der Wardt, T. J. T., Musters, R. J. P., van der Velden, J., & Stienen, G. J. M. (2017) · The Journal of Physiology · doi:10.1113/jp273589 · Cited by 43

IP3-mediated Ca2+ release regulates atrial Ca2+ transients and pacemaker function by stimulation of adenylyl cyclases

Capel, R. A., Bose, S. J., Collins, T. P., Rajasundaram, S., Ayagama, T., Zaccolo, M., Burton, R.-A. B., & Terrar, D. A. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00380.2020 · Cited by 40

Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs

Chen, G., Li, S., Karakikes, I., Ren, L., Zi-Ying Chow, M., Chopra, A., Keung, W., Yan, B., Chan, C. W. Y., Costa, K. D., et al. (2015) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.114.002049 · Cited by 38

Targeted gene transfer increases contractility and decreases oxygen cost of contractility in normal rat hearts

Sakata, S., Lebeche, D., Sakata, N., Sakata, Y., Chemaly, E. R., Liang, L. F., Takewa, Y., Jeong, D., Park, W. J., Kawase, Y., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01310.2006 · Cited by 36

Nutrient sensing and utilization: getting to the heart of metabolic flexibility

Griffin, T. M., Humphries, K. M., Kinter, M., Lim, H.-Y., & Szweda, L. I. (2016) · Biochimie · doi:10.1016/j.biochi.2015.10.013 · Cited by 36

Integrating ER and Mitochondrial Proteostasis in the Healthy and Diseased Heart

Arrieta, A., Blackwood, E. A., Stauffer, W. T., & Glembotski, C. C. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00193 · Cited by 27

Chronic Sympathetic Hyperactivity Triggers Electrophysiological Remodeling and Disrupts Excitation-Contraction Coupling in Heart

Joca, H. C., Santos‐Miranda, A., Joviano-Santos, J. V., Maia-Joca, R. P. M., Brum, P. C., Williams, G. S. B., & Cruz, J. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-64949-7 · Cited by 24

Mechanistic basis of excitation-contraction coupling in human pluripotent stem cell-derived ventricular cardiomyocytes revealed by Ca2+ spark characteristics: direct evidence of functional Ca2+-induced Ca2+ release

Li, S., Cheng, H., Tomaselli, G. F., & Li, R. A. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2013.10.006 · Cited by 24

Arrhythmogenic and metabolic remodelling of failing human heart

Gloschat, C. R., Koppel, A. C., Aras, K. K., Brennan, J. A., Holzem, K. M., & Efimov, I. R. (2016) · The Journal of Physiology · doi:10.1113/jp271992 · Cited by 23

Mitochondrial Colocalization with Ca2+ Release Sites is Crucial to Cardiac Metabolism

Hatano, A., Okada, J.-I., Washio, T., Hisada, T., & Sugiura, S. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2012.12.004 · Cited by 19

Pulmonary artery banding alters the expression of Ca2+transport proteins in the right atrium in rabbits

Gupta, S. C., Varian, K. D., Bal, N. C., Abraham, J. L., Periasamy, M., & Janssen, P. M. L. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00026.2009 · Cited by 18

Overexpressed cardiac Gsα in rabbits

Nishizawa, T., Vatner, S. F., Hong, C., Shen, Y.-T., Hardt, S. E., Robbins, J., Ishikawa, Y., Sadoshima, J., & Vatner, D. E. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.03.008 · Cited by 11