Signalling through the lipid products of phosphoinositide-3-OH kinase

Phosphatidylinositol-3-OH kinase direct target of Ras

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Cellular survival: a play in three Akts

Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216

Untitled work

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Mechanisms of phagocytosis in macrophages

Aderem, A., & Underhill, D. M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.593 · Cited by 2,854

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

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Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

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The IL-4 receptor: signaling mechanisms and biologic functions

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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Regulation of p53 in response to DNA damage

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Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

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Beclin–phosphatidylinositol 3‐kinase complex functions at the trans‐Golgi network

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AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

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The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

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Metal-induced oxidative stress and signal transduction

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Fab1p PtdIns(3)P 5-Kinase Function Essential for Protein Sorting in the Multivesicular Body

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FYVE fingers bind PtdIns(3)P

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Dual Regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine d1 receptor

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PHOSPHOINOSITIDE LIPIDS AS SIGNALING MOLECULES: Common Themes for Signal Transduction, Cytoskeletal Regulation, and Membrane Trafficking

Martin, T. F. J. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.231 · Cited by 522

Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α

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Phospholipase Cγ2 Is Essential in the Functions of B Cell and Several Fc Receptors

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TOR signalling and control of cell growth

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The role of phosphoinositides in membrane transport

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Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

Terauchi, Y., Tsuji, Y., Satoh, S., Minoura, H., Murakami, K., Okuno, A., Inukai, K., Asano, T., Kaburagi, Y., Ueki, K., et al. (1999) · Nature Genetics · doi:10.1038/6023 · Cited by 399

DIFFERENCES BETWEEN PATHOLOGICAL AND PHYSIOLOGICAL CARDIAC HYPERTROPHY: NOVEL THERAPEUTIC STRATEGIES TO TREAT HEART FAILURE

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Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ

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Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells

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Identification and analysis of PH domain‐containing targets of phosphatidylinositol 3‐kinase using a novel in vivo assay in yeast

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Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells

Várnai, P., Rother, K. I., & Balla, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10983 · Cited by 295

Growth and survival signals controlling sympathetic nervous system development

Glebova, N. O., & Ginty, D. D. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135659 · Cited by 243

Integrin signalling in neutrophils and macrophages

Berton, G., & Lowell, C. A. (1999) · Cellular Signalling · doi:10.1016/s0898-6568(99)00003-0 · Cited by 224

Regulation of Proliferation, Differentiation and Survival by the IL-3/IL-5/GM-CSF Receptor Family

de Groot, R. P., Coffer, P. J., & Koenderman, L. (1998) · Cellular Signalling · doi:10.1016/s0898-6568(98)00023-0 · Cited by 215

Ca2+ and synaptotagmin VII–dependent delivery of lysosomal membrane to nascent phagosomes

Czibener, C., Sherer, N. M., Becker, S. M., Pypaert, M., Hui, E., Chapman, E. R., Mothes, W., & Andrews, N. W. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200605004 · Cited by 165

The Phox Homology (PX) Domain-dependent, 3-Phosphoinositide-mediated Association of Sorting Nexin-1 with an Early Sorting Endosomal Compartment Is Required for Its Ability to Regulate Epidermal Growth Factor Receptor Degradation

Cozier, G. E., Carlton, J., McGregor, A. H., Gleeson, P. A., Teasdale, R. D., Mellor, H., & Cullen, P. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206986200 · Cited by 164

The Inositol Phosphatase SHIP Inhibits Akt/PKB Activation in B Cells

Aman, M. J., Lamkin, T. D., Okada, H., Kurosaki, T., & Ravichandran, K. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.33922 · Cited by 162

A Novel SH2-Containing Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase (SHIP2) Is Constitutively Tyrosine Phosphorylated and Associated With src Homologous and Collagen Gene (SHC) in Chronic Myelogenous Leukemia Progenitor Cells

Wisniewski, D., Strife, A., Swendeman, S., Erdjument-Bromage, H., Geromanos, S., Kavanaugh, W. M., Tempst, P., & Clarkson, B. (1999) · Blood · doi:10.1182/blood.v93.8.2707 · Cited by 162

Estradiol Induces Hypothalamic Dendritic Spines by Enhancing Glutamate Release: A Mechanism for Organizational Sex Differences

Schwarz, J. M., Liang, S.-L., Thompson, S. M., & McCarthy, M. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.03.008 · Cited by 139

Growth factor‐dependent signaling and cell cycle progression

Jones, S. M., & Kazlauskas, A. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02113-5 · Cited by 124

Current State and Future Challenges for PI3K Inhibitors in Cancer Therapy

Sirico, M., D’Angelo, A., Gianni, C., Casadei, C., Merloni, F., & De Giorgi, U. (2023) · Cancers · doi:10.3390/cancers15030703 · Cited by 121

Glucose-Dependent Insulinotropic Polypeptide Stimulation of Lipolysis in Differentiated 3T3-L1 Cells: Wortmannin-Sensitive Inhibition by Insulin**This work was supported by grants from Zymogenetics Inc. (Seattle, WA), the Medical Research Council of Canada (5–90007-RAP/CHSM) and the Canadian Diabetes Association (CHSM/RAP).

McIntosh, C. H. S., Bremsak, I., Lynn, F. C., Gill, R., Hinke, S. A., Gelling, R., Nian, C., McKnight, G., Jaspers, S., & Pederson, R. A. (1999) · Endocrinology · doi:10.1210/endo.140.1.6464 · Cited by 73

R-Ras3, a brain-specific Ras-related protein, activates Akt and promotes cell survival in PC12 cells

Kimmelman, A. C., Osada, M., & Chan, A. M.-L. (2000) · Oncogene · doi:10.1038/sj.onc.1203530 · Cited by 50

Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus

Matera, A., Compagnion, A.-C., Pedicone, C., Kotah, J. M., Ivanov, A., Monsorno, K., Labouèbe, G., Leggio, L., Pereira-Iglesias, M., Beule, D., et al. (2025) · Immunity · doi:10.1016/j.immuni.2024.11.003 · Cited by 34

Generation of PTEN-knockout (-/-) murine prostate cancer cells using the CRISPR/Cas9 system and comprehensive gene expression profiling

Takao, A., Yoshikawa, K., Karnan, S., Ota, A., Uemura, H., De Velasco, M., Kura, Y., Suzuki, S., Ueda, R., Nishino, T., et al. (2018) · Oncology Reports · doi:10.3892/or.2018.6683 · Cited by 26