Molecular basis for Rac2 regulation of phagocyte NADPH oxidase

NADPH Oxidase: An Update

BABIOR, B. M. (1999) · Blood · doi:10.1182/blood.v93.5.1464 · Cited by 2,147 · see citing works

Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase.

Guan, K., & Dixon, J. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90534-z · Cited by 1,735 · see citing works

Cell transformation by the superoxide-generating oxidase Mox1

Suh, Y.-A., Arnold, R. S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., Chung, A. B., Griendling, K. K., & Lambeth, J. D. (1999) · Nature · doi:10.1038/43459 · Cited by 1,480 · see citing works

Cloning of Two Human Thyroid cDNAs Encoding New Members of the NADPH Oxidase Family

Deken, X. D., Wang, D., Many, M., Costagliola, S., Libert, F., Vassart, G., Dumont, J. E., & Miot, F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000916200 · Cited by 639 · see citing works

Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense

Roberts, A. W., Kim, C., Zhen, L., Lowe, J. B., Kapur, R., Petryniak, B., Spaetti, A., Pollock, J. D., Borneo, J. B., Bradford, G. B., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80019-9 · Cited by 556 · see citing works

Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation

Ambruso, D. R., Knall, C., Abell, A. N., Panepinto, J. A., Kurkchubasche, A. G., Thurman, G. W., Gonzalez-Aller, C., Hiester, A. A., deBoer, M., Harbeck, R. J., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.080074897 · Cited by 480 · see citing works

New ribose-modified fluorescent analogs of adenine and guanine nucleotides available as subtrates for various enzymes

Hiratsuka, T. (1983) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(83)90267-4 · Cited by 403 · see citing works

Interaction of Rac with p67 phox and Regulation pf Phagocytic NADPH Oxidase Activity

Diekmann, D., Abo, A., Johnston, C. L., Segal, A. W., & Hall, A. (1994) · Science · doi:10.1126/science.8036496 · Cited by 382 · see citing works

Activation of NADPH-dependent superoxide production in a cell-free system by sodium dodecyl sulfate.

Bromberg, Y., & Pick, E. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38756-2 · Cited by 356 · see citing works

Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes

Segal, A. W., West, I., Wientjes, F. B., Nugent, J. H. A., Chavan, A. J., Haley, B. E., Garcia, R. C., Rosen, H., & Scrace, G. (1992) · Biochemical Journal · doi:10.1042/bj2840781 · Cited by 347 · see citing works

Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components.

Quinn, M. T., Evans, T., Loetterle, L. R., Jesaitis, A. J., & Bokoch, G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36882-6 · Cited by 311 · see citing works

A Mammalian H + Channel Generated Through Alternative Splicing of the NADPH Oxidase Homolog NOH-1

Bánfi, B., Maturana, A. D., Jaconi, S., Arnaudeau, S., Laforge, T., Sinha, B. N. M., Ligeti, E., Demaurex, N., & Krause, K. (2000) · Science · doi:10.1126/science.287.5450.138 · Cited by 309 · see citing works

Reconstitution of neutrophil NADPH oxidase activity in the cell-free system by four components: p67-phox, p47-phox, p21rac1, and cytochrome b-245.

Abo, A., Boyhan, A., West, I., Thrasher, A. J., & Segal, A. W. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41846-7 · Cited by 267 · see citing works

Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.

Heyworth, P. G., Bohl, B. P., Bokoch, G., & Curnutte, J. T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47341-3 · Cited by 263 · see citing works

Signal transduction by reactive oxygen species in non-phagocytic cells

Finkel, T. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.3.337 · Cited by 256 · see citing works

Regulation of the Neutrophil Respiratory Burst Oxidase

Han, C., Freeman, J. L. R., Lee, T., Motalebi, S. A., & Lambeth, J. D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.27.16663 · Cited by 229 · see citing works

The p67 Activation Domain Regulates Electron Flow from NADPH to Flavin in Flavocytochromeb 558

Nisimoto, Y., Motalebi, S. A., Han, C., & Lambeth, J. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.22999 · Cited by 204 · see citing works

Increased neutrophil respiratory burst in bcr-null mutants

Voncken, J. W., van Schaick, H., Kaartinen, V., Deemer, K., Coates, T. D., Landing, B. H., Pattengale, P. K., Dorseuil, O., Bokoch, G., Groffen, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90350-x · Cited by 196 · see citing works

A Rac1 Effector Site Controlling Mitogenesis through Superoxide Production

Joneson, T., & Bar‐Sagi, D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.17991 · Cited by 185 · see citing works

The Cytosolic Component p47 Is Not a Sine Qua Non Participant in the Activation of NADPH Oxidase but Is Required for Optimal Superoxide Production

Koshkin, V., Lotan, O., & Pick, E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.48.30326 · Cited by 158 · see citing works

NADPH Oxidase Activity Is Independent of p47

Freeman, J. L. R., & Lambeth, J. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22578 · Cited by 157 · see citing works

Rac “Insert Region” Is a Novel Effector Region That Is Implicated in the Activation of NADPH Oxidase, but Not PAK65

Freeman, J. L. R., Abo, A., & Lambeth, J. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.33.19794 · Cited by 155 · see citing works

Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins

Bokoch, G. (1994) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(94)90138-4 · Cited by 146 · see citing works

Rac Binding to p67

Nisimoto, Y., Freeman, J. L. R., Motalebi, S. A., Hirshberg, M., & Lambeth, J. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18834 · Cited by 138 · see citing works

Requirement for posttranslational processing of Rac GTP-binding proteins for activation of human neutrophil NADPH oxidase.

Heyworth, P. G., Knaus, U. G., Xu, X., Uhlinger, D. J., Conroy, L., Bokoch, G., & Curnutte, J. T. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.3.261 · Cited by 128 · see citing works

Inhibition of superoxide production in B lymphocytes by rac antisense oligonucleotides.

Dorseuil, O., Vázquez, A., Lang, P., Bertoglio, J. H., Gâcon, G., & Leca, G. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36716-x · Cited by 118 · see citing works

Cytochrome b−245 of the Neutrophil Superoxide-generating System Contains Two Nonidentical Hemes

Cross, A. R., Rae, J., & Curnutte, J. T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.29.17075 · Cited by 117 · see citing works

The Cytosolic Activating Factors p47phox and p67phox Have Distinct Roles in the Regulation of Electron Flow in NADPH Oxidase

Cross, A. R., & Curnutte, J. T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.12.6543 · Cited by 106 · see citing works

Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac.

Xu, X., Barry, D. C., Settleman, J. E., Schwartz, M. A., & Bokoch, G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31553-3 · Cited by 92 · see citing works

Dissociation of Rac translocation from p47phox/p67phox movements in human neutrophils by tyrosine kinase inhibitors

Dorseuil, O., Quinn, M. T., & Bokoch, G. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.58.1.108 · Cited by 91 · see citing works

Cryptic Rac-binding and p21 -activated Kinase Phosphorylation Sites of NADPH Oxidase Component p67

Ahmed, S., Prigmore, E., Govind, S., Veryard, C., Kozma, R., Wientjes, F. B., Segal, A. W., & Lim, L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15693 · Cited by 85 · see citing works

The superoxide-generating system of human neutrophils possesses a novel diaphorase activity. Evidence for distinct regulation of electron flow within NADPH oxidase by p67-phox and p47-phox.

Cross, A. R., Yarchover, J. L., & Curnutte, J. T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31824-0 · Cited by 83 · see citing works

A Variant X-linked Chronic Granulomatous Disease Patient (X91+) with Partially Functional Cytochrome b

Cross, A. R., Heyworth, P. G., Rae, J., & Curnutte, J. T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.14.8194 · Cited by 65 · see citing works

Simultaneous Presence of p47 and Flavocytochrome b −245 Are Required for the Activation of NADPH Oxidase by Anionic Amphiphiles

Cross, A. R., Erickson, R. W., & Curnutte, J. T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.22.15519 · Cited by 55 · see citing works

Translocation of p21rac2 from Cytosol to Plasma Membrane Is Neither Necessary nor Sufficient for Neutrophil NADPH Oxidase Activity

Philips, M. R., Feoktistov, A. S., Pillinger, M. H., & Abramson, S. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.19.11514 · Cited by 39 · see citing works

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989 · see citing works

Phagocytosis of Microbes: Complexity in Action

Underhill, D. M., & Ozinsky, A. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.103001.114744 · Cited by 1,124 · see citing works

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

Simpson, D. S. A., & Oliver, P. L. (2020) · Antioxidants · doi:10.3390/antiox9080743 · Cited by 1,044 · see citing works

NADPH oxidases: An overview from structure to innate immunity-associated pathologies

Panday, A., Sahoo, M. K., Osorio, D., & Batra, S. (2015) · Cellular & Molecular Immunology · doi:10.1038/cmi.2014.89 · Cited by 944 · see citing works

The Neutrophil NADPH Oxidase

BABIOR, B. M., Lambeth, J. D., & Nauseef, W. M. (2002) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2642 · Cited by 911 · see citing works

Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

Martyn, K. D., Frederick, L. M., von Loehneysen, K., Dinauer, M. C., & Knaus, U. G. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2005.03.023 · Cited by 783 · see citing works

Hydrogen peroxide as second messenger in lymphocyte activation

Reth, M. G. (2002) · Nature Immunology · doi:10.1038/ni1202-1129 · Cited by 777 · see citing works

The superoxide-generating NADPH oxidase: structural aspects and activation mechanism

Vignais, P. V. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8520-9 · Cited by 773 · see citing works

Neutrophils to the ROScue: Mechanisms of NADPH oxidase activation and bacterial resistance

Nguyen, G. T., Green, E. R., & Mecsas, J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00373 · Cited by 741 · see citing works

Structure, regulation and evolution of Nox‐family NADPH oxidases that produce reactive oxygen species

Sumimoto, H. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06488.x · Cited by 718 · see citing works

NADPH Oxidases in Cardiovascular Health and Disease

Cave, A. C., Brewer, A. C., Narayanapanicker, A., Ray, R., Grieve, D. J., Walker, S., & Shah, A. M. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.691 · Cited by 630 · see citing works

Activation and assembly of the NADPH oxidase: a structural perspective

Groemping, Y., & Rittinger, K. (2005) · Biochemical Journal · doi:10.1042/bj20041835 · Cited by 559 · see citing works

Regulation of NADPH Oxidases

Hordijk, P. L. (2006) · Circulation Research · doi:10.1161/01.res.0000204727.46710.5e · Cited by 525 · see citing works

Regulation of Nox and Duox enzymatic activity and expression.

Lambeth, J., Kawahara, T., & Diebold, B. (2007) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2007.03.028 · Cited by 509 · see citing works

The NADPH oxidase of professional phagocytes—prototype of the NOX electron transport chain systems

Cross, A. R., & Segal, A. W. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2004.03.008 · Cited by 489 · see citing works

Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases

Quinn, M. T., & Gauss, K. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0404216 · Cited by 480 · see citing works

Mechanisms of Degranulation in Neutrophils

Lacy, P. (2006) · Allergy Asthma and Clinical Immunology · doi:10.1186/1710-1492-2-3-98 · Cited by 473 · see citing works

Reactive oxygen species as essential mediators of cell adhesion

Chiarugi, P., Pani, G., Giannoni, E., Taddei, L., Colavitti, R., Raugei, G., Symons, M. C. R., Borrello, S., Galeotti, T., & Ramponi, G. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211118 · Cited by 444 · see citing works

Assembly of the phagocyte NADPH oxidase

Nauseef, W. M. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0679-8 · Cited by 427 · see citing works

Reactive Oxygen Species Activation of Plant Ca2+ Channels. A Signaling Mechanism in Polar Growth, Hormone Transduction, Stress Signaling, and Hypothetically Mechanotransduction

Mori, I. C., & Schroeder, J. I. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.042069 · Cited by 426 · see citing works

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

Ellson, C. D., Gobert, S., Anderson, K. E., Davidson, K., Erdjument‐Bromage, H., Tempst, P., Thuring, J. W., Cooper, M. A., Lim, Z., Holmes, A. B., et al. (2001) · Nature Cell Biology · doi:10.1038/35083076 · Cited by 406 · see citing works

NF-κB Regulates Phagocytic NADPH Oxidase by Inducing the Expression of gp91

Anrather, J., Racchumi, G., & Iadecola, C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506172200 · Cited by 387 · see citing works

NADPH oxidases: not just for leukocytes anymore!

Bokoch, G., & Knaus, U. G. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00194-4 · Cited by 383 · see citing works

Novel Human Homologues of p47 and p67 Participate in Activation of Superoxide-producing NADPH Oxidases

Takeya, R., Ueno, N., Kami, K., Taura, M., Kohjima, M., Izaki, T., Nunoi, H., & Sumimoto, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212856200 · Cited by 380 · see citing works

Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation

Sheppard, F. R., Kelher, M. R., Moore, E. E., McLaughlin, N. J. D., Banerjee, A. M., & Silliman, C. C. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0804442 · Cited by 374 · see citing works

Cdc42, Rac1, and Rac2 Display Distinct Patterns of Activation during Phagocytosis

Hoppe, A. D., & Swanson, J. A. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-11-0847 · Cited by 365 · see citing works

The RHO Family GTPases: Mechanisms of Regulation and Signaling

Mosaddeghzadeh, N., & Ahmadian, M. R. (2021) · Cells · doi:10.3390/cells10071831 · Cited by 364 · see citing works

Current molecular models for NADPH oxidase regulation by Rac GTPase

Bokoch, G. M., & Diebold, B. A. (2002) · Blood · doi:10.1182/blood-2002-04-1149 · Cited by 336 · see citing works

The coordination of signaling during Fc receptor-mediated phagocytosis

Swanson, J. A., & Hoppe, A. D. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0804439 · Cited by 326 · see citing works

The life cycle of phagosomes: formation, maturation, and resolution

Levin‐Konigsberg, R., Grinstein, S., & Canton, J. (2016) · Immunological Reviews · doi:10.1111/imr.12439 · Cited by 319 · see citing works

Reactive oxygen species (ROS) – a family of fate deciding molecules pivotal in constructive inflammation and wound healing

Bryan, N., Ahswin, H., Smart, N. J., Bayon, Y., Wohlert, S., & Hunt, J. A. (2012) · European Cells and Materials · doi:10.22203/ecm.v024a18 · Cited by 317 · see citing works

Molecular composition and regulation of the Nox family NAD(P)H oxidases.

Sumimoto, H., Miyano, K., & Takeya, R. (2005) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2005.08.210 · Cited by 314 · see citing works

Regulation of innate immunity by Rho GTPases

Bokoch, G. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.01.002 · Cited by 295 · see citing works

Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells

van Wetering, S., van Buul, J. D., Quik, S., Mul, E. P. J., Anthony, E. C., ten Klooster, J. P., Collard, J. G., & Hordijk, P. L. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.9.1837 · Cited by 278 · see citing works

Nox1-dependent Reactive Oxygen Generation Is Regulated by Rac1*

Cheng, G.-J., Diebold, B., Hughes, Y., & Lambeth, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512751200 · Cited by 288 · see citing works

Regulation and termination of NADPH oxidase activity

DeCoursey, T. E., & Ligeti, E. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5177-1 · Cited by 268 · see citing works

Superoxide Production in Galleria mellonella Hemocytes: Identification of Proteins Homologous to the NADPH Oxidase Complex of Human Neutrophils

Bergin, D. A., Reeves, E. P., Renwick, J. A. A., Wientjes, F. B., & Kavanagh, K. A. (2005) · Infection and Immunity · doi:10.1128/iai.73.7.4161-4170.2005 · Cited by 258 · see citing works

The many roles of NOX2 NADPH oxidase-derived ROS in immunity

Lam, G. Y., Huang, J., & Brumell, J. H. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0221-0 · Cited by 243 · see citing works

NADPH oxidase-dependent reactive oxygen species formation required for root hair growth depends on ROP GTPase

Jones, M. A., Raymond, M. J., Yang, Z., & Smirnoff, N. (2007) · Journal of Experimental Botany · doi:10.1093/jxb/erl279 · Cited by 242 · see citing works

NADPH oxidases in fungi: Diverse roles of reactive oxygen species in fungal cellular differentiation

Takemoto, D., Tanaka, A., & Scott, B. (2007) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2007.04.011 · Cited by 238 · see citing works

The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease.

Wilkinson, B. L., & Landreth, G. E. (2006) · Journal of Neuroinflammation · doi:10.1186/1742-2094-3-30 · Cited by 235 · see citing works

Point Mutations in the Proline-rich Region of p22 Are Dominant Inhibitors of Nox1- and Nox2-dependent Reactive Oxygen Generation

Kawahara, T., Ritsick, D., Cheng, G., & Lambeth, J. D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501882200 · Cited by 231 · see citing works

Sequential Activation of Phosphatidylinositol 3-Kinase, βPix, Rac1, and Nox1 in Growth Factor-Induced Production of H2O2

Park, H. S., Lee, S. H., Park, D., Lee, J. S., Ryu, S. H., Lee, W., Rhee, S. G., & Bae, Y. S. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4384-4394.2004 · Cited by 225 · see citing works

Deep sequencing of the zebrafish transcriptome response to mycobacterium infection

Hegedűs, Z., Zakrzewska, A., Ágoston, V. C., Ordas, A., Rácz, P., Mink, M., Spaink, H. P., & Meijer, A. H. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.07.002 · Cited by 216 · see citing works

Regulation of the NADPH Oxidase and Associated Ion Fluxes During Phagocytosis

Nunes, P., Demaurex, N., & Dinauer, M. C. (2013) · Traffic · doi:10.1111/tra.12115 · Cited by 204 · see citing works

The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts

Liang, S., Kisseleva, T., & Brenner, D. A. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00017 · Cited by 197 · see citing works

The NADPH Oxidase Nox3 Constitutively Produces Superoxide in a p22 -dependent Manner

Ueno, N., Takeya, R., Miyano, K., Kikuchi, H., & Sumimoto, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414548200 · Cited by 195 · see citing works

Link between Mitochondria and NADPH Oxidase 1 Isozyme for the Sustained Production of Reactive Oxygen Species and Cell Death

Lee, S. B., Bae, I. H., Bae, Y. S., & Um, H.-D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606702200 · Cited by 187 · see citing works

A p67Phox-Like Regulator Is Recruited to Control Hyphal Branching in a Fungal–Grass Mutualistic Symbiosis

Takemoto, D., Tanaka, A., & Scott, B. (2006) · The Plant Cell · doi:10.1105/tpc.106.046169 · Cited by 183 · see citing works

Rho GTPases modulate malignant transformation of tumor cells

Orgaz, J. L., Herráiz, C., & Sanz‐Moreno, V. (2014) · Small GTPases · doi:10.4161/sgtp.29019 · Cited by 177 · see citing works

Role of Reactive Oxygen Species in Tumor Necrosis Factor-alpha Induced Endothelial Dysfunction

Chen, X., Andresen, B. T., Hill, M. A., Zhang, J., Booth, F. W., & Zhang, C. (2008) · Current Hypertension Reviews · doi:10.2174/157340208786241336 · Cited by 179 · see citing works

NADPH oxidases in oxidant production by microglia: activating receptors, pharmacology and association with disease

Haslund‐Vinding, J., McBean, G., Jaquet, V, & Vilhardt, F. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13425 · Cited by 169 · see citing works

Structure and Function of the PB1 Domain, a Protein Interaction Module Conserved in Animals, Fungi, Amoebas, and Plants

Sumimoto, H., Kamakura, S., & Ito, T. (2007) · Science s STKE · doi:10.1126/stke.4012007re6 · Cited by 172 · see citing works

Rho GTPases in hematopoiesis and hemopathies

Mulloy, J. C., Cancelas, J. A., Filippi, M., Kalfa, T. A., Guo, F., & Zheng, Y. (2009) · Blood · doi:10.1182/blood-2009-09-198127 · Cited by 165 · see citing works

Architecture of the p40-p47-p67 Complex in the Resting State of the NADPH Oxidase

Lapouge, K., Smith, S. J., Groemping, Y., & Rittinger, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112065200 · Cited by 166 · see citing works

Always look on the bright site of Rho: structural implications for a conserved intermolecular interface

Dvorský, R., & Ahmadian, M. R. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400293 · Cited by 165 · see citing works

Receptor Activation of NADPH Oxidases

Petry, A., Weitnauer, M., & Görlach, A. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.3026 · Cited by 162 · see citing works

Constitutive NADPH-Dependent Electron Transferase Activity of the Nox4 Dehydrogenase Domain

Nisimoto, Y., Jackson, H. M., Ogawa, H., Kawahara, T., & Lambeth, J. D. (2010) · Biochemistry · doi:10.1021/bi9022285 · Cited by 161 · see citing works

Protein Tyrosine Phosphorylation and Protein Tyrosine Nitration in Redox Signaling

Monteiro, H. P., Arai, R. J., & Travassos, L. R. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1853 · Cited by 157 · see citing works

Rho Family GTPases Are Required for Activation of Jak/STAT Signaling by G Protein-Coupled Receptors

Pelletier, S. W., Duhamel, F., Coulombe, P., Popoff, M. R., & Meloche, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1316-1333.2003 · Cited by 156 · see citing works

The impact of reactive oxygen species in the development of cardiometabolic disorders: a review

Akhigbe, R. E., & Ajayi, A. F. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01435-7 · Cited by 154 · see citing works

Chemoattractant-Stimulated Rac Activation in Wild-Type and Rac2-Deficient Murine Neutrophils: Preferential Activation of Rac2 and Rac2 Gene Dosage Effect on Neutrophil Functions

Li, S., 山内, 明., Marchal, C. C., Molitoris, J. K., Quilliam, L. A., & Dinauer, M. C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.5043 · Cited by 150 · see citing works

Membrane Binding Mechanisms of the PX Domains of NADPH Oxidase p40 and p47

Stahelin, R. V., Burian, A., Bruzik, K. S., Murray, D., & Cho, W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212579200 · Cited by 143 · see citing works

Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guinea pig gastric mucosal cells

Kawahara, T., Kohjima, M., Kuwano, Y., Mino, H., Teshima-Kondo, S., Takeya, R., Tsunawaki, S., Wada, A., Sumimoto, H., & Rokutan, K. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00319.2004 · Cited by 143 · see citing works

Regulation of the Phagocyte NADPH Oxidase by Rac GTPase

Bokoch, G., & Zhao, T. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1533 · Cited by 142 · see citing works

Crossroads of PI3K and Rac pathways

Campa, C. C., Ciraolo, E., Ghigo, A., Germena, G., & Hirsch, E. (2015) · Small GTPases · doi:10.4161/21541248.2014.989789 · Cited by 141 · see citing works

The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcγIIA receptor–induced phagocytosis

Suh, C.-I., Stull, N. D., Li, X. J., Tian, W., Price, M. O., Grinstein, S., Yaffe, M. B., Atkinson, S. J., & Dinauer, M. C. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052085 · Cited by 141 · see citing works

Direct Involvement of the Small GTPase Rac in Activation of the Superoxide-producing NADPH Oxidase Nox1

Miyano, K., Ueno, N., Takeya, R., & Sumimoto, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513665200 · Cited by 137 · see citing works

Reactive Oxygen Species in Pulmonary Vascular Remodeling

Aggarwal, S., Groß, C., Sharma, S., Fineman, J. R., & Black, S. M. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120024 · Cited by 136 · see citing works

NoxA activation by the small GTPase RacA is required to maintain a mutualistic symbiotic association between Epichloë festucae and perennial ryegrass

Tanaka, A., Takemoto, D., Hyon, G., Park, P., & Scott, B. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06217.x · Cited by 134 · see citing works

Rac2-Deficient Murine Macrophages Have Selective Defects in Superoxide Production and Phagocytosis of Opsonized Particles

山内, 明., Kim, C., Li, S., Marchal, C. C., Towe, J., Atkinson, S. J., & Dinauer, M. C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.10.5971 · Cited by 133 · see citing works

High glucose-induced oxidative stress inhibits Na+/glucose cotransporter activity in renal proximal tubule cells

Han, H. J., Lee, Y. J., Park, S. H., Lee, J., & Taub, M. L. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00327.2004 · Cited by 132 · see citing works

PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation

Ellson, C. D., Davidson, K., Anderson, K. E., Stephens, L., & Hawkins, P. T. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601346 · Cited by 127 · see citing works

The Role of the NADPH Oxidase Complex, p38 MAPK, and Akt in Regulating Human Monocyte/Macrophage Survival

Wang, Y., Zeigler, M. M., Lam, G. K., Hunter, M. G., Eubank, T. D., Khramtsov, V. V., Tridandapani, S., Sen, C. K., & Marsh, C. B. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0165oc · Cited by 128 · see citing works

Variants in Nicotinamide Adenine Dinucleotide Phosphate Oxidase Complex Components Determine Susceptibility to Very Early Onset Inflammatory Bowel Disease

Dhillon, S. S., Fattouh, R., Elkadri, A. A., Xu, W., Murchie, R., Walters, T. D., Guo, C., Mack, D. R., Huynh, H. Q., Baksh, S., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.06.005 · Cited by 123 · see citing works

Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system

Price, M. O., McPhail, L. C., Lambeth, J. D., Han, C., Knaus, U. G., & Dinauer, M. C. (2002) · Blood · doi:10.1182/blood.v99.8.2653 · Cited by 121 · see citing works

NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

Jaquet, V., Marcoux, J., Forest, É., Leidal, K. G., McCormick, S. J., Westermaier, Y., Perozzo, R., Plastre, O., Fioraso-Cartier, L., Diebold, B. A., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01439.x · Cited by 120 · see citing works

G Protein βγ Subunits Stimulate p114RhoGEF, a Guanine Nucleotide Exchange Factor for RhoA and Rac1

Niu, J., Profirovic, J., Pan, H., Vaiškunaite, R., & Voyno-Yasenetskaya, T. (2003) · Circulation Research · doi:10.1161/01.res.0000097607.14733.0c · Cited by 120 · see citing works

Stress Response and Pathogenicity of the Necrotrophic Fungal Pathogen Alternaria alternata

Chung, K.-R. (2012) · Scientifica · doi:10.6064/2012/635431 · Cited by 119 · see citing works

Carcinogenesis and Reactive Oxygen Species Signaling: Interaction of the NADPH Oxidase NOX1–5 and Superoxide Dismutase 1–3 Signal Transduction Pathways

Parascandolo, A., & Laukkanen, M. O. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7268 · Cited by 117 · see citing works

The p40 and p47 PX Domains of NADPH Oxidase Target Cell Membranes via Direct and Indirect Recruitment by Phosphoinositides

Zhan, Y., Virbasius, J. V., Song, X., Pomerleau, D. P., & Zhou, G. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109520200 · Cited by 115 · see citing works

Particulate Matter-Induced Emerging Health Effects Associated with Oxidative Stress and Inflammation

Lim, E. Y., & Kim, G.-D. (2024) · Antioxidants · doi:10.3390/antiox13101256 · Cited by 128 · see citing works

The Src Family Kinases Hck and Fgr Regulate Neutrophil Responses to N -Formyl-Methionyl-Leucyl-Phenylalanine

Fumagalli, L., Zhang, H., Baruzzi, A., Lowell, C. A., & Berton, G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3874 · Cited by 108 · see citing works

Rac Activation Induces NADPH Oxidase Activity in Transgenic COS Cells, and the Level of Superoxide Production Is Exchange Factor-dependent

Price, M. O., Atkinson, S. J., Knaus, U. G., & Dinauer, M. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200061200 · Cited by 108 · see citing works

NADPH oxidases: redox regulation of cell homeostasis and disease

Kračun, D., Lopes, L. R., Cifuentes-Pagano, E., & Pagano, P. J. (2025) · Physiological Reviews · doi:10.1152/physrev.00034.2023 · Cited by 104 · see citing works

Photobiomodulation by low-power laser irradiation attenuates Aβ-induced cell apoptosis through the Akt/GSK3β/β-catenin pathway

Liang, J., Liu, L., & Xing, D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.003 · Cited by 102 · see citing works

The HIV-1 Nef Protein and Phagocyte NADPH Oxidase Activation

Vilhardt, F., Plastre, O., Sawada, M., Suzuki, K. T., Wiznerowicz, M., Kiyokawa, E., Trono, D., & Krause, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200862200 · Cited by 100 · see citing works

Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase

Pick, E. (2014) · Small GTPases · doi:10.4161/sgtp.27952 · Cited by 98 · see citing works

Repression of rac2 mRNA Expression by Anaplasma phagocytophila Is Essential to the Inhibition of Superoxide Production and Bacterial Proliferation

Carlyon, J. A., Chan, W.-T., Galán, J. E., Roos, D., & Fikrig, E. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.12.7009 · Cited by 94 · see citing works

Control of granule exocytosis in neutrophils

Lacy, P. (2008) · Frontiers in bioscience · doi:10.2741/3099 · Cited by 94 · see citing works

Mapping of Functional Domains in the p22 Subunit of Flavocytochrome b 559 Participating in the Assembly of the NADPH Oxidase Complex by “Peptide Walking”

Dahan, I. M., Issaeva, I., Gorzalczany, Y., Sigal, N., Hirshberg, M., & Pick, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109778200 · Cited by 94 · see citing works

Antagonistic Cross-talk between Rac and Cdc42 GTPases Regulates Generation of Reactive Oxygen Species

Diebold, B. A., Fowler, B. J., Lu, J., Dinauer, M. C., & Bokoch, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313891200 · Cited by 94 · see citing works

Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes

Kawahara, T., & Lambeth, J. D. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-178 · Cited by 92 · see citing works

GTPases and reactive oxygen species: switches for killing and signaling

Werner, E. (2003) · Journal of Cell Science · doi:10.1242/jcs.00937 · Cited by 92 · see citing works

Candidate Gene Association Studies of Anthracycline-induced Cardiotoxicity: A Systematic Review and Meta-analysis

Leong, S. L., Chaiyakunapruk, N., & Lee, S. W. H. (2017) · Scientific Reports · doi:10.1038/s41598-017-00075-1 · Cited by 91 · see citing works

Invasion and survival strategies ofAnaplasma phagocytophilum

Carlyon, J. A., & Fikrig, E. (2003) · Cellular Microbiology · doi:10.1046/j.1462-5822.2003.00323.x · Cited by 91 · see citing works

A RHOse by any other name: a comparative analysis of animal and plant Rho GTPases

Brembu, T., Winge, P., Bones, A. M., & Yang, Z. (2006) · Cell Research · doi:10.1038/sj.cr.7310055 · Cited by 89 · see citing works

Central Nervous System Injury and Nicotinamide Adenine Dinucleotide Phosphate Oxidase: Oxidative Stress and Therapeutic Targets

von Leden, R. E., Yauger, Y. J., Khayrullina, G., & Byrnes, K. R. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4486 · Cited by 90 · see citing works

Molecular Mechanism for Activation of Superoxide-producing NADPH Oxidases

Takeya, R., & Sumimoto, H. (2003) · Molecules and Cells · doi:10.1016/s1016-8478(23)13800-3 · Cited by 86 · see citing works

Vav proteins control MyD88-dependent oxidative burst

Miletic, A. V., Graham, D. B., Montgrain, V., Fujikawa, K., Kloeppel, T., Brim, K. L., Weaver, B., Schreiber, R. D., Xavier, R. J., & Swat, W. (2006) · Blood · doi:10.1182/blood-2006-07-033662 · Cited by 84 · see citing works

Regulation of the Phagocyte NADPH Oxidase by Rac GTPase

Bokoch, G., & Zhao, T. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1533 · Cited by 142 · see citing works

Regulation of NADPH Oxidases by Rac GTPase

Bokoch, G., Gianni, D., Kim, J., & Kao, Y.-Y. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00216-3

Current molecular models for NADPH oxidase regulation by Rac GTPase

Bokoch, G. M., & Diebold, B. A. (2002) · Blood · doi:10.1182/blood-2002-04-1149 · Cited by 336 · see citing works

Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase

Pick, E. (2014) · Small GTPases · doi:10.4161/sgtp.27952 · Cited by 98 · see citing works

Regulation of the NADPH Oxidase by Rac GTPase

Diebold, B. A., & Bokoch, G. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50599-4 · Cited by 1 · see citing works