Diagnosis and management of chronic constipation in adults

The functional gastrointestinal disorders and the Rome III process

Drossman, D. A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.008 · Cited by 2,416 · see citing works

A Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome

Halmos, E. P., Power, V. A., Shepherd, S. J., Gibson, P. R., & Muir, J. G. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.09.046 · Cited by 1,249 · see citing works

Irritable Bowel Syndrome

Chey, W. D., Kurlander, J. E., & Eswaran, S. L. (2015) · JAMA · doi:10.1001/jama.2015.0954 · Cited by 1,086 · see citing works

Epidemiology of Constipation in North America: A Systematic Review

Higgins, P., & Johanson, J. (2004) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04114.x · Cited by 1,048 · see citing works

Epidemiology of constipation in children and adults: A systematic review

Mugie, S. M., Benninga, M. A., & Lorenzo, C. D. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2010.12.010 · Cited by 944 · see citing works

American Gastroenterological Association Technical Review on Constipation

Bharucha, A. E., Pembérton, J. H., & Locke, G. R. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.10.028 · Cited by 914 · see citing works

Functional anorectal disorders.

Bharucha, A., Wald, A., Enck, P., & Rao, S. S. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.064 · Cited by 770 · see citing works

Systematic review: impact of constipation on quality of life in adults and children

Belsey, J., Greenfield, S., Candy, D., & Geraint, M. (2010) · Alimentary Pharmacology and Therapeutics · doi:10.1111/j.1365-2036.2010.04273.x · Cited by 554 · see citing works

The brain-gut axis in abdominal pain syndromes.

Mayer, E. A., & Tillisch, K. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-012309-103958 · Cited by 511 · see citing works

Efficacy and Safety of Traditional Medical Therapies for Chronic Constipation: Systematic Review

Ramkumar, D. P., & Rao, S. S. C. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40925.x · Cited by 494 · see citing works

Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety

Chey, W. D., Lembo, A. J., Lavins, B. J., Shiff, S. J., Kurtz, C. B., Currie, M. G., MacDougall, J. E., Jia, X. D., Shao, J. Z., Fitch, D. A., et al. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.254 · Cited by 463 · see citing works

Biofeedback Is Superior to Laxatives for Normal Transit Constipation Due to Pelvic Floor Dyssynergia

Chiarioni, G., Whitehead, W. E., Pezza, V., Morelli, A., & Bassotti, G. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.014 · Cited by 460 · see citing works

An epidemiological survey of constipation in Canada: definitions, rates, demographics, and predictors of health care seeking

Paré, P., Ferrazzi, S., Thompson, W., Irvine, E. J., & Rance, L. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.05259.x · Cited by 445 · see citing works

Randomized Controlled Trial of Biofeedback, Sham Feedback, and Standard Therapy for Dyssynergic Defecation

Rao, S. S. C., Seaton, K. K., Miller, M. J., Brown, K., Nygaard, I., Stumbo, P., Zimmerman, B., & Schulze, K. S. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.12.023 · Cited by 387 · see citing works

Evaluation of gastrointestinal transit in clinical practice: position paper of the American and European Neurogastroenterology and Motility Societies

Rao, S. S. C., Camilleri, M., Hasler, W. L., Maurer, A. H., Parkman, H. P., Saad, R., Scott, S. M., Simrén, M., Soffer, E., & Szarka, L. A. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01612.x · Cited by 383 · see citing works

A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation

Rao, S. S. C., Lembo, A. J., Shiff, S. J., Lavins, B. J., Currie, M. G., Jia, X. D., Shi, K., MacDougall, J. E., Shao, J. Z., Eng, P., et al. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.255 · Cited by 383 · see citing works

Effect of laxatives and pharmacological therapies in chronic idiopathic constipation: systematic review and meta-analysis

Ford, A. C., & Suares, N. C. (2011) · Gut · doi:10.1136/gut.2010.227132 · Cited by 378 · see citing works

Obstructive Defecation: A Failure of Rectoanal Coordination

Rao, S. S. C., Welcher, K., & Leistikow, J. (1998) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1998.00326.x · Cited by 364 · see citing works

The health-related quality of life and economic burden of constipation

Dennison, C., Prasad, M., Lloyd, A., Bhattacharyya, S., Dhawan, R., & Coyne, K. (2012) · PharmacoEconomics (Auckland) · doi:10.2165/00019053-200523050-00006 · Cited by 354 · see citing works

Systematic review: dietary fibre and<scp>FODMAP</scp>‐restricted diet in the management of constipation and irritable bowel syndrome

Rao, S. S. C., Yu, S., & Fedewa, A. (2015) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/apt.13167 · Cited by 343 · see citing works

Systematic Review on the Management of Chronic Constipation in North America

Brandt, L. J., Prather, C. M., Quigley, E. M. M., Schiller, L. R., Schoenfeld, P., & Talley, N. J. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.50613_2.x · Cited by 342 · see citing works

Association between physical activity, fiber intake, and other lifestyle variables and constipation in a study of women

Dukas, L., Willett, W. C., & Giovannucci, E. L. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07591.x · Cited by 337 · see citing works

Naloxegol for Opioid-Induced Constipation in Patients with Noncancer Pain

Chey, W. D., Webster, L. R., Sostek, M. B., Lappalainen, J., Barker, P. N., & Tack, J. F. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1310246 · Cited by 328 · see citing works

Lactulose versus Polyethylene Glycol for Chronic Constipation

Lee‐Robichaud, H., Thomas, K., Morgan, J. L., & Nelson, R. L. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007570.pub2 · Cited by 325 · see citing works

Systematic review: the role of different types of fibre in the treatment of irritable bowel syndrome

Bijkerk, C. J., Muris, J. W. M., Knottnerus, J. A., Hoes, A. W., & de Wit, N. J. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.0269-2813.2004.01862.x · Cited by 325 · see citing works

Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate

Castro, J., Harrington, A. M., Hughes, P. A., Martin, C. M., Ge, P., Shea, C. M., Jin, H., Jacobson, S., Hannig, G., Mann, E., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.017 · Cited by 295 · see citing works

ANMS ‐ ESNM position paper and consensus guidelines on biofeedback therapy for anorectal disorders

Rao, S. S. C., Benninga, M. A., Bharucha, A. E., Chiarioni, G., Lorenzo, C. D., & Whitehead, W. E. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12520 · Cited by 282 · see citing works

Short-Chain Carbohydrates and Functional Gastrointestinal Disorders

Shepherd, S., Lomer, M. C. E., & Gibson, P. R. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.96 · Cited by 270 · see citing works

Clinical Utility of Diagnostic Tests for Constipation in Adults: A Systematic Review

Rao, S. S. C., Öztürk, R., & Laine, L. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41845.x · Cited by 261 · see citing works

Sacral nerve stimulation for intractable constipation

Kamm, M., Dudding, T., Melenhorst, J., Jarrett, M., Wang, Z. J., Buntzen, S., Johansson, C., Laurberg, S., Rosen, H., Vaizey, C., et al. (2010) · Gut · doi:10.1136/gut.2009.187989 · Cited by 261 · see citing works

Systematic review: the effects of fibre in the management of chronic idiopathic constipation

Suares, N. C., & Ford, A. C. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04602.x · Cited by 259 · see citing works

Oral bisacodyl is effective and well-tolerated in patients with chronic constipation

Kamm, M. A., Mueller–Lissner, S., Wald, A., Richter, E., Swallow, R., & Gessner, U. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.03.026 · Cited by 257 · see citing works

American Neurogastroenterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice

Camilleri, M., Bharucha, A. E., Lorenzo, C. D., Hasler, W. L., Prather, C. M., Rao, S. S. C., & Wald, A. M. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01230.x · Cited by 255 · see citing works

Association of low dietary intake of fiber and liquids with constipation: Evidence from the National Health and Nutrition Examination Survey

Markland, A. D., Palsson, O., Goode, P. S., Burgio, K. L., Busby-Whitehead, J., & Whitehead, W. E. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.73 · Cited by 254 · see citing works

Digital Rectal Examination Is a Useful Tool for Identifying Patients With Dyssynergia

Tantiphlachiva, K., Rao, P., Attaluri, A., & Rao, S. S. C. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2010.06.031 · Cited by 254 · see citing works

Evaluation and Surgical Treatment of Severe Chronic Constipation

Pembérton, J. H., Rath, D. M., & Ilstrup, D. M. (1991) · Annals of Surgery · doi:10.1097/00000658-199110000-00005 · Cited by 254 · see citing works

Overlap of gastrointestional symptom complexes in a US community

Locke, G., Zinsmeister, A., Fett, S., Melton, L., & Talley, N. (2005) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2004.00581.x · Cited by 254 · see citing works

Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers

Camilleri, M., Bharucha, A. E., Ueno, R., Burton, D., Thomforde, G. M., Baxter, K., McKinzie, S., & Zinsmeister, A. R. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00264.2005 · Cited by 253 · see citing works

Dyssynergic Defecation: Demographics, Symptoms, Stool Patterns, and Quality of Life

Rao, S. S. C., Tuteja, A. K., Vellema, T., Kempf, J. S., & Stessman, M. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000135929.78074.8c · Cited by 246 · see citing works

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

Busby, R. W., Bryant, A. P., Bartolini, W. P., Cordero, E. A., Hannig, G., Kessler, M. M., Mahajan‐Miklos, S., Pierce, C. M., Solinga, R. M., Sun, L. J., et al. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.09.019 · Cited by 236 · see citing works

Dyssynergic Defecation and Biofeedback Therapy

Rao, S. S. C. (2008) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2008.06.011 · Cited by 231 · see citing works

Outcome of Colectomy for Slow Transit Constipation

Knowles, C. H., Scott, S. M., & Lunniss, P. J. (1999) · Annals of Surgery · doi:10.1097/00000658-199911000-00004 · Cited by 228 · see citing works

Dynamic MR Imaging of the Pelvic Floor Performed with Patient Sitting in an Open-Magnet Unit versus with Patient Supine in a Closed-Magnet Unit

Bertschinger, K. M., Hetzer, F. H., Roos, J. E., Treiber, K., Marinček, B., & Hilfiker, P. R. (2002) · Radiology · doi:10.1148/radiol.2232010665 · Cited by 228 · see citing works

Sacral nerve stimulation for faecal incontinence and constipation in adults

Thaha, M. A., Abukar, A. A., Thin, N. N., Ramsanahie, A. P., & Knowles, C. H. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004464.pub3 · Cited by 212 · see citing works

TREATMENT OF ANISMUS IN INTRACTABLE CONSTIPATION WITH BOTULINUM A TOXIN

Hallan, R. I., Melling, J., Womack, N. R., Williams, N. S., Waldron, D. J., & Morrison, J. (1988) · The Lancet · doi:10.1016/s0140-6736(88)90188-2 · Cited by 208 · see citing works

Wireless pH‐motility capsule for colonic transit: prospective comparison with radiopaque markers in chronic constipation

Camilleri, M., Thorne, N. K., Ringel, Y., Hasler, W. L., Kuo, B., Esfandyari, T., Gupta, A., Scott, S. M., McCallum, R. W., Parkman, H. P., et al. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01517.x · Cited by 206 · see citing works

Emerging treatments in neurogastroenterology: a multidisciplinary working group consensus statement on opioid‐induced constipation

Camilleri, M., Drossman, D. A., Becker, G., Webster, L. R., Davies, A. N., & Mawe, G. M. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12417 · Cited by 200 · see citing works

Ambulatory 24-Hour Colonic Manometry in Slow-Transit Constipation

Rao, S. S. C., Sadeghi, P., Beaty, J. S., & Kavlock, R. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.40453.x · Cited by 188 · see citing works

Colonic Transit Time and IBS Symptoms: What's the Link?

Törnblom, H., Van Oudenhove, L., Sadik, R., Abrahamsson, H., Tack, J., & Simrén, M. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.5 · Cited by 185 · see citing works

An Update on Post-infectious Irritable Bowel Syndrome: Role of Genetics, Immune Activation, Serotonin and Altered Microbiome

Spiller, R. E., & Lam, C. (2012) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2012.18.3.258 · Cited by 175 · see citing works

Randomised clinical trial: dried plums (prunes) vs. psyllium for constipation

Attaluri, A., Donahoe, R., Valestin, J., Brown, K., & Rao, S. S. C. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04594.x · Cited by 174 · see citing works

Results of colectomy for severe idiopathic constipation in women (Arbuthnot Lane's disease)

Preston, D. M., Hawley, P. R., Lennard‐Jones, J. E., & Todd, I. P. (1984) · British journal of surgery · doi:10.1002/bjs.1800710726 · Cited by 170 · see citing works

Yamada' s Textbook of Gastroenterology

(2015) · Wiley eBooks · doi:10.1002/9781118512074 · Cited by 168 · see citing works

Validation of the Balloon Evacuation Test: Reproducibility and Agreement With Findings From Anorectal Manometry and Electromyography

Chiarioni, G., Kim, S. M., Vantini, I., & Whitehead, W. E. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.03.013 · Cited by 161 · see citing works

Colectomy for constipation: Physiologic investigation is the key to success

Wexner, S., Daniel, N., & Jagelman, D. (1991) · Diseases of the Colon & Rectum · doi:10.1007/bf02049695 · Cited by 156 · see citing works

Systematic review with meta‐analysis: highly selective 5‐HT4 agonists (prucalopride, velusetrag or naronapride) in chronic constipation

Shin, A., Camilleri, M., Kolar, G. J., Erwin, P. J., West, C. P., & Murad, M. H. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12571 · Cited by 145 · see citing works

Physiological tests to predict long-term outcome of total abdominal colectomy for intractable constipation.

Jm, R., Gw, S., Barofsky, I., Ratych, R. E., Dc, G., & Schuster, M. M. (1995) · PubMed · Cited by 141 · see citing works

American Gastroenterological Association Institute Technical Review on the Pharmacological Management of Irritable Bowel Syndrome

Chang, L., Lembo, A. J., & Sultan, S. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.09.002 · Cited by 135 · see citing works

Influence of Body Position and Stool Characteristics on Defecation in Humans

Rao, S. S. C., Kavlock, R., & Rao, S. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00827.x · Cited by 132 · see citing works

Psychological profiles and quality of life differ between patients with dyssynergia and those with slow transit constipation

Rao, S. S. C., Seaton, K. K., Miller, M. J., Schulze, K. S., Brown, C. K., Paulson, J. A., & Zimmerman, B. M. (2007) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2007.05.016 · Cited by 130 · see citing works

Treatment Efficacy of Sacral Nerve Stimulation in Slow Transit Constipation: A Two-Phase, Double-Blind Randomized Controlled Crossover Study

Dinning, P. G., Hunt, L., Patton, V. E., Zhang, T. G., Szczesniak, M. M., Gebski, V., Jones, M., Stewart, P., Lubowski, D. Z., & Cook, I. J. (2015) · The American Journal of Gastroenterology · doi:10.1038/ajg.2015.101 · Cited by 129 · see citing works

Open‐magnet MR defaecography compared with evacuation proctography in the diagnosis and management of patients with rectal intussusception

Dvorkin, L. S., Hetzer, F. H., Scott, S. M., Williams, N. S., Gedroyc, W., & Lunniss, P. J. (2003) · Colorectal Disease · doi:10.1111/j.1463-1318.2004.00577.x · Cited by 115 · see citing works

Management of obstructed defecation

Podzemny, V. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i4.1053 · Cited by 113 · see citing works

Colonic motility in man: features in normal subjects and in patients with chronic idiopathic constipation

Bassotti, G., Iantorno, G., Fiorella, S., Bustos-Fernández, L., & Bilder, C. (1999) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01203.x · Cited by 111 · see citing works

Long-Term Safety and Effectiveness of Lubiprostone, a Chloride Channel (ClC-2) Activator, in Patients with Chronic Idiopathic Constipation

Lembo, A. J., Johanson, J. F., Parkman, H. P., Rao, S. S. C., Miner, P. B., & Ueno, R. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1801-0 · Cited by 108 · see citing works

DYSSYNERGIC DEFECATION

Rao, S. S. C. (2001) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70169-2 · Cited by 106 · see citing works

Pathophysiology and Role of Biofeedback Therapy in Solitary Rectal Ulcer Syndrome

Rao, S. S. C., Öztürk, R., Ocampo, S. D., & Stessman, M. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00466.x · Cited by 102 · see citing works

Pancolonic spatiotemporal mapping reveals regional deficiencies in, and disorganization of colonic propagating pressure waves in severe constipation

Dinning, P. G., Zárate-López, N., Hunt, L. M., Fuentealba, S. E., Mohammed, S. D., Szczesniak, M. M., Lubowski, D. Z., Preston, S. L., Fairclough, P. D., Lunniss, P. J., et al. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01597.x · Cited by 101 · see citing works

Gastrointestinal neuromuscular pathology in chronic constipation

Knowles, C., & Farrugia, G. (2011) · Best practice & research. Clinical gastroenterology · doi:10.1016/j.bpg.2010.12.001 · Cited by 98 · see citing works

MR defecography in patients with dyssynergic defecation: spectrum of imaging findings and diagnostic value

Reiner, C. S., Tutuian, R. I., Solopova, A. E., Pohl, D., Marinček, B., & Weishaupt, D. (2011) · British Journal of Radiology · doi:10.1259/bjr/28989463 · Cited by 96 · see citing works

Normal aspects of colorectal motility and abnormalities in slow transit constipation

Bassotti, G. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i18.2691 · Cited by 92 · see citing works

Phenotypic Variation of Colonic Motor Functions in Chronic Constipation

Ravi, K., Bharucha, A. E., Camilleri, M., Rhoten, D., Bakken, T., & Zinsmeister, A. R. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.07.057 · Cited by 92 · see citing works

Biofeedback therapy for constipation in adults

Rao, S. S. C. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2011.01.004 · Cited by 91 · see citing works

Ileorectal anastomosis for slow transit constipation: Long-term functional and quality of life results

Hassan, I., Pemberton, J., Young-Fadok, T., You, Y., Drelichman, E. R., Rath-Harvey, D., Schleck, C., & Larson, D. (2006) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2006.09.006 · Cited by 90 · see citing works

Brain and Gut Interactions in Irritable Bowel Syndrome: New Paradigms and New Understandings

Coss‐Adame, E., & Rao, S. S. C. (2014) · Current Gastroenterology Reports · doi:10.1007/s11894-014-0379-z · Cited by 89 · see citing works

Prospective, randomized trial comparing four biofeedback techniques for patients with constipation

Heymen, S., Wexner, S. D., Vickers, D. E., Nogueras, J. J., Weiss, E. G., & Pikarsky, A. J. (1999) · Diseases of the Colon & Rectum · doi:10.1007/bf02235034 · Cited by 88 · see citing works

Diagnostic testing for dyssynergic defecation in chronic constipation: meta‐analysis

Videlock, E. J., Lembo, A. J., & Cremonini, F. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12096 · Cited by 88 · see citing works

Meta‐analysis: alvimopan vs. placebo in the treatment of post‐operative ileus

Tan, E., Cornish, J. A., Darzi, A. W., & Tekkis, P. P. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03150.x · Cited by 86 · see citing works

Outcome of segmental colonic resection for slow-transit constipation

Lundin, E., Karlbom, U., Påhlman, L., & Graf, W. D. (2002) · British journal of surgery · doi:10.1046/j.1365-2168.2002.02213.x · Cited by 86 · see citing works

Constipation: evaluation and treatment of colonic and anorectal motility disorders.

Rao, S. S. C. (2007) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2007.07.013 · Cited by 84 · see citing works

Tolerability, Gut Effects, and Pharmacokinetics of Methylnaltrexone Following Repeated Intravenous Administration in Humans

Yuan, C., Doshan, H. D., Charney, M. R., O’Connor, M. F., Karrison, T., Maleckar, S., Israel, R. J., & Moss, J. (2005) · The Journal of Clinical Pharmacology · doi:10.1177/0091270004273491 · Cited by 84 · see citing works

Influence of Body Position and Stool Characteristics on Defecation in Humans

Barkin, J. S. (2007) · Yearbook of Medicine · doi:10.1016/s0084-3873(08)70265-7 · Cited by 83 · see citing works

Colonic dysmotility in constipation.

Dinning, P. G., & Lorenzo, C. D. (2011) · Best practice & research. Clinical gastroenterology · doi:10.1016/j.bpg.2010.12.006 · Cited by 80 · see citing works

Functional morphology of anal sphincter complex unveiled by high definition anal manometery and three dimensional ultrasound imaging

Raizada, V., Bhargava, V., Karsten, A., & Mittal, R. K. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01782.x · Cited by 79 · see citing works

High Resolution and High Definition Anorectal Manometry and Pressure Topography: Diagnostic Advance or a New Kid on the Block?

Lee, Y. Y., Erdoğan, A., & Rao, S. S. C. (2013) · Current Gastroenterology Reports · doi:10.1007/s11894-013-0360-2 · Cited by 77 · see citing works

Results of 24‐h manometric recording of colonic motor activity with endoluminal instillation of bisacodyl in patients with severe chronic slow transit constipation

Hervé, S., Savoye, G., Behbahani, A., Leroi, A., Denis, P., & Ducrotte, P. R. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00535.x · Cited by 75 · see citing works

Rectal sensorimotor dysfunction in constipation

Scott, S. M., van den Berg, M. M., & Benninga, M. A. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2011.01.001 · Cited by 70 · see citing works

Percutaneous colonoscopic cecostomy for management of chronic constipation in children

Rivera, M. T., Kugathasan, S., Berger, W. L., & Werlin, S. L. (2001) · Gastrointestinal Endoscopy · doi:10.1067/mge.2001.112182 · Cited by 70 · see citing works

Clinical utility of colonic manometry in slow transit constipation

Singh, S. M., Heady, S., Coss‐Adame, E., & Rao, S. S. C. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12092 · Cited by 69 · see citing works

Biofeedback Therapy for Defecation Disorders

Rao, S. S. C., Enck, P., & Loening-Baucke, V. A. (2008) · Digestive Diseases · doi:10.1159/000171623 · Cited by 67 · see citing works

Altered periodic rectal motor activity: a mechanism for slow transit constipation

Rao, S. S. C., Sadeghi, P., Batterson, K., & Beaty, J. (2001) · Neurogastroenterology and Motility · doi:10.1046/j.1365-2982.2001.00292.x · Cited by 66 · see citing works

Long‐term results of the antegrade continent enema procedure for constipation in adults

Lees, N. P., Hodson, P., Hill, J., Pearson, R., & MacLennan, I. (2004) · Colorectal Disease · doi:10.1111/j.1463-1318.2004.00669.x · Cited by 65 · see citing works

Diagnostic testing in patients with chronic constipation

Remes-Troche, J. M., & Rao, S. S. C. (2006) · Current Gastroenterology Reports · doi:10.1007/s11894-006-0028-2 · Cited by 60 · see citing works

Long‐term efficacy of biofeedback therapy in patients with dyssynergic defecation: results of a median 44 months follow‐up

Lee, H., Boo, S., Jung, K., Han, S., Seo, S., Koo, H. S., Yoon, I., Park, S., Yang, D.-H., Kim, K.-J., et al. (2015) · Neurogastroenterology and Motility · doi:10.1111/nmo.12552 · Cited by 50 · see citing works

Functional Chest Pain

Mudipalli, R. S., Remes-Troche, J. M., Andersen, L., & Rao, S. S. C. (2007) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000225521.36160.1b · Cited by 48 · see citing works

Pharmacologic Management of Chronic Constipation

Singh, S., & Rao, S. S. C. (2010) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.08.001 · Cited by 43 · see citing works

Assessment of rectal afferent neuronal function and brain activity in patients with constipation and rectal hyposensitivity

Burgell, R., Lelic, D., Carrington, E. V., Lunniss, P. J., Olesen, S. S., Surguy, S. M., Drewes, A. M., & Scott, S. M. (2012) · Neurogastroenterology & Motility · doi:10.1111/nmo.12047 · Cited by 42 · see citing works

Guanylate Cyclase C Agonists: Emerging Gastrointestinal Therapies and Actions

Camilleri, M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.01.003 · Cited by 42 · see citing works

Prucalopride: evaluation of the pharmacokinetics, pharmacodynamics, efficacy and safety in the treatment of chronic constipation

Tack, J. F., & Corsetti, M. (2012) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2012.719497 · Cited by 41 · see citing works

Antibiotics for Irritable Bowel Syndrome: Rationale and Current Evidence

Sachdev, A. H., & Pimentel, M. (2012) · Current Gastroenterology Reports · doi:10.1007/s11894-012-0284-2 · Cited by 40 · see citing works

Review article: the role of serotonergic agents in the treatment of patients with primary chronic constipation

Cash, B. D., & Chey, W. D. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02696.x · Cited by 38 · see citing works

APPENDICEAL VERSUS ILEAL SEGMENT FOR ANTEGRADE CONTINENCE ENEMA

TACKETT, L. D., Minevich, E. A., BENEDICT, J. F., Wacksman, J., & Sheldon, C. A. (2002) · The Journal of Urology · doi:10.1016/s0022-5347(01)69125-0 · Cited by 35 · see citing works

Plecanatide, a Novel Uroguanylin Analog: A 12-Week, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Trial to Evaluate Efficacy and Safety in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)

Miner, P. B., DeLuca, R., Portilla, M. D. L., Padila, E., Koltun, W. D., Wiltz, O., Shailubhai, K., Jacob, G., Griffin, P. H., & Barrow, L. (2014) · The American Journal of Gastroenterology · doi:10.14309/00000434-201410002-01831 · Cited by 34 · see citing works

Advances in pharmacotherapy for opioid-induced constipation – a systematic review

Siemens, W., Gaertner, J., & Becker, G. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.995625 · Cited by 31 · see citing works

Naloxegol, a new drug for the treatment of opioid-induced constipation

Corsetti, M., & Tack, J. F. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.991306 · Cited by 25 · see citing works

Methylnaltrexone

Garnock-Jones, K. P., & McKeage, K. (2010) · Drugs · doi:10.2165/11204520-000000000-00000 · Cited by 21 · see citing works

Emerging treatments in Neurogastroenterology: Perspectives of guanylyl cyclase C agonists use in functional gastrointestinal disorders and inflammatory bowel diseases

Jarmuż, A., Zielińska, M., Storr, M., & Fichna, J. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12574 · Cited by 17 · see citing works

Sa2029 Rectal Hyposensitivity: Randomized Controlled Trial of Barostat vs. Syringe-Assisted Sensory Training

Rao, S. S. C., Erdoğan, A., Coss‐Adame, E., Valestin, J., & Mattos, M. L. (2013) · Gastroenterology · doi:10.1016/s0016-5085(13)61338-4 · Cited by 7 · see citing works

The investigation of chronic constipation for surgical management.

Ho, Y. H., & Goh, H. S. (1996) · PubMed · Cited by 6 · see citing works

APPENDICEAL VERSUS ILEAL SEGMENT FOR ANTEGRADE CONTINENCE ENEMA

TACKETT, L. D., Minevich, E. A., BENEDICT, J. F., et al. (2002) · The Journal of Urology · doi:10.1097/00005392-200202000-00064 · Cited by 5 · see citing works

Is there a genetic component in chronic functional constipation

Coremans, G., Margaritis, & Gebruers, K. (2005) · Gastroenterology · Cited by 3 · see citing works

Dyssynergia or No Dyssynergia: Phenotypic Categorization of Constipated Patients With High Resolution Anorectal Manometry (HRAM) ACG Fellows-In-Training Award Presidential Poster

Rattanakovit, K., Rao, S. S. C., Amieva, M., Mack, A., & Dewitt, A. (2015) · The American Journal of Gastroenterology · doi:10.14309/00000434-201510001-01373 · Cited by 3 · see citing works

Small Intestinal Bacterial Overgrowth (SIBO) and Fungal Overgrowth (SIFO): A Frequent and Unrecognized Complication of Colectomy: ACG Category Award: Presidential Poster

Abdulla, H., Yu, S., Rattanakovit, K., Badger, C., & Rao, S. S. C. (2015) · The American Journal of Gastroenterology · doi:10.14309/00000434-201510001-02397 · Cited by 2 · see citing works

Chronic constipation

Camilleri, M., Ford, A. C., Mawe, G. M., Dinning, P. G., Rao, S. S., Chey, W. D., Simrén, M., Lembo, A., Young-Fadok, T. M., & Chang, L. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.95 · Cited by 411 · see citing works

Chronic constipation

Forootan, M., Bagheri, N., & Darvishi, M. (2018) · Medicine · doi:10.1097/md.0000000000010631 · Cited by 173 · see citing works

Antibiotics-induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility

Ge, X., Ding, C., Zhao, W., Xu, L., Tian, H., Gong, J., Zhu, M., Li, J., & Li, N. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-016-1105-4 · Cited by 274 · see citing works

Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine

Cao, H., Liu, X., An, Y., Zhou, G., Liu, Y., Xu, M., Dong, W., Wang, S., Yan, F., Jiang, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10835-8 · Cited by 253 · see citing works

Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders

Sasso, J. M., Ammar, R. M., Tenchov, R., Lemmel, S. A., Kelber, O., Grieswelle, M., & Zhou, Q. A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00127 · Cited by 218 · see citing works

Role of gut microbiota in functional constipation

Zhang, S., Wang, R., Li, D., Zhao, L., & Zhu, L. (2021) · Gastroenterology Report · doi:10.1093/gastro/goab035 · Cited by 175 · see citing works

Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults

Zhang, C., Jiang, J., Tian, F., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.01.005 · Cited by 131 · see citing works

Gut dysbacteriosis and intestinal disease: mechanism and treatment

Meng, X., ZHANG, G., Cao, H., Yu, D., Fang, X., de Vos, W. M., & Wu, H. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14661 · Cited by 127 · see citing works

An Orally Active Cannabis Extract with High Content in Cannabidiol attenuates Chemically-induced Intestinal Inflammation and Hypermotility in the Mouse

Pagano, E., Capasso, R., Piscitelli, F., Romano, B., Parisi, O. A., Finizio, S., Lauritano, A., Marzo, V. D., Izzo, A. A., & Borrelli, F. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00341 · Cited by 119 · see citing works

Efficacy and safety of over-the-counter therapies for chronic constipation: An updated systematic review

Rao, S. S. C., & Brenner, D. M. (2021) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001222 · Cited by 97 · see citing works

Effect of Durio zibethinus rind polysaccharide on functional constipation and intestinal microbiota in rats

Jiang, H., Dong, J., Jiang, S., Liang, Q., Zhang, Y., Liu, Z., Ma, C., Wang, J., & Kang, W. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109316 · Cited by 95 · see citing works

Fruits and their impact on the gut microbiota, gut motility and constipation

Katsirma, Z., Dimidi, E., Rodriguez‐Mateos, A., & Whelan, K. (2021) · Food & Function · doi:10.1039/d1fo01125a · Cited by 95 · see citing works

Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation

Scott, S. M., Simrén, M., Farmer, A. D., Dinning, P. G., Carrington, E. V., Benninga, M. A., Burgell, R., Dimidi, E., Fikree, A., Ford, A. C., et al. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.14050 · Cited by 93 · see citing works

Review article: diagnosis, management and patient perspectives of the spectrum of constipation disorders

Sharma, A., Rao, S. S. C., Kearns, K., Orleck, K. D., & Waldman, S. A. (2021) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/apt.16369 · Cited by 84 · see citing works

Prevention of loperamide induced constipation in mice by KGM and the mechanisms of different gastrointestinal tract microbiota regulation

Zhang, Q., Zhong, D., Sun, R., Zhang, Y., Pegg, R. B., & Zhong, G. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117418 · Cited by 83 · see citing works

Transplantation of enteric nervous system stem cells rescues nitric oxide synthase deficient mouse colon

McCann, C. J., Cooper, J. E., Natarajan, D., Jevans, B., Burnett, L. E., Burns, A. J., & Thapar, N. (2017) · Nature Communications · doi:10.1038/ncomms15937 · Cited by 79 · see citing works

Fermented milk containing Lactobacillus casei Zhang and Bifidobacterium animalis ssp. lactis V9 alleviated constipation symptoms through regulation of intestinal microbiota, inflammation, and metabolic pathways

Wang, J., Bai, X., Peng, C., Yu, Z., Li, B., Zhang, W., Sun, Z., & Zhang, H. (2020) · Journal of Dairy Science · doi:10.3168/jds.2020-18639 · Cited by 78 · see citing works

Prevalence of constipation in adults with obesity class II and III and associated factors

Silveira, É. A., Santos, A. S. E. A. D. C., Ribeiro, J. N., Noll, M. A., Rodrigues, A. P. D. S., & de Oliveira, C. M. (2021) · BMC Gastroenterology · doi:10.1186/s12876-021-01806-5 · Cited by 73 · see citing works

Antipsychotic-Induced Constipation: A Review of the Pathogenesis, Clinical Diagnosis, and Treatment

Xu, Y., Amdanee, N., & Zhang, X.-R. (2021) · CNS Drugs · doi:10.1007/s40263-021-00859-0 · Cited by 67 · see citing works

Bifidobacterium longum relieves constipation by regulating the intestinal barrier of mice

Wang, L., Chai, M., Wang, J., Yu, Q., Wang, G., Zhang, H., Zhao, J., & Chen, W. (2022) · Food & Function · doi:10.1039/d1fo04151g · Cited by 66 · see citing works

Bamboo shavings derived O-acetylated xylan alleviates loperamide-induced constipation in mice

Huang, J., Lin, B., Zhang, Y., Xie, Z., Zheng, Y., Wang, Q., & Xiao, H. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118761 · Cited by 65 · see citing works

Pediococcus pentosaceus B49 from human colostrum ameliorates constipation in mice

Huang, J., Li, S., Wang, Q., Guan, X., Qian, L., Li, J., Zheng, Y., & Lin, B. (2020) · Food & Function · doi:10.1039/d0fo00208a · Cited by 64 · see citing works

The Composition of Intestinal Microbiota and its Association with Functional Constipation of the Elderly Patients

Guo, M., Yao, J., Yang, F. H., Liu, W., Bai, H., Ma, J., Ma, X., Zhang, J., Fang, Y., Miao, Y., et al. (2020) · Future Microbiology · doi:10.2217/fmb-2019-0283 · Cited by 63 · see citing works

Long-term follow-up of the effects of fecal microbiota transplantation in combination with soluble dietary fiber as a therapeutic regimen in slow transit constipation

Zhang, X., Tian, H., Gu, L., Nie, Y., Ding, C., Ge, X., Yang, B. K., Gong, J., & Li, N. (2018) · Science China Life Sciences · doi:10.1007/s11427-017-9229-1 · Cited by 64 · see citing works

Diagnosis and treatment of constipation: a clinical update based on the Rome IV criteria

Sobrado, C. W., Neto, I. J. F. C., Pinto, R. A., Sobrado, L. F., Nahas, S. C., & Cecconello, I. (2018) · Journal of Coloproctology · doi:10.1016/j.jcol.2018.02.003 · Cited by 62 · see citing works

Adhesive Bifidobacterium Induced Changes in Cecal Microbiome Alleviated Constipation in Mice

Wang, L., Chen, C., Cui, S., Lee, Y. K., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01721 · Cited by 62 · see citing works

Neuromechanism of acupuncture regulating gastrointestinal motility

Yu, Z. H. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i23.3182 · Cited by 62 · see citing works

The “rectosigmoid brake”: Review of an emerging neuromodulation target for colorectal functional disorders

Lin, A. Y., Dinning, P. G., Milne, T. G. E., Bissett, I. P., & O’Grady, G. (2017) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12760 · Cited by 60 · see citing works

Prevalence and Risk Factors of Functional Constipation According to the Rome Criteria in China: A Systematic Review and Meta-Analysis

Chen, Z., Peng, Y., Shi, Q., Chen, Y., Cao, L., Jia, J., Liu, C., & Zhang, J. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.815156 · Cited by 61 · see citing works

Efficacy of MaZiRenWan, a Chinese Herbal Medicine, in Patients With Functional Constipation in a Randomized Controlled Trial

Zhong, L. L. D., Cheng, C. W., Kun, W., Dai, L., Hu, D.-D., Ning, Z., Xiao, H., Lin, C., Zhao, L., Huang, T., et al. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.04.005 · Cited by 56 · see citing works

SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation

Haggie, P. M., Cil, O., Lee, S., Tan, J.-A., Rivera, A. A., Phuan, P.-W., & Verkman, A. S. (2018) · JCI Insight · doi:10.1172/jci.insight.121370 · Cited by 56 · see citing works

Different Bifidobacterium bifidum strains change the intestinal flora composition of mice via different mechanisms to alleviate loperamide-induced constipation

Chai, M., Wang, L., Li, X., Zhao, J., Zhang, H., Wang, G., & Chen, W. (2021) · Food & Function · doi:10.1039/d1fo00559f · Cited by 55 · see citing works

Efficacy of Synbiotics in Patients with Slow Transit Constipation: A Prospective Randomized Trial

Ding, C., Ge, X., Zhang, X., Tian, H., Wang, H., Gu, L., Gong, J., Zhu, W., & Li, N. (2016) · Nutrients · doi:10.3390/nu8100605 · Cited by 55 · see citing works

Systemic sclerosis gastrointestinal dysmotility: risk factors, pathophysiology, diagnosis and management

McMahan, Z. H., Kulkarni, S., Chen, J. W., Chen, J. Z., Xavier, R. J., Pasricha, P. J., & Khanna, D. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00900-6 · Cited by 54 · see citing works

Chronic functional constipation is strongly linked to vitamin D deficiency

Panarese, A., Pesce, F., Porcelli, P., Riezzo, G., Iacovazzi, P., Leone, C. M., Carne, M. D., Rinaldi, C., & Shahini, E. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i14.1729 · Cited by 49 · see citing works

Effect of Physical Activity on the Association Between Dietary Fiber and Constipation: Evidence From the National Health and Nutrition Examination Survey 2005-2010

Li, Y., Tong, W., & Yang, Q. (2020) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm20051 · Cited by 51 · see citing works

Abnormal bile acid metabolism is an important feature of gut microbiota and fecal metabolites in patients with slow transit constipation

Fan, Y., Xu, C., Xie, L., Wang, Y., Zhu, S., An, J., Li, Y., Tian, Z., Yan, Y., Yu, S., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.956528 · Cited by 52 · see citing works

Character and laxative activity of polysaccharides isolated from Dendrobium officinale

Luo, D., Qu, C., Lin, G., Zhang, Z., Xie, J., Chen, H., Liang, J.-L., Li, C., Wang, H., & Su, Z. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.04.024 · Cited by 50 · see citing works

Neurogenic Bowel and Management after Spinal Cord Injury: A Narrative Review

Rodriguez, G. M., & Gater, D. R. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12071141 · Cited by 49 · see citing works

Efficacy of Probiotic Compounds in Relieving Constipation and Their Colonization in Gut Microbiota

He, Y., Zhu, L., Chen, J., Tang, X., Pan, M., Yuan, W., & Wang, H. (2022) · Molecules · doi:10.3390/molecules27030666 · Cited by 49 · see citing works

Prevention of Loperamide-Induced Constipation in Mice and Alteration of 5-Hydroxytryotamine Signaling by Ligilactobacillus salivarius Li01

Qiu, B., Zhu, L. Q., Zhang, S., Han, S., Fei, Y., Ba, F., Berglund, B., Li, L., & Yao, M. (2022) · Nutrients · doi:10.3390/nu14194083 · Cited by 51 · see citing works

Ion channelopathies in functional GI disorders

Beyder, A., & Farrugia, G. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00237.2016 · Cited by 47 · see citing works

Diagnosis and treatment of gastrointestinal dysfunction in hereditary TTR amyloidosis

Obici, L. P., & Suhr, O. B. (2019) · Clinical Autonomic Research · doi:10.1007/s10286-019-00628-6 · Cited by 47 · see citing works

Regional gastrointestinal contractility parameters using the wireless motility capsule: inter‐observer reproducibility and influence of age, gender and study country

Farmer, A., Wegeberg, A., Brock, B., Hobson, A., Mohammed, S., Scott, S., Bruckner-Holt, C., Semler, J., Hasler, W., Hellström, P., et al. (2018) · Alimentary Pharmacology and Therapeutics · doi:10.1111/apt.14438 · Cited by 46 · see citing works

The protective effects of yellow tea extract against loperamide-induced constipation in mice

Cao, P.-Q., Li, X., Ouyang, J., Jiang, R., Huang, F.-F., Wen, B., Zhang, X.-N., Huang, J., & Liu, Z. (2021) · Food & Function · doi:10.1039/d0fo02969f · Cited by 47 · see citing works

Prebiotic Galacto-Oligosaccharides Impact Stool Frequency and Fecal Microbiota in Self-Reported Constipated Adults: A Randomized Clinical Trial

Schoemaker, M. H., Hageman, J. H. J., ten Haaf, D. S. M., Hartog, A., Scholtens, P. A. M. J., Boekhorst, J., Nauta, A., & Bos, R. (2022) · Nutrients · doi:10.3390/nu14020309 · Cited by 45 · see citing works

Functional Constipation: Individualising Assessment and Treatment

Pannemans, J., Masuy, I., & Tack, J. (2020) · Drugs · doi:10.1007/s40265-020-01305-z · Cited by 44 · see citing works

Nanocrystalline Cellulose Cures Constipation via Gut Microbiota Metabolism

Wang, M., Cha, R., Hao, W., Du, R., Zhang, P., Hu, Y., & Jiang, X. (2022) · ACS Nano · doi:10.1021/acsnano.2c05809 · Cited by 43 · see citing works

Physicochemical properties and laxative effects of polysaccharides from Anemarrhena asphodeloides Bge. in loperamide-induced rats

Li, X., Liu, Y., Guan, W., Xia, Y., Zhou, Y., Yang, B., & Kuang, H. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.111961 · Cited by 42 · see citing works

Intestinal Anti-Inflammatory Effect of a Peptide Derived from Gastrointestinal Digestion of Buffalo (Bubalus bubalis) Mozzarella Cheese

Tenore, G. C., Pagano, E., Lama, S., Vanacore, D., Maro, S. D., Maisto, M., Capasso, R., Merlino, F., Borrelli, F., Stiuso, P., et al. (2019) · Nutrients · doi:10.3390/nu11030610 · Cited by 41 · see citing works

The combined therapy of fecal microbiota transplantation and laxatives for functional constipation in adults

Fang, S., Wu, S., Ji, L., Fan, Y., Wang, X., & Yang, K. (2021) · Medicine · doi:10.1097/md.0000000000025390 · Cited by 38 · see citing works

Characteristics of the Gut Microbiome and Serum Metabolome in Patients with Functional Constipation

Wang, J., Wang, L., Yu, Q., Tang, N., Mei, C., Zhang, H., Wang, G., Lu, J., & Chen, W. (2023) · Nutrients · doi:10.3390/nu15071779 · Cited by 36 · see citing works

Functional Fecal Incontinence in Children

Rajindrajith, S., Devanarayana, N. M., Thapar, N., & Benninga, M. A. (2021) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000003056 · Cited by 36 · see citing works

Effects of the vibrating capsule on colonic circadian rhythm and bowel symptoms in chronic idiopathic constipation

Rao, S. S. C., Lembo, A. J., Chey, W. D., Friedenberg, K., & Quigley, E. M. M. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13890 · Cited by 35 · see citing works

Gut indigenous Ruminococcus gnavus alleviates constipation and stress-related behaviors in mice with loperamide-induced constipation

Li, R., Xu, S., Li, B., Zhang, B., Chen, W., Dai, D., & Liu, Z. (2023) · Food & Function · doi:10.1039/d2fo03574j · Cited by 34 · see citing works

Nicotinamide adenine dinucleotide replenishment rescues colon degeneration in aged mice

Zhu, X., Shen, W., Wang, Y., Jaiswal, A., Ju, Z., & Sheng, Q. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.17 · Cited by 31 · see citing works

Effects of Allium mongolicum Regel and Its Flavonoids on Constipation

Chen, Y., Ding, Z., Wu, Y. C., Chen, Q., Liu, M., Yu, H., Wang, D., Zhang, Y., & Wang, T. (2019) · Biomolecules · doi:10.3390/biom10010014 · Cited by 32 · see citing works

Peripherally acting μ-opioid receptor antagonists as treatment options for constipation in noncancer pain patients on chronic opioid therapy

Pergolizzi, J. V., Raffa, R. B., Pappagallo, M., Fleischer, C., Pergolizzi, J. V., Zampogna, G., Duval, E., Hishmeh, J., LeQuang, J. A., & Taylor, R. (2017) · Patient Preference and Adherence · doi:10.2147/ppa.s78042 · Cited by 31 · see citing works

Home Biofeedback for the Treatment of Dyssynergic Defecation: Does It Improve Quality of Life and Is It Cost-Effective?

Rao, S. S. C., Go, J. T., Valestin, J., & Schneider, J. E. (2019) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000278 · Cited by 31 · see citing works

Soluble Dietary Fiber of Hawthorn Relieves Constipation Induced by Loperamide Hydrochloride by Improving Intestinal Flora and Inflammation, Thereby Regulating the Aquaporin Ion Pathway in Mice

Zhang, H., Zu, Q., Zhang, J., Liu, S., Zhang, G., Chang, X., & Li, X. (2024) · Foods · doi:10.3390/foods13142220 · Cited by 30 · see citing works

Pretest and Post-test Probabilities of Diagnoses of Rectal Evacuation Disorders Based on Symptoms, Rectal Exam, and Basic Tests: a Systematic Review

Brandler, J., & Camilleri, M. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2019.11.049 · Cited by 30 · see citing works

The Psychobiological Etiology of Gastrointestinal Distress in Sport

Wilson, P. B. (2019) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001308 · Cited by 30 · see citing works

Effect of konjac glucomannan on metabolites in the stomach, small intestine and large intestine of constipated mice and prediction of the KEGG pathway

Zhang, Q., Zhong, D., Ren, Y., Meng, Z.-K., Pegg, R. B., & Zhong, G. (2021) · Food & Function · doi:10.1039/d0fo02682d · Cited by 30 · see citing works

Hong Kong Chinese Medicine Clinical Practice Guideline for Cancer Palliative Care: Pain, Constipation, and Insomnia

Lam, W. C., Zhong, L. L. D., Liu, Y., Shi, N., Ng, B. F. L., Ziea, E. T. C., Bian, Z., & Lü, A. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/1038206 · Cited by 30 · see citing works

Polysaccharides from Holothuria leucospilota Relieve Loperamide-Induced Constipation Symptoms in Mice

Wang, Z., Shi, Y., Zeng, S., Zheng, Y., Wang, H., Liao, H., Song, J., Zhang, X., Cao, J., & Li, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032553 · Cited by 29 · see citing works

Expert consensus on the assessment and treatment of chronic constipation in the elderly

Zheng, S., Yao, J., & the Chinese Geriatric Society, E. B. O. C. J. O. G. (2018) · Aging Medicine · doi:10.1002/agm2.12013 · Cited by 28 · see citing works

Formulation of traditional Chinese medicine and its application on intestinal flora of constipated rats

Li, S., He, Y., Zhang, H., Zheng, R., Xu, R., Liu, Q., Tang, S., Ke, X., & Huang, M. (2020) · Microbial Cell Factories · doi:10.1186/s12934-020-01473-3 · Cited by 28 · see citing works

Chinese patent medicine shouhui tongbian capsule attenuated loperamide-induced constipation through modulating the gut microbiota in rat

Lin, Q., Liu, M., Erhunmwunsee, F., Li, B., Mou, Y., Wang, S., Zhang, G., & Tian, J. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115575 · Cited by 29 · see citing works

Lactic acid bacteria in relieving constipation: mechanism, clinical application, challenge, and opportunity

Zhang, T., Liu, W., Lu, H., Cheng, T., Wang, L., Wang, G., Zhang, H., & Chen, W. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2278155 · Cited by 28 · see citing works

Plecanatide: a new guanylate cyclase agonist for the treatment of chronic idiopathic constipation

Rao, S. S. C. (2018) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284818777945 · Cited by 27 · see citing works

Bile Reflux Gastropathy and Functional Dyspepsia

Lake, A., Rao, S. S. C., Larion, S., Spartz, H., & Kavuri, S. (2021) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm20102 · Cited by 27 · see citing works

How do probiotics alleviate constipation? A narrative review of mechanisms

Huang, Y.-P., Shi, J.-Y., Luo, X.-T., Luo, S.-C., Cheung, P. C. K., Corke, H., Yang, Q.-Q., & Zhang, B. (2024) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2024.2336531 · Cited by 28 · see citing works

Cinnamic acid regulates the intestinal microbiome and short-chain fatty acids to treat slow transit constipation

Jiang, J.-G., Luo, Q., Li, S., Tan, T.-Y., Xiong, K., Yang, T., & Xiao, T. (2023) · World Journal of Gastrointestinal Pharmacology and Therapeutics · doi:10.4292/wjgpt.v14.i2.4 · Cited by 26 · see citing works

Lactobacillus plantarum Lp3a improves functional constipation: evidence from a human randomized clinical trial and animal model

Zhang, C., Zhang, Y., Ma, K., Wang, G., Tang, M., Wang, R., Xia, Z., Xu, Z., Sun, M., Bao, X., et al. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-458 · Cited by 25 · see citing works

Laxative Use in the Community: A Literature Review

Werth, B. L., & Christopher, S. A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10010143 · Cited by 25 · see citing works

A Shigella species variant is causally linked to intractable functional constipation

Chen, X., Qiu, T.-T., Wang, Y., Xu, L.-Y., Sun, J., Jiang, Z., Zhao, W. H., Tao, T., Zhou, Y., Wei, L., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci150097 · Cited by 24 · see citing works

Xylooligosaccharides from corn cobs alleviate loperamide-induced constipation in mice via modulation of gut microbiota and SCFA metabolism

Song, H., Guo, R. H., Sun, X., Kou, Y., Ma, X., Chen, Y., Song, L., Yuan, C., & Wu, Y. (2023) · Food & Function · doi:10.1039/d3fo02688d · Cited by 24 · see citing works

A Pilot Study of Non-invasive Sacral Nerve Stimulation in Treatment of Constipation in Childhood and Adolescence

Besendörfer, M., Kohl, M., Schellerer, V. S., Carbon, R. T., & Diez, S. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00169 · Cited by 23 · see citing works

Diagnosis of colonic dysmotility associated with autonomic dysfunction in patients with chronic refractory constipation

Liu, L., Milkova, N., Nirmalathasan, S., Ali, M. K., Sharma, K., Huizinga, J. D., & Chen, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-15945-6 · Cited by 27 · see citing works

Stool-softening effect and action mechanism of free anthraquinones extracted from Rheum palmatum L. on water deficit-induced constipation in rats

Lv, H., Niu, J., Pan, W., Wang, Y., Wang, L., Wang, M., Shi, Y., Zhang, G., Hamyari, B. A., Wang, S., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117336 · Cited by 23 · see citing works

4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation

Lee, S., Çil, O., Haggie, P. M., & Verkman, A. S. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01192 · Cited by 23 · see citing works

Non-pharmacological interventions to improve constipation amongst older adults in long-term care settings: A systematic review of randomised controlled trials

Dobarrio‐Sanz, I., Hernández‐Padilla, J. M., López‐Rodriguez, M. M., Fernández‐Sola, C., Granero‐Molina, J., & Fernández, M. D. R. (2020) · Geriatric Nursing · doi:10.1016/j.gerinurse.2020.07.012 · Cited by 23 · see citing works

Clinical Evaluation of a Patient With Symptoms of Colonic or Anorectal Motility Disorders

Curtin, B. F., Jimenez, E., & Rao, S. S. C. (2020) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm20012 · Cited by 22 · see citing works

Predicting the Role of the Human Gut Microbiome in Constipation Using Machine-Learning Methods: A Meta-Analysis

Chen, Y., Wu, T., Lu, W., Yuan, W., Pan, M., Lee, Y. K., Zhao, J., Zhang, H., Chen, W., Zhu, J., et al. (2021) · Microorganisms · doi:10.3390/microorganisms9102149 · Cited by 21 · see citing works

Update S3-Leitlinie Intestinale Motilitätsstörungen: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM)

Keller, J., Wedel, T., Seidl, H., Kreis, M. E., van der Voort, I., Gebhard, M., Langhorst, J., Jansen, P. L., Schwandner, O., Storr, M., et al. (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1646-1279 · Cited by 22 · see citing works

The effect of aroma massage on constipation in elderly individuals

Lafçı, D., & Kaşıkçı, M. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.112023 · Cited by 22 · see citing works

Aster tataricus alleviates constipation by antagonizing the binding of acetylcholine to muscarinic receptor and inhibiting Ca2+ influx

Wu, H., Chen, Y., Huang, B., Yu, Y., Zhao, S., Liu, J., Jia, Z., & Xiao, H. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111005 · Cited by 21 · see citing works

The role of neuromodulation in chronic functional constipation : a systematic review

Pauwels, N., Willemse, C. A., Hellemans, S., Komen, N., den Broeck, S. V., Roenen, J., Aggelpoel, T. V., & Schepper, H. U. D. (2021) · Acta gastro-enterologica belgica · doi:10.51821/84.3.012 · Cited by 21 · see citing works

Proteomics Analysis in Dairy Products: Cheese, a Review

Bouroutzika, E. V., Proikakis, S., Anagnostopoulos, A. K., Katsafadou, A. I., Fthenakis, G. C., & Tsangaris, G. T. (2021) · Applied Sciences · doi:10.3390/app11167622 · Cited by 22 · see citing works

Exploring the Dose–Effect Relationship of Bifidobacterium longum in Relieving Loperamide Hydrochloride-Induced Constipation in Rats through Colon-Released Capsules

Zhou, X., Mao, B., Tang, X., Zhang, Q., Zhao, J., Zhang, H., & Cui, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076585 · Cited by 21 · see citing works

The rhizomes of Atractylodes macrocephala relieve loperamide-induced constipation in rats by regulation of tryptophan metabolism

Qin, L.-L., Yu, M., Yang, P., & Zou, Z. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117637 · Cited by 21 · see citing works

Hepatocyte SHP-1 is a Critical Modulator of Inflammation During Endotoxemia

Adhikari, A., Martel, C., Marette, A., & Olivier, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-02512-7 · Cited by 22 · see citing works

Long-term Risks of Parkinson's Disease, Surgery, and Colorectal Cancer in Patients with Slow-transit Constipation.

Song, E., Lee, H., Jung, K., Kim, M. J., Hwang, S., Park, S., Yang, D.-H., Ye, B., Byeon, J., Choe, J., et al. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.08.059 · Cited by 18 · see citing works

Functional constipation in patients with hemorrhoids: a systematic review and meta-analysis

Kalkdijk, J., Broens, P., ten Broek, R., van der Heijden, J., Trzpis, M., Pierie, J. P., & Klarenbeek, B. (2022) · European Journal of Gastroenterology &amp; Hepatology · doi:10.1097/meg.0000000000002361 · Cited by 19 · see citing works

Safety and efficacy of intermittent colonic exoperistalsis device to treat chronic constipation: a prospective multicentric clinical trial

McClurg, D., Booth, L., & Herrero-Fresneda, I. (2020) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000267 · Cited by 18 · see citing works

Balloon Expulsion Test Does Not Seem to Be Useful for Screening or Exclusion of Dyssynergic Defecation as a Single Test

Lee, J., Hong, K. S., Kim, J. S., & Jung, H. C. (2017) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16158 · Cited by 19 · see citing works

Topical therapy with rhubarb navel plasters in patients with chronic constipation: Results from a prospective randomized multicenter study

Wei, L., Luo, Y., Zhang, X., Liu, Y., Gasser, M., Tang, F., Ouyang, W., Wei, H., Lu, S., Yang, Z. H., et al. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113096 · Cited by 19 · see citing works

Synergistic effects of Ligilactobacillus salivarius Li01 and psyllium husk prevent mice from developing loperamide-induced constipation

Xu, L., Qiu, B., Ba, F., Zhang, S., Han, S., Chen, H., Wu, Y., Gao, W., Xie, S., Chen, Y., et al. (2024) · Food & Function · doi:10.1039/d4fo04444d · Cited by 20 · see citing works

Milk fermented by combined starter cultures comprising three Lactobacillus strains exerts an alleviating effect on loperamide-induced constipation in BALB/c mice

Jiang, Y. L., Guo, H., Sun, M., Jiang, C., Jiang, S., Mu, G., Tuo, Y., & Gao, P. (2023) · Food & Function · doi:10.1039/d3fo00222e · Cited by 18 · see citing works

Tongbian formula alleviates slow transit constipation by increasing intestinal butyric acid to activate the 5-HT signaling

Li, D., Si, X., Hua, Y., Qian, Y., Li, H., Lv, N., Fang, Q., Han, X., & Xu, T. (2024) · Scientific Reports · doi:10.1038/s41598-024-68473-w · Cited by 18 · see citing works

Mechanisms, evaluation, and management of chronic constipation

Bharucha, A. E., & Lacy, B. E. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.12.034 · Cited by 655 · see citing works

Chronic constipation

Camilleri, M., Ford, A. C., Mawe, G. M., Dinning, P. G., Rao, S. S., Chey, W. D., Simrén, M., Lembo, A., Young-Fadok, T. M., & Chang, L. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.95 · Cited by 411 · see citing works

A practical approach to diagnosis and management of functional constipation in adults

Bassotti, G., & Villanacci, V. (2013) · Internal and Emergency Medicine · doi:10.1007/s11739-011-0698-0 · Cited by 40 · see citing works

Constipation:

Rao, S. S. C. (2003) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(03)00026-8 · Cited by 123 · see citing works

Constipation and Dyssynergic Defecation

Mion, F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815346-8.00017-5