Effect of antidepressants and psychological therapies, including hypnotherapy, in irritable bowel syndrome: systematic review and meta-analysis
Abstract
OBJECTIVES: Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder. Evidence relating to the treatment of this condition with antidepressants and psychological therapies continues to accumulate. METHODS: We performed an updated systematic review and meta-analysis of randomized controlled trials (RCTs). MEDLINE, EMBASE, and the Cochrane Controlled Trials Register were searched (up to December 2013). Trials recruiting adults with IBS, which compared antidepressants with placebo, or psychological therapies with control therapy or "usual management," were eligible. Dichotomous symptom data were pooled to obtain a relative risk (RR) of remaining symptomatic after therapy, with a 95% confidence interval (CI). RESULTS: The search strategy identified 3,788 citations. Forty-eight RCTs were eligible for inclusion: thirty-one compared psychological therapies with control therapy or "usual management," sixteen compared antidepressants with placebo, and one compared both psychological therapy and antidepressants with placebo. Ten of the trials of psychological therapies, and four of the RCTs of antidepressants, had been published since our previous meta-analysis. The RR of IBS symptom not improving with antidepressants vs. placebo was 0.67 (95% CI=0.58-0.77), with similar treatment effects for both tricyclic antidepressants and selective serotonin reuptake inhibitors. The RR of symptoms not improving with psychological therapies was 0.68 (95% CI=0.61-0.76). Cognitive behavioral therapy, hypnotherapy, multicomponent psychological therapy, and dynamic psychotherapy were all beneficial. CONCLUSIONS: Antidepressants and some psychological therapies are effective treatments for IBS. Despite the considerable number of studies published in the intervening 5 years since we last examined this issue, the overall summary estimates of treatment effect have remained remarkably stable.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The all-trials meta-analysis finding conflicts with previous meta-analyses, and this results from the inclusion of a single study that had the most infrequent sessions and the lowest volume of intervention among the included studies.
“which conflicts with the findings of previous meta-analyses.11,13 This results from the inclusion of a single study, which had the most infrequent sessions and the lowest volume of intervention 18 of the included studies.”
From Systematic review, meta-analysis with subgroup analysis of hypnotherapy for irritable bowel syndrome, effect of intervention characteristics (2021) · cites this paper as [11]
The results were similar to a recently published meta-analysis that used binary outcome data to compare psychotherapy versus antidepressant medications for reducing GI symptoms in IBS.
“Our results were similar to a recently published metaanalysis that used binary outcome data to compare the efficacy of psychotherapy vs antidepressant medications for reducing GI symptoms in IBS.”
From Short-term and long-term efficacy of psychological therapies for irritable bowel syndrome: a systematic review and meta-analysis (2016) · cites this paper as [5]
Psychological therapies are as effective as antidepressants in reducing GI symptoms in IBS immediately after treatment, with a number needed to treat between 2 and 4.
“Meta-analyses suggest that psychological therapies are as effective as antidepressants in reducing GI symptoms in IBS immediately after treatment, with a number needed to treat between 2 and 4. [5][6][7]”
From Short-term and long-term efficacy of psychological therapies for irritable bowel syndrome: a systematic review and meta-analysis (2016) · cites this paper as [5]
Antidepressants have efficacy over placebo in improving somatic bowel symptoms in irritable bowel syndrome (relative risk 0.67; 95% CI 0.58,0.77), with similar effects for SSRIs and tricyclic antidepressants.
“found antidepressants to have efficacy over placebo in the improvement of somatic bowel symptoms (relative risk 0.67; 95% CI 0.58,0.77) with similar effects observed for both selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) 3”
From Antidepressants in Inflammatory Bowel Disease: A Systematic Review (2017) · cites this paper as [3]
Antidepressants have been shown to be effective in treating gastro-intestinal symptoms associated with some other disorders.
“Antidepressants have also been shown to be effective in treating gastro-intestinal (GI) symptoms associated with some other disorders.”
From Antidepressants in Inflammatory Bowel Disease: A Systematic Review (2017) · cites this paper as [3]
Cites
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139 · see citing works
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
Sterne, J. A. C., Sutton, A. J., Ioannidis, J. P. A., Terrin, N., Jones, D. R., Lau, J., Carpenter, J., Rucker, G., Harbord, R. M., Schmid, C. H., et al. (2011) · BMJ · doi:10.1136/bmj.d4002 · Cited by 7,709 · see citing works
Assessing the quality of controlled clinical trials
Jüni, P., Altman, D. G., & Egger, M. (2001) · BMJ · doi:10.1136/bmj.323.7303.42 · Cited by 3,309 · see citing works
Drossman, D. A., Li, Z., Andruzzi, E., Temple, R. D., Talley, N. J., Grant Thompson, W., Whitehead, W. E., Janssens, J., Funch-Jensen, P., Corazziari, E., et al. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303162 · Cited by 2,198 · see citing works
Global Prevalence of and Risk Factors for Irritable Bowel Syndrome: A Meta-analysis
Lovell, R. M., & Ford, A. C. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.02.029 · Cited by 2,155 · see citing works
Self-citationWhitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116 · see citing works
A systematic review of antidepressants in neuropathic pain
McQuay, H. J., Tramèr, M. R., Nye, B., Carroll, D., Wiffen, P. J., & Moore, A. (1996) · Pain · doi:10.1016/s0304-3959(96)03140-5 · Cited by 926 · see citing works
Antidepressants for neuropathic pain
Saarto, T., & Wiffen, P. J. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005454.pub2 · Cited by 806 · see citing works
Drossman, D. A., Toner, B. B., Whitehead, W. E., Diamant, N. E., Dalton, C. B., Duncan, S., Emmott, S., Proffitt, V., Akman, D., Frusciante, K., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00669-3 · Cited by 614 · see citing works
Everhart, J. E., & Ruhl, C. E. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.12.015 · Cited by 604 · see citing works
Ford, A. C., Talley, N. J., Schoenfeld, P. S., Quigley, E. M. M., & Moayyedi, P. (2009) · Gut · doi:10.1136/gut.2008.163162 · Cited by 582 · see citing works
Self-citationDesign of Treatment Trials for Functional Gastrointestinal Disorders
Irvine, E. J., Tack, J., Crowell, M. D., Gwee, K. A., Ke, M., Schmulson, M. J., Whitehead, W. E., & Spiegel, B. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.010 · Cited by 550 · see citing works
Self-citationA controlled trial of psychological treatment for the irritable bowel syndrome
Guthrie, E., Creed, F. H., Dawson, D., & Tomenson, B. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90215-7 · Cited by 461 · see citing works
The cost-effectiveness of psychotherapy and paroxetine for severe irritable bowel syndrome
Creed, F., Fernandes, L., Guthrie, E., Palmer, S., Ratcliffe, J., Read, N., Rigby, C., Thompson, D., & Tomenson, B. (2003) · Gastroenterology · doi:10.1053/gast.2003.50055 · Cited by 443 · see citing works
Tillisch, K., Mayer, E. A., & Labus, J. S. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.07.053 · Cited by 412 · see citing works
Tack, J. F., Broekaert, D., Fischler, B., Oudenhove, L. V., Gevers, A. M., & Janssens, J. (2006) · Gut · doi:10.1136/gut.2005.077503 · Cited by 289 · see citing works
Design of Treatment Trials for Functional Gastrointestinal Disorders
Irvine, E. J., Whitehead, W. E., Chey, W. D., Matsueda, K., Shaw, M., Talley, N. J., & Veldhuyzen van Zanten, S. J. O. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.058 · Cited by 286 · see citing works
Gaylord, S. A., Palsson, O. S., Garland, E. L., Faurot, K. R., Coble, R. S., Mann, D. J., Frey, W., Leniek, K., & Whitehead, W. E. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.184 · Cited by 281 · see citing works
Ljótsson, B., Falk, L., Vesterlund, A. W., Hedman, E., Lindfors, P., Rück, C., Hursti, T., Andréewitch, S., Jansson, L., Lindefors, N., et al. (2010) · Behaviour Research and Therapy · doi:10.1016/j.brat.2010.03.003 · Cited by 270 · see citing works
Morgan, V (2005) · Gut · doi:10.1136/gut.2004.047423 · Cited by 269 · see citing works
Craske, M. G., Wolitzky-Taylor, K. B., Labus, J., Wu, S., Frese, M., Mayer, E. A., & Naliboff, B. D. (2011) · Behaviour Research and Therapy · doi:10.1016/j.brat.2011.04.001 · Cited by 243 · see citing works
Heightened visceral sensation in functional gastrointestinal disease is not site-specific
Trimble, K. C., Farouk, R., Pryde, A., Douglas, S., & Heading, R. C. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02212678 · Cited by 243 · see citing works
An Evidence-Based Systematic Review on the Management of Irritable Bowel Syndrome
Brandt, L. J., Chey, W. D., Foxx-Orenstein, A. E., Quigley, E. M. M., Schiller, L. R., Schoenfeld, P. S., Spiegel, B. M., Talley, N. J., & Moayyedi, P. (2009) · American Journal of Gastroenterology · doi:10.14309/00000434-200901001-00002 · Cited by 225 · see citing works
Self-citationGORARD, D. A., LIBBY, G. W., & FARTHING, M. J. G. (1994) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1994.tb00273.x · Cited by 211 · see citing works
Kuiken, S. D., Tytgat, G. N. J., & Boeckxstaens, G. E. (2003) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(03)70039-1 · Cited by 206 · see citing works
Tabas, G., Beaves, M., Wang, J., Friday, P., Mardini, H. E., & Arnold, G. L. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04127.x · Cited by 192 · see citing works
The economic impact of irritable bowel syndrome
Inadomi, J. M., Fennerty, M. B., & Bjorkman, D. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.t01-1-01736.x · Cited by 190 · see citing works
Kennedy, T., Jones, R. H., Darnley, S., Seed, P. T., Wessely, S. C., & Chalder, T. (2005) · BMJ · doi:10.1136/bmj.38545.505764.06 · Cited by 190 · see citing works
Cognitive therapy for irritable bowel syndrome.
Greene, B., & Blanchard, E. B. (1994) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.62.3.576 · Cited by 188 · see citing works
Moss-Morris, R., McAlpine, L., Didsbury, L. P., & Spence, M. J. (2010) · Psychological Medicine · doi:10.1017/s0033291709990195 · Cited by 187 · see citing works
Payne, A., & Blanchard, E. B. (1995) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.63.5.779 · Cited by 186 · see citing works
Vahedi, H., Merat, S., RASHIDIOON, A., Ghoddoosi, A. R., & Malekzadeh, R. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02566.x · Cited by 181 · see citing works
Lackner, J. M., Jaccard, J., Krasner, S. S., Katz, L. A., Gudleski, G. D., & Holroyd, K. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.03.004 · Cited by 176 · see citing works
Boyce, P. M., Talley, N. J., Balaam, B., Koloski, N. A., & Truman, G. (2003) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07716.x · Cited by 167 · see citing works
Payne, A., & Blanchard, E. B. (1995) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.63.5.779 · Cited by 166 · see citing works
Vahedi, H., Merat, S., Momtahen, S., Kazzazi, A., GHAFFARI, N., Olfati, G., & Malekzadeh, R. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03633.x · Cited by 155 · see citing works
Two controlled evaluations of multicomponent psychological treatment of irritable bowel syndrome
Blanchard, E. B., Schwarz, S. P., Suls, J. M., Gerardi, M. A., Scharff, L., Greene, B., Taylor, A. E., Berreman, C. F., & Malamood, H. S. (1992) · Behaviour Research and Therapy · doi:10.1016/0005-7967(92)90141-3 · Cited by 148 · see citing works
The treatment of irritable bowel syndrome with hypnotherapy
Galovski, T. E., & Blanchard, E. B. (1998) · Applied Psychophysiology and Biofeedback · doi:10.1023/a:1022209631047 · Cited by 147 · see citing works
Relaxation training as a treatment for irritable bowel syndrome
Blanchard, E. B., Greene, B., Scharff, L., & Schwarz, S. P. (1993) · Applied Psychophysiology and Biofeedback · doi:10.1007/bf00999789 · Cited by 142 · see citing works
Cognitive therapy for irritable bowel syndrome.
Greene, B., & Blanchard, E. B. (1994) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.62.3.576 · Cited by 140 · see citing works
Brief cognitive-behavioral internet therapy for irritable bowel syndrome
Hunt, M. G., Moshier, S., & Milonova, M. (2009) · Behaviour Research and Therapy · doi:10.1016/j.brat.2009.05.002 · Cited by 139 · see citing works
Moser, G., Trägner, S., Gajowniczek, E. E., Mikulits, A., Michalski, M., Kazemi-Shirazi, L., Kulnigg-Dabsch, S., Führer, M., Ponocny-Seliger, E., Dejaco, C., et al. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.19 · Cited by 139 · see citing works
Lindfors, P., Unge, P., Arvidsson, P., Nyhlin, H., Björnsson, E., Abrahamsson, H., & Simrén, M. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.340 · Cited by 138 · see citing works
Talley, N. J., Kellow, J. E., Boyce, P. M., Tennant, C., Huskic, S., & Jones, M. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-9830-4 · Cited by 130 · see citing works
Stress Management for Irritable Bowel Syndrome: A Controlled Trial
Shaw, G., Srivastava, E. D., Sadlier, M., Swann, P., James, J., & Rhodes, J. (2009) · Digestion · doi:10.1159/000200738 · Cited by 125 · see citing works
Functional abdominal pain: further evidence that whole gut is affected.
Moriarty, K. J., & Dawson, A. M. (1982) · BMJ · doi:10.1136/bmj.284.6330.1670 · Cited by 123 · see citing works
Lowén, M. B. O., Mayer, E. A., Sjöberg, M., Tillisch, K., Naliboff, B., Labus, J., Lundberg, P., Ström, M., Engström, M., & Walter, S. A. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12319 · Cited by 121 · see citing works
A multi-component treatment for irritable bowel syndrome
Neff, D. F., & Blanchard, E. B. (1987) · Behavior Therapy · doi:10.1016/s0005-7894(87)80052-7 · Cited by 119 · see citing works
Self-management for women with irritable bowel syndrome
Heitkemper, M. M., Jarrett, M. E., Levy, R. L., Cain, K. C., Burr, R. L., Feld, A., Barney, P., & Weisman, P. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00242-3 · Cited by 119 · see citing works
Irritable colon and depression
Heefner, J., Wilder, R. M., & Wilson, I. D. (1978) · Psychosomatics · doi:10.1016/s0033-3182(78)70930-8 · Cited by 111 · see citing works
Simrén, M., Ringström, G., Björnsson, E. S., & Abrahamsson, H. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000116964.76529.6e · Cited by 111 · see citing works
Keefer, L., & Blanchard, E. B. (2001) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(00)00078-4 · Cited by 104 · see citing works
A Population Study on Irritable Bowel Syndrome and Mental Health
E. Österberg, L. B. (2000) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655200750024128 · Cited by 104 · see citing works
The Effect of Trimipramine in Patients with the Irritable Bowel Syndrome
Myren, J., Groth, H., Larssen, S.-E., Larsen, S., & The Multicentre Study Group (1982) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528209181108 · Cited by 101 · see citing works
Antidepressants in Neuropathic Pain
Sindrup, S. H., & Jensen, T. S. (2006) · Springer eBooks · doi:10.1007/978-3-540-29805-2_249 · Cited by 98 · see citing works
Lovell, R. M., & Ford, A. C. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.336 · Cited by 95 · see citing works
Self-citationCitalopram Provides Little or No Benefit in Nondepressed Patients With Irritable Bowel Syndrome
Ladabaum, U., Sharabidze, A., Levin, T. R., Zhao, W. K., Chung, E. H., Bacchetti, P., Jin, C., Grimes, B. A., & Pepin, C. J. (2009) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2009.09.008 · Cited by 95 · see citing works
Jarrett, M. E., Cain, K. C., Burr, R. L., Hertig, V. L., Rosen, S. N., & Heitkemper, M. M. (2009) · American Journal of Gastroenterology · doi:10.1038/ajg.2009.479 · Cited by 89 · see citing works
Ladabaum, U., Boyd, E., Zhao, W. K., Mannalithara, A., Sharabidze, A., Singh, G., Chung, E. H., & Levin, T. R. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.08.015 · Cited by 87 · see citing works
Masand, P. S., Pae, C., Krulewicz, S., Peindl, K., Mannelli, P., Varia, I. M., & Patkar, A. A. (2009) · Psychosomatics · doi:10.1176/appi.psy.50.1.78 · Cited by 82 · see citing works
A controlled behavioral treatment study of Irritable Bowel syndrome
Lynch, P. M., & Zamble, E. (1989) · Behavior Therapy · doi:10.1016/s0005-7894(89)80130-3 · Cited by 78 · see citing works
Controlled comparison of individual versus group cognitive therapy for irritable bowel syndrome
Vollmer, A., & Blanchard, E. B. (1998) · Behavior Therapy · doi:10.1016/s0005-7894(98)80016-6 · Cited by 68 · see citing works
Shinozaki, M., Kanazawa, M., Kano, M., Endo, Y., Nakaya, N., Hongo, M., & Fukudo, S. (2010) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-009-9125-y · Cited by 67 · see citing works
Different therapeutic regimens in irritable bowel syndrome.
Nigam, P., Kk, K., Ck, R., Kumar, A., & Gupta, A. (1984) · PubMed · Cited by 64 · see citing works
Tkachuk, G. A., Graff, L. A., Martin, G. L., & Bernstein, C. N. (2003) · Journal of Clinical Psychology in Medical Settings · doi:10.1023/a:1022809914863 · Cited by 62 · see citing works
Clinical trial: short‐ and long‐term benefit of relaxation training for irritable bowel syndrome
van der Veek, P. P. J., van Rood, Y. R., & Masclee, A. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03437.x · Cited by 59 · see citing works
A randomized controlled trial of imipramine in patients with irritable bowel syndrome
Abdul-Baki, H. A., Hajj, I. I. E., El-Zahabi, L. M., Azar, C. R., Aoun, E. G., Skoury, A. M., Chaar, H. F., & Sharara, A. I. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.3636 · Cited by 57 · see citing works
Ford, A. C., Guyatt, G. H., Talley, N. J., & Moayyedi, P. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.658 · Cited by 55 · see citing works
Self-citationSanders, K. A., Blanchard, E. B., & Sykes, M. A. (2007) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-007-9037-7 · Cited by 43 · see citing works
Harkness, E. F., Harrington, V., Hinder, S., O’Brien, S. J., Thompson, D. G., Beech, P., & Chew-Graham, C. A. (2013) · BMC Family Practice · doi:10.1186/1471-2296-14-92 · Cited by 34 · see citing works
Camilleri, M., & Mayer, E. A. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.030 · Cited by 25 · see citing works
Ghadir, M. R., Habibinejad, H., Heidari, A., & Vahedi, H. (2011) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Lacy, B. E., Mearin, F., Chang, L., Chey, W. D., Lembo, A. J., Simren, M., & Spiller, R. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.031 · Cited by 2,866 · see citing works
Self-citationChey, W. D., Kurlander, J. E., & Eswaran, S. L. (2015) · JAMA · doi:10.1001/jama.2015.0954 · Cited by 1,086 · see citing works
Enck, P., Aziz, Q., Barbara, G., Farmer, A. D., Fukudo, S., Mayer, E. A., Niesler, B., Quigley, E. M. M., Rajilić-Stojanović, M. D., Schemann, M., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.14 · Cited by 1,057 · see citing works
Self-citationACG Clinical Guideline: Management of Irritable Bowel Syndrome
Lacy, B. E., Pimentel, M., Brenner, D. M., Chey, W. D., Keefer, L. A., Long, M. D., & Moshiree, B. (2021) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001036 · Cited by 893 · see citing works
Self-citationCherry, S. R., Jones, T., Karp, J. S., Qi, J., Moses, W. W., & Badawi, R. D. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.184028 · Cited by 763 · see citing works
ACG and CAG Clinical Guideline: Management of Dyspepsia
Moayyedi, P., Lacy, B. E., Andrews, C. N., Enns, R., Howden, C. W., & Vakil, N. B. (2017) · The American Journal of Gastroenterology · doi:10.1038/ajg.2017.154 · Cited by 704 · see citing works
Self-citationFord, A. C., Moayyedi, P., Lacy, B. E., Lembo, A. J., Saito, Y. A., Schiller, L. R., Soffer, E., Spiegel, B. M. R., & Quigley, E. M. M. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.187 · Cited by 648 · see citing works
Self-citationPathophysiology of irritable bowel syndrome
Holtmann, G. J., Ford, A. C., & Talley, N. J. (2016) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(16)30023-1 · Cited by 590 · see citing works
Self-citationRome criteria and a diagnostic approach to irritable bowel syndrome
Lacy, B., & Patel, N. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6110099 · Cited by 575 · see citing works
Self-citationDrossman, D. A., Tack, J., Ford, A. C., Szigethy, E., Törnblom, H., & Van Oudenhove, L. (2018) · Gastroenterology · doi:10.1053/j.gastro.2017.11.279 · Cited by 470 · see citing works
Self-citationFord, A. C., Lacy, B. E., Harris, L. A., Quigley, E. M. M., & Moayyedi, P. (2019) · American Journal of Gastroenterology · doi:10.1038/s41395-018-0222-5 · Cited by 467 · see citing works
Self-citationAmerican College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome
Ford, A. C., Moayyedi, P., Chey, W. D., Harris, L. A., Lacy, B. E., Saito, Y. A., & Quigley, E. M. M. (2018) · American Journal of Gastroenterology · doi:10.1038/s41395-018-0084-x · Cited by 388 · see citing works
Self-citationBonaz, B., Sinniger, V., & Pellissier, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01452 · Cited by 405 · see citing works
The mucosal immune system: master regulator of bidirectional gut-brain communications
Powell, N., Walker, M. M., & Talley, N. J. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.191 · Cited by 379 · see citing works
Diagnosis and Treatment of Irritable Bowel Syndrome
Camilleri, M. (2021) · JAMA · doi:10.1001/jama.2020.22532 · Cited by 370 · see citing works
Management of functional somatic syndromes and bodily distress
Henningsen, P., Zipfel, S., Sattel, H., & Creed, F. (2018) · Psychotherapy and Psychosomatics · doi:10.1159/000484413 · Cited by 335 · see citing works
Sex-gender differences in irritable bowel syndrome
Kim, Y. S., & Kim, N. (2018) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18082 · Cited by 322 · see citing works
Koloski, N. A., Jones, M., & Talley, N. J. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13738 · Cited by 318 · see citing works
Lembo, A., Pimentel, M., Rao, S. S., Schoenfeld, P., Cash, B., Weinstock, L. B., Paterson, C., Bortey, E., & Forbes, W. P. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.08.003 · Cited by 310 · see citing works
Self-citationWhelan, K., Martin, L. D., Staudacher, H. M., & Lomer, M. C. E. (2018) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12530 · Cited by 301 · see citing works
Krouwel, M., Jolly, K. B., & Greenfield, S. (2019) · BMC Medical Research Methodology · doi:10.1186/s12874-019-0867-9 · Cited by 292 · see citing works
Mayer, E. A., Labus, J. S., Tillisch, K., Cole, S. W., & Baldi, P. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.121 · Cited by 282 · see citing works
Gracie, D. J., Irvine, A. J., Sood, R., Mikocka-Walus, A., Hamlin, P. J., & Ford, A. C. (2017) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(16)30206-0 · Cited by 271 · see citing works
Self-citationThe neurobiology of irritable bowel syndrome
Mayer, E. A., Ryu, H. J., & Bhatt, R. R. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01972-w · Cited by 285 · see citing works
Serra, J., Pohl, D., Azpiroz, F., Chiarioni, G., Ducrotté, P., Gourcerol, G., Hungin, A. P. S., Layer, P., Mendive, J., Pfeifer, J., et al. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13762 · Cited by 244 · see citing works
Probiotics in Disease Prevention and Treatment
Liu, Y., Tran, D. Q., & Rhoads, J. M. (2018) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.1121 · Cited by 238 · see citing works
Moayyedi, P., Andrews, C., MacQueen, G., Korownyk, C., Marsiglio, M., Graff, L., Kvern, B., Lazarescu, A., Liu, L. W. C., Paterson, W., et al. (2019) · Journal of the Canadian Association of Gastroenterology · doi:10.1093/jcag/gwy071 · Cited by 182 · see citing works
Self-citationLackner, J. M., Jaccard, J., Keefer, L., Brenner, D. M., Firth, R. S., Gudleski, G. D., Hamilton, F. A., Katz, L. A., Krasner, S. S., Ma, C.-X., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.03.063 · Cited by 191 · see citing works
Chronic Diarrhea and Constipation Are More Common in Depressed Individuals
Ballou, S., Katon, J. M., Singh, P., Rangan, V., Lee, H. N., McMahon, C., Iturrino, J., Lembo, A. J., & Nee, J. W. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2019.03.046 · Cited by 183 · see citing works
Self-citationLeigh, S., Uhlig, F., Wilmes, L., Sánchez-Díaz, P., Gheorghe, C. E., Goodson, M. S., Kelley‐Loughnane, N., Hyland, N. P., Cryan, J. F., & Clarke, G. A. (2023) · The Journal of Physiology · doi:10.1113/jp281951 · Cited by 193 · see citing works
Best practice update: Incorporating psychogastroenterology into management of digestive disorders
Keefer, L., Palsson, O. S., & Pandolfino, J. E. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.01.045 · Cited by 173 · see citing works
Black, C. J., Yuan, Y., Selinger, C. P., Camilleri, M., Quigley, E. M. M., Moayyedi, P., & Ford, A. C. (2020) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(19)30324-3 · Cited by 171 · see citing works
Self-citationBlack, C. J., Burr, N. E., Quigley, E. M. M., Moayyedi, P., Houghton, L. A., & Ford, A. C. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.08.021 · Cited by 166 · see citing works
Self-citationDietary and pharmacological treatment of abdominal pain in IBS
Camilleri, M., & Boeckxstaens, G. (2017) · Gut · doi:10.1136/gutjnl-2016-313425 · Cited by 144 · see citing works
Psychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis
Person, H., & Keefer, L. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110209 · Cited by 158 · see citing works
Irritable bowel syndrome: the clinical approach
Adriani, A., Ribaldone, D. G., Astegiano, M., Durazzo, M., Saracco, G. M., & Pellicano, R. (2018) · Panminerva Medica · doi:10.23736/s0031-0808.18.03541-3 · Cited by 149 · see citing works
Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs
Harvie, R. M., Chisholm, A. W., Bisanz, J. E., Burton, J. P., Herbison, P., Schultz, K., & Schultz, M. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i25.4632 · Cited by 143 · see citing works
Laird, K. T., Tanner-Smith, E., Russell, A. C., Hollon, S., & Walker, L. (2017) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.11.001 · Cited by 140 · see citing works
Pinto-Sánchez, M. I., Ford, A. C., Avila, C., Verdu, E. F., Collins, S. M., Morgan, D., Moayyedi, P., & Berčík, P. (2015) · The American Journal of Gastroenterology · doi:10.1038/ajg.2015.128 · Cited by 140 · see citing works
Self-citationNew treatments and therapeutic targets for IBS and other functional bowel disorders
Simrén, M., & Tack, J. (2018) · Nature reviews: Gastroenterology & hepatology · doi:10.1038/s41575-018-0034-5 · Cited by 127 · see citing works
Laird, K. T., Tanner-Smith, E. E., Russell, A. C., Hollon, S. D., & Walker, L. S. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.11.020 · Cited by 135 · see citing works
Torres, J., Ellul, P., Langhorst, J., Mikocka‐Walus, A. A., Acosta, M. B., Basnayake, C., Ding, N. S., Gilardi, D., Katsanos, K. H., Moser, G., et al. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz051 · Cited by 138 · see citing works
Review article: treatment options for functional dyspepsia
Masuy, I., Oudenhove, L. V., & Tack, J. F. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15191 · Cited by 137 · see citing works
Management of functional gastrointestinal disorders
Fikree, A., & Byrne, P. (2021) · Clinical Medicine · doi:10.7861/clinmed.2020-0980 · Cited by 137 · see citing works
Irritable bowel syndrome diagnosis and management: A simplified algorithm for clinical practice
Moayyedi, P., Mearin, F., Azpiroz, F., Andresen, V., Barbara, G., Corsetti, M., Emmanuel, A., Hungin, A. P. S., Layer, P., Stanghellini, V., et al. (2017) · United European Gastroenterology Journal · doi:10.1177/2050640617731968 · Cited by 135 · see citing works
Self-citationManagement Options for Irritable Bowel Syndrome
Camilleri, M. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.04.032 · Cited by 132 · see citing works
Age, Gender, and Women’s Health and the Patient
Houghton, L. A., Heitkemper, M. M., Crowell, M. D., Emmanuel, A. V., Halpert, A. D., McRoberts, J. A., & Toner, B. B. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.017 · Cited by 120 · see citing works
Opioid misuse in gastroenterology and non-opioid management of abdominal pain
Szigethy, E., Knisely, M., & Drossman, D. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.141 · Cited by 117 · see citing works
Cognitive-behavioral therapy for patients with irritable bowel syndrome: current insights
Kinsinger, S. W. (2017) · Psychology Research and Behavior Management · doi:10.2147/prbm.s120817 · Cited by 119 · see citing works
Flik, C. E., Laan, W., Zuithoff, N. P. A., van Rood, Y. R., Smout, A. J. P. M., Weusten, B. L. A. M., Whorwell, P. J., & de Wit, N. J. (2019) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(18)30310-8 · Cited by 118 · see citing works
Patel, P., Bercik, P., Morgan, D. G., Bolino, C., Pintos‐Sanchez, M. I., Moayyedi, P., & Ford, A. C. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13074 · Cited by 115 · see citing works
Self-citationPeters, S. L., Muir, J. G., & Gibson, P. R. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13202 · Cited by 113 · see citing works
The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel Diseases
Peppas, S., Pansieri, C., Piovani, D., Danese, S., Peyrin‐Biroulet, L., Tsantes, A. G., Brunetta, E., Tsantes, A. Ε., & Bonovas, S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030377 · Cited by 114 · see citing works
Second Asian Consensus on Irritable Bowel Syndrome
Gwee, K., Gonlachanvit, S., Ghoshal, U. C., Chua, A. S. B., Miwa, H., Wu, J. C. Y., Bak, Y., Lee, O. Y., Lu, C., Park, H., et al. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm19041 · Cited by 112 · see citing works
The Efficacy, Safety and Applications of Medical Hypnosis: A Systematic Review of Meta-analyses
Häuser, W., Hagl, M., Schmierer, A., & Hansen, E. (2016) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2016.0289 · Cited by 110 · see citing works
Savarino, V., Pace, F., Scarpignato, C., & the Esoxx Study Group (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13914 · Cited by 109 · see citing works
Xie, C., Tang, Y., Wang, Y., Yu, T., Wang, Y., Jiang, L., & Lin, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127815 · Cited by 106 · see citing works
Irritable bowel syndrome in children: Current knowledge, challenges and opportunities
Devanarayana, N. M., & Rajindrajith, S. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i21.2211 · Cited by 106 · see citing works
Coates, M. D., Tekin, I., Vrana, K. E., & Mawe, G. M. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14226 · Cited by 107 · see citing works
Roenneberg, C., Sattel, H., Schaefert, R., Henningsen, P., & Hausteiner-Wiehle, C. (2019) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2019.0553 · Cited by 111 · see citing works
Does central sensitization help explain idiopathic overactive bladder?
Reynolds, W. M., Dmochowski, R. R., Wein, A. J., & Bruehl, S. P. (2016) · Nature Reviews Urology · doi:10.1038/nrurol.2016.95 · Cited by 99 · see citing works
Pathways in gut-brain communication: Evidence for distinct gut-to-brain and brain-to-gut syndromes
Keightley, P., Koloski, N. A., & Talley, N. J. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415569801 · Cited by 97 · see citing works
The Place of Stress and Emotions in the Irritable Bowel Syndrome
Sonia Pellissier, A., & Bonaz, B. L. (2016) · Vitamins and hormones · doi:10.1016/bs.vh.2016.09.005 · Cited by 97 · see citing works
Gracie, D. J., Hamlin, P. J., & Ford, A. C. (2018) · The American Journal of Gastroenterology · doi:10.1038/s41395-018-0021-z · Cited by 97 · see citing works
Self-citationRutten, J. M. T. M., Vlieger, A. M., Frankenhuis, C., George, E. K., Groeneweg, M., Norbruis, O. F., Ten, W. T. A., van Wering, H. M., Dijkgraaf, M. G. W., Merkus, M. P., et al. (2017) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2017.0091 · Cited by 97 · see citing works
Antidepressants in Inflammatory Bowel Disease: A Systematic Review
Macer, B. J. D., Prady, S. L., & Mikocka-Walus, A. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001059 · Cited by 92 · see citing works
Hypnosis Treatment of Gastrointestinal Disorders: A Comprehensive Review of the Empirical Evidence
Palsson, O. S. (2015) · American Journal of Clinical Hypnosis · doi:10.1080/00029157.2015.1039114 · Cited by 95 · see citing works
Antidepressants in inflammatory bowel disease
Mikocka-Walus, A., Ford, A. C., & Drossman, D. A. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0259-y · Cited by 93 · see citing works
Self-citationThakur, E. R., Holmes, H. J., Lockhart, N. A., Carty, J. N., Ziadni, M. S., Doherty, H. K., Lackner, J. M., Schubiner, H. H., & Lumley, M. A. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13143 · Cited by 92 · see citing works
Weaver, K. R., Melkus, G. D., & Henderson, W. A. (2017) · AJN American Journal of Nursing · doi:10.1097/01.naj.0000520253.57459.01 · Cited by 91 · see citing works
Riggott, C., Mikocka-Walus, A., Gracie, D. J., & Ford, A. C. (2023) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(23)00186-3 · Cited by 83 · see citing works
Self-citationManagement of the multiple symptoms of irritable bowel syndrome
Simrén, M., Törnblom, H., Palsson, O. S., & Whitehead, W. E. (2017) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(16)30116-9 · Cited by 82 · see citing works
Regulation of the serotonin transporter in the pathogenesis of irritable bowel syndrome
Jin, D., Cao, H., Xu, M., Wang, S.-N., Wang, Y., Yan, F., & Wang, B. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i36.8137 · Cited by 82 · see citing works
Proton pump inhibitor-refractory gastroesophageal reflux disease: challenges and solutions
Mermelstein, J., Mermelstein, A. C., & Chait, M. M. (2018) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s121056 · Cited by 79 · see citing works
Layer, P., Andresen, V., Allescher, H. ‐., Bischoff, S. C., Claßen, M., Elsenbruch, S., Freitag, M., Frieling, T., Gebhard, M., Goebel‐Stengel, M., et al. (2021) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1591-4794 · Cited by 78 · see citing works
Health-Related Quality of Life in Irritable Bowel Syndrome
Cassar, G. E., Youssef, G., Knowles, S., Moulding, R., & Austin, D. (2020) · Gastroenterology Nursing · doi:10.1097/sga.0000000000000530 · Cited by 27 · see citing works
Effects of Antidepressants on Gastric Function in Patients with Functional Dyspepsia
Lacy, B. E., Saito, Y. A., Camilleri, M., Bouras, E. P., DiBaise, J. K., Herrick, L. M., Szarka, L. A., Tilkes, K. E., Zinsmeister, A. R., & Talley, N. J. (2017) · The American Journal of Gastroenterology · doi:10.1038/ajg.2017.458 · Cited by 74 · see citing works
Self-citationZhang, J., Liu, J., Zhu, S., Fang, Y., Wang, B., Jia, Q., Hao, H., Kao, J. Y., He, Q., Song, L., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00601-4 · Cited by 75 · see citing works
Treating empty nose syndrome as a somatic symptom disorder
Lemogne, C., Consoli, S. M., Limosin, F., & Bonfils, P. (2015) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2015.02.005 · Cited by 73 · see citing works
Physical comorbidities of post‐traumatic stress disorder in Australian Vietnam War veterans
McLeay, S. C., Harvey, W., Romaniuk, M., Crawford, D. H., Colquhoun, D. M., Young, R. M., Dwyer, M., Gibson, J. M., O’Sullivan, R., Cooksley, G., et al. (2017) · The Medical Journal of Australia · doi:10.5694/mja16.00935 · Cited by 73 · see citing works
Vasant, D. H., & Whorwell, P. J. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13573 · Cited by 74 · see citing works
Preston, K., Krumian, R., Hattner, J., de Montigny, D., Stewart, M., & Gaddam, S. (2018) · Beneficial Microbes · doi:10.3920/bm2017.0105 · Cited by 70 · see citing works
Lores, T. J., Goess, C., Mikocka‐Walus, A. A., Collins, K., Burke, A. L. J., Chur‐Hansen, A., Delfabbro, P., & Andrews, J. M. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz026 · Cited by 70 · see citing works
Windgassen, S., Moss‐Morris, R., Chilcot, J., Sibelli, A., Goldsmith, K., & Chalder, T. (2017) · British Journal of Health Psychology · doi:10.1111/bjhp.12250 · Cited by 67 · see citing works
New insights into irritable bowel syndrome: from pathophysiology to treatment
Hadjivasilis, A. (2019) · Annals of Gastroenterology · doi:10.20524/aog.2019.0428 · Cited by 71 · see citing works
Citalopram for pediatric functional abdominal pain: a randomized, placebo‐controlled trial
Roohafza, H., Pourmoghaddas, Z., Saneian, H., & Gholamrezaei, A. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12444 · Cited by 69 · see citing works
Kwekkeboom, K. L., & Bratzke, L. C. (2015) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000274 · Cited by 70 · see citing works
Behavioural medicine and gastrointestinal disorders: the promise of positive psychology
Keefer, L. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0001-1 · Cited by 69 · see citing works
Khlevner, J., Park, Y., & Margolis, K. G. (2018) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2018.07.002 · Cited by 70 · see citing works
Central neuromodulators for treating functional GI disorders: a primer
Sobin, H. W., Heinrich, T. W., & Drossman, D. A. (2017) · American Journal of Gastroenterology · doi:10.1038/ajg.2017.57 · Cited by 64 · see citing works
Emerging Treatment Options in Mild to Moderate Ulcerative Colitis.
Lichtenstein, G. R., Hanauer, S. B., & Sandborn, W. J. (2015) · Europe PMC (PubMed Central) · Cited by 66 · see citing works
Söderquist, F., Syk, M., Just, D., Novičić, Z. K., Rasmusson, A. J., Hellström, P. M., Ramklint, M., & Cunningham, J. L. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02940-2 · Cited by 63 · see citing works
Hoekman, D. R., Zeevenhooven, J., van Etten‐Jamaludin, F. S., Dekker, I. D., Benninga, M. A., Tabbers, M. M., & Vlieger, A. M. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.12.022 · Cited by 63 · see citing works
Chen, M., Tang, T., Wang, Y., Shui, J., Xiao, X.-H., Lan, X., Yu, P., Zhang, C., Wang, S.-H., Yao, J., et al. (2018) · Alimentary Pharmacology and Therapeutics · doi:10.1111/apt.14817 · Cited by 62 · see citing works
Zhang, Q., Wang, F., Geng, Q., Zheng, W., Ng, C. H., Ungvari, G. S., Yuan, Z., Mei, S., Wang, G., & Xiang, Y. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.25001 · Cited by 63 · see citing works
Psychotropics, Antidepressants, and Visceral Analgesics in Functional Gastrointestinal Disorders
Törnblom, H., & Drossman, D. (2018) · Current Gastroenterology Reports · doi:10.1007/s11894-018-0664-3 · Cited by 55 · see citing works
Ghaffari, P., Shoaie, S., & Nielsen, L. K. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03365-z · Cited by 58 · see citing works
Pharmacologic Treatment in Functional Abdominal Pain Disorders in Children: A Systematic Review
Rexwinkel, R., de Bruijn, C. M. A., Gordon, M. A., Benninga, M. A., & Tabbers, M. M. (2021) · PEDIATRICS · doi:10.1542/peds.2020-042101 · Cited by 55 · see citing works
Flik, C. E., Bakker, L., Laan, W., van Rood, Y. R., Smout, A. J. P. M., & de Wit, N. J. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i12.2223 · Cited by 55 · see citing works
Guidelines on the management of irritable bowel syndrome
Pietrzak, A. M., Skrzydło-Radomańska, B., Mulak, A., Lipiński, M., Malecka-Panas, E. I., Reguła, J., & Rydzewska, G. M. (2018) · Gastroenterology Review · doi:10.5114/pg.2018.78343 · Cited by 56 · see citing works
- Authors
- Ford, A. C., Quigley, E. M. M., Lacy, B. E., Lembo, A. J., Saito, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R., & Moayyedi, P.
- Affiliations
- University of Leeds (GB)
- Houston Methodist (US)
- Dartmouth–Hitchcock Medical Center (US)
- Beth Israel Deaconess Medical Center (US)
- Mayo Clinic (US)
- Baylor University Medical Center (US)
- University of Southern California (US)
- VA Greater Los Angeles Healthcare System (US)
- McMaster University (CA)
- Corresponding author
- Ford, Alexander C
- ORCID
- Venue
- American Journal of Gastroenterology
- Published
- 2014-09
- Volume
- 109
- Issue
- 9
- Pages
- 1350-1365
- ISSN
- 0002-9270 (ISSN-L)
- OpenAlex
- W2171220209
- Cited by
- 405
- References
- 72
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 15 · 2023: 13 · 2022: 27 · 2021: 29 · 2020: 28 · 2019: 51 · 2018: 60 · 2017: 61 · 2016: 46 · 2015: 41 · 2014: 6
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American College of Gastroenterology
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- irritable bowel syndrome, antidepressants, psychotherapy, hypnotherapy, cognitive behavioral therapy, tricyclic antidepressants, selective serotonin reuptake inhibitors, psychodynamic psychotherapy, symptom remission, functional gastrointestinal disorders
- MeSH terms
- Antidepressive Agents, Antidepressive Agents, Tricyclic, Humans, Hypnosis, Psychotherapy, Relaxation Therapy, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic, Selective Serotonin Reuptake Inhibitors, Irritable Bowel Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review