Psychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis
Open accessAbstract
The high comorbidity of psychological disorders in both functional and organic gastrointestinal diseases suggests the intimate and complex link between the brain and the gut. Termed the brain-gut axis, this bidirectional communication between the central nervous system and enteric nervous system relies on immune, endocrine, neural, and metabolic pathways. There is increasing evidence that the gut microbiome is a key part of this system, and dysregulation of the brain-gut-microbiome axis (BGMA) has been implicated in disorders of brain-gut interaction, including irritable bowel syndrome, and in neuropsychiatric disorders, including depression, Alzheimer's disease, and autism spectrum disorder. Further, alterations in the gut microbiome have been implicated in the pathogenesis of organic gastrointestinal diseases, including inflammatory bowel disease. The BGMA is an attractive therapeutic target, as using prebiotics, probiotics, or postbiotics to modify the gut microbiome or mimic gut microbial signals could provide novel treatment options to address these debilitating diseases. However, despite significant advancements in our understanding of the BGMA, clinical data is lacking. In this article, we will review current understanding of the comorbidity of gastrointestinal diseases and psychological disorders. We will also review the current evidence supporting the key role of the BGMA in this pathology. Finally, we will discuss the clinical implications of the BGMA in the evaluation and management of psychological and gastrointestinal disorders.
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Gastrointestinal disorders such as IBD and IBS are frequently accompanied by persistent psychiatric comorbidities.
“Furthermore, gastrointestinal disorders such as IBD and IBS are frequently accompanied by persistent psychiatric comorbidities[6], [7], reinforcing the need for an integrated perspective in investigating these interconnected systems. [8].”
From The hidden genetic and microbial networks connecting neuropsychiatric and digestive disorders (2025) · cites this paper as [7]
The Introduction describes significant, persistent psychological comorbidity in organic gastrointestinal disorders, including IBD. The Irritable bowel syndrome section reports frequent comorbidity with depression and anxiety, but does not establish that those comorbidities are persistent in IBS. Page numbers are unavailable in our copy. (LLM, conf=0.85)
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Cites
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579 · see citing works
Revised Estimates for the Number of Human and Bacteria Cells in the Body
Sender, R., Fuchs, S., & Milo, R. (2016) · PLOS Biology · doi:10.1371/journal.pbio.1002533 · Cited by 5,425 · see citing works
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614 · see citing works
Gut flora in health and disease
Guarner, F., & Malagelada, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12489-0 · Cited by 3,395 · see citing works
The clinical application of the biopsychosocial model
ENGEL, G. L. (1980) · American Journal of Psychiatry · doi:10.1176/ajp.137.5.535 · Cited by 3,345 · see citing works
Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life
Bäckhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.004 · Cited by 3,315 · see citing works
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00025 · Cited by 3,043 · cited 1× · see citing works
“Gut microbiota can interact with the CNS through the bioactive compounds they produce, and the best understood compounds are short chain fatty acids, secondary bile acids, and tryptophan metabolites (Silva et al., 2020; van de Wouw et al., 2018; Yano et al., 2015).”
BackgroundRole of the normal gut microbiota
Jandhyala, S. M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i29.8787 · Cited by 3,001 · see citing works
Lacy, B. E., Mearin, F., Chang, L., Chey, W. D., Lembo, A. J., Simren, M., & Spiller, R. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.031 · Cited by 2,866 · see citing works
Alatab, S., Sepanlou, S. G., Ikuta, K., Vahedi, H., Bisignano, C., Safiri, S., Sadeghi, A., Nixon, M. R., Abdoli, A., Abolhassani, H., et al. (2020) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(19)30333-4 · Cited by 2,313 · see citing works
Sperber, A. D., Bangdiwala, S. I., Drossman, D. A., Ghoshal, U. C., Simren, M., Tack, J., Whitehead, W. E., Dumitrascu, D. L., Fang, X., Fukudo, S., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.04.014 · Cited by 2,263 · see citing works
Mindfulness-based therapy: a comprehensive meta-analysis
Khoury, B., Lecomte, T., Fortin, G., Masse, M., Therien, P., Bouchard, V., Chapleau, M.-A., Paquin, K., & Hofmann, S. G. (2013) · Clinical Psychology Review · doi:10.1016/j.cpr.2013.05.005 · Cited by 2,003 · see citing works
Gut microbiome structure and metabolic activity in inflammatory bowel disease
Franzosa, E. A., Sirota-Madi, A., Avila-Pacheco, J., Fornelos, N., Haiser, H. J., Reinker, S., Vatanen, T., Hall, A. B., Mallick, H., McIver, L. J., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0306-4 · Cited by 1,995 · see citing works
Rome IV—Functional GI Disorders: Disorders of Gut-Brain Interaction
Drossman, D. A., & Hasler, W. L. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.035 · Cited by 1,928 · see citing works
Lloyd-Price, J., Abu-Ali, G., & Huttenhower, C. (2016) · Genome Medicine · doi:10.1186/s13073-016-0307-y · Cited by 1,891 · see citing works
Gut feelings: the emerging biology of gut-brain communication
Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726 · see citing works
Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683 · see citing works
Raison, C. L., Rutherford, R. E., Woolwine, B. J., Shuo, C., Schettler, P., Drake, D. F., Haroon, E., & Miller, A. H. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.4 · Cited by 1,617 · see citing works
Vago, D. R., & Silbersweig, D. A. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00296 · Cited by 1,310 · see citing works
Martin, C. R., Osadchiy, V., Kalani, A., & Mayer, E. A. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.04.003 · Cited by 1,284 · see citing works
Consumption of fermented milk product with probiotic modulates brain activity
Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192 · see citing works
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116 · see citing works
Celiac disease: a comprehensive current review
Caio, G., Volta, U., Sapone, A., Leffler, D. A., GIORGIO, R. D., Catassi, C., & Fasano, A. (2019) · BMC Medicine · doi:10.1186/s12916-019-1380-z · Cited by 1,114 · see citing works
Jacka, F. N., O’Neil, A., Opie, R., Itsiopoulos, C., Cotton, S., Mohebbi, M., Castle, D., Dash, S., Mihalopoulos, C., Chatterton, M. L., et al. (2017) · BMC Medicine · doi:10.1186/s12916-017-0791-y · Cited by 1,093 · see citing works
Psychobiotics and the manipulation of bacteria–gut–brain signals
Sarkar, A., Lehto, S. M., Harty, S., Dinan, T. G., Cryan, J. F., & Burnet, P. W. J. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.09.002 · Cited by 1,068 · see citing works
Lassale, C., Batty, G. D., Baghdadli, A., Jacka, F., Sánchez-Villegas, A., Kivimäki, M., & Akbaraly, T. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0237-8 · Cited by 931 · see citing works
Towards the human intestinal microbiota phylogenetic core
Tap, J., Mondot, S., Levenez, F., Pelletier, E., Caron, C., Furet, J., Ugarte, E., Muñoz‐Tamayo, R., Paslier, D. L. E., Nalin, R., et al. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01982.x · Cited by 927 · see citing works
Keller, J., Gomez, R., Williams, G., Lembke, A., Lazzeroni, L., Murphy, G. M., & Schatzberg, A. F. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.120 · Cited by 922 · see citing works
American Gastroenterological Association Technical Review on Constipation
Bharucha, A. E., Pembérton, J. H., & Locke, G. R. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.10.028 · Cited by 914 · see citing works
The microbiome and inflammatory bowel disease
Glassner, K. L., Abraham, B. P., & Quigley, E. M. M. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.11.003 · Cited by 837 · see citing works
The enteric nervous system and gastrointestinal innervation: integrated local and central control
Furness, J. B., Callaghan, B. P., Rivera, L. R., & Cho, H.-J. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_3 · Cited by 827 · see citing works
Probiotic bacteria and intestinal epithelial barrier function
Ohland, C., & MacNaughton, W. K. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00243.2009 · Cited by 808 · see citing works
Postbiotics—A Step Beyond Pre- and Probiotics
Żółkiewicz, J., Marzec, A., Ruszczyński, M., & Feleszko, W. (2020) · Nutrients · doi:10.3390/nu12082189 · Cited by 797 · see citing works
van de Wouw, M., Boehme, M., Lyte, J. M., Wiley, N., Strain, C., O'Sullivan, O., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2018) · The Journal of Physiology · doi:10.1113/jp276431 · Cited by 789 · see citing works
Gut microbiota depletion from early adolescence in mice: implications for brain and behaviour
Desbonnet, L., Clarke, G., Traplin, A., O’Sullivan, O., Crispie, F., Moloney, R. D., Cotter, P. D., Dinan, T. G., & Cryan, J. F. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.004 · Cited by 760 · see citing works
Dynamics and stabilization of the human gut microbiome during the first year of life
Bäckhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.05.012 · Cited by 738 · see citing works
The Prevalence of Celiac Disease in the United States
Rubio‐Tapia, A., Ludvigsson, J. F., Brantner, T. L., Murray, J. A., & Everhart, J. E. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.219 · Cited by 737 · see citing works
Diet and depression: Exploring the biological mechanisms of action
Marx, W., Lane, M., Hockey, M., Aslam, H., Berk, M., Walder, K., Borsini, A., Firth, J., Pariante, C. M., Berding, K., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00925-x · Cited by 685 · see citing works
Diets that differ in their FODMAP content alter the colonic luminal microenvironment
Halmos, E. P., Christophersen, C. T., Bird, A. R., Shepherd, S. J., Gibson, P. R., & Muir, J. G. (2015) · Gut · doi:10.1136/gutjnl-2014-307264 · Cited by 681 · see citing works
Fond, G., Loundou, A., Hamdani, N., Boukouaci, W., Dargel, A., Oliveira, J., Roger, M., Tamouza, R., Leboyer, M., & Boyer, L. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0502-z · Cited by 647 · see citing works
Regulation of prefrontal cortex myelination by the microbiota
Hoban, A. E., Stilling, R. M., Ryan, F. J., Shanahan, F., Dinan, T. G., Claesson, M. J., Clarke, G., & Cryan, J. F. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.42 · Cited by 635 · see citing works
Parletta, N., Zarnowiecki, D., Cho, J., Wilson, A., Bogomolova, S., Villani, A., Itsiopoulos, C., Niyonsenga, T., Blunden, S., Meyer, B., et al. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1411320 · Cited by 629 · see citing works
Prevalence of Inflammatory Bowel Disease Among Adults Aged ≥18 Years — United States, 2015
Dahlhamer, J. M., Zammitti, E. P., Ward, B. W., Wheaton, A. G., & Croft, J. B. (2016) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6542a3 · Cited by 625 · see citing works
Functional Esophageal Disorders
Galmiche, J. P., Clouse, R. E., Bálint, A. F., Cook, I. J., Kahrilas, P. J., Paterson, W. G., & Smout, A. J. P. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.08.060 · Cited by 599 · see citing works
The Gut Microbiota in the Pathogenesis and Therapeutics of Inflammatory Bowel Disease
Zuo, T., & Ng, S. C. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02247 · Cited by 590 · see citing works
Anxiety, depression, and the microbiome: A role for gut peptides
Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0585-0 · Cited by 573 · cited 1× · see citing works
“Lastly, studies of depression and the BGMA have suggested potentially direct and indirect signaling from the gut microbiome to the CNS, which could become dysregulated in an inflammatory state (Barandouzi et al., 2020; Lach et al., 2018).”
BackgroundDepression and anxiety in patients with Inflammatory Bowel Disease: a systematic review
Neuendorf, R., Harding, A., Stello, N., Hanes, D., & Wahbeh, H. (2016) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2016.06.001 · Cited by 561 · see citing works
Infant gut microbiome associated with cognitive development
Carlson, A. L., Xia, K., Azcarate-Peril, M. A., Goldman, B. D., Ahn, M., Styner, M. A., Thompson, A. L., Geng, X., Gilmore, J. H., & Knickmeyer, R. C. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.021 · Cited by 541 · see citing works
Van Oudenhove, L., Levy, R. L., Crowell, M. D., Drossman, D. A., Halpert, A. D., Keefer, L., Lackner, J. M., Murphy, T. B., & Naliboff, B. D. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.027 · Cited by 512 · cited 8× · see citing works
“[PubMed: 30066368] Van Oudenhove L, Crowell MD, Drossman DA, Halpert AD, Keefer L, Lackner JM, Levy RL, 2016.”
BackgroundInfluentialSelf-citationThe brain-gut axis in abdominal pain syndromes.
Mayer, E. A., & Tillisch, K. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-012309-103958 · Cited by 511 · see citing works
De Palma, G., Lynch, M. D. J., Lu, J., Dang, V. T., Deng, Y., Jury, J., Umeh, G., Miranda, P. M., Pigrau Pastor, M., Sidani, S., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf6397 · Cited by 505 · see citing works
El-Salhy, M., Hatlebakk, J. G., Gilja, O. H., Bråthen Kristoffersen, A., & Hausken, T. (2020) · Gut · doi:10.1136/gutjnl-2019-319630 · Cited by 498 · see citing works
Drossman, D. A., Tack, J., Ford, A. C., Szigethy, E., Törnblom, H., & Van Oudenhove, L. (2018) · Gastroenterology · doi:10.1053/j.gastro.2017.11.279 · Cited by 470 · see citing works
Palsson, O. S., Whitehead, W., Törnblom, H., Sperber, A. D., & Simren, M. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.12.021 · Cited by 461 · see citing works
Altered Composition of Gut Microbiota in Depression: A Systematic Review
Barandouzi, Z. A., Starkweather, A. R., Henderson, W. A., Gyamfi, A., & Cong, X. S. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00541 · Cited by 461 · see citing works
Ananthakrishnan, A. N., Luo, C., Yajnik, V., Khalili, H., Garber, J. J., Stevens, B. W., Cleland, T., & Xavier, R. J. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.04.010 · Cited by 451 · see citing works
Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut
Roager, H. M., Hansen, L. B. S., Bahl, M. I., Frandsen, H. L., Carvalho, V., Gøbel, R. J., Dalgaard, M. D., Plichta, D. R., Sparholt, M. H., Vestergaard, H., et al. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.93 · Cited by 449 · see citing works
Walker, J. R., Ediger, J. P., Graff, L. A., Greenfeld, J. M., Clara, I., Lix, L., Rawsthorne, P., Miller, N., Rogala, L., McPhail, C. M., et al. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.01980.x · Cited by 437 · see citing works
Paramsothy, S., Paramsothy, R., Rubin, D. T., Kamm, M. A., Kaakoush, N. O., Mitchell, H. M., & Castaño-Rodríguez, N. (2017) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjx063 · Cited by 436 · see citing works
Whitehead, W. E., Crowell, M. D., Robinson, J. C., Heller, B. R., & Schuster, M. M. (1992) · Gut · doi:10.1136/gut.33.6.825 · Cited by 432 · see citing works
Staudacher, H. M., Lomer, M. C. E., Farquharson, F. M., Louis, P., Fava, F., Franciosi, E., Scholz, M., Tuohy, K. M., Lindsay, J. O., Irving, P. M., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.06.010 · Cited by 430 · see citing works
The progress of gut microbiome research related to brain disorders
Zhu, S., Jiang, Y., Xu, K., Cui, M., Ye, W., Zhao, G., Jin, L., & Chen, X. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1705-z · Cited by 419 · see citing works
Tillisch, K., Mayer, E. A., & Labus, J. S. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.07.053 · Cited by 412 · see citing works
Bi-directionality of brain–gut interactions in patients with inflammatory bowel disease
Gracie, D. J., Guthrie, E. A., Hamlin, P. J., & Ford, A. C. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.01.027 · Cited by 408 · cited 24× · see citing works
“[PubMed: 31056802] Mikocka-Walus A, Pittet V, Rossel JB, von Kanel R, Swiss IBDCSG, 2016.”
BackgroundInfluentialThe gut microbiome and its role in obesity
Davis, C. D. (2016) · Nutrition Today · doi:10.1097/nt.0000000000000167 · Cited by 407 · see citing works
Level of chronic life stress predicts clinical outcome in irritable bowel syndrome
Bennett, E. J., Tennant, C. C., Piesse, C., Badcock, C.-A., & Kellow, J. E. (1998) · Gut · doi:10.1136/gut.43.2.256 · Cited by 405 · cited 24× · see citing works
“[PubMed: 31056802] Mikocka-Walus A, Pittet V, Rossel JB, von Kanel R, Swiss IBDCSG, 2016.”
BackgroundInfluentialFord, A. C., Quigley, E. M. M., Lacy, B. E., Lembo, A. J., Saito, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R., & Moayyedi, P. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.148 · Cited by 405 · see citing works
Tsilingiri, K., & Rescigno, M. (2012) · Beneficial Microbes · doi:10.3920/bm2012.0046 · Cited by 396 · see citing works
The Not-so-Sterile Womb: Evidence That the Human Fetus Is Exposed to Bacteria Prior to Birth
Stinson, L. F., Boyce, M. C., Payne, M. S., & Keelan, J. A. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01124 · Cited by 389 · see citing works
Wilder‐Smith, C. H., Schindler, D., Lövblad, K., Redmond, S. M., & Nirkko, A. (2004) · Gut · doi:10.1136/gut.2003.028514 · Cited by 386 · see citing works
Dionne, J., Ford, A. C., Yuan, Y., Chey, W. D., Lacy, B. E., Saito, Y. A., Quigley, E. M. M., & Moayyedi, P. (2018) · American Journal of Gastroenterology · doi:10.1038/s41395-018-0195-4 · Cited by 379 · see citing works
Saint-Antoine IBD Network, Sokol, H., Landman, C., Seksik, P., Berard, L., Montil, M., Nion-Larmurier, I., Bourrier, A., Le Gall, G., Lalande, V., et al. (2020) · Microbiome · doi:10.1186/s40168-020-0792-5 · Cited by 378 · see citing works
Houlden, A., Goldrick, M., Brough, D., Vizi, E. S., Lénárt, N., Martinecz, B., Roberts, I. S., & Dénes, Á. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.04.003 · Cited by 369 · see citing works
Mikocka-Walus, A., Pittet, V., Rossel, J.-B., von Känel, R., Anderegg, C., Bauerfeind, P., Beglinger, C., Begré, S., Belli, D., Bengoa, J. M., et al. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.12.045 · Cited by 348 · see citing works
The HPA axis dysregulation in severe mental illness: Can we shift the blame to gut microbiota?
Misiak, B., Łoniewski, I., Marlicz, W., Frydecka, D., Szulc, A., Rudzki, L., & Samochowiec, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109951 · Cited by 343 · see citing works
Enck, P., Azpiroz, F., Boeckxstaens, G. E., Elsenbruch, S., Feinle‐Bisset, C., Holtmann, G., Lackner, J. M., Ronkainen, J., Schemann, M., Stengel, A., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.81 · Cited by 342 · see citing works
Why does the microbiome affect behaviour?
Johnson, K. V.-A., & Foster, K. R. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0014-3 · Cited by 333 · see citing works
Talley, N. J., Locke, G. R., Saito, Y. A., Almazar, A. E., Bouras, E. P., Howden, C. W., Lacy, B. E., DiBaise, J. K., Prather, C. M., Abraham, B. P., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.020 · Cited by 331 · see citing works
Association Between Early Adverse Life Events and Irritable Bowel Syndrome
Bradford, K., Shih, W., Videlock, E. J., Presson, A. P., Naliboff, B. D., Mayer, E. A., & Chang, L. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.12.018 · Cited by 322 · see citing works
AGRAWAL, A., HOUGHTON, L. A., MORRIS, J., REILLY, B., GUYONNET, D., GOUPIL FEUILLERAT, N., SCHLUMBERGER, A., JAKOB, S., & WHORWELL, P. J. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03853.x · Cited by 322 · cited 3× · see citing works
“Interestingly, probiotics may exert their beneficial effects both on the gut and CNS. Treatment with Bifidobacterium lactis was shown in one study to accelerate whole-gut transit and improve symptoms in patients with IBS-C (Agrawal et al., 2009).”
BackgroundThe Enteric Nervous System: A Second Brain
Gershon, M. D. (1999) · Hospital Practice · doi:10.3810/hp.1999.07.153 · Cited by 319 · see citing works
Iob, E., Kirschbaum, C., & Steptoe, A. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0501-6 · Cited by 305 · see citing works
Liu, Y., Zhang, L., Wang, X., Wang, Z., Zhang, J., Jiang, R., Wang, X., Wang, K., Liu, Z., Xia, Z., et al. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.05.033 · Cited by 301 · see citing works
Black, C. J., Thakur, E. R., Houghton, L. A., Quigley, E. M. M., Moayyedi, P., & Ford, A. C. (2020) · Gut · doi:10.1136/gutjnl-2020-321191 · Cited by 299 · see citing works
Altered colonic function and microbiota profile in a mouse model of chronic depression
Park, A. J., Collins, J., Blennerhassett, P. A., Ghia, J., Verdu, E. F., Berčík, P., & Collins, S. M. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12153 · Cited by 291 · see citing works
Diätumstellung gegen Depression
(2017) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-0043-103782 · Cited by 287 · see citing works
Labus, J. S., Hollister, E. B., Jacobs, J., Kirbach, K., Oezguen, N., Gupta, A., Acosta, J., Luna, R. A., Aagaard, K., Versalovic, J., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0260-z · Cited by 284 · see citing works
Mayer, E. A., Labus, J. S., Tillisch, K., Cole, S. W., & Baldi, P. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.121 · Cited by 282 · see citing works
Somatic comorbidities of irritable bowel syndrome: A systematic analysis
Riedl, A., Schmidtmann, M., Stengel, A., Goebel, M., Wisser, A.-S., Klapp, B. F., & Mönnikes, H. (2008) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2008.02.021 · Cited by 274 · see citing works
Long-term improvement in functional dyspepsia using hypnotherapy
Calvert, E., Houghton, L. A., Cooper, P., Morris, J., & Whorwell, P. J. (2002) · Gastroenterology · doi:10.1053/gast.2002.37071 · Cited by 264 · see citing works
Labus, J. S., Mayer, E. A., Chang, L., Bolus, R., & Naliboff, B. D. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31802e2f24 · Cited by 257 · see citing works
Incidence, Outcomes, and Health Services Burden of Very Early Onset Inflammatory Bowel Disease
Benchimol, E. I., Mack, D. R., Nguyen, G. C., Snapper, S. B., Li, W., Mojaverian, N., Quach, P., & Muise, A. M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.06.023 · Cited by 255 · see citing works
Nutritional Psychiatry: Where to Next?
Jacka, F. N. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.02.020 · Cited by 253 · see citing works
Symptoms and visceral perception in severe functional and organic dyspepsia
Mertz, H., Fullerton, S. C., Naliboff, B. D., & Mayer, E. A. (1998) · Gut · doi:10.1136/gut.42.6.814 · Cited by 252 · see citing works
Role of the Kynurenine Metabolism Pathway in Inflammation-Induced Depression: Preclinical Approaches
Dantzer, R. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_6 · Cited by 248 · see citing works
Mechanisms and efficacy of dietary FODMAP restriction in IBS
Staudacher, H. M., Irving, P. M., Lomer, M. C. E., & Whelan, K. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.259 · Cited by 243 · see citing works
Gut microbiome composition and diversity are related to human personality traits
Johnson, K. V. ‐. (2019) · Human Microbiome Journal · doi:10.1016/j.humic.2019.100069 · Cited by 241 · see citing works
Antibiotic Exposure and the Risk for Depression, Anxiety, or Psychosis: A Nested Case-Control Study
Lurie, I., Yang, Y.-X., Haynes, K., Mamtani, R., & Boursi, B. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.15m09961 · Cited by 231 · see citing works
Pharmacological Treatment of Anxiety Disorders: The Role of the HPA Axis
Tafet, G. E., & Nemeroff, C. B. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00443 · Cited by 216 · see citing works
Garland, E. L., Gaylord, S. A., Palsson, O., Faurot, K., Douglas Mann, J., & Whitehead, W. E. (2012) · Journal of Behavioral Medicine · doi:10.1007/s10865-011-9391-z · Cited by 210 · see citing works
Neurologic and Psychiatric Manifestations of Celiac Disease and Gluten Sensitivity
Jackson, J. R., Eaton, W. W., Cascella, N. G., Fasano, A., & Kelly, D. L. (2011) · Psychiatric Quarterly · doi:10.1007/s11126-011-9186-y · Cited by 207 · see citing works
Israelyan, N., Colle, A. D., Li, Z., Park, Y., Xing, A., Jacobsen, J. P. R., Luna, R. A., Jensen, D. D., Madra, M., Saurman, V. E., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.04.022 · Cited by 206 · see citing works
The past and future of cognitive therapy.
Beck, A. T. (1997) · PubMed Central · Cited by 205 · see citing works
Kurokawa, S., Kishimoto, T., Mizuno, S., Masaoka, T., Naganuma, M., Liang, K.-C., Kitazawa, M., Nakashima, M., Shindo, C., Suda, W., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.04.038 · Cited by 205 · see citing works
The impact of functional gastrointestinal disorders on quality of life
Koloski, N. A., Talley, N. J., & Boyce, P. M. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.01735.x · Cited by 204 · cited 1× · see citing works
“DGBI are associated with lower quality of life, more frequent doctor’s visits, and disability (Cunningham et al., 2017; Koloski et al., 2000; Williams et al., 2006).”
BackgroundMcIntyre, R. S., Subramaniapillai, M., Lee, Y., Pan, Z., Carmona, N. E., Shekotikhina, M., Rosenblat, J. D., Brietzke, E., Soczynska, J. K., Cosgrove, V. E., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.0779 · Cited by 200 · see citing works
Videlock, E. J., Adeyemo, M. A., Licudine, A., Hirano, M., Ohning, G., Mayer, M., Mayer, E. A., & Chang, L. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.058 · Cited by 198 · see citing works
Cheng, C., Chan, A. O. O., Hui, W. M., & Lam, S. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01663.x · Cited by 191 · see citing works
Tillisch, K., Mayer, E. A., Gupta, A., Gill, Z., Brazeilles, R., Le Nevé, B., van Hylckama Vlieg, J. E. T., Guyonnet, D., Derrien, M., & Labus, J. S. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000493 · Cited by 185 · see citing works
The impact of functional gastrointestinal disorders on quality of life
Koloski, N. A. (2000) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(99)00794-7 · Cited by 179 · see citing works
Zernicke, K. A., Campbell, T. S., Blustein, P. K., Fung, T. S., Johnson, J. A., Bacon, S. L., & Carlson, L. E. (2013) · International Journal of Behavioral Medicine · doi:10.1007/s12529-012-9241-6 · Cited by 178 · see citing works
Gracie, D. J., Williams, C. J. M., Sood, R., Mumtaz, S., Bholah, H. M., Hamlin, J. P., & Ford, A. C. (2016) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.59 · Cited by 173 · see citing works
Mindfulness-based interventions for chronic pain: evidence and applications
Majeed, M. H., Ali, A. A., & Sudak, D. M. (2018) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2017.11.025 · Cited by 173 · see citing works
Systemic low-grade inflammation in post-traumatic stress disorder: a systematic review
Speer, K. E., Upton, D., Semple, S., & McKune, A. J. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s155903 · Cited by 172 · see citing works
Molecular mechanisms of postbiotics in colorectal cancer prevention and treatment
Rad, A. H., Maleki, L. A., Kafil, H. S., & Abbasi, A. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1765310 · Cited by 168 · see citing works
Psychological Interventions for Irritable Bowel Syndrome and Inflammatory Bowel Diseases
Ballou, S., & Keefer, L. (2017) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.69 · Cited by 167 · see citing works
Self-citationMind-body dualism: A critique from a health perspectiveFNx08
Mehta, N. (2011) · Mens Sana monographs · doi:10.4103/0973-1229.77436 · Cited by 166 · see citing works
The gut Microbiome in adult and pediatric functional gastrointestinal disorders
Shin, A., Preidis, G. A., Shulman, R., & Kashyap, P. C. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.054 · Cited by 163 · see citing works
Postbiotics for Preventing and Treating Common Infectious Diseases in Children: A Systematic Review
Malagón-Rojas, J., Mantziari, A., Salminen, S., & Szajewska, H. (2020) · Nutrients · doi:10.3390/nu12020389 · Cited by 163 · see citing works
Anxiety Is Linked to New-Onset Dyspepsia in the Swedish Population: A 10-Year Follow-up Study
Aro, P., Talley, N. J., Johansson, S.-E., Agréus, L., & Ronkainen, J. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.01.039 · Cited by 162 · see citing works
Wang, H., Braun, C., Murphy, E. F., & Enck, P. (2019) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000203 · Cited by 159 · see citing works
Celiac Disease and the Microbiome
Valitutti, F., Cucchiara, S., & Fasano, A. (2019) · Nutrients · doi:10.3390/nu11102403 · Cited by 157 · see citing works
Vlieger, A. M., Rutten, J. M. T. M., Govers, A. M. A. P., Frankenhuis, C., & Benninga, M. A. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.487 · Cited by 156 · see citing works
Park, S. H., Videlock, E. J., Shih, W., Presson, A. P., Mayer, E. A., & Chang, L. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12826 · Cited by 156 · see citing works
Impact of Fecal Incontinence and Its Treatment on Quality of Life in Women
Meyer, I., & Richter, H. E. (2015) · Women s Health · doi:10.2217/whe.14.66 · Cited by 152 · see citing works
van Tilburg, M. A. L., Palsson, O. S., & Whitehead, W. E. (2013) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2013.03.004 · Cited by 151 · see citing works
Exclusive enteral nutrition in Crohn's disease: Evidence and practicalities
Ashton, J. J., Gavin, J., & Beattie, R. M. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.01.020 · Cited by 148 · see citing works
The gut microbiome as a driver of individual variation in cognition and functional behaviour
Davidson, G. L., Cooke, A. C., Johnson, C. N., & Quinn, J. L. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0286 · Cited by 148 · see citing works
Activation of Enteroendocrine Cells via TLRs Induces Hormone, Chemokine, and Defensin Secretion
Palazzo, M., Balsari, A., Rossini, A., Selleri, S., Calcaterra, C., Gariboldi, S., Zanobbio, L., Arnaboldi, F., Shirai, Y. F., Serrao, G., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4296 · Cited by 147 · see citing works
A review of antibiotics, depression, and the gut microbiome
Hao, W., Li, X., Zhang, P.-W., & Chen, J. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.112691 · Cited by 144 · see citing works
Jansson, C., Nordenstedt, H., Wallander, M.-A. A., Johansson, S., Johnsen, R., Hveem, K., & Lagergren, J. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03411.x · Cited by 140 · see citing works
Condition-specific deactivation of brain regions by 5-HT3 receptor antagonist Alosetron
Berman, S. M., Chang, L., Suyenobu, B., Derbyshire, S. W., Stains, J., FitzGerald, L., Mandelkern, M., Hamm, L., Vogt, B., Naliboff, B. D., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.35990 · Cited by 139 · see citing works
Role of brain imaging in disorders of brain–gut interaction: a Rome Working Team Report
Mayer, E. A., Labus, J., Aziz, Q., Tracey, I., Kilpatrick, L., Elsenbruch, S., Schweinhardt, P., Van Oudenhove, L., & Borsook, D. (2019) · Gut · doi:10.1136/gutjnl-2019-318308 · Cited by 138 · see citing works
Labus, J. S., Osadchiy, V., Hsiao, E. Y., Tap, J., Derrien, M., Gupta, A., Tillisch, K., Nevé, B. L., Grinsvall, C., Ljungberg, M., et al. (2019) · Microbiome · doi:10.1186/s40168-019-0656-z · Cited by 136 · see citing works
The role of the microbiome in the neurobiology of social behaviour
Sarkar, A., Harty, S., Johnson, K. V. ‐., Moeller, A. H., Carmody, R. N., Lehto, S. M., Erdman, S. E., Dunbar, R. I. M., & Burnet, P. W. J. (2020) · Biological Reviews · doi:10.1111/brv.12603 · Cited by 135 · see citing works
Ng, Q. X., Soh, A. Y. S., Loke, W., Venkatanarayanan, N., Lim, D. Y., & Yeo, W. (2019) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.14446 · Cited by 134 · see citing works
Compare, D., Rocco, A., Coccoli, P., Angrisani, D., Sgamato, C., Iovine, B., Salvatore, U., & Nardone, G. (2017) · BMC Gastroenterology · doi:10.1186/s12876-017-0605-x · Cited by 133 · see citing works
Igarashi, M., Nakae, H., Matsuoka, T., Takahashi, S., Hisada, T., Tomita, J., & Koga, Y. (2017) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2017-000144 · Cited by 133 · see citing works
Gut-directed hypnotherapy significantly augments clinical remission in quiescent ulcerative colitis
Keefer, L., Taft, T. H., Kiebles, J. L., Martinovich, Z., Barrett, T. A., & Palsson, O. S. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12449 · Cited by 132 · see citing works
Self-citationIL1β‐ and LPS‐induced serotonin secretion is increased in EC cells derived from Crohn’s disease
Kidd, M., Gustafsson, B. I., Drozdov, I., & Modlin, I. M. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01210.x · Cited by 130 · see citing works
The Gut-Microglia Connection: Implications for Central Nervous System Diseases
Wang, Y., Wang, Z., Wang, Y., Li, F., Jia, J., Song, X., Qin, S., Wang, R., Jin, F., Kitazato, K., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02325 · Cited by 128 · see citing works
Wu, J. C. (2012) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2012.18.1.13 · Cited by 126 · see citing works
Bonnert, M., Olén, O., Lalouni, M., Benninga, M., Bottai, M., Engelbrektsson, J., Hedman, E., Lenhard, F., Bo, M.-L., Simrén, M., et al. (2017) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.503 · Cited by 121 · see citing works
Cognitive-behavioral therapy for patients with irritable bowel syndrome: current insights
Kinsinger, S. W. (2017) · Psychology Research and Behavior Management · doi:10.2147/prbm.s120817 · Cited by 119 · see citing works
Flik, C. E., Laan, W., Zuithoff, N. P. A., van Rood, Y. R., Smout, A. J. P. M., Weusten, B. L. A. M., Whorwell, P. J., & de Wit, N. J. (2019) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(18)30310-8 · Cited by 118 · cited 1× · see citing works
“HT has shown benefit in reducing symptom severity in IBS, functional abdominal pain, and FD, and this benefit sustains at least one year after treatment (Calvert et al., 2002; Flik et al., 2019; Vlieger et al., 2012).”
BackgroundEveritt, H. A., Landau, S., O'Reilly, G., Sibelli, A., Hughes, S., Windgassen, S., Holland, R., Little, P., McCrone, P., Bishop, F. L., et al. (2019) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(19)30243-2 · Cited by 116 · see citing works
Patel, P., Bercik, P., Morgan, D. G., Bolino, C., Pintos‐Sanchez, M. I., Moayyedi, P., & Ford, A. C. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13074 · Cited by 115 · see citing works
Midenfjord, I., Polster, A. V., Sjövall, H., Törnblom, H., & Simrén, M. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13619 · Cited by 115 · see citing works
Sun, M., Ma, K., Wen, J., Wang, G., Zhang, C., Li, Q., Bao, X., & Wang, H. (2020) · Journal of Alzheimer’s Disease · doi:10.3233/jad-190872 · Cited by 113 · see citing works
Rumination syndrome: pathophysiology, diagnosis, and treatment
Absah, I., Rishi, A. R., Talley, N. J., Katzka, D. A., & Halland, M. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12954 · Cited by 109 · see citing works
Quigley, E. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7010006 · Cited by 109 · see citing works
Rutten, J. M. T. M., Reitsma, J. B., Vlieger, A. M., & Benninga, M. A. (2012) · Archives of Disease in Childhood · doi:10.1136/archdischild-2012-302906 · Cited by 102 · see citing works
Depressive symptoms in inflammatory bowel disease: an extraintestinal manifestation of inflammation?
Moulton, C. D., Pavlidis, P., Norton, C. S., Norton, S., Pariante, C. M., Hayee, B., & Powell, N. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13276 · Cited by 102 · see citing works
Dysfunctional Cognitions, Anxiety and Depression in Irritable Bowel Syndrome
Thijssen, A. Y., Jonkers, D. M. A. E., Leue, C., van der Veek, P. P. J., Vidakovic-Vukic, M., van Rood, Y. R., Clemens, C. H. M., & Masclee, A. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181eed5d8 · Cited by 97 · see citing works
Vaghef‐Mehrabany, E., Maleki, V., Behrooz, M., Ranjbar, F., & Ebrahimi‐Mameghani, M. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.06.004 · Cited by 95 · see citing works
The link between psychosocial factors and functional dyspepsia: an epidemiological study.
Li, Y., Nie, Y., Sha, W., & Su, H. (2002) · PubMed · Cited by 94 · see citing works
Kumano, H., Kaiya, H., Yoshiuchi, K., Yamanaka, G., Sasaki, T., & Kuboki, T. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04048.x · Cited by 93 · see citing works
Anxiety and depression in various functional gastrointestinal disorders: Do differences exist?
Hartono, J. L., Mahadeva, S., & Goh, K. (2012) · Journal of Digestive Diseases · doi:10.1111/j.1751-2980.2012.00581.x · Cited by 91 · see citing works
Icenhour, A., Witt, S. T., Elsenbruch, S., Lowén, M., Engström, M., Tillisch, K., Mayer, E. A., & Walter, S. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.06.001 · Cited by 89 · see citing works
Ewais, T., Begun, J., Kenny, M. A., Rickett, K., Hay, K. E., Ajilchi, B., & Kisely, S. R. (2018) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.11.010 · Cited by 89 · see citing works
Editorial: Gastrointestinal Illness and the Biopsychosocial Model
Drossman, D. A. (1996) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-199606000-00002 · Cited by 88 · see citing works
Paramsothy, S., Paramsothy, R., Kamm, M. A., Kaakoush, N. O., Mitchell, H. M., Rubin, D. T., & Castaño‐Rodríguez, N. (2017) · Gastroenterology · doi:10.1016/s0016-5085(17)33417-0 · Cited by 87 · see citing works
Szigethy, E., Bujoreanu, S. I., Youk, A. O., Weisz, J., Benhayon, D., Fairclough, D., Ducharme, P., Gonzalez-Heydrich, J., Keljo, D., Srinath, A., et al. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.04.014 · Cited by 86 · see citing works
The relationship between schizophrenia and irritable bowel syndrome (IBS)
Gupta, S., Masand, P. S., Kaplan, D. S., Bhandary, A. N., & Hendricks, S. E. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(96)00099-0 · Cited by 85 · see citing works
Microbiome in Reflux Disorders and Esophageal Adenocarcinoma
Yang, L., Chaudhary, N., Baghdadi, J. D., & Pei, Z. (2014) · The Cancer Journal · doi:10.1097/ppo.0000000000000044 · Cited by 84 · see citing works
Lazzarino, A. I., Hamer, M., Stamatakis, E., & Steptoe, A. (2013) · JAMA Internal Medicine · doi:10.1001/2013.jamainternmed.951 · Cited by 81 · see citing works
Neilson, K., Ftanou, M., Monshat, K., Salzberg, M., Bell, S., Kamm, M. A., Connell, W., Knowles, S. R., Sevar, K., Mancuso, S. G., et al. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000629 · Cited by 80 · see citing works
Sexton, K. A., Walker, J. R., Graff, L. A., Bernstein, M. T., Beatie, B., Miller, N., Sargent, M., & Targownik, L. E. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001040 · Cited by 79 · see citing works
The use of psychotropic drugs in irritable bowel syndrome
Dekel, R., Drossman, D. A., & Sperber, A. D. (2013) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2013.761205 · Cited by 78 · see citing works
Initial Assessment of Post-traumatic Stress in a US Cohort of Inflammatory Bowel Disease Patients
Taft, T., Bedell, A., Craven, M. R. A., Guadagnoli, L. A., Quinton, S., & Hanauer, S. B. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz032 · Cited by 77 · see citing works
Naliboff, B. D., Smith, S. R., Serpa, J. G., Laird, K. T., Stains, J., Connolly, L. S., Labus, J. S., & Tillisch, K. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13828 · Cited by 77 · see citing works
Gut Microbiota Dysbiosis in Functional Dyspepsia
Tziatzios, G., Gkolfakis, P., Papanikolaou, I. S., Mathur, R., Pimentel, M., Giamarellos‐Bourboulis, E. J., & Τriantafyllou, Κ. (2020) · Microorganisms · doi:10.3390/microorganisms8050691 · Cited by 76 · see citing works
Psychological controversies in gastroparesis: a systematic review
Woodhouse, S., Hebbard, G., & Knowles, S. R. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i7.1298 · Cited by 75 · see citing works
Levy, A. N., & Allegretti, J. R. (2019) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284819836893 · Cited by 75 · see citing works
Psychological disorders in patients with chronic constipation.
Hosseinzadeh, S. T., Poorsaadati, S., Radkani, B., & Forootan, M. (2011) · Europe PMC (PubMed Central) · Cited by 70 · see citing works
Khlevner, J., Park, Y., & Margolis, K. G. (2018) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2018.07.002 · Cited by 70 · see citing works
Reed, C. C., Corder, S. R., Kim, E., Sanders, E. C., Tappata, M., Eluri, S., & Dellon, E. S. (2020) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000597 · Cited by 69 · see citing works
Determinants of healthcare‐seeking behaviour among subjects with irritable bowel syndrome
Williams, R., BLACK, C. L., KIM, H. ‐., Andrews, E. B., Mangel, A. W., Buda, J. J., & Cook, S. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02928.x · Cited by 68 · see citing works
Stevens, B. W., Borren, N. Z., Velonias, G., Conway, G. M., Cleland, T., Andrews, E., Khalili, H., Garber, J. G., Xavier, R. J., Yajnik, V., et al. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4356-2 · Cited by 68 · see citing works
Park, S. H., Naliboff, B. D., Shih, W., Presson, A. P., Videlock, E. J., Ju, T., Kilpatrick, L. A., Gupta, A., Mayer, E. A., & Chang, L. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13155 · Cited by 67 · see citing works
Taft, T., Guadagnoli, L. A., & Edlynn, E. S. (2019) · Journal of Asthma and Allergy · doi:10.2147/jaa.s193045 · Cited by 67 · see citing works
Gatti, S., Galeazzi, T., Franceschini, E., Annibali, R., Albano, V., Verma, A. K., Angelis, M. D., Lionetti, E., & Catassi, C. (2017) · Nutrients · doi:10.3390/nu9080832 · Cited by 65 · see citing works
Araki, M., Shinzaki, S., Yamada, T., Arimitsu, S., Komori, M., Shibukawa, N., Mukai, A., Nakajima, S., Kinoshita, K., Kitamura, S., et al. (2020) · PLOS ONE · doi:10.1371/journal.pone.0233365 · Cited by 65 · see citing works
Hong, J. ‐., Naliboff, B. D., Labus, J. S., Gupta, A., Kilpatrick, L. A., Ashe-McNalley, C., Stains, J., Heendeniya, N., Smith, S. R., Tillisch, K., et al. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12710 · Cited by 63 · see citing works
The Relationship of Irritable Bowel Syndrome (IBS) and Panic Disorder1
Kaplan, D. S., Masand, P. M., & Gupta, S. (1996) · Annals of Clinical Psychiatry · doi:10.3109/10401239609148805 · Cited by 62 · see citing works
Psychosocial Correlates of Survival in Diabetes
Davis, W. K., Hess, G. E., & Hiss, R. G. (1988) · Diabetes Care · doi:10.2337/diacare.11.7.538 · Cited by 61 · see citing works
Labus, J. S., Mayer, E. A., Jarcho, J. M., Kilpatrick, L. A., Kilkens, T. O. C., Evers, E. A. T., Backes, W. H., Brummer, R. J., & van Nieuwenhoven, M. A. (2011) · Gut · doi:10.1136/gut.2010.213447 · Cited by 61 · see citing works
Lackner, J. M., Jaccard, J., Radziwon, C. D., Firth, R. S., Gudleski, G. D., Hamilton, F., Katz, L. A., Keefer, L., Krasner, S. S., Ma, C.-X., et al. (2019) · American Journal of Gastroenterology · doi:10.1038/s41395-018-0396-x · Cited by 61 · cited 2× · see citing works
“CBT has been shown to provide a sustained benefit in IBS (H. A. Everitt et al., 2019; Lackner et al., 2018).”
BackgroundSelf-citationDisrupted functional connectivity density in irritable bowel syndrome patients
Weng, Y., Qi, R., Liu, C., Ke, J., Xu, Q., Wang, F., Zhang, L. J., & Lu, G. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9653-z · Cited by 58 · see citing works
González-Moret, R., Cebolla, A., Cortés, X., Baños, R., Navarrete, J., Rubia, J. E. D. L., Lisón, J. F., & Soria, J. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-63168-4 · Cited by 58 · see citing works
Top-Down Cortical Control of Acute and Chronic Pain
Urien, L., & Wang, J. (2019) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000744 · Cited by 55 · see citing works
Post-traumatic stress in Crohn's disease and its association with disease activity
Cámara, R. J. A., Gander, M., Begré, S., von Känel, R., & Swiss Inflammatory Bowel Disease Cohort Study Group (2010) · Frontline Gastroenterology · doi:10.1136/fg.2010.002733 · Cited by 52 · see citing works
Psychiatric Comorbidity in Children and Adults with Gluten-Related Disorders: A Narrative Review
Slim, M., Rico‐Villademoros, F., & Calandre, E. P. (2018) · Nutrients · doi:10.3390/nu10070875 · Cited by 51 · see citing works
Cognitive behavioral principles in managing chronic disease
White, C. A. (2001) · Western Journal of Medicine · doi:10.1136/ewjm.175.5.338 · Cited by 50 · see citing works
Farmer, A. D., Gallagher, J., Holt, C. E. M. B., & Aziz, Q. (2017) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(16)30217-5 · Cited by 49 · see citing works
Anxiety and depression in patients with gastroesophageal reflux disorder
Javadi, S. A. H. S., & Shafikhani, A. A. (2017) · Electronic physician · doi:10.19082/5107 · Cited by 49 · see citing works
Hiremath, G. S., Shilts, M. H., Boone, H. H., Correa, H., Acra, S. A., Tovchigrechko, A., Rajagopala, S. V., & Das, S. R. (2019) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000039 · Cited by 49 · see citing works
Hypnosis and Cognitive Behavioral Therapies for the Management of Gastrointestinal Disorders
Palsson, O. S., & Ballou, S. (2020) · Current Gastroenterology Reports · doi:10.1007/s11894-020-00769-z · Cited by 49 · see citing works
Cebolla, A., Galiana, L., Campos, D., Oliver, A., Soler, J., Demarzo, M., Baños, R., Feliu‐Soler, A., & García‐Campayo, J. (2017) · Mindfulness · doi:10.1007/s12671-017-0826-7 · Cited by 47 · see citing works
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1 of the 229 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Garland EL, Gaylord SA, Palsson O, Faurot K, Douglas Mann J, Whitehead WE, 2012b. Therapeutic mechanisms of a mindfulness-based treatment for IBS: effects on visceral sensitivity, catastrophizing, and affective processing of pain sensations. J Behav Med 35 (6), 591– 602. 10.1007/s10865-011-9391-z. 22161025 PMC3883954 · DOI · Paper page
Cited by
Sorted by citations
Gong, W., Guo, P., Li, Y., Liu, L., Yan, R., Liu, S., Wang, S., Xue, F., Zhou, X., & Yuan, Z. (2023) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2022.4974 · Cited by 225 · see citing works
Leigh, S., Uhlig, F., Wilmes, L., Sánchez-Díaz, P., Gheorghe, C. E., Goodson, M. S., Kelley‐Loughnane, N., Hyland, N. P., Cryan, J. F., & Clarke, G. A. (2023) · The Journal of Physiology · doi:10.1113/jp281951 · Cited by 193 · see citing works
Microbiota–neuroepithelial signalling across the gut–brain axis
Ohara, T. E., & Hsiao, E. Y. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01136-9 · Cited by 147 · see citing works
Research progress in the treatment of slow transit constipation by traditional Chinese medicine
Wang, L., Wu, F., Hong, Y., Shen, L., Zhao, L., & Lin, X. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115075 · Cited by 76 · see citing works
Hung, L. Y., Alves, N. D., Colle, A. D., Talati, A., Najjar, S. A., Bouchard, V., Gillet, V., Tong, Y., Huang, Z., Browning, K. N., et al. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.11.012 · Cited by 44 · see citing works
Luo, K.-C., Zhang, M.-T., Tu, Q.-W., Li, J., Wang, Y., Wan, S.-L., Li, D.-J., Qian, Q., & Xia, L. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03476-6 · Cited by 41 · see citing works
Zhangyin, S., Wang, X., Feng, S., Chaoju, X., Xing, Y., Guo, L., Zhao, J., & Ji, C. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.934341 · Cited by 39 · see citing works
Psychogenic dysphagia in children, and the success of family-based treatment
Batara, R., Ardani, I. G. A. I., Wardani, I. A. K., Windiani, I. G. A. T., Adnyana, I. G. A. N. S., & Setiawati, Y. (2022) · International journal of health & medical sciences · doi:10.21744/ijhms.v5n1.1894 · Cited by 37 · see citing works
Wang, Y., Sun, W., Wu, E., Wang, K., Chen, X., Cui, Y., Zhang, G., Lv, F., Wang, Y., Peng, X., et al. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.868433 · Cited by 31 · see citing works
Varied Composition and Underlying Mechanisms of Gut Microbiome in Neuroinflammation
Farooq, R. K., Alamoudi, W., Alhibshi, A., Rehman, S., Sharma, A. R., & Abdulla, F. A. (2022) · Microorganisms · doi:10.3390/microorganisms10040705 · Cited by 30 · see citing works
The Impact of Probiotic Bacillus subtilis on Injurious Behavior in Laying Hens
Jiang, S., Hu, J., & Cheng, H. W. (2022) · Animals · doi:10.3390/ani12070870 · Cited by 29 · see citing works
Madva, E. N., Harnedy, L. E., Longley, R. M., Amaris, A. R., Castillo, C., Bomm, M. D., Murray, H. B., Staller, K. D., Kuo, B., Keefer, L., et al. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14531 · Cited by 28 · see citing works
Self-citationYan, R., Andrew, L., Marlow, E., Kunaratnam, K., Devine, A., Dunican, I. C., & Christophersen, C. T. (2021) · Nutrients · doi:10.3390/nu13072159 · Cited by 28 · see citing works
Disorders of the brain-gut interaction and eating disorders
Stănculete, M. F., Chiarioni, G., Dumitrascu, D. L., Dumitraşcu, D. I., & Popa, S. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i24.3668 · Cited by 27 · see citing works
The molecular signaling of exercise and obesity in the microbiota-gut-brain axis
Ribeiro, F. M., Silva, M. A., Lyssa, V., Marques, G., Lima, H. K., Franco, O. L., & Petriz, B. A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.927170 · Cited by 25 · see citing works
Molecular bases of comorbidities: present and future perspectives
Sánchez-Valle, J., & Valencia, A. (2023) · Trends in Genetics · doi:10.1016/j.tig.2023.06.003 · Cited by 24 · see citing works
Decoding the Role of Gut-Microbiome in the Food Addiction Paradigm
Novelle, M. G. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18136825 · Cited by 23 · see citing works
The potential influence of microplastics on the microbiome and disease susceptibility in sea turtles
Iurk, V. B., Ingles, M., Correa, G. S., Silva, C. R., Staichak, G., Pileggi, S. A. V., Christo, S. W., Domit, C., & Pileggi, M. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174298 · Cited by 21 · see citing works
Madva, E. N., Staller, K. D., Huffman, J. C., Kuo, B., Garcia‐Fischer, I., Atkins, M., Keefer, L., Celano, C. M., & Murray, H. B. (2022) · Neurogastroenterology & Motility · doi:10.1111/nmo.14493 · Cited by 19 · see citing works
Self-citationGuo, W., Zhang, J., & Feng, Y. (2024) · Phytotherapy Research · doi:10.1002/ptr.8180 · Cited by 19 · see citing works
Zhou, M., Niu, B., Ma, J., Ge, Y., Han, Y., Wu, W., & Yue, C. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1535455 · Cited by 22 · see citing works
Chen, B. K., & Denny, C. A. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109345 · Cited by 18 · see citing works
Role of the gut microbiome in psychological symptoms associated with inflammatory bowel diseases
Atanasova, K., Knödler, L.-L., Reindl, W., Ebert, M. P. A., & Thomann, A. (2025) · Seminars in Immunopathology · doi:10.1007/s00281-025-01036-x · Cited by 19 · see citing works
Positive psychological well-being and clinical characteristics in IBS: A systematic review
Madva, E. N., Sadlonova, M., Harnedy, L. E., Longley, R. M., Amonoo, H. L., Feig, E. H., Millstein, R. A., Zambrano, J., Amaris, A. R., Jurayj, J., et al. (2023) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2023.01.004 · Cited by 17 · see citing works
Self-citationZhao, G., Lu, Z., Liao, Y., Sun, Y., Zhang, Y., Kang, Z., Feng, X., Sun, J., & Yue, W. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.05.002 · Cited by 18 · see citing works
Priego-Parra, B. A., & Remes-Troche, J. M. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i48.5104 · Cited by 17 · see citing works
Probiotics reduce negative mood over time: the value of daily self-reports in detecting effects
Johnson, K. V. ‐., & Steenbergen, L. (2025) · npj Mental Health Research · doi:10.1038/s44184-025-00123-z · Cited by 17 · see citing works
Hypnotherapy and IBS: Implicit, long-term stress memory in the ENS?
Császár-Nagy, N., & Bókkon, I. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e12751 · Cited by 14 · see citing works
Lv, C., Song, G., Liu, J., Wang, W., Huang, Y., Wang, B., Tian, J.-S., Yin, M.-Q., & Yu, Y. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i41.5657 · Cited by 12 · see citing works
Biobehavioral approach to distinguishing panic symptoms from medical illness
Tunnell, N. C., Corner, S. E., Roque, A. D., Kroll, J. L., Ritz, T., & Meuret, A. E. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1296569 · Cited by 15 · see citing works
Fang, X., Gao, C., Wu, W., Hu, X., Shao, M., Zhou, C., Cai, R., Fang, J., Li, Y., Xu, Y., et al. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115463 · Cited by 11 · see citing works
Neutrophils in the Focus: Impact on Neuroimmune Dynamics and the Gut–Brain Axis
Kršek, A., & Batičić, L. (2024) · Gastrointestinal Disorders · doi:10.3390/gidisord6030039 · Cited by 12 · see citing works
Zhou, K., Huang, X., Chen, M., Li, Z., Qin, J., Ji, Y., Yu, X., & Yan, F. (2024) · Journal of Advanced Nursing · doi:10.1111/jan.16044 · Cited by 10 · see citing works
Transitions of care for adolescents with disorders of gut–brain interaction
Atkins, M., Huynh, D. J., Madva, E. N., Kuo, B., Zar‐Kessler, C., Murray, H. B., & Vélez, C. D. (2024) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/jpn3.12352 · Cited by 10 · see citing works
Possible application of Akkermansia muciniphila in stress management
Misera, A., Marlicz, W. M., Podkówka, A., Łoniewski, I., & Skonieczna‐Żydecka, K. (2024) · Microbiome Research Reports · doi:10.20517/mrr.2023.81 · Cited by 10 · see citing works
Calcaterra, V., Cena, H., Loperfido, F., Porri, D., Basilico, S., Gazzola, C., Rizzo, C. R., Conti, M. V., Luppino, G., Wasniewska, M. G., et al. (2024) · Nutrients · doi:10.3390/nu17010123 · Cited by 13 · see citing works
Franco, C., Bonomini, F., Borsani, E., Castrezzati, S., Franceschetti, L., & Rezzani, R. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182111328 · Cited by 10 · see citing works
Wu, J., Cao, M., Hu, M., Gong, Y., Xue, J., Yang, Y., & Zhou, H. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/9855411 · Cited by 9 · see citing works
Tian, X.-T., Zhan, J., Qiao, C., Ge, J.-L., & Li, D.-H. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i9.103145 · Cited by 9 · see citing works
Therapeutic Potential of Flavonoids and Flavonoid-Rich Compounds in Irritable Bowel Syndrome
Xia, Y., Liang, C., Luo, H., & Zhang, Y. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s515004 · Cited by 9 · see citing works
Xie, Y., Zhao, Y., Zhou, Y., Jiang, Y., Zhang, Y., Du, J., Cai, M., Fu, J., & Liu, H. (2024) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae099 · Cited by 8 · see citing works
Chen, L., Cao, H., Zhang, X., Du, X., Guan, Y., Li, M., Chang, A. K., He, X., Li, X., & Bi, X. (2024) · Food & Function · doi:10.1039/d3fo05278h · Cited by 9 · see citing works
Targeting the Gut–Brain Axis with Plant-Derived Essential Oils: Phytocannabinoids and Beyond
Camarda, L., Mattioli, L., Corazza, I., Marzetti, C., & Budriesi, R. (2025) · Nutrients · doi:10.3390/nu17091578 · Cited by 8 · see citing works
Microbial tryptophan metabolites modulate blood-brain and gut barriers in vitro
Rosell‐Cardona, C., Knox, E. G., Sánchez-Díaz, P., Leigh, S., Tirelli, E., Goodson, M. S., Kelley‐Loughnane, N., Aburto, M. R., Kittel‐Schneider, S., Cryan, J. F., et al. (2025) · Neuroscience Applied · doi:10.1016/j.nsa.2025.106876 · Cited by 8 · see citing works
Wang, H., Liu, W.-J., Wang, X., Chen, X., Cai, R.-L., Zhang, M.-T., Wang, H., He, G., Zhang, Z., & Shen, G.-M. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1074979 · Cited by 8 · see citing works
Singh, G., Dixit, I., Kalman, D., & Gogineni, N. T. (2024) · Journal of the American Nutrition Association · doi:10.1080/27697061.2024.2346073 · Cited by 9 · see citing works
Schiepatti, A., Maimaris, S., Randazzo, S., Maniero, D., Biti, R., Caio, G., Lungaro, L., Carroccio, A., Seidita, A., Scalvini, D., et al. (2024) · Nutrients · doi:10.3390/nu16162595 · Cited by 8 · see citing works
Tian, C., Yang, M., Chen, K., Luo, D., Yue, N.-N., Zhao, H., Zhang, Y., Lu, J., Liang, Y.-J., Song, Y., et al. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s514838 · Cited by 7 · see citing works
Wang, R., Zhao, F., Li, Y., Zhu, J., Liu, Y., Li, J., Yao, G. X., Liu, H., Guan, S., & Ma, S. (2023) · PeerJ · doi:10.7717/peerj.15113 · Cited by 7 · see citing works
Aberrant intrinsic functional brain networks in patients with functional constipation
Xiang, Y., Yu, J., Li, Y., Cong, J., Wang, C., Fan, R., Wang, W., Zhou, L., Xu, C., Liu, Y., et al. (2022) · Neuroradiology · doi:10.1007/s00234-022-03064-y · Cited by 7 · see citing works
Zhao, Z., Zhang, X., Sun, N., Duan, L., Xin, J., Li, H., Ni, X., Wang, H., Ma, H., & Bai, Y. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1561400 · Cited by 6 · see citing works
Xiang, Y., Yu, J., Li, Y., Cong, J., Wang, C., Fan, R., Wang, W., Zhou, L., Xu, C., Li, Y., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1241993 · Cited by 6 · see citing works
Pascoe, L. A., Mikhail, M. E., Burt, S. A., Culbert, K. M., & Klump, K. L. (2023) · Psychological Medicine · doi:10.1017/s003329172300301x · Cited by 6 · see citing works
Giorgianni, C. M., Martino, G., Brunetto, S., Buta, F., Lund-Jacobsen, T., Tonacci, A., Gangemi, S., & Ricciardi, L. (2024) · Healthcare · doi:10.3390/healthcare12141429 · Cited by 6 · see citing works
Tagi, V. M., Tosi, M., Greco, I. P., Stucchi, E., Verduci, E., & Zuccotti, G. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1477893 · Cited by 6 · see citing works
Zhang, M., Zhao, J., Ji, H., Tan, Y., Zhou, S., Sun, J., Ding, Y., & Li, X. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03299-2 · Cited by 7 · see citing works
Sex Differences in Comorbidity Combinations in the Swedish Population
Basso, L., Boecking, B., Neff, P. K. A., Brüeggemann, P., Cederroth, C. R., Rose, M., & Mazurek, B. (2022) · Biomolecules · doi:10.3390/biom12070949 · Cited by 7 · see citing works
Zheng, J., Li, J., Pei, T., Zhu, T., Li, X., & Wang, H. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.04.025 · Cited by 5 · see citing works
When the gut Speaks: The hidden toll of irritable bowel syndrome on body and mind
Mustafa, Y. F. (2025) · Gastroenterology & Endoscopy · doi:10.1016/j.gande.2025.05.002 · Cited by 5 · see citing works
Riva, A., Arienti, G., Zuin, G., Spini, L., Sansotta, N., Cavanna, A. E., & Nacinovich, R. (2025) · Nutrients · doi:10.3390/nu17101706 · Cited by 5 · see citing works
Dietary microbes and functional dyspepsia: modulating the gut microecology for therapeutic benefit
Huang, Q., You, F., Liang, F.-X., & Ma, C. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1625987 · Cited by 5 · see citing works
Cillis, F. D., Petrillo, G., D’Aprile, I., Marizzoni, M., Saleri, S., Mazzelli, M., Zonca, V., Benedetto, M. G. D., Riva, M. A., & Cattaneo, A. (2025) · Nutrients · doi:10.3390/nu17172812 · Cited by 6 · see citing works
Flores, F. J. B., Tamez, J. A. G., Winkelman, T., Flores, R. B., & Madva, E. N. (2025) · Frontiers in Gastroenterology · doi:10.3389/fgstr.2025.1637172 · Cited by 5 · see citing works
Jin, Q., Li, X., Liu, Z., Qi, T., Xiao, D., & Yang, W. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1718358 · Cited by 5 · see citing works
Serotonin and the gut microbiome: Pathways, functions, and health implications
Abubaker, S., Miri, S., & Hammami, R. (2026) · The Microbe · doi:10.1016/j.microb.2026.100668 · Cited by 5 · see citing works
Liu, R., Song, Q.-C., Liu, L.-M., Yang, Y., & Zhu, W. (2024) · Annals of General Psychiatry · doi:10.1186/s12991-024-00537-7 · Cited by 5 · see citing works
Martinotti, G., Dell’Osso, B. M., Nicola, M. D., Cipelli, R., Peduto, I., Pugliese, A., Signorelli, M. S., & Ventriglio, A. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220222142310 · Cited by 5 · see citing works
Modulation of Intestinal Motility in an Adolescent Rat Model of Irritable Bowel Syndrome
Kyodo, R., Kudo, T., Ito, N., Tokita, K., Arai, N., Sato, M., Ikuse, T., Jimbo, K., Ohtsuka, Y., & Shimizu, T. (2023) · Digestion · doi:10.1159/000534732 · Cited by 5 · see citing works
Hassib, L., Kanashiro, A., Pedrazzi, J. F. C., Vercesi, B. F., Higa, S., Arruda, Í., Soares, Y., de Souza, A. P., Jordão, A. A., Guimarães, F. S., et al. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100923 · Cited by 5 · see citing works
Dong, Q., Li, S., Zhu, X., Lin, K., Li, Y., Wang, S., & Shi, Y. (2026) · BMC Gastroenterology · doi:10.1186/s12876-025-04590-8 · Cited by 4 · see citing works
López-Fernández-Roldán, Á., Serrano-Fernandez, V., Laredo‐Aguilera, J. A., Barroso‐Corroto, E., de Paz-Montón, L. P., & Carmona‐Torres, J. M. (2026) · Nutrients · doi:10.3390/nu18020299 · Cited by 4 · see citing works
Plesz, S. B., Adlan, L. G., Büki, A., Makra, N., Ligeti, B., Ágg, B., Szabó, D., Zádori, Z., Ferdinándy, P., Horváth, G., et al. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111276 · Cited by 4 · see citing works
Constantinidis, D. D., O’Brien, C. L., Hebbard, G., Kanaan, R., & Castle, D. J. (2025) · Psychology Health & Medicine · doi:10.1080/13548506.2025.2497001 · Cited by 4 · see citing works
Lv, Q., Yuan, Y., Qu, S.-P., Diao, Y.-H., Hai, Z.-X., Xiang, Z., & Peng, D. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1380535 · Cited by 4 · see citing works
Serotonin Sensing Technologies to Promote Understanding of the Gut–Brain Axis
Overton, S. N., Han, J., Straker, M. A., Levy, J. A., Stine, J. M., Ho, T.-W., Herberholz, J., & Reza Ghodssi, A. (2024) · IEEE Sensors Letters · doi:10.1109/lsens.2024.3394236 · Cited by 4 · see citing works
Guarnieri, L., Bosco, F., Ruga, S., Tallarico, M., Leo, A., Sarro, G. D., & Citraro, R. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04593-8 · Cited by 4 · see citing works
Psychogenic Dysphagia in an Elderly: A Case of Eating Disorder Due to Trauma and Grief
Alzuabi, H. A., Altamimi, A. A., Harbi, A. A., Alshahrani, S. M., & Alfaris, A. M. (2023) · Cureus · doi:10.7759/cureus.47137 · Cited by 4 · see citing works
Omolaso, B. O., Ogunmiluyi, O. E., Adeniran, A. G., Adesanwo, J. K., & Akinlaja, D. O. (2024) · Nutrire · doi:10.1186/s41110-024-00286-3 · Cited by 4 · see citing works
The hidden genetic and microbial networks connecting neuropsychiatric and digestive disorders
Xiong, J., Xu, T., Wang, Z., Huang, Y., Zhang, S., Yang, G., Yang, J., Gao, S., Wang, T., Jian, X., et al. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.07.029 · Cited by 3 · see citing works
“Furthermore, gastrointestinal disorders such as IBD and IBS are frequently accompanied by persistent psychiatric comorbidities[6,7], reinforcing the need for an integrated perspective in investigating these interconnected systems.”
Exploring the Mechanisms of Gastroesophageal Reflux Disease Based on the Brain-Gut Axis Theory
Du, S., Zhang, L., Chen, Y., Zhang, Q., Chen, B., & Chen, S. (2025) · International Journal of General Medicine · doi:10.2147/ijgm.s558504 · Cited by 6 · see citing works
Taft, T., & Aswani-Omprakash, T. (2024) · Indian Journal of Gastroenterology · doi:10.1007/s12664-024-01653-8 · Cited by 3 · see citing works
Dobre, M., Manuc, T. E., Mănuc, M., Matei, I.-C., Dobre, A.-M., Dragne, A.-D., Maffioletti, E., Pelisenco, I. A., & Milanesi, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157321 · Cited by 5 · see citing works
The role of arousal in maintaining the relationship between insomnia and gastrointestinal conditions
Rameshkumar, S., Arizmendi, B. J., & Salwen‐Deremer, J. K. (2024) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh-23-126 · Cited by 6 · see citing works
Gut Microbiota-Derived butyric acid attenuates kidney stone formation in humans and mice
Isogai, M., Hamamoto, S., Unno, R., Taguchi, K., Okada, A., & Yasui, T. (2025) · Urolithiasis · doi:10.1007/s00240-025-01812-2 · Cited by 3 · see citing works
Pochakom, A., MacNevin, G., Madden, R. F., Moss, A. C., Martin, J. M., Lalonde-Bester, S., Parnell, J. A., Stein, E., & Shearer, J. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1543158 · Cited by 2 · see citing works
Bertalan, E., Horváth, Z., Gajdos, P., Magyaródi, T., & Rigó, A. (2025) · BMC Psychology · doi:10.1186/s40359-025-02918-3 · Cited by 2 · see citing works
Microbiota–Drug Interaction and Its Influence on Drug Metabolism and Toxicity
Pal, R., Bhowmick, P., Mahanty, J., Halder, P., & Bhowmick, M. (2025) · Interdisciplinary biotechnological advances · doi:10.1007/978-981-95-2104-3_3 · Cited by 2 · see citing works
Ravishankar, S., Ekambaram, B., Boopathy, N., Sakthivel, S. R., & Christan, M. (2025) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2025.106908 · Cited by 2 · see citing works
Exploring the Animal Models of Gastrointestinal and Emotional Comorbidity
Wang, Y., Kong, X., Ye, X. F., Pu, S., Ren, X., Huang, Q., Lu, Y., & Wang, H. (2025) · Brain and Behavior · doi:10.1002/brb3.71135 · Cited by 2 · see citing works
A new paradigm of bidirectional regulation of the gut–spinal cord axis
Ni, S., Chen, K., Wang, H., Chen, S., Qiu, Y., Wang, T., Mo, F., Wang, S., Li, B., Bai, Y., et al. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-01016 · Cited by 2 · see citing works
Cussotto, S., Abdennebi, S. R., Etting, I., Denny, C. A., Hen, R., Colle, R., Corruble, E., Alvarez, J., David, D. J. P., & Mendez‐David, I. (2026) · npj Biofilms and Microbiomes · doi:10.1038/s41522-026-00928-6 · Cited by 2 · see citing works
Immune dysregulation in pediatric tic disorders: mechanisms, biomarkers, and therapeutic frontiers
Sun, X., & Bai, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1708940 · Cited by 2 · see citing works
Yue, X., Zhu, L., & Zhang, Z. (2025) · Microorganisms · doi:10.3390/microorganisms13010165 · Cited by 2 · see citing works
Persister Intestinal Bacteria, Epigenetics and Major Depression
Vitetta, L., Bambling, M., & Strodl, E. S. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl26837 · Cited by 2 · see citing works
Patel, P. (2022) · Annals of Gastroenterology · doi:10.20524/aog.2022.0767 · Cited by 2 · see citing works
Carmody, J. K., Kramer, R., Distel, L. M. L., Davidson, R. D., Snyder, J. M., Villa, M., Nemec, G. E., & Hale, A. E. (2023) · Clinical Practice in Pediatric Psychology · doi:10.1037/cpp0000501 · Cited by 2 · see citing works
Lang, P. A., Thomas, L., & Lidbury, B. A. (2024) · Digestive Diseases and Sciences · doi:10.1007/s10620-024-08629-w · Cited by 1 · see citing works
Su, Q., Liu, L., Hua, T., Gong, J., Tian, H., Yun, J., & Cai, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-00148-6 · Cited by 1 · see citing works
Kucher, S. V., Мудра, У. О., Hanberher, І. І., Мисула, М. С., Mysula, Y., Dzhyvak, V. G., & Vastyanov, R. S. (2025) · World of Medicine and Biology · doi:10.26724/2079-8334-2025-2-92-89-94 · Cited by 4 · see citing works
Madva, E. N., Huffman, J. C., Castillo, C., Harnedy, L. E., Franklin, T., Song, M., Murray, H. B., Healy, B. C., Staller, K. D., Bartels, S., et al. (2025) · Neurogastroenterology & Motility · doi:10.1111/nmo.70146 · Cited by 1 · see citing works
Self-citation
- Authors
- Person, H., & Keefer, L.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Person, Hannibal
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 107
- Pages
- 110209
- ISSN
- 0278-5846 (ISSN-L)
- PMC
- PMC8382262
- OpenAlex
- W3111424608
- Cited by
- 158
- References
- 229
- Citations by year
- 2026: 31 · 2025: 52 · 2024: 28 · 2023: 23 · 2022: 19 · 2021: 5
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (TL1TR001434)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut-brain axis, psychological comorbidity, gastrointestinal diseases, irritable bowel syndrome, depression, Alzheimer's disease, autism spectrum disorder, inflammatory bowel disease, enteric nervous system, prebiotics, probiotics, postbiotics, gut dysbiosis
- MeSH terms
- Gastrointestinal Microbiome, Brain-Gut Axis, Mental Disorders, Brain, Gastrointestinal Diseases, Humans, Comorbidity, Enteric Nervous System, Probiotics, Irritable Bowel Syndrome, Prebiotics
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