Telomerase is an independent prognostic marker of overall survival in patients with colorectal cancer
Open accessAbstract
BACKGROUND: Colorectal cancer (CRC) is an important cause of cancer-related death. Prediction of recurrence is an important issue in the treatment of disease, particularly for stage II patients. The level of telomere-specific reverse transcriptase (hTERT), the catalytic component of the telomerase complex, increases along with CRC progression, but its prognostic value is still unclear. METHODS: One hundred and thirty-seven CRC patients were studied for hTERT expression in tumour cells by real-time PCR. hTERT level was evaluated as a prognostic factor of overall survival (OS) in all patients and of disease recurrence in a subgroup of 50 stage II patients. RESULTS: The median hTERT level was 93.8 copies (interquartile range 48-254). Patients with high hTERT levels (above the median) showed a significantly worse survival than those with low hTERT levels (below the median; log-rank test P<0.0001; hazard ratio (HR)=3.30 (95% confidence interval (CI) 1.98-5.52); P<0.0001). The negative prognostic value of high hTERT level is independent of the pathological stage and microsatellite instability (HR=2.09 (95% CI 1.20-3.64), P=0.009). Moreover, in stage II CRC, high hTERT levels identified patients with a higher risk of disease recurrence (HR=3.06 (95% CI 1.03-9.04), P=0.043) and death (HR=3.24 (95% CI 1.37-7.71), P=0.008). CONCLUSION: hTERT level is an independent prognostic marker of OS in CRC patients. In addition, assessment of hTERT level could improve stratification of stage II CRC patients for the risk of disease recurrence.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Bertorelle et al. showed that stage II CRC patients with lower levels of hTERT had better overall survival, while its presence at higher levels was correlated with a poor response to chemotherapy (as an independent prognostic factor) and with a higher risk of disease recurrence and death.
“Bertorelle et al. showed that stage II CRC patients with lower levels of hTERT had better OS, while its presence at higher levels was correlated with a poor response to chemotherapy (as an independent prognostic factor) and with a higher risk of disease recurrence and death [207].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [207]
Elevated levels of hTERT have been linked to overall survival in CRC patients.
“Additionally, elevated levels of hTERT have been linked to OS in CRC patients [207].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [207]
Ample evidence supports telomerase as a useful marker for monitoring and predicting outcomes in CRC.
“In summary, ample evidence supports telomerase as a useful marker for monitoring and predicting outcomes in CRC [207].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [207]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 54,708 · see citing works
Modeling Survival Data: Extending the Cox Model
Therneau, T. M., & Grambsch, P. M. (2000) · Statistics for Biology and Health · doi:10.1007/978-1-4757-3294-8 · Cited by 8,674 · see citing works
Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer
Van Cutsem, E., Köhne, C.-H., Hitre, E., Zaluski, J., Chang Chien, C.-R., Makhson, A., D'Haens, G., Pintér, T., Lim, R., Bodoky, G., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0805019 · Cited by 3,877 · see citing works
Microsatellite Instability in Colorectal Cancer
Boland, C. R., & Goel, A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.064 · Cited by 2,456 · see citing works
André, T., Boni, C., Navarro, M., Tabernero, J. M., Hickish, T., Topham, C., Bonetti, A. V., Clingan, P. R., Bridgewater, J. A., Rivera, F., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.20.6771 · Cited by 2,276 · see citing works
Benson, A. B., Abrams, T. A., Ben‐Josef, E., Bloomston, M., Botha, J. F., Clary, B. M., Covey, A. M., Curley, S. A., D'Angelica, M. I., Davila, R., et al. (2009) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2009.0027 · Cited by 2,271 · see citing works
Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256 · see citing works
Ribic, C. M., Sargent, D. J., Moore, M. J., Thibodeau, S. N., French, A. J., Goldberg, R. M., Hamilton, S. R., Laurent-Puig, P., Gryfe, R., Shepherd, L. E., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022289 · Cited by 2,160 · see citing works
Molecular Basis of Colorectal Cancer
Markowitz, S. D., & Bertagnolli, M. M. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804588 · Cited by 2,052 · see citing works
Telomere reduction in human colorectal carcinoma and with ageing
Hastie, N. D., Dempster, M., Dunlop, M. G., Thompson, A. M., Green, D. K., & Allshire, R. C. (1990) · Nature · doi:10.1038/346866a0 · Cited by 1,650 · see citing works
Sargent, D. J., Marsoni, S., Monges, G., Thibodeau, S. N., Labianca, R., Hamilton, S. R., French, A. J., Kabat, B., Foster, N. R., Torri, V., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.1825 · Cited by 1,623 · see citing works
Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study
QUASAR Collaborative Group (2007) · The Lancet · doi:10.1016/s0140-6736(07)61866-2 · Cited by 1,435 · see citing works
Benson, A. B., Schrag, D., Somerfield, M. R., Cohen, A. M., Figueredo, A. T., Flynn, P. J., Krzyzanowska, M. K., Maroun, J. A., McAllister, P. K., Cutsem, E. V., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.05.063 · Cited by 1,430 · see citing works
Cunningham, D., Atkin, W. S., Lenz, H., Lynch, H. T., Minsky, B. D., Nordlinger, B., & Starling, N. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60353-4 · Cited by 1,407 · see citing works
Gill, S., Loprinzi, C. L., Sargent, D. J., Thomé, S. D., Alberts, S. R., Haller, D. G., Benedetti, J., Francini, G., Shepherd, L. E., Seitz, J. F., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.09.059 · Cited by 1,019 · see citing works
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging
Blackburn, E. H., Greider, C. W., & Szostak, J. W. (2006) · Nature Medicine · doi:10.1038/nm1006-1133 · Cited by 992 · see citing works
The Chromosomal Instability Pathway in Colon Cancer
Pino, M. S., & Chung, D. C. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.065 · Cited by 941 · see citing works
Telomeres and telomerase in cancer
Artandi, S. E., & DePinho, R. A. (2010) · Carcinogenesis · doi:10.1093/carcin/bgp268 · Cited by 823 · see citing works
Calado, R. T., & Young, N. S. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0903373 · Cited by 783 · see citing works
Engstrom, P. F., Arnoletti, J. P., Benson, A. B., Chen, Y., Choti, M. A., Cooper, H. S., Covey, A. M., Dilawari, R. A., Early, D. S., Enzinger, P. C., et al. (2009) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2009.0056 · Cited by 682 · see citing works
de Kok, J. B., Roelofs, R., Giesendorf, B. A. J., Pennings, J. L. A., Waas, E. T., Feuth, T. B., Swinkels, D. W., & Span, P. N. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700208 · Cited by 580 · see citing works
Collett, D. (1994) · Springer eBooks · doi:10.1007/978-1-4899-3115-3_3 · Cited by 524 · see citing works
Adjuvant Chemotherapy for Stage II Colon Cancer With Poor Prognostic Features
O’Connor, E. S., Greenblatt, D. Y., LoConte, N. K., Gangnon, R. E., Liou, J., Heise, C. P., & Smith, M. A. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.34.3426 · Cited by 453 · see citing works
Compton, C. C., Byrd, D. R., García‐Aguilar, J., Kurtzman, S. H., Olawaiye, A. B., & Washington, M. K. (2012) · Springer eBooks · doi:10.1007/978-1-4614-2080-4_14 · Cited by 396 · see citing works
TERT regulates cell survival independent of telomerase enzymatic activity
Cao, Y., He, L., Deb, S., & Liu, J. (2002) · Oncogene · doi:10.1038/sj.onc.1205419 · Cited by 214 · see citing works
Rufer, N., Migliaccio, M., Antonchuk, J., Humphries, R. K., Roosnek, E. E., & Lansdorp, P. M. (2001) · Blood · doi:10.1182/blood.v98.3.597 · Cited by 180 · see citing works
Gertler, R., Rosenberg, R., Stricker, D., Friederichs, J., Hoos, A., Werner, M., Ulm, K., Holzmann, B., Nekarda, H., & Siewert, J.-R. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.09.160 · Cited by 180 · see citing works
hTERT antagonizes p53-induced apoptosis independently of telomerase activity
Rahman, R., Latonen, L., & Wiman, K. G. (2004) · Oncogene · doi:10.1038/sj.onc.1208232 · Cited by 157 · see citing works
hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway
Massard, C., Zermati, Y., Pauleau, A.-L., Larochette, N., Métivier, D., Sabatier, L., Kroemer, G., & Soria, J.-C. (2006) · Oncogene · doi:10.1038/sj.onc.1209487 · Cited by 144 · see citing works
Targeting the Limitless Replicative Potential of Cancer: The Telomerase/Telomere Pathway
Kèlland, L. R. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0422 · Cited by 142 · see citing works
Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function
Bufalo, D. D., Rizzo, A., Trisciuoglio, D., Cardinali, G., Torrisi, M. R., Zangemeister‐Wittke, U., Zupi, G., & Biroccio, A. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401670 · Cited by 140 · see citing works
Tatsumoto, N., Hiyama, E., Murakami, Y., Imamura, Y., Shay, J. W., Matsuura, Y., & Yokoyama, T. (2000) · PubMed · Cited by 132 · see citing works
Rampazzo, E., Bertorelle, R., Serra, L., Terrin, L., Candiotto, C., Pucciarelli, S., Bianco, P. D., Nitti, D., & De Rossi, A. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605644 · Cited by 125 · see citing works
Self-citationMenin, C., Scaini, M. C., Salvo, G. L. D., Biscuola, M., Quaggio, M., Esposito, G., Belluco, C., Montagna, M., Agata, S., D’Andrea, E., et al. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj054 · Cited by 121 · see citing works
Self-citationGarcia‐Aranda, C., de Juan, C., Diaz‐Lopez, A., Sanchez‐Pernaute, A., Torres, A., Diaz‐Rubio, E., Balibrea, J., Benito, M., & Iniesta, P. (2006) · Cancer · doi:10.1002/cncr.21625 · Cited by 105 · see citing works
Terrin, L., Rampazzo, E., Pucciarelli, S., Agostini, M., Bertorelle, R., Esposito, G., DelBianco, P., Nitti, D., & De Rossi, A. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0478 · Cited by 91 · see citing works
Self-citationPrognostic significance of biologic factors in squamous cell carcinoma of the esophagus
Ikeda, G., Isaji, S., Das, B. C., Watanabe, M., & Kawarada, Y. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19991015)86:8 · Cited by 82 · see citing works
Jin, X., Beck, S. J., Sohn, Y.-W., Kim, J.-K., Kim, S.-H., Yin, J., Pian, X., Kim, S.-C., Choi, Y.-J., & Kim, H. (2010) · Experimental & Molecular Medicine · doi:10.3858/emm.2010.42.8.058 · Cited by 50 · see citing works
(2010) · Springer eBooks · doi:10.1007/978-0-387-88441-7_14 · Cited by 49 · see citing works
Gertler, R., Rosenberg, R., Stricker, D., Werner, M., Laßmann, S., Ulm, K., Nekarda, H., & Siewert, J. R. (2002) · Cancer · doi:10.1002/cncr.10939 · Cited by 43 · see citing works
Real-time PCR quantification of human telomerase reverse transcriptase (hTERT) in colorectal cancer
Saleh, S., Lam, A. K.-Y., & Ho, Y. (2007) · Pathology · doi:10.1080/00313020701716425 · Cited by 42 · see citing works
Nowak, J., Januszkiewicz, D., Lewandowski, K., Nowicka-Kujawska, K., Pernak, M., Rembowska, J., Nowak, T., & Wysocki, J. (2003) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200301000-00013 · Cited by 38 · see citing works
Terrin, L., Dolcetti, R., Corradini, I., Indraccolo, S., Col, J. D., Bertorelle, R., Bonaldi, L., Esposito, G., & Rossi, A. D. (2007) · International Journal of Cancer · doi:10.1002/ijc.22661 · Cited by 37 · see citing works
Self-citationLopez (2002) · doi:10.1002/cncr.10911 · Cited by 36 · see citing works
Dolcetti, R., & Rossi, A. D. (2010) · Medicinal Research Reviews · doi:10.1002/med.20211 · Cited by 33 · see citing works
Telomerase Activity as a Prognostic Factor in Colorectal Cancer
Casla, M. T. S., Vidaurreta, M., Sanchez-Rueda, D., Maestro, M. L., Arroyo, M., & Cerdán, F. J. (2005) · Oncology Research and Treatment · doi:10.1159/000088525 · Cited by 29 · see citing works
Folini, M., Bandiera, R., Millo, E., Gandellini, P., Sozzi, G., Gasparini, P., Longoni, N., Binda, M., Daidone, M. G., Berg, K., et al. (2007) · Cell Proliferation · doi:10.1111/j.1365-2184.2007.00470.x · Cited by 28 · see citing works
Pucciarelli, S., Agostini, M., Viel, A., Bertorelle, R., Russo, V. M., Toppan, P., & Lise, M. (2003) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-6546-9 · Cited by 25 · see citing works
Self-citationTelomerase as a diagnostic and predictive marker in colorectal carcinoma.
Maláska, J., Kunická, Z., Borský, M., Skleničková, M., Novotna, M., Fajkusová, L., Žaloudík, J., & Fajkus, J. (2004) · PubMed · Cited by 23 · see citing works
Vidaurreta, M. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i28.3868 · Cited by 19 · see citing works
Kojima, K., Hiyama, E., Otani, K., Ohtaki, M., Fukuba, I., Fukuda, E., Sueda, T., & Hiyama, K. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01786.x · Cited by 14 · see citing works
Predictive Value of Microsatellite Instability-High Remains Controversial
Kim, G. P., Colangelo, L. H., Paik, S., O’Connell, M. J., Kirsch, I. R., Allegra, C. J., & Wolmark, N. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.13.2019 · Cited by 12 · see citing works
Safont, M. J., Gil-Raga, M., Sirera, R., Lewintre, E. J., Sanmartín, E., Gallach, S., Caballero, C., del Pozo, N., Palomares, E., & Camps, C. (2011) · Clinical & Translational Oncology · doi:10.1007/s12094-011-0673-2 · Cited by 10 · see citing works
Telomere function in colorectal cancer
Frías, C. (2009) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v1.i1.3 · Cited by 8 · see citing works
Harrell, F., Jr. (1996) · doi:10.1002/(sici)1097-0258(19960229)15:4
Flagged first, then by citations
Cited by
Sorted by citations
Tumor biomarkers for diagnosis, prognosis and targeted therapy
Zhou, Y., Tao, L., Qiu, J., Xu, J., Yang, X., Zhang, Y., Tian, X., Guan, X., Cen, X., & Zhao, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01823-2 · Cited by 772 · see citing works
Genetic and biological hallmarks of colorectal cancerPreprint
Li, J., Ma, X., Chakravarti, D., Shalapour, S., & DePinho, R. A. (2021) · Genes & Development · doi:10.1101/gad.348226.120 · Cited by 588 · see citing works
Novel Diagnostic Biomarkers in Colorectal Cancer
Zygulska, A. L., & Pierzchalski, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020852 · Cited by 253 · see citing works
The circulating transcriptome as a source of cancer liquid biopsy biomarkers
Solé, C., Arnaiz, E., Manterola, L., Otaegui, D., & Lawrie, C. H. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.01.003 · Cited by 132 · see citing works
Pellino, G., Gallo, G., Pallante, P., Capasso, R., Stefano, A. D., Maretto, I., Malapelle, U., Qiu, S., Nikolaou, S., Barina, A., et al. (2018) · Gastroenterology Research and Practice · doi:10.1155/2018/2397863 · Cited by 95 · see citing works
Self-citationThe Association between Telomere Length and Cancer Prognosis: Evidence from a Meta-Analysis
Zhang, C., Chen, X., Li, L., Zhou, Y. Y., Wang, C., & Hou, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133174 · Cited by 95 · see citing works
Telomeres, telomerase and colorectal cancer
Bertorelle, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i8.1940 · Cited by 82 · see citing works
Self-citationTelomere Maintenance Mechanisms in Cancer: Clinical Implications
Reddel, R. R. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140630101047 · Cited by 78 · see citing works
Surgery for colorectal liver metastases: The evolution of determining prognosis
Spolverato, G. (2013) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v5.i12.207 · Cited by 77 · see citing works
Wang, Y., Chen, S., Yan, Z., & Pei, M. (2019) · Cell & Bioscience · doi:10.1186/s13578-018-0264-9 · Cited by 64 · see citing works
Boscolo‐Rizzo, P., Mosto, M. C. D., Rampazzo, E., Giunco, S., Mistro, A. D., Menegaldo, A., Baboçi, L., Mantovani, M., Tirelli, G., & Rossi, A. D. (2016) · Cancer and Metastasis Reviews · doi:10.1007/s10555-016-9633-1 · Cited by 63 · see citing works
Self-citationOligonucleotides Targeting Telomeres and Telomerase in Cancer
Schrank, Z., Khan, N. H., Osude, C., Singh, S., Miller, R. J., Merrick, C., Mabel, A., Kuckovic, A., & Puri, N. (2018) · Molecules · doi:10.3390/molecules23092267 · Cited by 54 · see citing works
TERT activates endogenous retroviruses to promote an immunosuppressive tumour microenvironment
Mao, J., Zhang, Q., Wang, Y., Yang, Z., Xu, L., Ma, X., Guan, D., Zhou, J., Liu, J., Wu, X., et al. (2022) · EMBO Reports · doi:10.15252/embr.202152984 · Cited by 49 · see citing works
The prognostic significance of hTERT overexpression in cancers
Wang, K., Wang, R.-L., Liu, J., Zhou, J., Li, X., Hu, W., Jiang, W., & Hao, N.-B. (2018) · Medicine · doi:10.1097/md.0000000000011794 · Cited by 50 · see citing works
Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer
Fernández‐Marcelo, T., Sánchez-Pernaute, A., Pascua, I. P., de Juan, C., Head, J., Torres, A.-J., & Iniesta, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149626 · Cited by 49 · see citing works
Ellingsen, E. B., Mangsbo, S. M., Hovig, E. J., & Gaudernack, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.682492 · Cited by 44 · see citing works
Ellingsen, E. B., Aamdal, E., Guren, T. K., Lilleby, W. A., Brunsvig, P. F., Mangsbo, S. M., Aamdal, S., Hovig, E. J., Mensali, N., Gaudernack, G., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-004345 · Cited by 43 · see citing works
Boscolo‐Rizzo, P., Rampazzo, E., Perissinotto, E., Piano, M. A., Giunco, S., Baboçi, L., Spinato, G., Spinato, R., Tirelli, G., Mosto, M. C. D., et al. (2015) · Oral Oncology · doi:10.1016/j.oraloncology.2015.02.100 · Cited by 43 · see citing works
Self-citationCurrent and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy
Nikolouzakis, T. K., Chrysos, E., Docea, A. O., Fragkiadaki, P., Souglakos, J., Tsiaoussis, J., & Tsatsakis, A. (2024) · Cancers · doi:10.3390/cancers16111995 · Cited by 37 · see citing works
Deloria, A. J., Höflmayer, D., Kienzl, P., Łopatecka, J., Sampl, S., Klimpfinger, M., Braunschmid, T., Bastian, F., Lu, L., Marian, B., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12070 · Cited by 34 · see citing works
Shigeyasu, K., Tazawa, H., Hashimoto, Y., Mori, Y., Nishizaki, M., Kishimoto, H., Nagasaka, T., Kuroda, S., Urata, Y., Goel, A., et al. (2014) · Gut · doi:10.1136/gutjnl-2014-306957 · Cited by 33 · see citing works
Screening and preliminary validation of miRNAs with the regulation of hTERT in colorectal cancer
Qin, Y., XIE, X.-C., Liu, H., LAI, H., Qiu, H. B., & Ge, L. (2015) · Oncology Reports · doi:10.3892/or.2015.3892 · Cited by 32 · see citing works
Telomerase and CD4 T Cell Immunity in Cancer
Dosset, M., Castro, A., Carter, H. K., & Zanetti, M. (2020) · Cancers · doi:10.3390/cancers12061687 · Cited by 29 · see citing works
Biomarkers in head and neck squamous cell carcinoma: unraveling the path to precision immunotherapy
Saini, K. S., Somara, S., Ko, H. C., Thatai, P., Quintana, A., Wallen, Z. D., Green, M. F., Mehrotra, R., McGuigan, S., Pang, L., et al. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1473706 · Cited by 31 · see citing works
Oligonucleotides and microRNAs Targeting Telomerase Subunits in Cancer Therapy
Eckburg, A., Dein, J., Berei, J., Schrank, Z., & Puri, N. (2020) · Cancers · doi:10.3390/cancers12092337 · Cited by 29 · see citing works
Zhao, T., HU, F., Qiao, B., Chen, Z., & Tao, Q. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.2927 · Cited by 29 · see citing works
Telomeres and telomere dynamics: relevance to cancers of the GI tract
Basu, N., Skinner, H. G., Litzelman, K., Vanderboom, R. J., Baichoo, E., & Boardman, L. A. (2013) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2013.848790 · Cited by 28 · see citing works
Rampazzo, E., Bianco, P. D., Bertorelle, R., Boso, C., Perin, A., Spiro, G., Bergamo, F., Belluco, C., Buonadonna, A., Palazzari, E., et al. (2018) · British Journal of Cancer · doi:10.1038/bjc.2017.492 · Cited by 27 · see citing works
Self-citationPan-Cancer Analysis of Alternative Lengthening of Telomere Activity
Sung, J., Lim, H., Joung, J., & Park, W. (2020) · Cancers · doi:10.3390/cancers12082207 · Cited by 26 · see citing works
Haakensen, V. D., Nowak, A. K., Ellingsen, E. B., Farooqi, S. J., Bjaanæs, M. M., Horndalsveen, H., McCulloch, T., Grundberg, O., Cedrés, S., & Helland, Å. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02905-3 · Cited by 24 · see citing works
Zou, M., Lv, G., Li, J., She, X., & Jiang, Y. (2016) · PubMed Central · Cited by 23 · see citing works
Ellingsen, E. B., Bounova, G., Kerzeli, I. K., Anzar, I., Simnica, D., Aamdal, E., Guren, T. K., Clancy, T., Mezheyeuski, A., Inderberg, E. M., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03624-z · Cited by 22 · see citing works
Zhang, Y., Li, Q.-S., Liu, H., Tang, H.-T., Yang, H.-L., Wu, D.-Q., Huang, Y., Li, L., Liu, L., & Li, M. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02788-w · Cited by 22 · see citing works
SMYD3 promoter Hypomethylation is Associated with the Risk of Colorectal Cancer
Li, B., Pan, R., Zhou, C., Dai, J., Mao, Y., Chen, M., Huang, T., Ying, X., Hu, H., Zhao, J., et al. (2018) · Future Oncology · doi:10.2217/fon-2017-0682 · Cited by 20 · see citing works
Kim, S., Kim, B. J., Kim, I. H., Kim, J. H., Kim, H. K., Ryu, H., Choi, D. R., Hwang, I. G., Song, H., Kwon, J. H., et al. (2022) · Journal of Cancer · doi:10.7150/jca.70385 · Cited by 18 · see citing works
Molecular markers of prognosis and therapeutic targets in metastatic colorectal cancer
Ronnekleiv‐Kelly, S. M., Burkhart, R. A., & Pawlik, T. M. (2016) · Surgical Oncology · doi:10.1016/j.suronc.2016.05.018 · Cited by 19 · see citing works
Toward a Molecular Classification of Colorectal Cancer: The Role of Telomere Length
Baichoo, E., & Boardman, L. A. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00158 · Cited by 17 · see citing works
Tissue Specific Promoters in Colorectal Cancer
Rama, A. R., Aguilera, A., Melguizo, C., Caba, O., & Prados, J. C. (2015) · Disease Markers · doi:10.1155/2015/390161 · Cited by 17 · see citing works
Zhao, T., Hu, F., Liu, X., & Tao, Q. (2015) · Oncotarget · doi:10.18632/oncotarget.5468 · Cited by 15 · see citing works
Association of TERT Polymorphisms with Clinical Outcome of Non-Small Cell Lung Cancer Patients
Zhao, X., Wang, S., Wu, J., Li, X., Wang, X., Gao, Z., Wu, W., Wang, H., Wang, J., Qian, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129232 · Cited by 14 · see citing works
Telomere and Telomerase in Carcinogenesis: Their Role as Prognostic Biomarkers
Giunco, S., Rampazzo, E., Celeghin, A., Petrara, M. R., & Rossi, A. D. (2015) · Current Pathobiology Reports · doi:10.1007/s40139-015-0087-x · Cited by 14 · see citing works
Self-citationTelomeres and telomerase in the clinical management of colorectal cancer
Piñol-Felis, C., Fernández-Marcelo, T., Viñas-Salas, J., & Valls-Bautista, C. (2017) · Clinical and Translational Oncology · doi:10.1007/s12094-016-1559-0 · Cited by 13 · see citing works
Deng, W., Jiao, N., Li, N., Wan, X., Luo, S., & Zhang, Y. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.04.011 · Cited by 12 · see citing works
Zhang, Y., Du, Y., Song, Z., Liu, S., Li, W., Wang, D., & Suo, J. (2020) · Oncology Letters · doi:10.3892/ol.2020.11510 · Cited by 12 · see citing works
Telomere Length and Telomerase Activity as Potential Biomarkers for Gastrointestinal Cancer
Loukopoulou, C., Νikolouzakis, Τ. Κ., Koliarakis, I., Vakonaki, E., & Tsiaoussis, J. (2024) · Cancers · doi:10.3390/cancers16193370 · Cited by 13 · see citing works
Shen, Y., Feng, X., Li, H., Luo, Y., Chen, C., & Wang, L. (2018) · IUBMB Life · doi:10.1002/iub.1758 · Cited by 9 · see citing works
Yin, H., Hardikar, S. S., Lindström, S., Hsu, L., Anderson, K. E., Banbury, B. L., Berndt, S. I., Chan, A. T., Giovanucci, E. L., Harrison, T. A., et al. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-19-1507 · Cited by 8 · see citing works
Aierken, Y., Tan, K., Liu, T., & Lv, Z. (2025) · Scientific Reports · doi:10.1038/s41598-025-88608-x · Cited by 7 · see citing works
Oncoselectivity in Oncolytic Viruses against Colorectal Cancer
Conrad, S. J., & Essani, K. (2014) · Journal of Cancer Therapy · doi:10.4236/jct.2014.513118 · Cited by 7 · see citing works
Laish, I., Levi, Z., Mahajna, H., Albshesh, A., Horesh, N., Katz, E., Feldman, D., Shinar, N., Picard, O., Yavzori, M., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.962473 · Cited by 6 · see citing works
Li, H., Wang, Q., Li, D., Wang, Q., & Wu, H. (2014) · Oncology Reports · doi:10.3892/or.2014.3697 · Cited by 6 · see citing works
Ganesh, M. S., Narayanan, G. S., & Kumar, R. (2019) · Reports of Practical Oncology & Radiotherapy · doi:10.1016/j.rpor.2019.10.011 · Cited by 6 · see citing works
Kuhn, C. K., Meister, J., Kreft, S., Stiller, M., Puppel, S.-H., Zaremba, A., Scheffler, B., Ullrich, V., Schöneberg, T., Schadendorf, D., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281487 · Cited by 6 · see citing works
Xie, X. C., Ge, L. Y., Lai, H., Qiu, H. B., Tang, F., & Qin, Y. (2016) · Balkan Medical Journal · doi:10.5152/balkanmedj.2015.151182 · Cited by 6 · see citing works
Variations in telomere maintenance and the role of telomerase inhibition in gastrointestinal cancer
Heeg, S. (2015) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s52808 · Cited by 3 · see citing works
d’Amati, A., Serio, G., Quaranta, A., Vimercati, L., Giorgis, M. D., Lorusso, L., Errede, M., Longo, V., Marzullo, A., Ribatti, D., et al. (2025) · Cancers · doi:10.3390/cancers17020252 · Cited by 2 · see citing works
Visfatin Proliferative Effect on Hct-116 Colorectal Cancer Cell Line
Ghaemmaghami, S., Hedayati, M., Mohaddes, S. M., Rahmati, M., & Zarghami, N. (2014) · Cited by 2 · see citing works
Kuhn, C. K., Meister, J., Kreft, S., Stiller, M., Puppel, S.-H., Zaremba, A., Scheffler, B., Ullrich, V., Schöneberg, T., Schadendorf, D., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.25.525565 · Cited by 2 · see citing works
Multiomics Research Strategies in Cancer: A Growing and Innovative Field
Du, Z., Liu, X., Lv, Z., Wang, B., Xia, Y., Al-duais, W. A. M., Yan, L., Zhang, F., & Li, Y. (2026) · MedComm · doi:10.1002/mco2.70644 · Cited by 1 · see citing works
Telomerase as Biomarker in Colorectal Cancer
Bertorelle, R., & Rossi, A. D. (2015) · Biomarkers in disease · doi:10.1007/978-94-007-7681-4_2 · Cited by 1 · see citing works
Self-citationTelomerase as Biomarker in Colorectal Cancer
Bertorelle, R., & Rossi, A. D. (2014) · Springer eBooks · doi:10.1007/978-94-007-7744-6_2-1 · Cited by 1 · see citing works
Self-citationShabani, S., Elahi, E., Bahraniasl, M., Babaheidarian, P., Sadeghpour, A., Majidzadeh, T., Talebi, A., & Mahjoubi, F. (2022) · Gastroenterology and hepatology from bed to bench. · Cited by 1 · see citing works
The Evolving Use of Prognostic Factors After Resection of Colorectal Liver Metastases
Karagkounis, G., & Choti, M. A. (2014) · Current Colorectal Cancer Reports · doi:10.1007/s11888-014-0220-y
Research Highlights: Highlights from the Latest Articles in Biomarkers in Medicine
Sauter, E. R. (2013) · Biomarkers in Medicine · doi:10.2217/bmm.13.66
Spontaneous Neoplasia: A Destiny of Viviparous Mammal
Mingomataj, E., & Shyri, R. M. (2013)
Should Liquid Biopsies Be Considered in Treatment Decisions?
Barina, A., Maretto, I., & Pucciarelli, S. (2018) · Springer eBooks · doi:10.1007/978-3-319-43217-5_68
Self-citationComprehensive identification of survival-associated genes for cancersPreprint
Liu, H., Luo, K., Li, H., & Sun, X. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/526285
Changes in mRNA expression of colon mucosa genes during natural aging
Goncharov, S. V., Bozhenko, K. V., Владимировна, З. М., Александрович, Ч. А., Михайловна, К. Т., & Solodkiy, V. А. (2023) · Russian Medical Inquiry · doi:10.32364/2587-6821-2023-7-6-2
Colorectal Cancer and Role of Biomarkers in Diagnosis, Prognostification and Personalized Treatment
Khosla, D., Singla, A. K., Gupta, R., & Kapoor, R. (2024) · Springer eBooks · doi:10.1007/978-981-99-3746-2_22
Huang, F., Zhao, W. G., Li, Z. Y., Fong, J. Y., Okechukwu, P. N., Ng, C. T., Venkatachalam, K., Alshawsh, M. A., Letchumanan, V., & Selvaraja, M. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1728178
Zhang, Y., Li, Q.-S., Liu, H.-L., Tang, H.-T., Yang, H.-L., Wu, D., Huang, Y.-Y., Li, L.-C., Liu, L.-H., & Li, M. (2023) · Figshare · doi:10.6084/m9.figshare.24030981
Zhang, Y., Li, Q.-S., Liu, H.-L., Tang, H.-T., Yang, H.-L., Wu, D., Huang, Y.-Y., Li, L.-C., Liu, L.-H., & Li, M. (2023) · Figshare · doi:10.6084/m9.figshare.24030987
Zhang, Y., Li, Q.-S., Liu, H.-L., Tang, H.-T., Yang, H.-L., Wu, D., Huang, Y.-Y., Li, L.-C., Liu, L.-H., & Li, M. (2023) · Figshare · doi:10.6084/m9.figshare.24030990
Zhang, Y., Li, Q.-S., Liu, H.-L., Tang, H.-T., Yang, H.-L., Wu, D., Huang, Y.-Y., Li, L.-C., Liu, L.-H., & Li, M. (2023) · Figshare · doi:10.6084/m9.figshare.24030993
Ellingsen, E. B., Bounova, G., Kerzeli, I. K., Anzar, I., Simnica, D., Aamdal, E., Guren, T. K., Clancy, T., Mezheyeuski, A., Inderberg, E. M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21080550
Zhang, Y., Li, Q.-S., Liu, H.-L., Tang, H.-T., Yang, H.-L., Wu, D., Huang, Y.-Y., Li, L.-C., Liu, L.-H., & Li, M. (2023) · Figshare · doi:10.6084/m9.figshare.24030984
Li, Q., Liu, S., Gao, J., Li, J., & Shi, H. (2026) · Biomolecules · doi:10.3390/biom16091239
- Authors
- Bertorelle, R., Briarava, M., Rampazzo, E., Biasini, L., Agostini, M., Maretto, I., Lonardi, S., Friso, M. L., Mescoli, C., Zagonel, V, Nitti, D., De Rossi, A., & Pucciarelli, S.
- Affiliations
- Istituto Oncologico Veneto (IT)
- University of Padua (IT)
- ORCID
- Venue
- British Journal of Cancer
- Published
- 2013-01-15
- Volume
- 108
- Issue
- 2
- Pages
- 278-284
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC3566802
- OpenAlex
- W1991098068
- Cited by
- 77
- References
- 55
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 9 · 2022: 8 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 7 · 2016: 7 · 2015: 11 · 2014: 9 · 2013: 4
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (unspecified)
- Locations
- British Journal of Cancer (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by-nc-sa)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- telomerase, hTERT, colorectal cancer, prognostic factors, overall survival, recurrence, stage II colorectal cancer, microsatellite instability, risk stratification
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Prognosis, RNA, Messenger, Biomarkers, Tumor, Colorectal Neoplasms, Disease Progression, Disease-Free Survival, Telomerase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
