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Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis
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“The observation that deficiency of Puma (or combined deficiency of Puma and Noxa or Puma and p21) promoted the development of C-myc-driven lymphoma,107,108 which suggested that p53-mediated apoptosis could exert obvious tumor-suppressive effects.”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [108]
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Cites
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The Bcl2 family: regulators of the cellular life-or-death switch
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Self-citationNoxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis
Oda, E., Ohki, R., Murasawa, H., Nemoto, J., Shibue, T., Yamashita, T., Tokino, T., Taniguchi, T., & Tanaka, †. N. (2000) · Science · doi:10.1126/science.288.5468.1053 · Cited by 2,112
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Self-citationp53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa
Villunger, A., Michalak, E. M., Coultas, L., Müllauer, F., Böck, G., Ausserlechner, M. J., Adams, J. M., & Strasser, A. (2003) · Science · doi:10.1126/science.1090072 · Cited by 1,327
Self-citationMyc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
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Cited by
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
Czabotar, P. E., Lessene, G., Strasser, A., & Adams, J. M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3722 · Cited by 3,219
Self-citationHow does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression
Aubrey, B. J., Kelly, G. L., Janic, A., Herold, M. J., & Strasser, A. (2018) · Cell Death & Differentiation · doi:10.1038/cdd.2017.169 · Cited by 1,395
Self-citationTumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence
Li, T., Kon, N., Jiang, L., Tan, M., Ludwig, T., Zhao, Y., Baer, R., & Gu, W. (2012) · Cell · doi:10.1016/j.cell.2012.04.026 · Cited by 912
A fate worse than death: apoptosis as an oncogenic process
Ichim, G., & Tait, S. W. G. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.58 · Cited by 451
Deconstructing p53 transcriptional networks in tumor suppression
Bieging, K. T., & Attardi, L. D. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.10.006 · Cited by 194
Metadata
- Authors
- Michalak, E. M., Jansen, E. S., Happo, L., Cragg, M. S., Tai, L., Smyth, G. K., Strasser, A., Adams, J. M., & Scott, C. L.
- Venue
- Cell Death & Differentiation
- Published
- 2009-01-16
- Volume
- 16
- Issue
- 5
- Pages
- 684-696
- ISSN
- 1350-9047
- 1476-5403
- Cited by
- 147
- References
- 8
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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- CoChat. (2026). Citation check: Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis. https://app.cochat.ai/papers/10.1038/cdd.2008.195
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- Michalak, E. M., Jansen, E. S., Happo, L., Cragg, M. S., Tai, L., Smyth, G. K., Strasser, A., Adams, J. M., & Scott, C. L. (2009). Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis. Cell Death & Differentiation. https://doi.org/10.1038/cdd.2008.195
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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