Cited by 808Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in CancerErythropoietin and Anemia Treatment

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The role of hypoxia-inducible factors in tumorigenesis

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Rankin, E B, Giaccia, A J·2008·Cell Death & Differentiation

DOI 10.1038/cdd.2008.21PMC PMC3050610

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Abstract

Hypoxia-inducible factors (HIFs) are essential mediators of the cellular oxygen-signaling pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive alpha subunit (HIF-alpha) and a constitutive beta subunit (HIF-beta) that facilitate both oxygen delivery and adaptation to oxygen deprivation by regulating the expression of genes that control glucose uptake, metabolism, angiogenesis, erythropoiesis, cell proliferation, and apoptosis. In most experimental models, the HIF pathway is a positive regulator of tumor growth as its inhibition often results in tumor suppression. In clinical samples, HIF is found elevated and correlates with poor patient prognosis in a variety of cancers. In summary, HIF regulates multiple aspects of tumorigenesis, including angiogenesis, proliferation, metabolism, metastasis, differentiation, and response to radiation therapy, making it a critical regulator of the malignant phenotype.

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Additional file 2 of Gene network analysis to determine the effect of hypoxia-associated genes on brain damages and tumorigenesis using an avian model
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Authors: Rankin, E. B., & Giaccia, A. J.
Affiliations: Stanford Medicine (US)
Corresponding author: Giaccia, A J
ORCID: Rankin, E B
Giaccia, A J
Venue: Cell Death & Differentiation
Publisher: Springer Science and Business Media LLC
Published: 2008-02-15
Volume: 15
Issue: 4
Pages: 678-685
ISSN: 1350-9047 (ISSN-L)
1476-5403
DOI: 10.1038/cdd.2008.21
PMC: PMC3050610
OpenAlex: W2014245338
Cited by: 806
References: 105
Citations by year: 2026: 18 · 2025: 24 · 2024: 30 · 2023: 34 · 2022: 43 · 2021: 42 · 2020: 39 · 2019: 38 · 2018: 33 · 2017: 44 · 2016: 45 · 2015: 48 · 2014: 56 · 2013: 51 · 2012: 46
FWCI: 5.10
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Cell Death and Differentiation (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (P01CA067166, T32CA009151)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Keywords: hypoxia-inducible factor, carcinogenesis, oxygen signaling, hypoxia-inducible factor alpha, angiogenesis, cancer metabolism, tumor growth, metastasis, radiation response, tumor differentiation, prognosis, apoptosis, cell proliferation
MeSH terms: Endothelial PAS Domain-Containing Protein 1, Adaptation, Physiological, Animals, Hypoxia, Cell Differentiation, Energy Metabolism, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, Oxygen, Signal Transduction, Cell Hypoxia, Cell Proliferation, Basic Helix-Loop-Helix Proteins, Hypoxia-Inducible Factor 1, alpha Subunit

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The role of hypoxia-inducible factors in tumorigenesis

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