Cited by 808Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in CancerErythropoietin and Anemia Treatment

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The role of hypoxia-inducible factors in tumorigenesis

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Rankin, E B, Giaccia, A J·2008·Cell Death & Differentiation

DOI 10.1038/cdd.2008.21PMC PMC3050610

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Abstract

Hypoxia-inducible factors (HIFs) are essential mediators of the cellular oxygen-signaling pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive alpha subunit (HIF-alpha) and a constitutive beta subunit (HIF-beta) that facilitate both oxygen delivery and adaptation to oxygen deprivation by regulating the expression of genes that control glucose uptake, metabolism, angiogenesis, erythropoiesis, cell proliferation, and apoptosis. In most experimental models, the HIF pathway is a positive regulator of tumor growth as its inhibition often results in tumor suppression. In clinical samples, HIF is found elevated and correlates with poor patient prognosis in a variety of cancers. In summary, HIF regulates multiple aspects of tumorigenesis, including angiogenesis, proliferation, metabolism, metastasis, differentiation, and response to radiation therapy, making it a critical regulator of the malignant phenotype.

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Background
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Background
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Background
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Background
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Background
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Influential
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Background
Glucose Transporters in Sex Steroid Hormone Related Cancer
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Evolution of the HIF targeted therapy in clear cell renal cell carcinoma
Golijanin, B., Malshy, K., Khaleel, S. S., Lagos, G., Amin, A., Liang Cheng, C., Golijanin, D., & Mega, A. E. (2023) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2023.102645 · Cited by 33
Pilocarpine Protects Cobalt Chloride-induced Apoptosis of RGC-5 Cells: Involvement of Muscarinic Receptors and HIF-1α Pathway
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In vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: a pilot study
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“We demonstrated that PEITC interfered with the ability of hypoxia to activate hypoxia-inducible factor (HIF)((24)), a key transcription factor that mediates cellular responses to low pO2 ((25,26)).”
CDK8 regulates the angiogenesis of pancreatic cancer cells in part via the CDK8-β-catenin-KLF2 signal axis
Wei, R., Kong, L., Xiao, Y., Yuan, H., Song, Y., Wang, J., Yu, H., Mao, S., & Xu, W. M. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.05.033 · Cited by 32
Activation of hypoxia-inducible factor 1 (Hif-1) enhanced bactericidal effects of macrophages to Mycobacterium tuberculosis
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Methylseleninic acid downregulates hypoxia‐inducible factor‐1α in invasive prostate cancer
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“It is well established that HIF-1a is induced both by hypoxia and PI3K pathway in several cell types.(20,42,43) Even though several reports including ours(31,44) showed that selenium compounds could influence PI3K/Akt pathway in various cancer cell lines, this interaction has yet to be addressed under hypoxic conditio…”
Background
Prognostic relevance of hypoxia inducible factor-1α expression in patients with melanoma
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Use of Attribute Driven Incremental Discretization and Logic Learning Machine to build a prognostic classifier for neuroblastoma patients
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“Hypoxia activates specific genes encoding angiogenic, metabolic and metastatic factors [18,21] and contributes to the acquisition of the tumor aggressive phenotype [18,22,23].”
Background
GRIM-19 opposes reprogramming of glioblastoma cell metabolism via HIF1α destabilization
Liu, Q., Wang, L., Wang, Z., Yang, Y., Tian, J., Liu, G., Guan, D., Cao, X., Zhang, Y., & Hao, A. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt125 · Cited by 32
“It acts as a transcriptional factor to activate genes that permit metabolic adaptation, such as HK2, GLUT-1 and PDK1, and facilitate production of VEGF (33).”
Background
Overexpression of AQP3 Modifies the Cell Cycle and the Proliferation Rate of Mammalian Cells in Culture
Galán‐Cobo, A., Ramírez‐Lorca, R., Serna‐Gallego, A., & Echevarrı́a, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137692 · Cited by 32
“Hence the similar effect over HIF stability displayed by the three AQPs would suggest a common mechanism in this process [17].”
Background
Serum amyloid A1 is upregulated in human glioblastoma
Knebel, F. H., Uno, M., Galatro, T. F. D. A., Bellé, L. P., Oba‐Shinjo, S. M., Marie, S. K. N., & Čampa, A. (2017) · Journal of Neuro-Oncology · doi:10.1007/s11060-017-2386-z · Cited by 32
Development of an oncolytic herpes simplex virus using a tumor-specific HIF-responsive promoter
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“One strategy involves transcriptional regulation of infected cell polypeptide 4 (ICP4) 10 .”
Influential
From tumor hypoxia to cancer progression: the implications of hypoxia-inducible factor-1 expression in cancers
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Targeting corneal inflammation by gene therapy: Emerging strategies for keratitis
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Exploiting S-nitrosylation for cancer therapy: facts and perspectives
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The GTPase RAB20 is a HIF target with mitochondrial localization mediating apoptosis in hypoxia
Hackenbeck, T., Huber, R., Schietke, R. E., Knaup, K. X., Monti, J., Wu, X., Klanke, B., Frey, B., Gaipl, U. S., Wullich, B., et al. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.10.019 · Cited by 31
“The latter is often discussed as being important in tumor progression, as well as therapy resistance [18].”
Background
Lipophilic 2,5-Disubstituted Pyrroles from the Marine Sponge Mycale sp. Inhibit Mitochondrial Respiration and HIF-1 Activation
Mao, S., Liu, Y., Morgan, J. B., Jekabsons, M. B., Zhou, Y., & Nagle, D. G. (2009) · Journal of Natural Products · doi:10.1021/np900444m · Cited by 31
Honokiol inhibits hypoxia-inducible factor-1 pathway
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“It serves as a transcription factor through binding to the hypoxia-responsive element (HRE), thereby regulating the expression of numerous genes linked to tumour progression and poor prognosis (Rankin and Giaccia 2008).”
Background
Natural Product-Derived Antitumor Compound Phenethyl Isothiocyanate Inhibits mTORC1 Activity via TSC2
Cavell, B. E., Alwi, S. S. S., Donlevy, A. M., Proud, C. G., & Packham, G. (2012) · Journal of Natural Products · doi:10.1021/np300049b · Cited by 31
Controlling matrix formation and cross-linking by hypoxia in cardiovascular tissue engineering
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Genetic drivers of metastatic dissemination in sonic hedgehog medulloblastoma
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“in oncology as the constitutively expressed binding partner of the hypoxia-inducible transcription factors HIF1α and HIF2α, whose downstream target genes play active roles in angiogenesis, proliferation, invasion, and metastasis (reviewed in [37]).”
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Chronic systemic hypoxia promotes LNCaP prostate cancer growth in vivo
Terraneo, L., Bianciardi, P., Caretti, A., Ronchi, R., & Samaja, M. (2010) · The Prostate · doi:10.1002/pros.21160 · Cited by 29
“Indeed, HIF-1a activation in cancer may also stem from O2-independent pathways, as for example the phosphatidylinositol-3-OH kinase (PI3K) signaling path [8].”
Background
Hypoxia induces hepatocellular carcinoma metastasis via the HIF-1α/METTL16/lnc-CSMD1-7/RBFOX2 axis
Wang, Y., Yang, Y., Yang, Y., Dang, Y., Guo, Z., Zhuang, Q., Zheng, X., Wang, F., Cheng, N., Liu, X., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108495 · Cited by 30
HIF-1α inhibition blocks the cross talk between multiple myeloma plasma cells and tumor microenvironment
Borsi, E., Perrone, G., Terragna, C., Martello, M., Zamagni, E., Tacchetti, P., Pantani, L., Brioli, A., Dico, A. F., Zannetti, B. A., et al. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.09.018 · Cited by 30
“[23] E.”
Background
Recent drug therapies for corneal neovascularization
Liu, X., Wang, S., Wang, X., Liang, J., & Zhang, Y. (2017) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13018 · Cited by 32
Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness
Bogeas, A., Morvan-Dubois, G., El-Habr, E. A., Lejeune, F., Defrance, M., Narayanan, A., Kuranda, K., Burel‐Vandenbos, F., Sayd, S., Delaunay, V., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1783-x · Cited by 29
“ARNT2, like its paralog ARNT, is considered to act as a dimerization partner of HIF1/2α, the heterodimers triggering the expression of hypoxia-related genes [46, 61].”
Background
Inhibition of lysine-specific demethylase LSD1 induces senescence in Glioblastoma cells through a HIF-1α-dependent pathway
Saccà, C. D., Gorini, F., Ambrosio, S., Amente, S., Faicchia, D., Matarese, G., Lania, L., & Majello, B. (2019) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2019.03.004 · Cited by 30
Expression of HIF-1α and CAIX in nasopharyngeal carcinoma and their correlation with patients’ prognosis
Chen, Y., Li, X., Wu, S., Xu, G., Zhou, Y., Gong, L., Li, Z., & Yang, D. (2014) · Medical Oncology · doi:10.1007/s12032-014-0304-1 · Cited by 31
“mined by the expression and activity of HIF-1a [4].”
Background
GD3 Synthase Overexpression Sensitizes Hepatocarcinoma Cells to Hypoxia and Reduces Tumor Growth by Suppressing the cSrc/NF-κB Survival Pathway
Lluis, J. M., Llacuna, L., von Montfort, C., Bárcena, C., Enrich, C., Morales, A., & Fernández-Checa, J. C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008059 · Cited by 30
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Coexpression of hypoxia‐inducible factor‐2α, TWIST2, and SIP1 may correlate with invasion and metastasis of salivary adenoid cystic carcinoma
Zhou, C., Liu, J., Tang, Y., Zhu, G., Zheng, M. H., Jiang, J. D., Yang, J., & Liang, X. (2011) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2011.01114.x · Cited by 31
Adrenomedullin is a therapeutic target in colorectal cancer
Wang, L., Gala, M. K., Yamamoto, M., Pino, M. S., Kikuchi, H., Shue, D. S., Shirasawa, S., Austin, T. R., Lynch, M. P., Rueda, B. R., et al. (2013) · International Journal of Cancer · doi:10.1002/ijc.28542 · Cited by 30
A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT
Mandl, M., Lieberum, M.-K., & Depping, R. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.187 · Cited by 30
“Hypoxia-dependent upregulation of ARNT is mediated by HIF-1α.”
BackgroundInfluential
CXCR7 promotes melanoma tumorigenesis via Src kinase signaling
Xu, S., Tang, J., Wang, C., Liu, J., Fu, Y., & Luo, Y. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1442-3 · Cited by 32
Hitting the Sweet Spot: How Glucose Metabolism Is Orchestrated in Space and Time by Phosphofructokinase-1
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“…promotes tumor growth, has been tied to increased PFK1 activity through allosteric activation, typically by fructose-2,6-bisphosphate (F-2,6-BP) [19–22]. the hypoxia-inducible factor pathway, which commonly promotes tumor growth, has been tied to increased PFK1 activity through allosteric…”
Background
Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis
Li, Q., Li, Y., Liang, L., Li, J., Luo, D., Liu, Q., Cai, S., & Li, X. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0241-2 · Cited by 28
“Solid tumor cells reside in a microenvironment far away from the blood vessels, leading to restricted nutrients and oxygen supply, thus tumor cells evolved an adaptation to survive under hypoxic conditions, known as hypoxic adaptations [51].”
H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer
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“The critical molecular mediators of hypoxia, the hypoxia-inducible factors HIF-1α and HIF-2α, are stabilized upon low oxygen tension and transcriptionally regulate multiple steps of tumorigenesis [16].”
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Treatment Strategies Considering Micro-Environment and Clonal Evolution in Multiple Myeloma
Suzuki, K., Nishiwaki, K., & Yano, S. (2021) · Cancers · doi:10.3390/cancers13020215 · Cited by 28
Semaphorin 4D and hypoxia-inducible factor-1α overexpression is related to prognosis in colorectal carcinoma
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Hypoxia-inducible factor-1β (HIF-1β) is upregulated in a HIF-1α-dependent manner in 518A2 human melanoma cells under hypoxic conditions
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A 17 gene panel for non‐small‐cell lung cancer prognosis identified through integrative epigenomic‐transcriptomic analyses of hypoxia‐induced epithelial–mesenchymal transition
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“Most studies ascribe the hypoxic response to the binding of canonical HIFs to functional hypoxia response elements (HREs) within the promoter of molecular targets that potently drive EMT and tumor metastasis (Rankin and Giaccia, 2008).”
Background
Birth characteristics and Wilms tumors in children in the Nordic countries: A register‐based case–control study
Schüz, J., Schmidt, L. S., Kogner, P., Lähteenmäki, P. M., Pal, N., Stokland, T., & Schmiegelow, K. (2010) · International Journal of Cancer · doi:10.1002/ijc.25541 · Cited by 29
“First, the low Apgar score might be a sign of hypoxia, leading to cell damage that subsequently leads to a Wilms tumor.(39,40) Second, the observed association might indicate that the neonatal treatment provided to newborns with a low Apgar score at 5 min could increase the risk of a subsequent Wilms tumor.”
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Overweight, Obesity, Oxidative Stress and the Risk of Breast Cancer
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“Indeed, elevated level of HIF-1 transcription factor has been reported in several cancers including breast (Rankin and Giaccia, 2008).”
Background
Association of the von Hippel–Lindau Protein with AUF1 and Posttranscriptional Regulation of VEGFA mRNA
Xin, H., Brown, J. A., Gong, C., Fan, H., Brewer, G., & Gnarra, J. R. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0435 · Cited by 29
“HIF activation stimulates transcription of several hundred genes whose products have varied functions, including nutrient uptake, glycolytic metabolism, and neovascularization (8, 9).”
Background

Authors: Rankin, E. B., & Giaccia, A. J.
Affiliations: Stanford Medicine (US)
Corresponding author: Giaccia, A J
ORCID: Rankin, E B
Giaccia, A J
Venue: Cell Death & Differentiation
Publisher: Springer Science and Business Media LLC
Published: 2008-02-15
Volume: 15
Issue: 4
Pages: 678-685
ISSN: 1350-9047 (ISSN-L)
1476-5403
DOI: 10.1038/cdd.2008.21
PMC: PMC3050610
OpenAlex: W2014245338
Cited by: 806
References: 105
Citations by year: 2026: 18 · 2025: 24 · 2024: 30 · 2023: 34 · 2022: 43 · 2021: 42 · 2020: 39 · 2019: 38 · 2018: 33 · 2017: 44 · 2016: 45 · 2015: 48 · 2014: 56 · 2013: 51 · 2012: 46
FWCI: 5.10
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Cell Death and Differentiation (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (P01CA067166, T32CA009151)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Keywords: hypoxia-inducible factor, carcinogenesis, oxygen signaling, hypoxia-inducible factor alpha, angiogenesis, cancer metabolism, tumor growth, metastasis, radiation response, tumor differentiation, prognosis, apoptosis, cell proliferation
MeSH terms: Endothelial PAS Domain-Containing Protein 1, Adaptation, Physiological, Animals, Hypoxia, Cell Differentiation, Energy Metabolism, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, Oxygen, Signal Transduction, Cell Hypoxia, Cell Proliferation, Basic Helix-Loop-Helix Proteins, Hypoxia-Inducible Factor 1, alpha Subunit

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The role of hypoxia-inducible factors in tumorigenesis

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