Selective survival rescue in 15-Lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1
Open accessAbstract
The integrity of the retinal pigment epithelial (RPE) cell is essential for the survival of rod and cone photoreceptor cells. Several stressors, including reactive oxygen species, trigger apoptotic damage in RPE cells preceded by an anti-inflammatory, pro-survival response, the formation of neuroprotectin D1 (NPD1), an oxygenation product derived from the essential omega-3 fatty acid family member docosahexaenoic acid. To define the ability of NPD1 and other endogenous novel lipid mediators in cell survival, we generated a stable knockdown human RPE (ARPE-19) cell line using short hairpin RNA to target 15-lipoxygenase-1. The 15-lipoxygenase-1-deficient cells exhibited 30% of the protein expression, and 15-lipoxygenase-2 remained unchanged, as compared with an ARPE-19 cell line control established using nonspecific short hairpin RNA transfected cells. NPD1 synthesis was stimulated by tumor necrosis factor alpha/H2O2-mediated oxidative stress in nonspecific cells (controls), whereas in silenced cells, negligible amounts of NPD1, 12(S)- and 15(S)-hydroxyeicosatetraenoic acid, and lipoxin A4 were found under these conditions. Neither control nor the deficient cells showed an increase in 15-lipoxygenase-1 protein content after 16 h of oxidative stress, suggesting that the increased activity of 15-lipoxygenase-1 is due to activation of pre-existing proteins. 15-Lipoxygenase-silenced cells also displayed an exacerbated sensitivity to oxidative stress-induced apoptosis when compared with the control cells. NPD1 selectively and potently rescued 15-lipoxygenase-silenced cells from oxidative stress-induced apoptosis. These results demonstrate that 15-lipoxygenase-1 is activated by oxidative stress in ARPE-19 cells and that NPD1 is part of an early survival signaling in RPE cells.
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sAPPα may activate NPD1 biosynthetic enzymes PLA2 and/or a 15-LOX-like enzyme integral to NPD1 biosynthesis.
“sAPPα may activate NPD1 biosynthetic enzymes PLA2 and/or a 15-LOX– like enzyme integral to NPD1 biosynthesis (Calandria et al., 2009; Marcheselli et al., 2003).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Calandria et al., 2009
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works
The Retinal Pigment Epithelium in Visual Function
Strauss, O. (2005) · Physiological Reviews · doi:10.1152/physrev.00021.2004 · Cited by 2,828 · see citing works
Resolvin E1 and protectin D1 activate inflammation-resolution programmes
Schwab, J. M., Chiang, N., Arita, M., & Serhan, C. N. (2007) · Nature · doi:10.1038/nature05877 · Cited by 1,188 · see citing works
Serhan, C. N. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141647 · Cited by 997 · see citing works
Lukiw, W. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25420 · Cited by 873 · see citing works
Marcheselli, V. L., Hong, S., Lukiw, W. J., Tian, X. H., Gronert, K., Musto, A., Hardy, M., Gimenez, J. M., Chiang, N., Serhan, C. N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305841200 · Cited by 802 · see citing works
Mukherjee, P. K., Marcheselli, V. L., Serhan, C. N., & Bazan, N. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402531101 · Cited by 753 · see citing works
Osakada, F., Ikeda, H. O., Mandai, M., Wataya, T., Watanabe, K., Yoshimura, N., Akaike, A., Sasai, Y., & Takahashi, M. (2008) · Nature Biotechnology · doi:10.1038/nbt1384 · Cited by 629 · see citing works
The retinal pigment epithelium: a versatile partner in vision
Bok, D. (1993) · Journal of Cell Science · doi:10.1242/jcs.1993.supplement_17.27 · Cited by 593 · see citing works
Membrane docosahexaenoate is supplied to the developing brain and retina by the liver.
Scott, B. L., & Bazan, N. (1989) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.86.8.2903 · Cited by 445 · see citing works
Discovery of a second 15 S -lipoxygenase in humans
BRASH, A. R., Boeglin, W. E., & Chang, M. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6148 · Cited by 402 · see citing works
PEDF: a multifaceted neurotrophic factor
Tombran‐Tink, J., & Barnstable, C. J. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1176 · Cited by 369 · see citing works
Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors
Bazan, N. G. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.03.005 · Cited by 353 · see citing works
Gronert, K., Maheshwari, N., Khan, N. A., Hassan, I., Dunn, M. W., & Schwartzman, M. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410638200 · Cited by 308 · see citing works
Ariel, A., Li, P., Wang, W., Tang, W.-X., Fredman, G., Hong, S., Gotlinger, K. H., & Serhan, C. N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509796200 · Cited by 247 · see citing works
Macular degeneration: recent advances and therapeutic opportunities
Rattner, A., & Nathans, J. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2007 · Cited by 230 · see citing works
Circadian nature of rod outer segment disc shedding in the rat.
LaVail, M. M. (1980) · PubMed · Cited by 199 · see citing works
Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling
Mukherjee, P. K., Marcheselli, V. L., Barreiro, S., Hu, J., Bok, D., & Bazan, N. G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705949104 · Cited by 170 · see citing works
Brinckmann, R., Schnurr, K., Heydeck, D., Rosenbach, T., Kolde, G., & Kühn, H. (1998) · Blood · doi:10.1182/blood.v91.1.64 · Cited by 146 · see citing works
Bazan, N. G. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0918 · Cited by 116 · see citing works
Mukherjee, P. K., Marcheselli, V. L., Vaccari, J. C. D. R., Gordon, W. C., Jackson, F. R., & Bazan, N. G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705963104 · Cited by 110 · see citing works
Defining the Arachidonic Acid Binding Site of Human 15-Lipoxygenase
Gan, Q.-F., Browner, M. F., Sloane, D. L., & Sigal, E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.41.25412 · Cited by 93 · see citing works
Retinal light damage in rats with altered levels of rod outer segment docosahexaenoate.
Organisciak, D. T., Darrow, R. M., Jiang, Y.-L., & Blanks, J. C. (1996) · PubMed · Cited by 83 · see citing works
Investigations into Calcium-dependent Membrane Association of 15-Lipoxygenase-1
Walther, M., Wiesner, R., & Kühn, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309564200 · Cited by 83 · see citing works
Engelhardt, M., Bogdahn, U., & Aigner, L. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.075 · Cited by 77 · see citing works
Aleem, A. M., Jankun, J., Dignam, J. D., Walther, M., Kühn, H., Svergun, D. I., & Skrzypczak‐Jankun, E. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.11.086 · Cited by 68 · see citing works
Chen, B., Tsui, S., Boeglin, W. E., Douglas, R. S., BRASH, A. R., & Smith, T. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603484200 · Cited by 48 · see citing works
McKay, B. S., Goodman, B. A., Falk, T., & Sherman, S. J. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.04.016 · Cited by 40 · see citing works
Detection and Subcellular Localization of Two 15S-Lipoxygenases in Human Cornea
Chang, M. S., Schneider, C. G., Roberts, R. L., Shappell, S. B., Haselton, F. R., Boeglin, W. E., & BRASH, A. R. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-1166 · Cited by 37 · see citing works
Kühn, H., Thiele, B. J., Ostareck‐Lederer, A., Stender, H., Suzuki, H., Yoshimoto, T., & Yamamoto, S. (1993) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(93)90268-e · Cited by 31 · see citing works
Liang, L., Yan, R., Li, X., Chimento, M. F., & Wang, S. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1380 · Cited by 15 · see citing works
Lanning, J. L., Wallace, J. S., Zhang, D., Diwakar, G., Jiao, Z., & Hornyak, T. J. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23819.x · Cited by 13 · see citing works
When Pigment Cells Turn Into Neurons
Bharti, K., & Arnheiter, H. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23876.x · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- Scott, B. L., and Bazan, N. G. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 2903-2907
- Mukherjee, P. K., Marcheselli, V. L., Serhan, C. N., and Bazan, N. G. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 8491-8496
- Mukherjee, P. K., Marcheselli, V. L., Barreiro, S., Hu, J., Bok, D., and Bazan, N. G. (2007) Proc. Natl. Acad. Sci. U. S. A. 104, 13152-13157
- Mukherjee, P. K., Marcheselli, V. L., de Rivero Vaccari, J. C., Gordon, W. C., Jackson, F. E., and Bazan, N. G. (2007) Proc. Natl. Acad. Sci. U. S. A. 104, 13158 -13163
- Brash, A. R., Boeglin, W. E., and Chang, M. S. (1997) Proc. Natl. Acad. Sci.
Cited by
Sorted by citations
Resolvins and protectins in inflammation resolution
Serhan, C. N., & Petasis, N. A. (2011) · Chemical Reviews · doi:10.1021/cr100396c · Cited by 996 · see citing works
Self-citationSerhan, C. N., Dalli, J., Colas, R. A., Winkler, J. W., & Chiang, N. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.006 · Cited by 492 · see citing works
Specialized pro-resolving lipid mediators in the inflammatory response: An update
Bannenberg, G., & Serhan, C. N. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.08.002 · Cited by 464 · see citing works
Bazan, N. G., Molina, M. F., & Gordon, W. C. (2011) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104635 · Cited by 441 · see citing works
Weylandt, K. H., Chiu, C., Gomolka, B., Waechter, S. F., & Wiedenmann, B. J. (2012) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2012.01.005 · Cited by 259 · see citing works
The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential
Becerra, S. P., & Notario, V. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3484 · Cited by 211 · see citing works
Zhao, Y., Calon, F., Julien, C., Winkler, J. W., Petasis, N. A., Lukiw, W. J., & Bazan, N. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015816 · Cited by 243 · see citing works
Dietary DHA and health: cognitive function ageing
Cardoso, C. L., Afonso, C. M., & Bandarra, N. M. (2016) · Nutrition Research Reviews · doi:10.1017/s0954422416000184 · Cited by 196 · see citing works
Bazan, N. G. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.09.003 · Cited by 148 · see citing works
Bazan, N. G., Calandria, J. M., & Serhan, C. N. (2010) · Journal of Lipid Research · doi:10.1194/jlr.r001131 · Cited by 140 · see citing works
Bazan, N. G., Musto, A. E., & Knott, E. J. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8200-6 · Cited by 125 · see citing works
Prieto, P., Cuenca, J., Través, P. G., Fernández‐Velasco, M., Martín‐Sanz, P., & Boscá, L. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2009.220 · Cited by 123 · see citing works
Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival
Rice, D. S., Calandria, J. M., Gordon, W. C., Jun, B., Zhou, Y., Gelfman, C. M., Li, S., Jin, M., Knott, E. J., Chang, B., et al. (2015) · Nature Communications · doi:10.1038/ncomms7228 · Cited by 124 · see citing works
Self-citationDocosahexaenoic acid, 22:6n‐3: Its roles in the structure and function of the brain
Mallick, R., Basak, S., & Duttaroy, A. K. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.10.004 · Cited by 113 · see citing works
Faghiri, Z., & Bazan, N. G. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2010.03.002 · Cited by 98 · see citing works
Wang, S. B., Hu, K. M., Seamon, K. J., Mani, V., Chen, Y., & Gronert, K. (2011) · The FASEB Journal · doi:10.1096/fj.11-198036 · Cited by 96 · see citing works
Asatryan, A., & Bazan, N. G. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.783076 · Cited by 95 · see citing works
Basak, S., Mallick, R., Banerjee, A., Pathak, S., & Duttaroy, A. K. (2021) · Nutrients · doi:10.3390/nu13062061 · Cited by 92 · see citing works
Proresolving Lipid Mediators: Endogenous Modulators of Oxidative Stress
Leuti, A., Maccarrone, M., & Chiurchiù, V. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8107265 · Cited by 90 · see citing works
Docosahexaenoic acid neurolipidomics
Niemoller, T. D., & Bazan, N. G. (2009) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2009.09.005 · Cited by 89 · see citing works
Hersberger, M. (2010) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2010.212 · Cited by 88 · see citing works
Eady, T. N., Belayev, L., Khoutorova, L., Atkins, K. D., Zhang, C., & Bazan, N. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046151 · Cited by 85 · see citing works
Jun, B., Mukherjee, P. K., Asatryan, A., Kautzmann, M.-A., Heap, J., Gordon, W. C., Bhattacharjee, S., Yang, R., Petasis, N. A., & Bazan, N. G. (2017) · Scientific Reports · doi:10.1038/s41598-017-05433-7 · Cited by 80 · see citing works
ω-3 and ω-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases
Gong, Y. Q., Fu, Z., Liegl, R. G.-H., Chen, J., Hellström, A., & Smith, L. E. H. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.153825 · Cited by 79 · see citing works
Significance of lipid mediators in corneal injury and repair
Kenchegowda, S., & Bazán, H. E. P. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r001347 · Cited by 77 · see citing works
Cortina, M. S., He, J., Russ, T. C., Bazan, N. G., & Bazán, H. E. P. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12075 · Cited by 72 · see citing works
Musto, A. E., Gjorstrup, P., & Bazan, N. G. (2011) · Epilepsia · doi:10.1111/j.1528-1167.2011.03081.x · Cited by 71 · see citing works
Antony, R., Lukiw, W. J., & Bazan, N. G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.095232 · Cited by 69 · see citing works
Endogenous LXA4 Circuits Are Determinants of Pathological Angiogenesis in Response to Chronic Injury
Leedom, A. J., Sullivan, A. B., Dong, B., Lau, D., & Gronert, K. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090678 · Cited by 67 · see citing works
He, J., Cortina, M. S., Kakazu, A. H., & Bazán, H. E. P. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-16755 · Cited by 55 · see citing works
Aursnes, M., Tungen, J. E., Vik, A., Dalli, J., & Hansen, T. V. (2013) · Organic & Biomolecular Chemistry · doi:10.1039/c3ob41902a · Cited by 53 · see citing works
O’Flaherty, J. T., Hu, Y., Wooten, R. E., Horita, D. A., Samuel, M. P., Thomas, M. J., Sun, H., & Edwards, I. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045480 · Cited by 51 · see citing works
Resolution, the grail for healthy ocular inflammation
Gronert, K. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2010.07.004 · Cited by 50 · see citing works
Pro-resolving lipid mediators: Agents of anti-ageing?
Doyle, R., Sadlier, D. M., & Godson, C. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.09.002 · Cited by 50 · see citing works
Stark, D. T., & Bazan, N. G. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8174-4 · Cited by 49 · see citing works
Taha, A. Y., Blanchard, H. C., Cheon, Y., Ramadan, E., Chen, M., Chang, L., & Rapoport, S. I. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9968-1 · Cited by 49 · see citing works
Calandria, J. M., Asatryan, A., Balaszczuk, V, Knott, E. J., Jun, B. K., Mukherjee, P. K., Belayev, L., & Bazan, N. G. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.233 · Cited by 47 · see citing works
Lipid metabolism and retinal diseases
Gabrielle, P. (2022) · Acta Ophthalmologica · doi:10.1111/aos.15226 · Cited by 48 · see citing works
Ariyoshi, T., Hagihara, M., Eguchi, S., Fukuda, A., Iwasaki, K., Oka, K., Takahashi, M., Yamagishi, Y., & Mikamo, H. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.587725 · Cited by 45 · see citing works
Petasis, N. A., Yang, R., Winkler, J. W., Zhu, M., Uddin, J., Bazan, N. G., & Serhan, C. N. (2012) · Tetrahedron Letters · doi:10.1016/j.tetlet.2012.01.032 · Cited by 45 · see citing works
Self-citationSuzumura, A., Terao, R., & Kaneko, H. (2020) · Antioxidants · doi:10.3390/antiox9100920 · Cited by 44 · see citing works
Lipid-Mediated Cell Signaling Protects against Injury and Neurodegeneration
Zhang, C., & Bazan, N. G. (2010) · Journal of Nutrition · doi:10.3945/jn.109.114884 · Cited by 43 · see citing works
Gordon, W. C., & Bazan, N. G. (2013) · Current Eye Research · doi:10.3109/02713683.2013.827211 · Cited by 43 · see citing works
Dietary DHA, bioaccessibility, and neurobehavioral development in children
Cardoso, C. L., Afonso, C. M., & Bandarra, N. M. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1338245 · Cited by 42 · see citing works
An update on adding docosahexaenoic acid (DHA) and arachidonic acid (AA) to baby formula
Tai, E. K. K., Wang, X. B., & Chen, Z. (2013) · Food & Function · doi:10.1039/c3fo60298b · Cited by 39 · see citing works
Bazan, N. G., Calandria, J. M., & Gordon, W. C. (2013) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000351395 · Cited by 35 · see citing works
Bannenberg, G. L. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.57 · Cited by 34 · see citing works
Singh, N. K., Quyền, Đ. V., Kundumani‐Sridharan, V., Brooks, P. C., & Rao, G. N. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.106187 · Cited by 35 · see citing works
Gao, Y., Su, J., Zhang, Y.-B., Chan, A. S. Y., Sin, J. H., Wu, D., Min, K., & Gronert, K. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0070-z · Cited by 34 · see citing works
Zhang, X., Qu, X., Sun, Y., Caruana, G., Bertram, J. F., Nikolic‐Paterson, D. J., & Li, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067471 · Cited by 34 · see citing works
The role of pro-resolving lipid mediators in ocular diseases
Wei, J., & Gronert, K. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.03.006 · Cited by 31 · see citing works
He, J., Pham, T. L., Kakazu, A. H., & Bazán, H. E. P. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-26384 · Cited by 31 · see citing works
Calandria, J. M., Mukherjee, P. K., Vaccari, J. C. D. R., Zhu, M., Petasis, N. A., & Bazan, N. G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.287078 · Cited by 30 · see citing works
Kenchegowda, S., He, J., & Bazán, H. E. P. (2012) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2012.03.010 · Cited by 28 · see citing works
Lindley, A. R., Crapster-Pregont, M., Liu, Y., & Kuperman, D. A. (2010) · Mediators of Inflammation · doi:10.1155/2010/727305 · Cited by 28 · see citing works
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Stahl, A., Krohne, T. U., Sapieha, P. S., Chen, J., Hellström, A., Chew, E. Y., Holz, F. G., & Smith, L. E. H. (2011) · British Journal of Ophthalmology · doi:10.1136/bjo.2010.194241 · Cited by 27 · see citing works
Fair‐Weather Friends: Evidence of Lipoxin Dysregulation in Neurodegeneration
Kim, C., Livne‐Bar, I., Gronert, K., & Sivak, J. M. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801076 · Cited by 26 · see citing works
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Trotta, M. C., Gesualdo, C., Petrillo, F., Lepre, C. C., Corte, A. D., Cavasso, G., Maggiore, G., Hermenean, A. O., Simonelli, F., D’Amico, M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094501 · Cited by 25 · see citing works
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Zheng, S., D’Souza, V., Bartis, D., Dancer, R. C. A., Parekh, D., Naidu, B. V., Smith, F. G., Wang, Q., Jin, S., Lian, Q., et al. (2016) · ERJ Open Research · doi:10.1183/23120541.00079-2015 · Cited by 23 · see citing works
Cieślik, M., Pyszko, J., & Strosznajder, J. B. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.02.016 · Cited by 23 · see citing works
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Knott, E. J., Gordon, W. C., Jun, B., Do, K., & Bazan, N. G. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0565-2 · Cited by 18 · see citing works
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Hong, S., Alapure, B. V., Lü, Y., Tian, H., & Wang, Q. (2014) · British Journal of Dermatology · doi:10.1111/bjd.12899 · Cited by 18 · see citing works
Calandria, J. M., Sharp, M., & Bazan, N. G. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0206-6 · Cited by 18 · see citing works
The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer
Mao, F., Wang, M., Wang, J., & Xu, W. (2015) · Inflammation Research · doi:10.1007/s00011-015-0852-7 · Cited by 17 · see citing works
Simard‐Bisson, C., Parent, L. A., Moulin, V. J., & de Laclos, B. F. (2018) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155418788117 · Cited by 16 · see citing works
Role of omega-3 fatty acids in maternal, fetal, infant and child wellbeing
Mozurkewich, E., Berman, D. R., & Chilimigras, J. L. (2009) · Expert Review of Obstetrics & Gynecology · doi:10.1586/eog.09.66 · Cited by 15 · see citing works
The role of lipids in corneal diseases and dystrophies: a systematic review
Rowsey, T. G., & Karamichos, D. (2017) · Clinical and Translational Medicine · doi:10.1186/s40169-017-0158-1 · Cited by 14 · see citing works
Videla, L. A., Vargas, R., Valenzuela, R., Muñoz, P., Corbari, A., & Hernández‐Rodas, M. C. (2018) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2018.11.013 · Cited by 14 · see citing works
Lin, Y., Xu, M., Wan, J., Wen, S.-Q., Sun, J., Zhao, H., & Lou, M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.06.024 · Cited by 14 · see citing works
Zia, B., Elmeky, M., Azimullah, S., Jha, N. K., Meeran, M. F. N., & Ojha, S. K. (2025) · Current Neuropharmacology · doi:10.2174/011570159x365720250225080257 · Cited by 13 · see citing works
Calandria, J. M., Do, K. V., Kala-Bhattacharjee, S., Obenaus, A., Belayev, L., & Bazan, N. G. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01231-6 · Cited by 10 · see citing works
Montgomery, C. L., Keereetaweep, J., Johnson, H. M., Grillo, S. L., Chapman, K. D., & Koulen, P. (2016) · Lipids · doi:10.1007/s11745-016-4161-x · Cited by 9 · see citing works
Asatryan, A., Calandria, J. M., Kautzmann, M.-A. I., Jun, B., Gordon, W. C., Do, K. V., Bhattacharjee, S., Pham, T. L., Bermúdez, V., Mateos, M. V., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.926629 · Cited by 7 · see citing works
Loss of 15-Lipoxygenase in Retinodegenerative RCS Rats
Mead, A. J., Ahluwalia, K., Ebright, B., Zhang, Z., Dave, P., Li, Z., Zhou, E., Naik, A. A., Ngu, R., Chester, C., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042309 · Cited by 7 · see citing works
HPLC method for determination of lipoxygenase positional specific products
Hoffman, P., Rauová, D., Bezáková, L., Obložinský, M., & Mikuš, P. (2013) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2013.05.041 · Cited by 6 · see citing works
Bazan, N. G., Stark, D. T., & Petasis, N. A. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-374947-5.00036-5 · Cited by 5 · see citing works
Autosomal-dominant macular dystrophy linked to a chromosome 17 tandem duplication
Adele, R., Hussein, R., Tavares, E. S., Ahmed, K., Scipio, M. D., Charish, J., Liang, M., Monis, S., Tumber, A. K., Chen, X., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.178768 · Cited by 4 · see citing works
Bazan, N. G., & Asatryan, A. (2011) · Oléagineux Corps gras Lipides · doi:10.1051/ocl.2011.0403 · Cited by 4 · see citing works
Ding, W., Yao, M., Liang, X., Wong, W., Yao, W., & Zhang, J. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06813-y · Cited by 2 · see citing works
A novel therapeutic strategy of obesity from the perspective of SPMs
Zhao, Z. (2026) · Exploration of Endocrine and Metabolic Diseases · doi:10.37349/eemd.2026.101453 · Cited by 2 · see citing works
Wu, Z., Lu, W., Zhang, X., Xia, Q., Zuo, H., Xi, G., Liu, J., Zhang, F., Zhang, X., & Zhang, L. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s494649 · Cited by 2 · see citing works
Narayana, V. K., Kvaskoff, D., & Meunier, F. A. (2017) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-49343-5_10 · Cited by 2 · see citing works
Brain Self-protection by Bioactive Lipids
Ng, B. (2025) · Springer eBooks · doi:10.1007/978-3-031-94431-4_11 · Cited by 1 · see citing works
Prevention and Treatment of Atherosclerotic Vascular Disease: Hypolipidemic Agents
Gotto, A. M., & Pownall, H. J. (2015) · Springer eBooks · doi:10.1007/978-3-319-15961-4_28 · Cited by 1 · see citing works
Savina, T. A., Aripovsky, A. V., & Kulagina, T. P. (2017) · Epilepsy Research · doi:10.1016/j.eplepsyres.2017.06.013 · Cited by 1 · see citing works
Omega 3 fatty acids in psychiatry: Myth and reality
Pavlović, D. M., Pavlovic, A. M., & Đordević, J. (2020) · Engrami · doi:10.5937/engrami2001044p · Cited by 1 · see citing works
Bioactive lipids and brain function: from their mechanistic roles to clinical trials
Duttaroy, A. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822405-2.00009-8 · Cited by 1 · see citing works
Wang, S. B. (2013) · eScholarship (California Digital Library) · Cited by 1 · see citing works
What is the Therapeutic Potential of Neuroprotectin D1 for Epilepsy?
Bazan, N. G., & Musto, A. E. (2015) · Future Neurology · doi:10.2217/fnl.15.25
- Simple Lipids with Only One Component
Leray, C. (2012) · CRC Press eBooks · doi:10.1201/b12894-7
Kulagina, T. P., Ариповский, А. В., Savina, T. A., Shchipakina, T. G., & Godukhin, O. V. (2016) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-016-0381-z
Wells, J. (2021) · DigitalCommons@UNMC
Bioactive lipids and their metabolism, function, and sources
Duttaroy, A. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822405-2.00020-7
Maternal DHA Impact on Child Neurodevelopment
Duttaroy, A. K. (2021) · MDPI eBooks · doi:10.3390/books978-3-0365-1615-8
Simple Lipids with Only One Component
(2012) · CRC Press eBooks · doi:10.1201/b12894-3
Acides gras polyinsaturés et physiologie de la rétine
Acar, N. (2023) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2023.06.002
Fatty acid-binding proteins and brain diseases
Duttaroy, A. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95700-7.00011-5
- Authors
- Calandria, J. M., Marcheselli, V. L., Mukherjee, P. K., Uddin, J., Winkler, J. W., Petasis, N. A., & Bazan, N. G.
- Affiliations
- Louisiana State University (US)
- University of Southern California (US)
- Corresponding author
- Bazan, Nicolas G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 284
- Issue
- 26
- Pages
- 17877-17882
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC2719426
- OpenAlex
- W2022004671
- Cited by
- 104
- References
- 33
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 9 · 2016: 5 · 2015: 9 · 2014: 2 · 2013: 10 · 2012: 9
- FWCI
- 10.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (EY0-05121, RR016816)
- National Eye Institute (R01EY005121)
- National Center for Research Resources (P20RR016816)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- neuroprotectin D1, 15-lipoxygenase-1, retinal pigment epithelial cells, docosahexaenoic acid, oxidative stress, apoptosis, lipoxin A4, hydroxyeicosatetraenoic acids, photoreceptor survival, ARPE-19 cells
- MeSH terms
- Arachidonate 15-Lipoxygenase, Docosahexaenoic Acids, Humans, Hydrogen Peroxide, Immunoenzyme Techniques, Pigment Epithelium of Eye, Retina, Tumor Necrosis Factor-alpha, Blotting, Western, Lipoxygenase Inhibitors, Oxidants, Apoptosis, Oxidative Stress, RNA, Small Interfering, Lipoxins
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