Molecular mechanisms regulating NLRP3 inflammasome activation

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1. A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1 β Secretion via Downregulation of NF-kB/Erk 1/2 and NALP3/ASC/Caspase-1 Activation in Human THP-1 Monocyte
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2. Tumor necrosis factor primes and metal particles activate the NLRP3 inflammasome in human primary macrophages
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4. NEK7: a novel promising therapy target for NLRP3-related inflammatory diseases
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5. The inflammasome in liver disease
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6. Inflammasomes, the cardinal pathology mediators are activated by pathogens, allergens and mutagens: A critical review with focus on NLRP3
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7. NLRP3 Inflammasome Participates in Host Response to Neospora caninum Infection
   Xiaocen Wang, Pengtao Gong, Xu Zhang, Shan Li, Xiang-Yun Lu, Chunyan Zhao, Qile Yu, Zhengkai Wei, Yongjun Yang, Qun Liu et al. · 2018 · Frontiers in Immunology
8. Deletion of aquaporin-4 aggravates brain pathology after blocking of the meningeal lymphatic drainage
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9. Carbon nanotubes and crystalline silica stimulate robust ROS production, inflammasome activation, and IL-1β secretion in macrophages to induce myofibroblast transformation
   Bridget Hindman, Qiang Ma · 2019 · Archives of Toxicology
10. Vasoactive intestinal peptide suppresses the NLRP3 inflammasome activation in lipopolysaccharide-induced acute lung injury mice and macrophages
    Yong Zhou, Chen‐Yu Zhang, Jia‐Xi Duan, Qing Li, Hui‐Hui Yang, Chen‐Chen Sun, Jun Zhang, Xiaoqin Luo, Shaokun Liu · 2019 · Biomedicine & Pharmacotherapy
11. Therapeutic Potential of Pharmacological Targeting NLRP3 Inflammasome Complex in Cancer
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13. LncRNA‐HOTAIR promotes endothelial cell pyroptosis by regulating the miR‐22/NLRP3 axis in hyperuricaemia
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15. Pyroptosis in Kidney Disease
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16. Cardiorenal syndrome: long road between kidney and heart
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17. NLRP3-Mediated Inflammation in Atherosclerosis and Associated Therapeutics
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18. The Antimalarial Chloroquine Suppresses LPS-Induced NLRP3 Inflammasome Activation and Confers Protection against Murine Endotoxic Shock
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19. Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration
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20. Hepcidin and IL-1β
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21. Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome
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22. RelA/MicroRNA-30a/NLRP3 signal axis is involved in rheumatoid arthritis via regulating NLRP3 inflammasome in macrophages
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23. Quillaja brasiliensis saponin-based nanoparticulate adjuvants are capable of triggering early immune responses
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24. Ginsenoside Rb2 improves insulin resistance by inhibiting adipocyte pyroptosis
    Yi Lin, Yepeng Hu, Xiang Hu, Lijuan Yang, Xueqin Chen, Qianqian Li, Xuejiang Gu · 2020 · Adipocyte
25. Mitochondrial Dysfunction and Inflammaging in Heart Failure: Novel Roles of CYP-Derived Epoxylipids
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26. Inflammatory response in the mid colon of ICR mice treated with polystyrene microplastics for two weeks
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27. Sex influences in behavior and brain inflammatory and oxidative alterations in mice submitted to lipopolysaccharide-induced inflammatory model of depression
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28. sORF-Encoded MicroPeptides: New players in inflammation, metabolism, and precision medicine
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29. Limonin Attenuates LPS-Induced Hepatotoxicity by Inhibiting Pyroptosis via NLRP3/Gasdermin D Signaling Pathway
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30. Indoxyl Sulfate Activates NLRP3 Inflammasome to Induce Cardiac Contractile Dysfunction Accompanied by Myocardial Fibrosis and Hypertrophy
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31. NLRP3 inflammasome plays an important role in caspase-1 activation and IL-1β secretion in macrophages infected with Pasteurella multocida
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32. Role of NLRP3-Inflammasome/Caspase-1/Galectin-3 Pathway on Atrial Remodeling in Diabetic Rabbits
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33. Electroacupuncture preconditioning attenuates acute myocardial ischemia injury through inhibiting NLRP3 inflammasome activation in mice
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34. Dehydroepiandrosterone exacerbates nigericin-induced abnormal autophagy and pyroptosis via GPER activation in LPS-primed macrophages
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35. The role of NLRP3 inflammasome in colorectal cancer: potential therapeutic target
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36. Effectiveness of targeting the NLRP3 inflammasome by using natural polyphenols: A systematic review of implications on health effects
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37. Inflammatory mediators ATP and S100A12 activate the NLRP3 inflammasome to induce MUC5AC production in airway epithelial cells
    Karam Kim, Hye Jeong Kim, Bert Binas, Jin Hyun Kang, Il Yup Chung · 2018 · Biochemical and Biophysical Research Communications
38. Detrimental Effects of UVB on Retinal Pigment Epithelial Cells and Its Role in Age-Related Macular Degeneration
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39. Corrigendum: H3 relaxin inhibits the collagen synthesis via ROS ‐ and P2X7R‐mediated NLRP 3 inflammasome activation in cardiac fibroblasts under high glucose
    Xinhua Yin · 2018 · Journal of Cellular and Molecular Medicine
40. Beyond Homeostasis: Potassium and Pathogenesis during Bacterial Infections
    Elyza A. Do, Casey M. Gries · 2021 · Infection and Immunity
41. Chikusetsu saponin IVa ameliorates high fat diet-induced inflammation in adipose tissue of mice through inhibition of NLRP3 inflammasome activation and NF-κB signaling
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42. Baicalin Inhibits NOD-Like Receptor Family, Pyrin Containing Domain 3 Inflammasome Activation in Murine Macrophages by Augmenting Protein Kinase A Signaling
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43. NLRP3 in somatic non-immune cells of rodent and primate testes
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44. Apocynin inhibited NLRP3/XIAP signalling to alleviate renal fibrotic injury in rat diabetic nephropathy
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45. Idebenone Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice Via Activation of the SIRT3-SOD2-mtROS Pathway
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46. COVID-19 and Gut Microbiota: A Potential Connection
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47. Hypoxia-Induced S100A8 Expression Activates Microglial Inflammation and Promotes Neuronal Apoptosis
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48. Maternal Inflammation During Pregnancy and Offspring Brain Development: The Role of Mitochondria
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49. Corticosterone effects induced by stress and immunity and inflammation: mechanisms of communication
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50. Effects of phosphorylation on the NLRP3 inflammasome
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51. UFL1 modulates NLRP3 inflammasome activation and protects against pyroptosis in LPS-stimulated bovine mammary epithelial cells
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52. Hesperetin, a SIRT1 activator, inhibits hepatic inflammation via AMPK/CREB pathway
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53. Malvidin alleviates mitochondrial dysfunction and ROS accumulation through activating AMPK-α/UCP2 axis, thereby resisting inflammation and apoptosis in SAE mice
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54. IFP35, a novel DAMP, aggravates neuroinflammation following acute ischemic stroke via TLR4/NF-κB/NLRP3 signaling
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55. Particulate matter air pollution from the city of Quito, Ecuador, activates inflammatory signaling pathways in vitro
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56. NLRP3 inflammasome and glia maturation factor coordinately regulate neuroinflammation and neuronal loss in MPTP mouse model of Parkinson’s disease
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57. Involvement of microglia in disturbed fear memory regulation: Possible microglial contribution to the pathophysiology of posttraumatic stress disorder
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58. Carbon monoxide-triggered health effects: the important role of the inflammasome and its possible crosstalk with autophagy and exosomes
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59. Baeckein E suppressed NLRP3 inflammasome activation through inhibiting both the priming and assembly procedure: Implications for gout therapy.
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60. Peripheral Blood Mitochondrial DNA Levels Were Modulated by SARS-CoV-2 Infection Severity and Its Lessening Was Associated With Mortality Among Hospitalized Patients With COVID-19
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61. Flow-Induced Shear Stress Primes NLRP3 Inflammasome Activation in Macrophages via Piezo1
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62. Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma.
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63. Exogenous hydrogen sulfide mitigates NLRP3 inflammasome-mediated inflammation through promoting autophagy via AMPK-mTOR pathway
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64. Trametes orientalis polysaccharide alleviates PM 2.5 -induced lung injury in mice through its antioxidant and anti-inflammatory activities
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65. Glaucocalyxin A alleviates LPS-mediated septic shock and inflammation via inhibiting NLRP3 inflammasome activation
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66. Different DOACs Control Inflammation in Cardiac Ischemia-Reperfusion Differently
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67. 1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis
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68. Suppression of lncRNA NLRP3 inhibits NLRP3-triggered inflammatory responses in early acute lung injury
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69. The Promising Role of Chemokines in Vitiligo: From Oxidative Stress to the Autoimmune Response
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70. Asbestos-Induced Chronic Inflammation in Malignant Pleural Mesothelioma and Related Therapeutic Approaches—A Narrative Review
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71. Network pharmacology analysis and animal experiment validation of neuroinflammation inhibition by total ginsenoside in treating CSM
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72. Involvement of NLRP3 and NLRC4 Inflammasome in Uropathogenic E. coli Mediated Urinary Tract Infections
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73. P2X7 Receptor Antagonism as a Potential Therapy in Amyotrophic Lateral Sclerosis
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74. Lysophosphatidic Acid Receptor 5 Contributes to Imiquimod-Induced Psoriasis-Like Lesions through NLRP3 Inflammasome Activation in Macrophages
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75. New perspectives in bronchial asthma: pathological, immunological alterations, biological targets, and pharmacotherapy
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76. From mitochondria to sarcopenia: Role of inflammaging and RAGE-ligand axis implication
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77. The Role of the Interplay Between Autophagy and NLRP3 Inflammasome in Metabolic Disorders
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78. Inflammasome‐mediated Inflammation by Malassezia in human keratinocytes: A comparative analysis with different strains
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79. Inflammation and Severe Cerebral Venous Thrombosis
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80. Low Weight Polysaccharide of Hericium erinaceus Ameliorates Colitis via Inhibiting the NLRP3 Inflammasome Activation in Association with Gut Microbiota Modulation
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81. Role of NLRP3 Inflammasome in Eosinophilic and Non-eosinophilic Chronic Rhinosinusitis with Nasal Polyps
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82. Plant and Animal Innate Immunity Complexes: Fighting Different Enemies with Similar Weapons
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83. Urate Crystals; Beyond Joints
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84. Disulfiram ameliorates ischemia/reperfusion-induced acute kidney injury by suppressing the caspase-11-GSDMD pathway
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85. Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing
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86. Research progress on pyroptosis and its effect on the central nervous system
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87. Extracellular ADP facilitates monocyte recruitment in bacterial infection via ERK signaling
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88. Association of NLRP3 polymorphisms with susceptibility to primary gouty arthritis in a Chinese Han population
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89. Paricalcitol attenuates TGF‐β1–induced phenotype transition of human peritoneal mesothelial cells (HPMCs) via modulation of oxidative stress and NLRP3 inflammasome
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90. Resveratrol Suppresses Gut-Derived NLRP3 Inflammasome Partly through Stabilizing Mast Cells in a Rat Model
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91. Germ cell apoptosis and survival in testicular inflammation
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92. Effects of α-lipoic acid on LPS-induced neuroinflammation and NLRP3 inflammasome activation through the regulation of BV-2 microglial cells activation
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93. Eicosapentaenoic Acid-Enriched Phosphatidylcholine Mitigated Aβ1-42-Induced Neurotoxicity via Autophagy-Inflammasome Pathway
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94. Quantification of uric acid in vasculature of patients with gout using dual-energy computed tomography
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95. Innate Immunity in Mucopolysaccharide Diseases
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96. Neurodegenerative Microbially-Shaped Diseases: Oxidative Stress Meets Neuroinflammation
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97. Melatonin as Modulator for Sulfur and Nitrogen Mustard-Induced Inflammation, Oxidative Stress and DNA Damage: Molecular Therapeutics
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98. Resveratrol ameliorates glioblastoma inflammatory response by reducing NLRP3 inflammasome activation through inhibition of the JAK2/STAT3 pathway
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99. Neuroprotective role of Carvacrol via Nrf2/HO-1/NLRP3 axis in Rotenone-induced PD mice model
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100. Regulation of epithelial injury and bile duct obstruction by NLRP3, IL-1R1 in experimental biliary atresia
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