Molecular mechanisms regulating NLRP3 inflammasome activation

The Inflammasome

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A role for mitochondria in nlrp3 inflammasome activation

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The Inflammasomes

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Gout-associated uric acid crystals activate the NALP3 inflammasome

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Autophagy and Viruses: Adversaries or Allies?

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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Immunological and inflammatory functions of the interleukin-1 family

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Cryopyrin activates the inflammasome in response to toxins and ATP

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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Unraveling the pathophysiologic role of galectin‐3 in chronically injured liver

Ezhilarasan, D. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.30956 · Cited by 18

Targeting Spike Glycoprotein S1 Mediated by NLRP3 Inflammasome Machinery and the Cytokine Releases in A549 Lung Epithelial Cells by Nanocurcumin

Chittasupho, C., Srisawad, K., Arjsri, P., Phongpradist, R., Tingya, W., Ampasavate, C., & Dejkriengkraikul, P. (2023) · Pharmaceuticals · doi:10.3390/ph16060862 · Cited by 18

GBP2 upregulated in LPS-stimulated macrophages-derived exosomes accelerates septic lung injury by activating epithelial cell NLRP3 signaling

Huang, W., Zhang, Y., Zheng, B., Ling, X., Wang, G., Li, L., Wang, W., Pan, M., Li, X., & Meng, Y. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111017 · Cited by 18

The effects of Leishmania RNA virus 2 (LRV2) on the virulence factors of L. major and pro-inflammatory biomarkers: an in vitro study on human monocyte cell line (THP-1)

Mirabedini, Z., Mirjalali, H., Kazemirad, E., Khamesipour, A., Samimi‐Rad, K., Koosha, M., Saberi, R., Rahimi, H. M., Mohebali, M., & Hajjaran, H. (2023) · BMC Microbiology · doi:10.1186/s12866-023-03140-0 · Cited by 18

Inflammasomes at the crossroads of traumatic brain injury and post-traumatic epilepsy

Javalgekar, M., Jupp, B., Vivash, L. E., O'Brien, T. J., Wright, D. K., Jones, N. C., & Ali, I. Y. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03167-8 · Cited by 19

Leptospira interrogans infection leads to IL-1β and IL-18 secretion from a human macrophage cell line through reactive oxygen species and cathepsin B mediated-NLRP3 inflammasome activation

Li, S., Wang, M., Ojcius, D. M., BiJun, Z., Hu, W., Liu, Y., Ma, Q., Tang, G., Wang, D., & Yan, J. (2018) · Microbes and Infection · doi:10.1016/j.micinf.2018.01.010 · Cited by 19

Macrophages in obesity

Pirzgalska, R. M., & Domingos, A. I. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.04.014 · Cited by 18

Raltegravir Attenuates Experimental Pulmonary Fibrosis In Vitro and In Vivo

Zhang, X., Huang, H., Zhang, G., Li, D., Wang, H., & Jiang, W. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00903 · Cited by 20

Tojapride prevents CaSR‐mediated NLRP3 inflammasome activation in oesophageal epithelium irritated by acidic bile salts

Yin, X., Wu, H., Zhang, B., Zhu, N., Chen, T., Ma, X., Zhang, L., Lv, L. L., Zhang, M., Wang, F., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14631 · Cited by 18

Regulated Cell Death in Pulpitis

Huang, M., Zhan, C., Yang, X., & Hou, J. L. (2020) · Journal of Endodontics · doi:10.1016/j.joen.2020.07.006 · Cited by 20

Inflammasome Caspase-1 Activity is Elevated in Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage and Predicts Functional Outcome

Hirsch, Y., Geraghty, J. R., Katz, E. A., & Testai, F. D. (2020) · Neurocritical Care · doi:10.1007/s12028-020-01113-z · Cited by 18

Sodium P-aminosalicylic Acid Inhibits Manganese-Induced Neuroinflammation in BV2 Microglial Cells via NLRP3-CASP1 Inflammasome Pathway

Fang, Y., Peng, D., Liang, Y., Lu, L., Li, J., Zhao, L., Ou, S., Li, S., Aschner, M., & Jiang, Y. (2020) · Biological Trace Element Research · doi:10.1007/s12011-020-02471-7 · Cited by 18

A bibliometric analysis of NLRP3 inflammasome in acute lung injury/acute respiratory distress syndrome from 2010 to 2021

Xiao, Z., Hu, S., Xu, W., Wang, S., Mo, W., Deng, H., Wei, J., Yang, H., Zhou, W., Li, Q., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1053658 · Cited by 18

Ubiquitin Ligases in Control: Regulating NLRP3 Inflammasome Activation

Beesetti, S. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl25970 · Cited by 18

Signal transduction analysis of the NLRP3-inflammasome pathway after cellular damage and its paracrine regulation

Veltman, D., Laeremans, T., Passante, E., & Huber, H. J. (2016) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2016.12.016 · Cited by 17

Leptin Induces Apoptotic and Pyroptotic Cell Death via NLRP3 Inflammasome Activation in Rat Hepatocytes

Baral, A., & Park, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212589 · Cited by 17

Tectoridin alleviates lipopolysaccharide-induced inflammation via inhibiting TLR4-NF-κB/NLRP3 signaling in vivo and in vitro

Niu, X., Song, H., Xiao, X., Yu, J., Yu, J., Yang, Y., Huang, Q., Zang, L., Han, T., Zhang, D., et al. (2022) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2022.2073890 · Cited by 17

Avanafil as a Novel Therapeutic Agent Against LPS-Induced Acute Lung Injury via Increasing CGMP to Downregulate the TLR4-NF-κB-NLRP3 Inflammasome Signaling Pathway

Aydın, P., Aksakalli-Magden, Z. B., Uzunçakmak, S. K., Halıcı, H., Akgun, N., Mendĭl, A. S., Mokhtare, B., & Çadırcı, E. (2022) · Lung · doi:10.1007/s00408-022-00564-9 · Cited by 17

Leptin-depended NLRP3 inflammasome activation in osteoarthritic chondrocytes is mediated by ROS

Mourmoura, E., Papathanasiou, I. V., Trachana, V., Konteles, V., Tsoumpou, A., Goutas, A., Papageorgiou, A.-A., Stefanou, N., & Tsezou, A. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111730 · Cited by 17

Quxie Capsule Alleviates Colitis-associated Colorectal Cancer Through Modulating the Gut Microbiota and Suppressing A. fumigatus -induced Aerobic Glycolysis

Zhang, Z., Chen, Y., Zheng, Y., Wang, L., Shen, S., Yang, G., Yang, Y., & Wang, T. (2022) · Integrative Cancer Therapies · doi:10.1177/15347354221138534 · Cited by 19

Benzyl isothiocyanate attenuates activation of the NLRP3 inflammasome in Kupffer cells and improves diet-induced steatohepatitis

Lo, C., Yen, C., Chen, C.-Y., Chen, H., & Lii, C. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116424 · Cited by 17

Decreased survival in patients with pancreatic cancer may be associated with an increase in histopathological expression of inflammasome marker NLRP3.

Fraile‐Μartinez, O., Montero, C. G., Pekarek, L., Saz, J. V., Álvarez-Mon, M. Á., Barrena-Blázquez, S., García‐Honduvilla, N., Buján, J., Asúnsolo, Á., Coca, S., et al. (2024) · PubMed · doi:10.14670/hh-18-617 · Cited by 17

Mitochondrial health, NLRP3 inflammasome activation, and white matter integrity in adolescent mood disorders: A pilot study

Zhou, X. Y., Thai, M., Roediger, D. J., Mueller, B. A., Cullen, K. R., Klimes‐Dougan, B., & Andreazza, A. C. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.08.039 · Cited by 17

Monotropein induces autophagy through activation of the NRF2/PINK axis, thereby alleviating sepsis-induced colonic injury

Qiang, J., Yang, R., Li, X., Xu, X., Zhou, M., Ji, X., Lu, Y., & Dong, Z. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111432 · Cited by 17

NLRP6 deficiency suppresses colorectal cancer liver metastasis growth by modulating M-MDSC-induced immunosuppressive microenvironment

Chang, L., Xu, L., Tian, Y., Liu, Z., Song, M., Li, S., Zhang, X., Chen, Y., Hao, Q., Lu, Y., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167035 · Cited by 17

Edaravone dexborneol promotes M2 microglia polarization against lipopolysaccharide-induced inflammation via suppressing TLR4/MyD88/NF-κB pathway

Huang, J., Hu, X., Li, J., & Gong, D. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03045-3 · Cited by 19

A Novel Catalase Nanogels for Effective Treatment of Neutrophilic Asthma

Xu, Z., Guo, X., Gu, Y., Zhao, D., Zou, Z., Shen, Y., He, C., Rong, Y., Xu, C., & Wang, F. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202316496 · Cited by 17

Molecular regulation of NLRP3 inflammasome activation during parasitic infection

Alonaizan, R. (2024) · Bioscience Reports · doi:10.1042/bsr20231918 · Cited by 18

Remdesivir ameliorates ulcerative colitis-propelled cell inflammation and pyroptosis in acetic acid rats by restoring SIRT6/FoxC1 pathway

Oraby, M. A., Mageed, S. S. A., Raouf, A. A., Abdelshafy, D. A., Ahmed, E. F., Khalil, R. T., Mangoura, S. A., & Fadaly, D. S. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112465 · Cited by 18

Human renal fibroblasts are strong immunomobilizers during a urinary tract infection mediated by uropathogenic Escherichia coli

Klarström-Engström, K., Zhang, B., & Demirel, I. (2019) · Scientific Reports · doi:10.1038/s41598-019-38691-8 · Cited by 17

FUN14 domain‐containing 1-mediated mitophagy suppresses interleukin-1β production in macrophages

Huang, J., Zhu, T., Rong, R., You, M., Ji, D., & Li, H. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106964 · Cited by 17

Weighted Gene Co‐Expression Network Analysis Identifies Gender Specific Modules and Hub Genes Related to Metabolism and Inflammation in Response to an Acute Lipid Challenge

Fatima, A., Connaughton, R. M., Weiser, A., Murphy, A. M., O’Grada, C. M., Ryan, M., Brennan, L., Gaora, P. Ó., & Roche, H. M. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700388 · Cited by 17

Ginsenoside F2 from the leaves of Panax ginseng alleviates DSS-induced ulcerative colitis: An in silico analysis and in vivo investigation

Niu, Z., Liu, Y., Zhou, D., Feng, J., Hu, Y., He, Z., Shen, T., Piao, J., Wu, H., & Hu, W. (2025) · Industrial Crops and Products · doi:10.1016/j.indcrop.2025.120458 · Cited by 16

S100 proteins as a key immunoregulatory mechanism for NLRP3 inflammasome

Acter, S., & Lin, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1663547 · Cited by 19

Bidirectional Regulation of NLRP3 Inflammasome and Mitochondrial Quality Control in Sepsis: Mechanisms and Therapeutic Implications

Liao, X., Wang, Y., Zhang, Z., Qu, X., & Zhou, G. (2026) · Mediators of Inflammation · doi:10.1155/mi/3168669 · Cited by 24

Therapeutic Effects of Dipterocarpus tuberculatus with High Antioxidative Activity Against UV-Induced Photoaging of NHDF Cells and Nude Mice

Lee, S. J., Kim, J. E., Choi, Y. J., Gong, J. E., Park, S. H., Douangdeuane, B., Souliya, O., Park, J. M., Lee, H. S., Kim, B.-H., et al. (2021) · Antioxidants · doi:10.3390/antiox10050791 · Cited by 16

Panaxadiol inhibits IL-1β secretion by suppressing zinc finger protein 91-regulated activation of non-canonical caspase-8 inflammasome and MAPKs in macrophages.

Wang, J.-Y., Xing, Y.-X., Li, M.-Y., Zhang, Z.-H., Jin, H.-L., Ma, J., Lee, J., Zhong, Y., Zuo, H.-X., & Jin, X.-J. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114715 · Cited by 16

Pulmonary hazard identifications of Graphene family nanomaterials: Adverse outcome pathways framework based on toxicity mechanisms

Ding, X., Pu, Y., Tang, M., & Zhang, T. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.159329 · Cited by 17

Subchronic Oral Cylindrospermopsin Exposure Alters the Host Gut Microbiome and Is Associated with Progressive Hepatic Inflammation, Stellate Cell Activation, and Mild Fibrosis in a Preclinical Study

Saha, P., Upright, M., Bose, D., Roy, S., Trivedi, A., More, M., Scott, G., Brooks, B. W., & Chatterjee, S. (2022) · Toxins · doi:10.3390/toxins14120835 · Cited by 17

Tivantinib alleviates inflammatory diseases by directly targeting NLRP3

Huang, Y., Guo, Y., Zhou, Y., Huang, Q., Ru, Y., Luo, Y., & Xu, W. (2023) · iScience · doi:10.1016/j.isci.2023.106062 · Cited by 16

Bilirubin induces microglial NLRP3 inflammasome activation in vitro and in vivo

Ercan, İ., Mıçılı, S. Ç., Soy, S., Engür, D., Tüfekçi, K. U., Kumral, A., & Genç, Ş. (2023) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2023.103850 · Cited by 16

Activation of the NLRP3 inflammasome by HMGB1 through inhibition of the Nrf2/HO-1 pathway promotes bleomycin-induced pulmonary fibrosis after acute lung injury in rats

Huang, Y., Wang, A., Jin, S., Liu, F., & Xu, F. (2023) · Allergologia et Immunopathologia · doi:10.15586/aei.v51i3.668 · Cited by 16

Essential oil and polyphenolics from Thymus satureioides Coss. counteract acrylamide-induced liver toxicity through suppression of NLRP3 inflammasome/NF-κB axis

Mahmoud, M. F., Elrashidy, R. A., Mohammed, H. O., Drissi, B., Mahdi, I., & Sobeh, M. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105641 · Cited by 16

Calcium-sensing receptor-mediated macrophage polarization improves myocardial remodeling in spontaneously hypertensive rats

Zhao, J., Lu, N., Qu, Y., Liu, W., Zhong, H., Tang, N., Li, J., Wang, L., Xi, D., & He, F. (2024) · Experimental Biology and Medicine · doi:10.3389/ebm.2024.10112 · Cited by 16

Sterile inflammation of peritoneal membrane caused by peritoneal dialysis: focus on the communication between immune cells and peritoneal stroma

Su, H.-Y., Zou, R., Su, J., Chen, X., Yang, H., An, N., Yang, C., Tang, J., Liu, J., & Yao, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1387292 · Cited by 16

Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells

Ono, H., Ohta, R., Kawasaki, Y., Niwa, A., Takada, H., Nakahata, T., Ohga, S., & Saito, M. K. (2018) · Inflammation Research · doi:10.1007/s00011-018-1178-z · Cited by 16

Anti-inflammatory Effects of Metformin on Neuro-inflammation and NLRP3 Inflammasome Activation in BV-2 Microglial Cells

Ha, J. S., Yeom, Y.-S., Jang, J.-H., Kim, Y., Im, J. I., Kim, I. S., & Yang, S.-J. (2019) · Journal of Experimental & Biomedical Sciences/Biomedical Science Letters · doi:10.15616/bsl.2019.25.1.92 · Cited by 16

Dietary oleuropein and its acyl derivative ameliorate inflammatory response in peritoneal macrophages from pristane-induced SLE mice via canonical and noncanonical NLRP3 inflammasomes pathway

Castejón, M. L., Montoya, T., Alarcón‐de‐la‐Lastra, C., González‐Benjumea, A., Vázquez‐Román, V., & Sánchéz‐Hidalgo, M. (2020) · Food & Function · doi:10.1039/d0fo00235f · Cited by 16

C5b-9 membrane attack complex activated NLRP3 inflammasome mediates renal tubular immune injury in trichloroethylene sensitized mice

Xie, H., Yang, L., Yang, Y., Jiang, W., Wang, X., Huang, M., Zhang, J., & Zhu, Q. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111439 · Cited by 16

Inflammasome Genetic Variants, Macrophage Function, and Clinical Outcomes in Cystic Fibrosis

Graustein, A. D., Berrington, W. R., Buckingham, K. J., Nguyen, F. K., Joudeh, L. L., Rosenfeld, M., Bamshad, M. J., Gibson, R. L., Hawn, T. R., & Emond, M. J. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0257oc · Cited by 14

The Nlrp3 inflammasome – the evolving story of its positive and negative effects on hematopoiesis

Ratajczak, M. Z., & Kucia, M. (2021) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000658 · Cited by 16

NLRP3 Deletion Attenuated Angiotensin II-Induced Renal Fibrosis by Improving Mitochondrial Dysfunction and Endoplasmic Reticulum Stress

Zhang, Y., Liu, Y., Bi, X., Hu, C., & Ding, W. Q. (2021) · The Nephron journals/Nephron journals · doi:10.1159/000513739 · Cited by 16

Skin Wounding–Induced Monocyte Expansion in Mice Is Not Abrogated by IL-1 Receptor 1 Deficiency

Barman, P. K., Pang, J., Urao, N., & Koh, T. J. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801481 · Cited by 16

Overexpressed CD39 mitigates sepsis‑induced kidney epithelial cell injury via suppressing the activation of NLR family pyrin domain containing 3

Yang, M., Lu, L., Kang, Z., Ma, T., & Wang, Y. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4349 · Cited by 16

Balanophora polyandra Griff. prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome

Guo, C., He, Y., Gai, L., Qu, J., Shi, Y., Xu, W., Cai, Y., Wang, B. L., Zhang, J., Zhao, Z., et al. (2020) · Food & Function · doi:10.1039/c9fo02494h · Cited by 16

The different faces of the NLRP3 inflammasome in cutaneous Leishmaniasis: A review

Kihel, A., Hammi, I., Darif, D., Lemrani, M., Riyad, M., Guessous, F., & Akarid, K. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155248 · Cited by 16

Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effects

Hu, H., Cai, Y., Shi, Y., Zhang, S., Yu, X., Ma, T., & Liao, S. (2024) · iScience · doi:10.1016/j.isci.2024.109544 · Cited by 15

Inflammasomes as the molecular hub of cardiovascular-metabolic-immune comorbidity networks

Qian, X., Sun, J. M., Li, F., Li, X., Hu, X., Dong, N., & Li, G. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1690443 · Cited by 18

Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer’s disease retina

Gaire, B. P., Koronyo, Y., Vit, J., Hutton, A., Subedi, L., Fuchs, D.-T. S., Swerdlow, N., Rentsendorj, A., Shahin, S., Martinon, D., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-68580-4 · Cited by 16

Downregulation of ROCK2 attenuates alcohol-induced inflammation and oxidative stress in astrocytes

Li, X., Tong, J., Liu, J., & Wang, Y. (2020) · International Journal of Neuroscience · doi:10.1080/00207454.2020.1825421 · Cited by 15

Involvement of NF-κB/NLRP3 axis in the progression of aseptic loosening of total joint arthroplasties: a review of molecular mechanisms

Qoreishi, M., Panahi, M., Dorodi, O., Ghanbari, N., & Jousheghan, S. S. (2022) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-022-02232-4 · Cited by 16

High-fidelity imaging of lysosomal enzyme through in situ ordered assembly of small molecular fluorescent probes

Lou, X., Ren, T., Chen, H., Huan, S., Yuan, L., & Zhang, X. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121657 · Cited by 15

Effects of estradiol on the virulence traits of Porphyromonas gingivalis

Demirel, K. J., Guimarães, A. N., & Demirel, I. (2022) · Scientific Reports · doi:10.1038/s41598-022-17019-z · Cited by 15

Extracellular vesicles derived from Pinctada martensii mucus regulate skin inflammation via the NF-κB/NLRP3/MAPK pathway

Wu, Z., Ma, L., Lin, P., Dai, Z., Lu, Z., Yan, L., Zhou, C., Qian, Z., Hong, P., & Li, C. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.09.115 · Cited by 15

The emerging role of pyroptosis in neuropathic pain

Li, B., Guo, J., Zhou, X., Li, W., Wang, N., Cao, R., & Cui, S. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110562 · Cited by 14

Combining idebenone and rosuvastatin prevents atherosclerosis by suppressing oxidative stress and NLRP3 inflammasome activation

Yu, W., Jiang, W., Wu, W., Wang, G., Zhao, D., Yan, C., & Lin, P. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175911 · Cited by 15

Discovery of a selective NLRP3-targeting compound with therapeutic activity in MSU-induced peritonitis and DSS-induced acute intestinal inflammation

Zhou, Y., Yang, Z., Ou, Y., Cai, H., Liu, Z., Lin, G., Liang, S., Hua, L., Yan, Y., Zhang, X., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04881-x · Cited by 15

Immune landscape and redox imbalance during neurological disorders in COVID-19

Thakur, A., Sharma, V., Averbek, S., Liang, L., Pandya, N., Kumar, G., Cili, A., & Zhang, K. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06102-6 · Cited by 15

Therapeutic potential of bixin on inflammation: a mini review

Shadisvaaran, S., Chin, K., Mohd-Said, S., & Leong, X.-F. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1209248 · Cited by 15

Triclosan and its alternatives, especially chlorhexidine, modulate macrophage immune response with distinct modes of action

Raps, S., Bahr, L. L., Karkossa, I., Rossol, M., von Bergen�, M., & Schubert, K. A. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.169650 · Cited by 15

A novel mechanism for regulating lung immune homeostasis: Zukamu granules alleviated acute lung injury in mice by inhibiting NLRP3 inflammasome activation and regulating Th17/Treg cytokine balance

Yu, C., Li, Y., Li, Y., Li, S., Zeng, F., Yu, J., Ji, Z., Li, K., & Zhai, H. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117831 · Cited by 15

Fenpropathrin provoked kidney damage via controlling the NLRP3/Caspase-1/GSDMD–mediated pyroptosis: The palliative role of curcumin-loaded chitosan nanoparticles

Abd‐Elhakim, Y. M., Mohamed, A. A.-R., Noreldin, A. E., Khamis, T., Eskandrani, A. A., Shamlan, G. H., Alansari, W. S., Alotaibi, B. S., Alosaimi, M. E., Hakami, M. A., et al. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.116869 · Cited by 15

Helicobacter pylori and gastric cancer: a lysosomal protease perspective

Soond, S. M., & Zamyatnin, A. A. (2021) · Gastric Cancer · doi:10.1007/s10120-021-01272-8 · Cited by 16

Disulfiram attenuates lipopolysaccharide-induced acute kidney injury by suppressing oxidative stress and NLRP3 inflammasome activation in mice

Huang, J., Wei, S., Peng, Z., Xiao, Z., Yang, Y., Liu, J., Zhang, B., & Li, W. (2021) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgab171 · Cited by 15

Immunomodulatory Role of Thioredoxin Interacting Protein in Cancer’s Impediments: Current Understanding and Therapeutic Implications

Katturajan, R., Nithiyanandam, S., Parthasarathy, M., Gopalakrishnan, A. V., Sathiyamoorthi, E., Lee, J., Ramesh, T., Iyer, M., Prince, S. E., & Ganesan, R. (2022) · Vaccines · doi:10.3390/vaccines10111902 · Cited by 15

Partial loss of ATP13A2 causes selective gliosis independent of robust lipofuscinosis

Rayaprolu, S., Seven, Y. B., Howard, J. C., Duffy, C., Altshuler, M. S., Moloney, C. M., Giasson, B. I., & Lewis, J. M. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.05.009 · Cited by 15

Darunavir alleviates irinotecan-induced intestinal toxicity in Vivo

Zhang, X., Zhang, G., Ren, Y., Lan, T., Li, D., Tian, J., & Jiang, W. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.07.044 · Cited by 14

The Antiemetic Effect of Xiao‐Ban‐Xia‐Tang Formula against Cisplatin‐Induced Emesis is Mediated through Inhibition of NLRP3 Inflammasome Activation in a Rat Pica Model

Meng, Q., Cheng, Q., Feng, X., Chen, S., Li, Y., Zhang, G., & Nie, K. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/5497078 · Cited by 15

Targeting the sAC-Dependent cAMP Pool to Prevent SARS-Cov-2 Infection

Aslam, M., & Ladilov, Y. V. (2020) · Cells · doi:10.3390/cells9091962 · Cited by 15

Possible Interaction of Suramin with Thalamic P2X Receptors and NLRP3 Inflammasome Activation Alleviates Reserpine-Induced Fibromyalgia-Like Symptoms

Mohamed, M. M., Zaki, H. F., & Kamel, A. S. E. D. (2025) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-025-10207-4 · Cited by 14

The microbiota-inflammasome-brain axis as a pathogenic mediator of neurodegenerative disorders

Sarkar, S. K., Gubert, C., & Hannan, A. J. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106276 · Cited by 15

Inflammasome Signaling and Other Factors Implicated in Atherosclerosis Development and Progression

Samani, Z. N., Sewell, R. D. E., & Rafieian‐Kopaei, M. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200504115045 · Cited by 14

Potential Therapeutic Approach of Melatonin against Omicron and Some Other Variants of SARS-CoV-2

Begum, R., Mamun-Or-Rashid, A. N. M., Lucy, T. T., Pramanik, M. K., Sil, B. K., Mukerjee, N., Tagde, P., Yagi, M., & Yonei, Y. (2022) · Molecules · doi:10.3390/molecules27206934 · Cited by 14

Knockdown of LRRK2 inhibits the progression of lung cancer by regulating TLR4/NF-κB pathways and NLRP3 inflammasome

Wu, J., Yang, S.-M., Wu, H., Huang, Y., & Miao, Y. (2023) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.22-122 · Cited by 14

Lobeglitazone inhibits LPS-induced NLRP3 inflammasome activation and inflammation in the liver

Seo, H.-Y., Lee, S. H., Park, J. Y., Han, E., Han, S., Hwang, J. S., Kim, M. K., & Jang, B. K. (2023) · PLoS ONE · doi:10.1371/journal.pone.0290532 · Cited by 13

Escherichia coli infection mediates pyroptosis via activating p53-p21 pathway-regulated apoptosis and cell cycle arrest in bovine mammary epithelial cells

Zhuang, C., Zhao, J., Zhang, S., & Shahid, M. S. (2023) · Microbial Pathogenesis · doi:10.1016/j.micpath.2023.106338 · Cited by 14

Empagliflozin alleviates the development of autoimmune myocarditis via inhibiting NF-κB-dependent cardiomyocyte pyroptosis

Lv, C., Hu, C., Zhu, C., Wan, X., Chen, C., Ji, X., Qin, Y., Lü, L., & Guo, X. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115963 · Cited by 15

Interleukins in Epilepsy: Friend or Foe

Dong, Y., Zhang, X., & Wang, Y. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-023-01170-2 · Cited by 16

Exogenous hydrogen sulfide ameliorates diabetes-associated cognitive dysfunction by regulating the nrf-2/HO-1 axis and the NLRP3 inflammasome pathway in diabetic rats

Chen, H., Sun, H., Hua, W., Chang, H., Chen, W.-J., & Ma, S. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176344 · Cited by 14

Integration of 16S rRNA sequencing and metabolomics to investigate the modulatory effect of ginsenoside Rb1 on atherosclerosis

Liang, Y., Fu, J., Shi, Y., Jiang, X., Lu, F., & Liu, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27597 · Cited by 14

Dicoumarol attenuates NLRP3 inflammasome activation to inhibit inflammation and fibrosis in knee osteoarthritis

Ge, W., Zhang, X., Wang, Q., Jianjie, M. A. O., Jia, P., & Cai, J. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13224 · Cited by 17

The effects of NLRP3 inflammasome inhibition or knockout in experimental apical periodontitis induced in mice

Pucinelli, C. M., da Silva, R. A. B., Nelson‐Filho, P., Lima, R. B., Lucisano, M. P., Marchesan, J. T., & da Silva, L. A. B. (2024) · Clinical Oral Investigations · doi:10.1007/s00784-024-05691-6 · Cited by 14

Modulating the HSP90 control over NFκB/NLRP3/Caspase-1 axis is a new therapeutic target in the management of liver fibrosis: Insights into the role of TAS-116 (Pimitespib)

Elmorsy, E. A., Saber, S., Hamad, R. S., Abdel‐Reheim, M. A., Nadwa, E. H., Alibrahim, A., Alkhamiss, A. S., Alsalloom, A. A., Mohamed, E. A. K., Nour-El-Din, M., et al. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122966 · Cited by 14

The role of mitochondria in cytokine and chemokine signalling during ageing

Kalykaki, M., Rubio‐Tomás, T., & Tavernarakis, N. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111993 · Cited by 14

Extracellular Hsp90 of Candida albicans contributes to the virulence of the pathogen by activating the NF-κB signaling pathway and inducing macrophage pyroptosis

Fang, T., Xiong, J., Huang, X., Fang, X., Shen, X., Jiang, Y., & Lu, H. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127964 · Cited by 14

Sulfasalazine as an Immunomodulator of the Inflammatory Process during HIV-1 Infection

Feria, M. G., Rugeles, M. T., Hernández, J. C., Luján, J., & Taborda, N. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184476 · Cited by 14

Differential Action of Connexin Hemichannel and Pannexin Channel Therapeutics for Potential Treatment of Retinal Diseases

Nor, M. N. M., Rupenthal, I. D., Green, C. R., & Acosta, M. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041755 · Cited by 14

BRD4 inhibition by JQ1 protects against LPS-induced cardiac dysfunction by inhibiting activation of NLRP3 inflammasomes

Li, W., Shen, X., Feng, S., Liu, Y., Zhao, H., Zhou, G., Sang, M., Sun, X., Jiao, R., & Liu, F. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07377-2 · Cited by 14

Protective effects of di‐caffeoylquinic acids from Artemisia selengensis Turcz leaves against monosodium urate‐induced inflammation via the modulation of NLRP3 inflammasome and Nrf2 signaling pathway in THP‐1 macrophages

Cao, W., Wu, T., Liang, F., Fang, Y., Cheng, Y., Pan, S., & Xu, X. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14252 · Cited by 14

Dual Role of PTPN22 but Not NLRP3 Inflammasome Polymorphisms in Type 1 Diabetes and Celiac Disease in Children

Schweiger, D. Š., Goričar, K., Hovnik, T., Mendez, A., Bratina, N., Brecelj, J., Vidan‐Jeras, B., Battelino, T., & Dolžan, V. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00063 · Cited by 14

The NLRP3 inflammasome: contributions to inflammation-related diseases

Chen, Y., Ye, X., Escames, G., Lei, W., Zhang, X., Li, M., Jing, T., Yao, Y., Qiu, Z., Wang, Z., et al. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00462-9 · Cited by 492

Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling

Kim, J. K., Jin, H. S., Suh, H., & Jo, E. (2017) · Immunology and Cell Biology · doi:10.1038/icb.2017.23 · Cited by 54

The Signaling Pathways Regulating NLRP3 Inflammasome Activation

Chen, M.-Y., Ye, X.-J., He, X.-H., & Ouyang, D.-Y. (2021) · Inflammation · doi:10.1007/s10753-021-01439-6 · Cited by 154

NLRP3 inflammasome: activation, regulation, and role in diseases

Zhou, R., Yan, Y., Jiang, W., & Jiang, H. (2017) · Scientia Sinica Vitae · doi:10.1360/n052016-00360 · Cited by 10

New progress on the activation mechanisms of NOD-like receptor, pyrin domain-containing 3 inflammasome

Wang, W., & Ma, Y. (2015) · Int J Immunol · doi:10.3760/cma.j.issn.1673-4394.2015.04.010