Molecular mechanisms regulating NLRP3 inflammasome activation

The Inflammasome

Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602

The Inflammasomes

Schroder, K., & Tschopp, J. (2010) · Cell · doi:10.1016/j.cell.2010.01.040 · Cited by 5,475

Gout-associated uric acid crystals activate the NALP3 inflammasome

Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326

Autophagy and Viruses: Adversaries or Allies?

Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,444

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026

Immunological and inflammatory functions of the interleukin-1 family

Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466

Cryopyrin activates the inflammasome in response to toxins and ATP

Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065

Dengue virus envelope protein domain III induces pro-inflammatory signature and triggers activation of inflammasome

Khan, R. A., Afroz, S., Minhas, G., Battu, S., & Khan, N. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154780 · Cited by 30

NLRP3 inflammasomes are involved in the progression of postoperative cognitive dysfunction: from mechanism to treatment

Zhao, S., Chen, F., Wang, D., Han, W., Zhang, Y., & Yin, Q. (2020) · Neurosurgical Review · doi:10.1007/s10143-020-01387-z · Cited by 30

SARS-CoV-2 morbidity and mortality in racial/ethnic minority populations: A window into the stress related inflammatory basis of health disparities?

Gelaye, B., Foster, S. L., Bhasin, M., Tawakol, A. A., & Fricchione, G. L. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100158 · Cited by 32

The Roles of Inflammasomes in Host Defense against Mycobacterium tuberculosis

Ma, J., Zhao, S., Gao, X., Wang, R., Liu, J., Zhou, X., & Zhou, Y. (2021) · Pathogens · doi:10.3390/pathogens10020120 · Cited by 29

Inorganic nitrate alleviates irradiation-induced salivary gland damage by inhibiting pyroptosis

Li, S., An, W., Wang, B., Li, J., Qu, Y., Zhang, H., Zhang, Y., Wang, S., & Qin, L. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.08.227 · Cited by 29

Ultramicronized Palmitoylethanolamide Inhibits NLRP3 Inflammasome Expression and Pro-Inflammatory Response Activated by SARS-CoV-2 Spike Protein in Cultured Murine Alveolar Macrophages

Re, A., Corpetti, C., Pesce, M., Seguella, L., Steardo, L., Palenca, I., Rurgo, S., Conno, B. D., Sarnelli, G., & Esposito, G. (2021) · Metabolites · doi:10.3390/metabo11090592 · Cited by 30

Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation and Protects Against Septic Shock In Vivo

Wei, Z., Zhan, X., Ding, K., Xu, G., Shi, W., Ren, L., Fang, Z., Liu, T., Hou, X., Zhao, J., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.750815 · Cited by 30

Paeoniflorin Ameliorates Diabetic Liver Injury by Targeting the TXNIP-Mediated NLRP3 Inflammasome in Db/Db Mice

Wang, A., Gong, Y., Pei, Z., Jiang, L., Xia, L., & Wu, Y. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108792 · Cited by 31

The Role of H2S Regulating NLRP3 Inflammasome in Diabetes

Zhao, H., Liu, H., Yang, Y., & Wang, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094818 · Cited by 31

Resveratrol alleviates acute lung injury in mice by promoting Pink1/Parkin-related mitophagy and inhibiting NLRP3 inflammasome activation

Wu, D., Zhang, H., Li, F., Liu, S., Wang, Y., Zhang, Z., Wang, J., & Wu, Q. (2024) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2024.130612 · Cited by 31

Aging as a loss of morphostatic information: A developmental bioelectricity perspective

Pio‐Lopez, L., & Levin, M. G. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102310 · Cited by 36

Long Non-coding RNA NEAT1, NOD-Like Receptor Family Protein 3 Inflammasome, and Acute Kidney Injury

Xue, R., Yiu, W. H., Chan, K. W., Lok, S. W. Y., Zou, Y., Ma, J., Li, H., Chan, L. Y. Y., Huang, X. R., Lai, K. N., et al. (2024) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000000000362 · Cited by 29

Supramolecular prodrug inspiried by the Rhizoma Coptidis-Fructus Mume herbal pair alleviated inflammatory diseases by inhibiting pyroptosis

Qian, W., Zhang, B., Gao, M., Wang, Y., Shen, J., Liang, D., Wang, C., Wei, W., Pan, X., Yan, Q., et al. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.101056 · Cited by 30

Immunologic role of macrophages in sepsis-induced acute liver injury

Xu, W., Hou, H., Yang, W., Tang, W., & Sun, L. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113492 · Cited by 32

ATF3 Stimulates IL-17A by Regulating Intracellular Ca2+/ROS-Dependent IL-1β Activation During Streptococcus pneumoniae Infection

Lee, S., Kim, G., Kim, N. Y., Kim, S., Ghosh, P., & Rhee, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01954 · Cited by 29

Immune Response in H. pylori-Associated Gastritis and Gastric Cancer

Niu, Q., Zhu, J., Yu, X., Feng, T., Ji, H., Li, Y., Zhang, W., & Hu, B. (2020) · Gastroenterology Research and Practice · doi:10.1155/2020/9342563 · Cited by 29

α-Hemolysin of uropathogenic E. coli regulates NLRP3 inflammasome activation and mitochondrial dysfunction in THP-1 macrophages

Verma, V., Kumar, P., Gupta, S., Yadav, S., Dhanda, R. S., Thorlacius, H., & Yadav, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-69501-1 · Cited by 30

Serum amyloid A and inflammasome activation: A link to breast cancer progression?

Fourie, C., Shridas, P., Davis, T., de Villiers, W. J. S., & Engelbrecht, A. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.10.006 · Cited by 30

Impact of Sodium Glucose Cotransporter 2 Inhibitors on Nonalcoholic Fatty Liver Disease Complicated by Diabetes Mellitus

Zhang, E., Zhao, Y., & Hu, H. (2021) · Hepatology Communications · doi:10.1002/hep4.1611 · Cited by 30

CCDC50 suppresses NLRP3 inflammasome activity by mediating autophagic degradation of NLRP3

Lin, Y., Li, Z., Wang, Y., Tian, T., Jia, P.-H., Ye, Y., He, M., Yang, Z.-X., Li, C.-M., Guo, D.-Y., et al. (2022) · EMBO Reports · doi:10.15252/embr.202154453 · Cited by 27

Promoting healthy cardiovascular aging: emerging topics

Clayton, Z. S., Craighead, D. H., Darvish, S., Coppock, M. E., Ludwig, K. R., Brunt, V. E., Seals, D. R., & Rossman, M. J. (2022) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.27 · Cited by 29

Echovirus 11 infection induces pyroptotic cell death by facilitating NLRP3 inflammasome activation

Wang, C., Yang, R., Yang, F., Han, Y., Ren, Y., Xiong, X., Wang, X., Bi, Y., Li, L., Qiu, Y., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010787 · Cited by 29

Role of aging in Blood–Brain Barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19

Adesse, D., Gladulich, L., Alvarez-Rosa, L., Siqueira, M., Marcos, A. C., Heider, M., Motta, C. S., Torices, S., Toborek, M. J., & Stipursky, J. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00357-5 · Cited by 30

Tanshinone I specifically suppresses NLRP3 inflammasome activation by disrupting the association of NLRP3 and ASC

Zhao, J., Liu, H., Hong, Z., Mu, W., Mu, W., Hou, X., Xu, G., 方志娥, Ren, L., Liu, T., et al. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00671-0 · Cited by 32

Tick bite-induced alpha-gal syndrome and immunologic responses in an alpha-gal deficient murine model

Sharma, S. R., Choudhary, S. K., Vorobiov, J., Commins, S. P., & Karim, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1336883 · Cited by 29

Caspase-11 Plays a Protective Role in Pulmonary Acinetobacter baumannii Infection

Wang, W., Shao, Y., Li, S., Xin, N., Ma, T., Zhao, C., & Song, M. (2017) · Infection and Immunity · doi:10.1128/iai.00350-17 · Cited by 29

The Emerging Link Between the Complement Cascade and Purinergic Signaling in Stress Hematopoiesis

Ratajczak, M. Z., Adamiak, M., Kucia, M., Tse, W. T., Ratajczak, J., & Wiktor-Jędrzejczak, W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01295 · Cited by 29

Liver Steatosis is a Driving Factor of Inflammation

Mooli, R. G. R., & Ramakrishnan, S. K. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.01.007 · Cited by 29

ALDH2 attenuates myocardial pyroptosis through breaking down Mitochondrion-NLRP3 inflammasome pathway in septic shock

Zhang, Y., Lv, Y., Zhang, Q., Wang, X., Han, Q., Liang, Y., He, S., Yuan, Q., Zheng, J., Xu, C., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1125866 · Cited by 30

Mitochondrial Impairment: A Link for Inflammatory Responses Activation in the Cardiorenal Syndrome Type 4

Amador‐Martínez, I., Aparicio‐Trejo, O. E., Bernabe-Yepes, B., Aranda‐Rivera, A. K., Cruz‐Gregorio, A., Sánchez‐Lozada, L. G., Pedraza‐Chaverrí, J., & Tapia, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115875 · Cited by 28

Ginsenosides from Panax ginseng as potential therapeutic candidates for the treatment of inflammatory bowel disease

Niu, Z., Liu, Y., Shen, R., Jiang, X., Wang, Y., He, Z., Li, J., Hu, Y., Zhang, J., Jiang, Y., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155474 · Cited by 30

Urolithin A alleviates NLRP3 inflammasome activation and pyroptosis by promoting microglial mitophagy following spinal cord injury

Chen, K., Ying, J., Zhu, J., Chen, L., Liu, R., Jing, M., Wang, Y., Zhou, K., Wu, L. H., Wu, C., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114057 · Cited by 29

NLRP3 Inflammasome Modulates Post-Burn Lipolysis and Hepatic Fat Infiltration via Fatty Acid Synthase

Vinaik, R., Stanojcic, M., & Jeschke, M. G. (2018) · Scientific Reports · doi:10.1038/s41598-018-33486-9 · Cited by 29

Adenovirus VA RNAI Blocks ASC Oligomerization and Inhibits NLRP3 Inflammasome Activation

Darweesh, M. F., Kamel, W., Gavrilin, M. A., Akusjärvi, G., & Svensson, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02791 · Cited by 28

RIPK3: A New Player in Renal Fibrosis

Shi, Y., Chen, X., Huang, C., & Pollock, C. A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00502 · Cited by 28

NLRP3 gene polymorphisms and expression in rheumatoid arthritis

Cheng, L., Liang, X., Qian, L., Luo, C., & Li, D. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10544 · Cited by 28

The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB

Xu, L., Wang, T., Fang, K., Zhao, Y., Wang, X., Ren, D., & Shen, T. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114694 · Cited by 28

Characterizing the NLRP3 Inflammasome in Mood Disorders: Overview, Technical Development, and Measures of Peripheral Activation in Adolescent Patients

Zhou, X. Y., Fernando, S. M., Pan, A. Y., Laposa, R. R., Cullen, K. R., Klimes‐Dougan, B., & Andreazza, A. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212513 · Cited by 29

Apigenin and apigenin-7, 4′-O-dioctanoate protect against acrolein-aggravated inflammation via inhibiting the activation of NLRP3 inflammasome and HMGB1/MYD88/NF-κB signaling pathway in Human umbilical vein endothelial cells (HUVEC)

Yu, J., Jiang, Q., Liu, N., Fan, D., Wang, M., & Zhao, Y. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.113400 · Cited by 28

Overnutrition-induced gout: An immune response to NLRP3 inflammasome dysregulation by XOD activity increased in quail

Wu, H., Wang, Y., Ren, Z., Li, Y., Huang, J., Lin, Z., & Zhang, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1074867 · Cited by 28

Ghrelin improves muscle function in dystrophin-deficient mdx mice by inhibiting NLRP3 inflammasome activation

Chang, L., Niu, F., Chen, J., Cao, X., Liu, Z., Bao, X., & Xu, Y. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116654 · Cited by 29

Autophagy and Inflammation: Regulatory Roles in Viral Infections

Chen, L., Yang, L., Li, Y., Liu, T., Yang, B., Liu, L., & Wu, R. (2023) · Biomolecules · doi:10.3390/biom13101454 · Cited by 29

Interleukin-1β converting enzyme (ICE): A comprehensive review on discovery and development of caspase-1 inhibitors.

Modi, P., Shah, B. M., & Patel, S. (2023) · European journal of medicinal chemistry · doi:10.1016/j.ejmech.2023.115861 · Cited by 26

MCC950 alleviates seizure severity and angiogenesis by inhibiting NLRP3/ IL-1β signaling pathway-mediated pyroptosis in mouse model of epilepsy

Hong, Y., Wei, C., Fu, M., Li, X., Zhang, H., & Yao, B. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111236 · Cited by 28

Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome in systemic lupus erythematosus

Wu, X., Yang, J., Wu, J., & Yang, X. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116261 · Cited by 29

Novel Perspectives in Chronic Kidney Disease-Specific Cardiovascular Disease

Xu, C., Tsihlis, G., Chau, K., Trinh, K., Rogers, N. M., & Julovi, S. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052658 · Cited by 30

Endothelial nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome regulation in atherosclerosis

Guo, S., Wang, L., Cao, K., Li, Z., Song, M., Huang, S., Li, Z., Wang, C., Chen, P., Wang, Y., et al. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae071 · Cited by 27

The interplay between mitochondrial dysfunction and NLRP3 inflammasome in multiple sclerosis: Therapeutic implications and animal model studies

Shadab, A., Abbasi‐Kolli, M., Saharkhiz, M., Ahadi, S. H., Shokouhi, B., & Nahand, J. S. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116673 · Cited by 27

NLRP3 regulates ferroptosis via the JAK2/STAT3 pathway in asthma inflammation: Insights from in vivo and in vitro studies

Zhang, Z., He, Y., Liu, H., Liu, Y., Wu, T., Li, R., Wang, Y., & Ma, W. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113416 · Cited by 30

Emodin Inhibits NLRP3 Inflammasome Activation and Protects Against Sepsis via Promoting FUNDC1-Mediated Mitophagy

Fu, W., Liu, S.-C., Xu, T.-X., Liu, Y., Zhang, T., Liu, D.-J., Wang, X., Wang, J., He, Y., & Ma, T. (2025) · International Journal of Biological Sciences · doi:10.7150/ijbs.110904 · Cited by 28

Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs)

Kinnunen, K., Piippo, N., Loukovaara, S., Hytti, M., Kaarniranta, K., & Kauppinen, A. (2017) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-017-0396-4 · Cited by 27

Overexpression of NLRP 3, NLRC 4 and AIM 2 inflammasomes and their priming‐associated molecules ( TLR 2, TLR 4, Dectin‐1, Dectin‐2 and NF κB) in Malassezia folliculitis

Liang, N., Yang, Y., Li, W., Wu, Y., Zhang, Z., Luo, Y., & Fan, Y. (2017) · Mycoses · doi:10.1111/myc.12711 · Cited by 27

Lactobacillus johnsonii L531 Ameliorates Escherichia coli-Induced Cell Damage via Inhibiting NLRP3 Inflammasome Activity and Promoting ATG5/ATG16L1-Mediated Autophagy in Porcine Mammary Epithelial Cells

Zou, Y., Xu, J., Wang, X., Zhu, Y., Wu, Q., & Wang, J. (2020) · Veterinary Sciences · doi:10.3390/vetsci7030112 · Cited by 29

DsbA-L Ameliorates Renal Injury Through the AMPK/NLRP3 Inflammasome Signaling Pathway in Diabetic Nephropathy

Yang, M., Luo, S., Jiang, N., Wang, X., Han, Y., Zhao, H., Xiong, X., Liu, Y., Zhao, C., Zhu, X., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.659751 · Cited by 28

CaMK4 Promotes Acute Lung Injury Through NLRP3 Inflammasome Activation in Type II Alveolar Epithelial Cell

Zhang, T., Li, M., Zhao, S., Zhou, M., Liao, H., Wu, H., Mo, X., Wang, H., Guo, C., Zhang, H., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.890710 · Cited by 27

Rapamycin‑induced autophagy attenuates hormone‑imbalance‑induced chronic non‑bacterial prostatitis in rats via the inhibition of NLRP3 inflammasome‑mediated inflammation

Lu, J., Yang, S., Chen, X., Chen, Y., Luo, P., Lin, F., & Zhang, J. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9683 · Cited by 27

Placental mesenchymal stem cells ameliorate NLRP3 inflammasome-induced ovarian insufficiency by modulating macrophage M2 polarization

Chen, D., Hu, N., Xing, S., Li, Y., Zhang, F., Guo, S., Liu, S., Ma, X., Liang, X., & Ma, H. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-023-01136-y · Cited by 30

The evolutionary tug-of-war of macrophage metabolism during bacterial infection

Almeida, L., Dhillon-LaBrooy, A., & Sparwasser, T. D. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.11.002 · Cited by 25

Recent progress of endoplasmic reticulum stress in the mechanism of atherosclerosis

Ni, L., Yang, L., & Lin, Y. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1413441 · Cited by 32

NLRP3 Inflammasome and Inflammatory Response in Aging Disorders: The Entanglement of Redox Modulation in Different Outcomes

Chhunchha, B., Kubo, E., Lehri, D., & Singh, D. P. (2025) · Cells · doi:10.3390/cells14130994 · Cited by 30

Cytokine signatures in hereditary fever syndromes (HFS)

Ibrahim, J.-N., Jéru, I., Lecron, J., & Medlej‐Hashim, M. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.11.001 · Cited by 26

Heme oxygenase-1 dampens the macrophage sterile inflammasome response and regulates its components in the hypoxic lung

Vitali, S. H., Fernandez‐Gonzalez, A., Nadkarni, J., Kwong, A., Rose, C. D., Mitsialis, S. A., & Kourembanas, S. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00074.2019 · Cited by 25

Recent Progress on the Discovery of NLRP3 Inhibitors and their Therapeutic Potential

Su, M., Wang, W., Liu, F., & Li, H. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200123093544 · Cited by 26

Celastrol alleviates metabolic disturbance in high‐fat diet‐induced obese mice through increasing energy expenditure by ameliorating metabolic inflammation

Yang, X., Wu, F., Li, L., Lynch, E. C., Xie, L., Zhao, Y. Q., Fang, K., Li, J., Luo, J., Xu, L., et al. (2020) · Phytotherapy Research · doi:10.1002/ptr.6800 · Cited by 26

Knockdown of miR‑205‑5p alleviates the inflammatory response in allergic rhinitis by targeting B‑cell lymphoma 6

Zhang, S., Lin, S., Tang, Q., & Yan, Z. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12458 · Cited by 24

The resilient phenotype elicited by ketamine against inflammatory stressors-induced depressive-like behavior is associated with NLRP3-driven signaling pathway

Camargo, A., Dalmagro, A. P., Wolin, I. A. V., Kaster, M. P., & Rodrigues, A. L. S. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.09.057 · Cited by 26

All-Trans Retinoic Acid–Preconditioned Mesenchymal Stem Cells Improve Motor Function and Alleviate Tissue Damage After Spinal Cord Injury by Inhibition of HMGB1/NF-κB/NLRP3 Pathway Through Autophagy Activation

Gholaminejhad, M., Jameie, S. B., Abdi, M., Abolhassani, F., Mohammed, I., & Hassanzadeh, G. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-01977-0 · Cited by 27

Nrf2 and NF-κB/NLRP3 inflammasome pathways are involved in Prototheca bovis infections of mouse mammary gland tissue and mammary epithelial cells

Zhao, W., Deng, Z., Barkema, H. W., Xu, M., Gao, J., Liu, G., Lin, Y.-S., Kastelic, J. P., & Han, B. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.04.005 · Cited by 26

NOD-like Receptors—Emerging Links to Obesity and Associated Morbidities

Bauer, S., Hezinger, L., Rexhepi, F., Ramanathan, S., & Kufer, T. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108595 · Cited by 26

Hydrogen-rich saline regulates NLRP3 inflammasome activation in sepsis-associated encephalopathy rat model

Dumbuya, J. S., Chen, X., Du, J., Li, S., Liang, L., Xie, H., & Zeng, Q. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110758 · Cited by 26

Novel role for epalrestat: protecting against NLRP3 inflammasome-driven NASH by targeting aldose reductase

Shi, W., Xu, G., Gao, Y., Zhao, J., Liu, T., Zhao, J. W., Yang, H., Wei, Z., Li, H., Xu, A., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04380-4 · Cited by 26

The role of melatonin in amyloid beta-induced inflammation mediated by inflammasome signaling in neuronal cell lines

Nopparat, C., Boontor, A., Kutpruek, S., & Govitrapong, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-45220-1 · Cited by 29

Canakinumab: Promises and Future in Cardiometabolic Diseases and Malignancy

Dhorepatil, A., Ball, S., Ghosh, R. K., Kondapaneni, M. D., & Lavie, C. J. (2018) · The American Journal of Medicine · doi:10.1016/j.amjmed.2018.10.013 · Cited by 26

Inflammasome activation restrains the intracellular Neospora caninum proliferation in bovine macrophages

Wang, X., Gong, P., Zhang, N., Lu, L., Chen, S., Jia, L., Liu, X., Li, J., & Zhang, X. (2019) · Veterinary Parasitology · doi:10.1016/j.vetpar.2019.02.008 · Cited by 26

Increased extracellular vesicle miRNA-466 family in the bronchoalveolar lavage fluid as a precipitating factor of ARDS

Shikano, S., Gon, Y., Maruoka, S., Shimizu, T., Kozu, Y., Iida, Y., Hikichi, M., Takahashi, M., Okamoto, S., Tsuya, K., et al. (2019) · BMC Pulmonary Medicine · doi:10.1186/s12890-019-0876-9 · Cited by 27

Decoding mitochondria's role in immunity and cancer therapy

Zhang, Y., YAN, H. H., Wei, Y., & Wei, X. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189107 · Cited by 30

Defective RuO 2 Nanospheres Attenuate Osteoarthritis Progression via Suppressing the ROS/NLRP3/Caspase-1 Signaling Pathway

Lv, J., Faheem, M., Wang, Z., Qiao, C., Gu, X., Liu, Y., Li, W., Gong, W., Lv, Z., Fei, Y., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c04011 · Cited by 26

Nutritional Modulation of Innate Immunity: The Fat–Bile–Gut Connection

Chèvre, R., Silvestre-Roig, C., & Soehnlein, O. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.08.002 · Cited by 24

Salvianolic Acid B Alleviates Myocardial Ischemia Injury by Suppressing NLRP3 Inflammasome Activation via SIRT1-AMPK-PGC-1α Signaling Pathway

Li, Q., Zuo, Z., Pan, Y., Zhang, Q., Li, X., & Jiang, B. (2022) · Cardiovascular Toxicology · doi:10.1007/s12012-022-09760-8 · Cited by 25

SIRT3 Modulates Endothelial Mitochondrial Redox State during Insulin Resistance

Martino, E., Balestrieri, A., Anastasio, C., Maione, M., Mele, L. L., Cautela, D., Campanile, G., Balestrieri, M. L., & D’Onofrio, N. (2022) · Antioxidants · doi:10.3390/antiox11081611 · Cited by 25

Induction of heme oxygenas-1 attenuates NLRP3 inflammasome activation in lipopolysaccharide-induced mastitis in mice

Hu, X., Si, H., Li, S., Wang, W., Guo, J., Li, Y., Cao, Y., Fu, Y., & Zhang, N. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.09.007 · Cited by 25

Imeglimin Exhibits Novel Anti-Inflammatory Effects on High-Glucose-Stimulated Mouse Microglia through ULK1-Mediated Suppression of the TXNIP–NLRP3 Axis

Kato, H., Iwashita, K., Iwasa, M., Kato, S., Yamakage, H., Suganami, T., Tanaka, M., & Satoh‐Asahara, N. (2024) · Cells · doi:10.3390/cells13030284 · Cited by 26

Dapagliflozin prevents kidney podocytes pyroptosis via miR-155-5p/HO-1/NLRP3 axis modulation

Zhang, Z.-W., Ming-qiu, T., Liu, W., Song, Y., Gao, M.-J., Ni, P., Zhang, D., Mo, Q., & Zhao, B. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111785 · Cited by 28

Forskolin attenuates the NLRP3 inflammasome activation and IL-1β secretion in human macrophages

Chen, Y., Wen, J., Feng, J. J., Wang, Y. H., Li, T. F., Nurmi, K., Eklund, K. K., & Xing, D. M. (2019) · Pediatric Research · doi:10.1038/s41390-019-0418-4 · Cited by 24

Humanin Ameliorates Free Fatty Acid-Induced Endothelial Inflammation by Suppressing the NLRP3 Inflammasome

Li, W., Zhang, D., Yuan, W., Wang, C., Huang, Q. Y., & Luo, J. (2020) · ACS Omega · doi:10.1021/acsomega.0c01778 · Cited by 25

Circulating cell-free mitochondrial DNA in brain health and disease: A systematic review and meta-analysis

Park, S. S., Jeong, H., & Andreazza, A. C. (2021) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2021.1938214 · Cited by 27

Neurological Implications of COVID-19: Role of Redox Imbalance and Mitochondrial Dysfunction

Kaundal, R. K., Kalvala, A. K., & Kumar, A. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02412-y · Cited by 24

The Role of Microbiota in the Pathogenesis of Esophageal Adenocarcinoma

Gillespie, M., Rai, V., Agrawal, S., & Nandipati, K. C. (2021) · Biology · doi:10.3390/biology10080697 · Cited by 24

The Crucial Role of NLRP3 Inflammasome in Viral Infection-Associated Fibrosing Interstitial Lung Diseases

Effendi, W. I., & Nagano, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910447 · Cited by 24

MiR-30a-5p and miR-153-3p regulate LPS-induced neuroinflammatory response and neuronal apoptosis by targeting NeuroD1

Choi, H.-R., Ha, J. S., Kim, E.-A. L., Cho, S., & Yang, S.-J. (2022) · BMB Reports · doi:10.5483/bmbrep.2022.55.9.061 · Cited by 27

Targeting autophagy regulation in NLRP3 inflammasome-mediated lung inflammation in COVID-19

Yong, Y.-Y., Zhang, L., Hu, Y.-J., Wu, J., Yan, L., Pan, Y., Tang, Y., Yu, L., Law, B. Y. K., Yu, C., et al. (2022) · Clinical Immunology · doi:10.1016/j.clim.2022.109093 · Cited by 25

Effect of age on the risk of immune-related adverse events in patients receiving immune checkpoint inhibitors

Yang, K., Li, J., Sun, Z., Bai, C., & Zhao, L. (2023) · Clinical and Experimental Medicine · doi:10.1007/s10238-023-01055-8 · Cited by 25

Manual Acupuncture Suppresses the Expression of Proinflammatory Proteins Associated with the NLRP3 Inflammasome in the Hippocampus of SAMP8 Mice

Ding, N., Jiang, J. H., Lu, M., Hu, J., Xu, Y., Liu, X., & Li, Z. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/3435891 · Cited by 24

Effect of pulegone on the NLPR3 inflammasome during inflammatory activation of THP‑1 cells

Yang, Q., Liu, Q., Lv, H., Wang, F., Liu, R., & Zeng, N. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8327 · Cited by 25

The Causal Role of Mitochondrial Dynamics in Regulating Innate Immunity in Diabetes

Chang, Y., Lin, H., Shen, F., Su, Y., Chuang, J., Lin, T., Liou, C., Lin, C., Weng, S., & Wang, P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00445 · Cited by 23

The efficiency of cytosolic drug delivery using pH-responsive endosomolytic polymers does not correlate with activation of the NLRP3 inflammasome

Baljon, J. J., Dandy, A., Wang-Bishop, L., Wehbe, M., Jacobson, M. E., & Wilson, J. T. (2019) · Biomaterials Science · doi:10.1039/c8bm01643g · Cited by 24

Research Progress on the Potential Mechanisms of Acute Kidney Injury and Chronic Kidney Disease Induced by Proton Pump Inhibitors

Song, Z., & Gong, X. (2023) · Integrative Medicine in Nephrology and Andrology · doi:10.1097/imna-d-22-00027 · Cited by 25

Diversification of molecular pattern recognition in bacterial NLR-like proteins

(2024) · doi:10.1038/s41467-024-54214-0 · Cited by 23

A new perspective on the regulation of neuroinflammation in intracerebral hemorrhage: mechanisms of NLRP3 inflammasome activation and therapeutic strategies

He, K.-L., Yu, X., Xia, L., Xie, Y., Qi, E., Wan, L., Hua, X., & Jing, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1526786 · Cited by 25

Microbial Photosynthetic Oxygenation and Radiotherapeutic Sensitization Enables Pyroptosis Induction for Combinatorial Cancer Therapy

Li, T., Zhang, Q., Li, C., Yan-wei, S., Jiang, T., Yin, Y., Chang, M., Song, X., Zheng, X., Zhang, W., et al. (2025) · Advanced Materials · doi:10.1002/adma.202503138 · Cited by 23

The NLRP3 inflammasome: contributions to inflammation-related diseases

Chen, Y., Ye, X., Escames, G., Lei, W., Zhang, X., Li, M., Jing, T., Yao, Y., Qiu, Z., Wang, Z., et al. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00462-9 · Cited by 492

Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling

Kim, J. K., Jin, H. S., Suh, H., & Jo, E. (2017) · Immunology and Cell Biology · doi:10.1038/icb.2017.23 · Cited by 54

The Signaling Pathways Regulating NLRP3 Inflammasome Activation

Chen, M.-Y., Ye, X.-J., He, X.-H., & Ouyang, D.-Y. (2021) · Inflammation · doi:10.1007/s10753-021-01439-6 · Cited by 154

NLRP3 inflammasome: activation, regulation, and role in diseases

Zhou, R., Yan, Y., Jiang, W., & Jiang, H. (2017) · Scientia Sinica Vitae · doi:10.1360/n052016-00360 · Cited by 10

New progress on the activation mechanisms of NOD-like receptor, pyrin domain-containing 3 inflammasome

Wang, W., & Ma, Y. (2015) · Int J Immunol · doi:10.3760/cma.j.issn.1673-4394.2015.04.010