Molecular mechanisms regulating NLRP3 inflammasome activation

The Inflammasome

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A role for mitochondria in nlrp3 inflammasome activation

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The Inflammasomes

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Gout-associated uric acid crystals activate the NALP3 inflammasome

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Autophagy and Viruses: Adversaries or Allies?

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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Immunological and inflammatory functions of the interleukin-1 family

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Cryopyrin activates the inflammasome in response to toxins and ATP

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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Does NLRP3 Inflammasome and Aryl Hydrocarbon Receptor Play an Interlinked Role in Bowel Inflammation and Colitis-Associated Colorectal Cancer?

Ngui, I. Q. H., Perera, A. P., & Eri, R. D. (2020) · Molecules · doi:10.3390/molecules25102427 · Cited by 38

Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome

Wang, H., Shi, X., Qiu, M., Lv, S., Zheng, H., Niu, B., & Liu, H. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.47595 · Cited by 40

Flavonoids with Inhibitory Effects on NLRP3 Inflammasome Activation from Millettia velutina

Ma, X., Zhao, M., Tang, M., Xue, L., Zhang, R., Liu, L., Ni, H., Cai, X., Kuang, S., Hong, F., et al. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.0c00478 · Cited by 38

Auranofin Attenuates Non-Alcoholic Fatty Liver Disease by Suppressing Lipid Accumulation and NLRP3 Inflammasome-Mediated Hepatic Inflammation In Vivo and In Vitro

Hwangbo, H., Kim, M. Y., Ji, S. Y., Kim, S. Y., Lee, H., Kim, G., Park, C., Keum, Y., Hong, S. H., Cheong, J., et al. (2020) · Antioxidants · doi:10.3390/antiox9111040 · Cited by 38

Diphenyl diselenide protects motor neurons through inhibition of microglia-mediated inflammatory injury in amyotrophic lateral sclerosis

Zhang, C., Wang, H., Liang, W., Yang, Y., Cong, C., Wang, Y., Wang, S., Wang, X., Wang, D., Huo, D., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105457 · Cited by 38

Parthenolide ameliorates 3-nitropropionic acid-induced Huntington’s disease-like aberrations via modulating NLRP3 inflammasome, reducing microglial activation and inducing astrocyte shifting

Noureldeen, M. E., Shahin, N. N., Amin, H. A. A., El‐Sawalhi, M. M., & Ghaiad, H. R. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00917-5 · Cited by 37

Myeloid C/EBPβ deficiency reshapes microglial gene expression and is protective in experimental autoimmune encephalomyelitis

Pulido-Salgado, M., Vidal-Taboada, J. M., Barriga, G. G.-D., Serratosa, J., Valente, T., Castillo, P., Matalonga, J., Straccia, M., Canals, J. M., Valledor, A. F., et al. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0834-5 · Cited by 41

Development of covalent NLRP3 inflammasome inhibitors: Chemistry and biological activity

Bertinaria, M., Gastaldi, S., Marini, E., & Giorgis, M. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.11.013 · Cited by 38

Inflammasome expression is higher in ovarian tumors than in normal ovary

Luborsky, J. L., Barua, A., Edassery, S., Bahr, J. M., & Edassery, S. L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227081 · Cited by 38

Screening of PRRSV- and ASFV-encoded proteins involved in the inflammatory response using a porcine iGLuc reporter

Song, J., Li, K., Li, T., Zhao, G., Zhou, S., Li, H., Li, J., & Weng, C. (2020) · Journal of Virological Methods · doi:10.1016/j.jviromet.2020.113958 · Cited by 37

MiR-1224-5p attenuates polycystic ovary syndrome through inhibiting NOD-like receptor protein 3 inflammasome activation via targeting Forkhead box O 1

Li, Y., Yao, N., Gao, Y., Wang, Y., Bai, L., Xu, J., & Wang, H. (2021) · Bioengineered · doi:10.1080/21655979.2021.1987125 · Cited by 38

Therapeutic Implications of Ferroptosis in Renal Fibrosis

Zhang, Y., Mou, Y., Zhang, J., Suo, C., Zhou, H., Gu, M. J., Wang, Z., & Tan, R. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.890766 · Cited by 38

Relationship between Brain Metabolic Disorders and Cognitive Impairment: LDL Receptor Defect

Hong, D.-Y., Lee, D.-H., Lee, J., Lee, E.-C., Park, S.-W., Lee, M. R., & Oh, J. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158384 · Cited by 37

SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis

Khader, A., Yang, W.-L., Hansen, L. W., Rajayer, S. R., Prince, J. M., Nicastro, J. M., Coppa, G. F., & Wang, P. (2017) · Journal of Surgical Research · doi:10.1016/j.jss.2017.06.031 · Cited by 37

Application of Disulfiram and its Metabolites in Treatment of Inflammatory Disorders

Guo, W., Chen, S., Li, C., Xu, J., & Wang, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.795078 · Cited by 38

NLRP3 inflammasome in digestive diseases: From mechanism to therapy

Qiang, R., Li, Y., Dai, X.-C., & Lv, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.978190 · Cited by 39

NLRP3 Inflammasome in Stress-Related Neuropsychiatric Disorders: Mechanisms of Neuron–Microglia–Astrocyte Crosstalk, HPA Axis Dysregulation, and Therapeutic Perspective

Woźny-Rasała, I., & Ogłodek, E. A. (2025) · Biomolecules · doi:10.3390/biom15091344 · Cited by 47

The Role of Reactive Oxygen Species (ROS) in Periodontitis: A Potential Therapeutic Target

Yang, S., & Yang, X. (2025) · Immunity Inflammation and Disease · doi:10.1002/iid3.70301 · Cited by 40

Role of Chronic Administration of Antidepressant Drugs in the Prenatal Stress-Evoked Inflammatory Response in the Brain of Adult Offspring Rats: Involvement of the NLRP3 Inflammasome-Related Pathway

Trojan, E., Chamera, K., Bryniarska, N., Kotarska, K., Leśkiewicz, M., Regulska, M., & Basta‐Kaim, A. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1458-1 · Cited by 37

Breed, Diet, and Interaction Effects on Adipose Tissue Transcriptome in Iberian and Duroc Pigs Fed Different Energy Sources

Benítez, R., Trakooljul, N., Núñez, Y., Isabel, B., Muráni, E., de Mercado, E., Gómez-Izquierdo, E., Casco, J. M. G., López-Bote, C. J., Wimmers, K., et al. (2019) · Genes · doi:10.3390/genes10080589 · Cited by 38

Salvianolic Acid A Ameliorates Early-Stage Atherosclerosis Development by Inhibiting NLRP3 Inflammasome Activation in Zucker Diabetic Fatty Rats

Ma, Q., Yang, Q., Chen, J., Yu, C., Zhang, L., Zhou, W., & Chen, M. (2020) · Molecules · doi:10.3390/molecules25051089 · Cited by 36

Anti-inflammatory effect of selenium on lead-induced testicular inflammation by inhibiting NLRP3 inflammasome activation in chickens

Huang, H., Li, X., Wang, Z., Xu, L., Tian, Y., Zhao, Q., & Zheng, P. (2020) · Theriogenology · doi:10.1016/j.theriogenology.2020.06.015 · Cited by 36

Tranilast Directly Targets NLRP3 to Protect Melanocytes From Keratinocyte-Derived IL-1β Under Oxidative Stress

Zhuang, T., Li, S., Yi, X., Guo, S., Wang, Y., Chen, J., Liu, L., Jian, Z., Gao, T., Kang, P., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00588 · Cited by 36

N-acetylserotonin Derivative Exerts a Neuroprotective Effect by Inhibiting the NLRP3 Inflammasome and Activating the PI3K/Akt/Nrf2 Pathway in the Model of Hypoxic-Ischemic Brain Damage

Luo, X., Zeng, H., Fang, C., & Zhang, B. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03169-x · Cited by 36

Somatic Mutations and the Risk of Undifferentiated Autoinflammatory Disease in MDS: An Under-Recognized but Prognostically Important Complication

Watad, ‬., Kačar, M., Bragazzi, N. L., Zhou, Q., Jassam, M., Taylor, J., Roman, E., Smith, A. G., Jones, R. A., Amital, H., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.610019 · Cited by 37

The role of lysosomal ion channels in lysosome dysfunction

Kendall, R. L., & Holian, A. (2021) · Inhalation Toxicology · doi:10.1080/08958378.2021.1876188 · Cited by 38

Dissecting the Molecular Mechanisms Surrounding Post-COVID-19 Syndrome and Neurological Features

Mohamed, M. S., Johansson, A., Jonsson, J., & Schiöth, H. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084275 · Cited by 37

Quercetin ameliorates XIAP deficiency–associated hyperinflammation

Chiang, S. C. C., Owsley, E., Panchal, N., Chaturvedi, V., Terrell, C. E., Jordan, M. B., Mehta, P. A., Davies, S. M., Akeno, N., Booth, C., et al. (2022) · Blood · doi:10.1182/blood.2021014335 · Cited by 36

Fisetin, a Natural Polyphenol, Ameliorates Endometriosis Modulating Mast Cells Derived NLRP-3 Inflammasome Pathway and Oxidative Stress

Arangia, A., Marino, Y., Fusco, R., Siracusa, R., Cordaro, M., D’Amico, R., Macrì, F., Raffone, E., Impellizzeri, D., Cuzzocrea, S., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065076 · Cited by 36

Medicinal chemistry strategies targeting NLRP3 inflammasome pathway: A recent update from 2019 to mid-2023

Duan, M., Sun, L., He, X., Wang, Z., Hou, Y., & Zhao, Y. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115750 · Cited by 36

miR-369-3p Modulates Intestinal Inflammatory Response via BRCC3/NLRP3 Inflammasome Axis

Scalavino, V., Piccinno, E., Valentini, A. M., Schena, N., Armentano, R., Giannelli, G., & Serino, G. (2023) · Cells · doi:10.3390/cells12172184 · Cited by 36

Nutritional metabolomics in critical illness

Christopher, K. B. (2017) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000451 · Cited by 35

Exogenous hydrogen sulfide mitigates LPS + ATP-induced inflammation by inhibiting NLRP3 inflammasome activation and promoting autophagy in L02 cells

Wu, D., Zhong, P., Wang, J., & Wang, H. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03519-6 · Cited by 35

Vildagliptin inhibits high free fatty acid (FFA)-induced NLRP3 inflammasome activation in endothelial cells

Qi, Y., Du, X., Yao, X., & Zhao, Y. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1578783 · Cited by 34

Modulating Pro-inflammatory Cytokines, Tissue Damage Magnitude, and Motor Deficit in Spinal Cord Injury with Subventricular Zone-Derived Extracellular Vesicles

Ijaz, S., Mohammed, I., Gholaminejhad, M., Mokhtari, T., Akbari, M., & Hassanzadeh, G. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01437-2 · Cited by 35

Exogenous stromal cell-derived factor-1 (SDF-1) suppresses the NLRP3 inflammasome and inhibits pyroptosis in synoviocytes from osteoarthritic joints via activation of the AMPK signaling pathway

Wang, S., Mobasheri, A., Zhang, Y., Wang, Y., Dai, T., & Zhang, Z. (2021) · Inflammopharmacology · doi:10.1007/s10787-021-00814-x · Cited by 36

Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities

Zhang, C., Hu, Y., Sun, P., Hua, L., Liang, S., Ou, Y., Wu, D., Wu, X., Chen, H. H., Hao, Y., et al. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113417 · Cited by 34

Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome

Kim, H., Choi, Y. J., Kim, S. K., Kim, H., Jun, D. W., Yoon, K., Kim, N., Hwang, J., Kim, Y. M., Lim, S., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02345-1 · Cited by 35

Cochlear Immune Response in Presbyacusis: a Focus on Dysregulation of Macrophage Activity

Noble, K. V., Brown, L. N., Elvis, P. R., & Lang, H. (2021) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-021-00819-x · Cited by 37

Inhibitory Role of Berberine, an Isoquinoline Alkaloid, on NLRP3 Inflammasome Activation for the Treatment of Inflammatory Diseases

Sarbadhikary, P., George, B. P. A., & Abrahamse, H. (2021) · Molecules · doi:10.3390/molecules26206238 · Cited by 38

Development of novel oridonin analogs as specifically targeted NLRP3 inflammasome inhibitors for the treatment of dextran sulfate sodium-induced colitis

Pang, L., Liu, H., Quan, H., Sui, H., & Jia, Y. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114919 · Cited by 38

NLRP3 inflammasome activation after ischemic stroke

Han, P.-P., Han, Y., Shen, X.-Y., Gao, Z.-K., & Bi, X. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114578 · Cited by 35

Activation of ATP-sensitive potassium channel by iptakalim normalizes stress-induced HPA axis disorder and depressive behaviour by alleviating inflammation and oxidative stress in mouse hypothalamus

Zhao, X., Zhao, Z., Yang, D., Cao, L., Zhang, L., Ji, J., Gu, J., Huang, J.-Y., & Sun, X. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.01.026 · Cited by 34

INT-777, a bile acid receptor agonist, extenuates pancreatic acinar cells necrosis in a mouse model of acute pancreatitis

Li, B., Yang, N., Li, C., Li, C., Gao, K., Xie, X., Dong, X., Yang, J., Yang, Q., Tong, Z., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.05.120 · Cited by 34

Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation

Calzaferri, F., Narros‐Fernández, P., de Pascual, R., de Diego, A. M. G., Nicke, A., Egea, J., de Diego, A. M. G., & Ríos, C. D. L. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c02145 · Cited by 35

Mitochondria and Mitochondrial DNA: Key Elements in the Pathogenesis and Exacerbation of the Inflammatory State Caused by COVID-19

Valdés-Aguayo, J. J., Veloz, I. G., Badillo-Almaraz, J. I., Bernal‐Silva, S., Martínez-Vázquez, M. C., Juárez-Alcalá, V., Vargas-Rodríguez, J. R., Gaeta-Velasco, M. L., González-Fuentes, C., Ávila-Carrasco, L., et al. (2021) · Medicina · doi:10.3390/medicina57090928 · Cited by 37

Angiotensin II Triggers NLRP3 Inflammasome Activation by a Ca2+ Signaling-Dependent Pathway in Rat Cardiac Fibroblast Ang-II by a Ca2+-Dependent Mechanism Triggers NLRP3 Inflammasome in CF

Espitia-Corredor, J., Boza, P., Espinoza-Pérez, C., Lillo, J., Rimassa-Taré, C., Machuca, V., Osorio, J. M., Vivar, R., Bolívar, S., Pardo-Jiménez, V., et al. (2022) · Inflammation · doi:10.1007/s10753-022-01707-z · Cited by 34

Mitochondrial Modulations, Autophagy Pathways Shifts in Viral Infections: Consequences of COVID-19

Singh, S. P., Amar, S., Gehlot, P., Patra, S. K., Kanwar, N., & Kanwal, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158180 · Cited by 35

New insights into anti-diabetes effects and molecular mechanisms of dietary saponins

Zhou, Y., & Xu, B. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2101425 · Cited by 37

Inflammation-related signaling pathways in tendinopathy

Jiang, L., Liu, T., Lyu, K., Chen, Y., Lu, J., Wang, X., Long, L., & Li, S. (2023) · Open Life Sciences · doi:10.1515/biol-2022-0729 · Cited by 37

Targeting toll-like receptor 4 (TLR4) and the NLRP3 inflammasome: Novel and emerging therapeutic targets for hyperuricaemia nephropathy

Zhang, C., & Yang, Y. (2023) · Biomolecules and Biomedicine · doi:10.17305/bb.2023.9838 · Cited by 33

Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke

Yu, K., Fu, L., Cao, Y., Zeng, X., Zhang, Y., Chen, Y., Gao, J., Lu, B., Zhu, H., Gu, L., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c18035 · Cited by 36

Nrf2–Keap1 Pathway and NLRP3 Inflammasome in Parkinson’s Disease: Mechanistic Crosstalk and Therapeutic Implications

Jain, R., Vora, L. K., Nathiya, D., & Khatri, D. K. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05389-0 · Cited by 36

Effects of metal ions on caspase-1 activation and interleukin-1β release in murine bone marrow-derived macrophages

Ferko, M.-A., & Catelas, I. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199936 · Cited by 33

Long-term cigarette smoking suppresses NLRP3 inflammasome activation in oral mucosal epithelium and attenuates host defense against Candida albicans in a rat model

Ye, P., Wang, X., Ge, S., Chen, W., Wang, W., & Han, X. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.01.058 · Cited by 33

ROS-mediated NLRP3 inflammasome activation participates in the response against Neospora caninum infection

Li, L., Wang, X., Gong, P., Zhang, N., Zhang, X., Li, S., Li, X., Liu, S.-X., Zhang, X.-X., Li, W., et al. (2020) · Parasites & Vectors · doi:10.1186/s13071-020-04331-8 · Cited by 33

The Purinergic P2X7 Receptor-NLRP3 Inflammasome Pathway: A New Target in Alcoholic Liver Disease?

Daré, B. L., Ferron, P., & Gicquel, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042139 · Cited by 35

Use of Antioxidants for the Neuro-Therapeutic Management of COVID-19

Cárdenas‐Rodríguez, N., Bandala, C., Vanoye–Carlo, A., Ignacio‐Mejía, I., Gómez‐Manzo, S., Cruz, E. Y. H., Pedraza‐Chaverrí, J., Carmona‐Aparicio, L., & Hernández‐Ochoa, B. (2021) · Antioxidants · doi:10.3390/antiox10060971 · Cited by 34

A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling

Hasan, D., Shono, A., van Kalken, C. K., van der Spek, P. J., Krenning, E. P., & Kotani, T. (2021) · Purinergic Signalling · doi:10.1007/s11302-021-09814-6 · Cited by 35

Syringaresinol Resisted Sepsis-Induced Acute Lung Injury by Suppressing Pyroptosis Via the Oestrogen Receptor-β Signalling Pathway

Zhuo, Y., Yang, L., Li, D., Zhang, L., Zhang, Q., Zhang, S., Li, C., Cui, L., Hao, J., Li, J., et al. (2021) · Inflammation · doi:10.1007/s10753-021-01587-9 · Cited by 33

Intranasal curcumin and dexamethasone combination ameliorates inflammasome (NLRP3) activation in lipopolysachharide exposed asthma exacerbations

Jaiswal, A., Dash, D., & Singh, R. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115861 · Cited by 33

Exosomes Regulate NLRP3 Inflammasome in Diseases

Li, Z., Chen, X., Tao, J., Shi, A., Zhang, J., & Yu, P. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.802509 · Cited by 36

Upregulation of postsynaptic cAMP/PKA/CREB signaling alleviates copper(Ⅱ)-induced oxidative stress and pyroptosis in MN9D cells

Zhou, Q., Zhang, Y., Lu, L., Shi, W., Zhang, H., Qin, W., Wang, Y., Pu, Y., & Yin, L. (2023) · Toxicology · doi:10.1016/j.tox.2023.153582 · Cited by 33

Pyroptosis in bone loss

Li, X., Ji, L., Men, X., Chen, X., Zhi, M., He, S., & Chen, S. (2023) · APOPTOSIS · doi:10.1007/s10495-022-01807-z · Cited by 32

Interactions between PCSK9 and NLRP3 inflammasome signaling in atherosclerosis

Wang, Y., Fang, D., Yang, Q., You, J., Wang, L., Wu, J., Zeng, M., & Luo, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1126823 · Cited by 36

Cognition and Mental Health in Pediatric Patients Following COVID-19

Avittan, H., & Kustovs, D. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20065061 · Cited by 35

Pyroptosis: A spoiler of peaceful coexistence between cells in degenerative bone and joint diseases

Li, Z., Cheng, W., Gao, K., Liang, S., Ke, L., Wang, M., Fan, J., Li, D., Zhang, P., Xu, Z., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.06.010 · Cited by 37

NLRP3 Inflammasome Activation in Liver Disorders: From Molecular Pathways to Therapeutic Strategies

Ma, W., Wang, Y., & Liu, J. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s532908 · Cited by 38

Purinergic signalling links mechanical breath profile and alveolar mechanics with the pro-inflammatory innate immune response causing ventilation-induced lung injury

Hasan, D., Blankman, P., & Nieman, G. F. (2017) · Purinergic Signalling · doi:10.1007/s11302-017-9564-5 · Cited by 31

Amyloidogenic proteins associated with neurodegenerative diseases activate the NLRP3 inflammasome

Shao, Q.-H., Zhang, X., Yang, P., Yuan, Y., & Chen, N. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.05.027 · Cited by 33

Hydrogen sulfide mitigates myocardial inflammation by inhibiting nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome activation in diabetic rats

Jia, Q., Mehmood, S., Liu, X., Ma, S., & Yang, R. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370219899899 · Cited by 32

Titanium Ions Play a Synergistic Role in the Activation of NLRP3 Inflammasome in Jurkat T Cells

Li, X., Tang, L., Thu, Y. M., & Chen, D. (2020) · Inflammation · doi:10.1007/s10753-020-01206-z · Cited by 32

The NLRP3 inflammasome as a bridge between neuro-inflammation in metabolic and neurodegenerative diseases

Söderbom, G., & Zeng, B. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.03.023 · Cited by 32

Toll-Like Receptor 9 Is Involved in NLRP3 Inflammasome Activation and IL-1β Production Through Monosodium Urate-Induced Mitochondrial DNA

Kim, S., Park, K.-Y., & Choe, J. (2020) · Inflammation · doi:10.1007/s10753-020-01299-6 · Cited by 32

Zinc: Roles in pancreatic physiology and disease

Wang, M., Phadke, M., Packard, D. G., Yadav, D. K., & Gorelick, F. S. (2020) · Pancreatology · doi:10.1016/j.pan.2020.08.016 · Cited by 32

Pristimerin protects against inflammation and metabolic disorder in mice through inhibition of NLRP3 inflammasome activation

Zhao, Q., Bi, Y., Guo, J., Liu, Y.-X., Zhong, J., Pan, L., Tan, Y. L., & Yu, X. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00527-x · Cited by 31

Inhibition of NLRP3-inflammasome mediated IL-1β release by phenylpropanoic acid derivatives: in-silico and in-vitro approach

Kinra, M., Joseph, A., Nampoothiri, M., Arora, D. S., & Mudgal, J. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105637 · Cited by 33

Pinocembrin relieves lipopolysaccharide and bleomycin induced lung inflammation via inhibiting TLR4-NF-κB-NLRP3 inflammasome signaling pathway

Gan, W., Li, X., Cui, Y., Xiao, T., Liu, R., Wang, M., Wei, Y., Cui, M., Ren, S., Helian, K., et al. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107230 · Cited by 35

Anthocyanins from Hibiscus syriacus L. Inhibit NLRP3 Inflammasome in BV2 Microglia Cells by Alleviating NF‐κB‐ and ER Stress‐Induced Ca2+ Accumulation and Mitochondrial ROS Production

Molagoda, I. M. N., Lee, K. T., Choi, Y. H., Jayasingha, J. A. C. C., & Kim, G. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1246491 · Cited by 33

Melatonin attenuates prostatic inflammation and pelvic pain via Sirt1‐dependent inhibition of the NLRP3 inflammasome in an EAP mouse model

Chen, J., Zhang, L., Du, H., Zhan, C., Liu, Y., Zhang, M., Chen, X., Wen, L., Zhang, L., & Liang, C. Y. (2021) · The Prostate · doi:10.1002/pros.24214 · Cited by 32

The NLRP3 Inflammasome as a Novel Therapeutic Target for Cardiac Fibrosis

Fan, J., Ren, M., Adhikari, B. K., Wang, H., & He, Y. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s370483 · Cited by 32

NLRP3 Inflammasome in Atherosclerosis: Putting Out the Fire of Inflammation

Shao, B., Xu, H., Zhao, Y.-C., Zheng, X.-R., Wang, F., & Zhao, G.-R. (2022) · Inflammation · doi:10.1007/s10753-022-01725-x · Cited by 34

Candida tropicalis induces NLRP3 inflammasome activation via glycogen metabolism-dependent glycolysis and JAK-STAT1 signaling pathway in myeloid-derived suppressor cells to promote colorectal carcinogenesis

Zhang, Z., Chen, Y., Yin, Y., Chen, Y., Chen, Q., Bing, Z., Zheng, Y., Hou, Y., Shen, S., Chen, Y., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109430 · Cited by 32

Medicinal Plants, Phytochemicals and Regulation of the NLRP3 Inflammasome in Inflammatory Bowel Diseases: A Comprehensive Review

Direito, R., Barbalho, S. M., Figueira, M. E., Minniti, G., de Carvalho, G. M., de Oliveira Zanuso, B., de Oliveira dos Santos, A. R., de Góes Corrêa, N., Rodrigues, V. D., de Alvares Goulart, R., et al. (2023) · Metabolites · doi:10.3390/metabo13060728 · Cited by 32

Rusty Microglia: Trainers of Innate Immunity in Alzheimer's Disease

Sfera, A., Gradini, R., Cummings, M., Diaz, E. L., Price, A. I., & Osorio, C. P. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01062 · Cited by 32

Mitochondrial dysfunction and inflammasome activation in neurodegenerative diseases: Mechanisms and therapeutic implications

Hamzeh, O., Rabiei, F., Shakeri, M., Parsian, H., Saadat, P., & Rostami-Mansoor, S. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.10.003 · Cited by 32

Silica nanoparticles activate purinergic signaling via P2X 7 receptor in dendritic cells, leading to production of pro-inflammatory cytokines

Nakanishi, K., Tsukimoto, M., Tanuma, S.-I., Takeda, K., & Kojima, S. (2016) · Toxicology in Vitro · doi:10.1016/j.tiv.2016.06.003 · Cited by 31

Group A Streptococcus Encounters with Host Macrophages

Valderrama, J. A., & Nizet, V. (2017) · Future Microbiology · doi:10.2217/fmb-2017-0142 · Cited by 34

UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells

Korhonen, E., Bisevac, J., Hyttinen, J. M. T., Piippo, N., Hytti, M., Kaarniranta, K., Petrovski, G., & Kauppinen, A. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.4.7 · Cited by 31

The Role of the Effects of Endoplasmic Reticulum Stress on NLRP3 Inflammasome in Diabetes

Lv, S.-Y., Li, X.-T., & Wang, H.-G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.663528 · Cited by 29

Ethyl Pyruvate Attenuates Microglial NLRP3 Inflammasome Activation via Inhibition of HMGB1/NF-κB/miR-223 Signaling

Olcum, M., Tüfekçi, K. U., Durur, D. Y., Tastan, B., atay, I. N. G., Genç, K., & Genç, Ş. (2021) · Antioxidants · doi:10.3390/antiox10050745 · Cited by 31

Dexmedetomidine alleviates inflammation in neuropathic pain by suppressing NLRP3 via Nrf2 activation

Shan, W., Liao, X., Tang, Y., & Liu, J. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10479 · Cited by 31

Danggui Buxue Tang Ameliorates Bleomycin-Induced Pulmonary Fibrosis by Suppressing the TLR4/NLRP3 Signaling Pathway in Rats

Wang, J., Wang, H., Fang, F., Fang, C., Wang, S., Lu, C., & Liu, N. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/8030143 · Cited by 32

Mitochondria in Injury, Inflammation and Disease of Articular Skeletal Joints

Early, J. O., Fagan, L. E., Curtis, A. M., & Kennedy, O. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.695257 · Cited by 33

Aspergillus niger fermented Tartary buckwheat ameliorates obesity and gut microbiota dysbiosis through the NLRP3/Caspase-1 signaling pathway in high-fat diet mice

Huang, Y., Zhang, K., Guo, W., Zhang, C., Chen, H., Xu, T., Lu, Y., Wu, Q.-X., Li, Y., & Chen, Y. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105171 · Cited by 31

Inflammasome Complexes: Crucial mediators in osteoimmunology and bone diseases.

Zhou, F., Zhang, G., Wu, Y.-Y., & Xiong, Y. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109072 · Cited by 26

Mast Cell Cytokines in Acute and Chronic Gingival Tissue Inflammation: Role of IL-33 and IL-37

Trimarchi, M., Lauritano, D., Ronconi, G., Caraffa, A., Gallenga, C. E., Frydas, I., Kritas, S. K., Calvisi, V., & Conti, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113242 · Cited by 33

DTX3L induced NLRP3 ubiquitination inhibit R28 cell pyroptosis in OGD/R injury

Zhou, Z., Shang, L., Zhāng, Q., Hu, X., Huang, J.-F., & Xiong, K. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119433 · Cited by 32

Oleanolic acid acetate attenuates polyhexamethylene guanidine phosphate-induced pulmonary inflammation and fibrosis in mice

Kim, M., Han, J.-Y., Kim, S. H., Jeon, D., Kim, H.-Y., Lee, S. W., Rho, M., & Lee, K. (2018) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2018.03.001 · Cited by 30

Guanylate-binding proteins at the crossroad of noncanonical inflammasome activation during bacterial infections

Gomes, M. T. R., Cerqueira, D. M., Guimarães, E. S., Campos, P. C., & Oliveira, S. C. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mr0119-013r · Cited by 32

The NLRP3 inflammasome: contributions to inflammation-related diseases

Chen, Y., Ye, X., Escames, G., Lei, W., Zhang, X., Li, M., Jing, T., Yao, Y., Qiu, Z., Wang, Z., et al. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00462-9 · Cited by 492

Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling

Kim, J. K., Jin, H. S., Suh, H., & Jo, E. (2017) · Immunology and Cell Biology · doi:10.1038/icb.2017.23 · Cited by 54

The Signaling Pathways Regulating NLRP3 Inflammasome Activation

Chen, M.-Y., Ye, X.-J., He, X.-H., & Ouyang, D.-Y. (2021) · Inflammation · doi:10.1007/s10753-021-01439-6 · Cited by 154

NLRP3 inflammasome: activation, regulation, and role in diseases

Zhou, R., Yan, Y., Jiang, W., & Jiang, H. (2017) · Scientia Sinica Vitae · doi:10.1360/n052016-00360 · Cited by 10

New progress on the activation mechanisms of NOD-like receptor, pyrin domain-containing 3 inflammasome

Wang, W., & Ma, Y. (2015) · Int J Immunol · doi:10.3760/cma.j.issn.1673-4394.2015.04.010