Molecular mechanisms regulating NLRP3 inflammasome activation

The Inflammasome

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The Inflammasomes

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Gout-associated uric acid crystals activate the NALP3 inflammasome

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Autophagy and Viruses: Adversaries or Allies?

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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Cryopyrin activates the inflammasome in response to toxins and ATP

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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Rapamycin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting IL-1β and IL-18 production

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Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome

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The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer

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NLRP3 inflammasome: a new therapeutic target for high-risk reproductive disorders?

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Xiaoyaosan Improves Antibiotic-Induced Depressive-Like and Anxiety-Like Behavior in Mice Through Modulating the Gut Microbiota and Regulating the NLRP3 Inflammasome in the Colon

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ALDOA maintains NLRP3 inflammasome activation by controlling AMPK activation

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Evodiamine Augments NLRP3 Inflammasome Activation and Anti-bacterial Responses Through Inducing α-Tubulin Acetylation

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Multi-Target Effects of ß-Caryophyllene and Carnosic Acid at the Crossroads of Mitochondrial Dysfunction and Neurodegeneration: From Oxidative Stress to Microglia-Mediated Neuroinflammation

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Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions

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The Role of Post-Translational Modifications in Regulation of NLRP3 Inflammasome Activation

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Control of Inflammasome Activation by Phosphorylation

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Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production

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27-Hydroxycholesterol Contributes to Lysosomal Membrane Permeabilization-Mediated Pyroptosis in Co-cultured SH-SY5Y Cells and C6 Cells

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NLRP3 inflammasome and NLRP3-related autoinflammatory diseases: From cryopyrin function to targeted therapies

Moltrasio, C., Romagnuolo, M., & Marzano, A. V. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1007705 · Cited by 71

Questions and controversies in innate immune research: what is the physiological role of NLRP3?

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Cellular senescence induced by S100A9 in mesenchymal stromal cells through NLRP3 inflammasome activation

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H3 relaxin inhibits the collagen synthesis via ROS‐ and P2X7R‐mediated NLRP3 inflammasome activation in cardiac fibroblasts under high glucose

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Acute stress induces chronic neuroinflammatory, microglial and behavioral priming: A role for potentiated NLRP3 inflammasome activation

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Chronic oral exposure to cadmium causes liver inflammation by NLRP3 inflammasome activation in pubertal mice

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Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis

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The Role of Melatonin on NLRP3 Inflammasome Activation in Diseases

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Repetitive transcranial magnetic stimulation exerts anti-inflammatory effects via modulating glial activation in mice with chronic unpredictable mild stress-induced depression

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Nanomaterials and Innate Immunity: A Perspective of the Current Status in Nanosafety

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Is There a Link Between the Pathogenic Human Coronavirus Envelope Protein and Immunopathology? A Review of the Literature

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Transcriptomic analysis identifies Toll‐like and Nod‐like pathways and necroptosis in pulmonary arterial hypertension

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Inhibition of NLRP3 Inflammasome Prevents LPS-Induced Inflammatory Hyperalgesia in Mice: Contribution of NF-κB, Caspase-1/11, ASC, NOX, and NOS Isoforms

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The NLRP3 Inflammasome: An Important Driver of Neuroinflammation in Hemorrhagic Stroke

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Nano-sized zinc oxide and silver, but not titanium dioxide, induce innate and adaptive immunity and antiviral response in differentiated THP-1 cells

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NLRX1 modulates differentially NLRP3 inflammasome activation and NF-κB signaling during Fusobacterium nucleatum infection

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Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling

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Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?

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Regulation of the NLRP3 Inflammasome by Posttranslational Modifications

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Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression

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NLRP3 inflammasome in health and disease (Review)

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Aspartate Metabolism Facilitates IL-1β Production in Inflammatory Macrophages

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NLRP3-mediated pyroptosis in diabetic nephropathy

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Comparison of Inhibitory Capacities of 6-, 8- and 10-Gingerols/Shogaols on the Canonical NLRP3 Inflammasome-Mediated IL-1β Secretion

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Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome

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An emerging interplay between extracellular vesicles and cytokines

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Spirulina maxima extract prevents activation of the NLRP3 inflammasome by inhibiting ERK signaling

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The Association of Major Depressive Disorder with Activation of NLRP3 Inflammasome, Lipid Peroxidation, and Total Antioxidant Capacity

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Transitions in metabolic and immune systems from pre-menopause to post-menopause: implications for age-associated neurodegenerative diseases

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Fisetin Attenuates Diabetic Nephropathy-Induced Podocyte Injury by Inhibiting NLRP3 Inflammasome

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Innate immunomodulation to trypanosomatid parasite infections

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Relationships Between Ion Channels, Mitochondrial Functions and Inflammation in Human Aging

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Electrical stimulation inhibits Val-boroPro-induced pyroptosis in THP-1 macrophages via sirtuin3 activation to promote autophagy and inhibit ROS generation

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Inhibiting NLRP3 inflammasome with MCC950 ameliorates perioperative neurocognitive disorders, suppressing neuroinflammation in the hippocampus in aged mice

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The Interplay between Autophagy and NLRP3 Inflammasome in Ischemia/Reperfusion Injury

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Estrogen plays an important role by influencing the NLRP3 inflammasome

Dong, W., Peng, Q., Liu, Z., Xie, Z., Guo, X., Li, Y., & Chen, C. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115554 · Cited by 68

GPCRs in NLRP3 Inflammasome Activation, Regulation, and Therapeutics

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Major depression model induced by repeated and intermittent lipopolysaccharide administration: Long-lasting behavioral, neuroimmune and neuroprogressive alterations

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Mitochondria in Focus: From Function to Therapeutic Strategies in Chronic Lung Diseases

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Interplay between early-life malnutrition, epigenetic modulation of the immune function and liver diseases

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The Role of Connexin and Pannexin Channels in Perinatal Brain Injury and Inflammation

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TMA/TMAO in Hypertension: Novel Horizons and Potential Therapies

Zhang, W., Wang, Y., Zhang, A., Ding, Y., Zhang, X., Jia, Q.-J., Zhu, Y., Li, Y., Lv, S., & Zhang, J. (2021) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-021-10115-x · Cited by 59

Host cell-intrinsic innate immune recognition of SARS-CoV-2

Madden, E. A., & Diamond, M. S. (2021) · Current Opinion in Virology · doi:10.1016/j.coviro.2021.11.002 · Cited by 60

Revisiting Regulated Cell Death Responses in Viral Infections

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MD-2 regulates LPS-induced NLRP3 inflammasome activation and IL-1beta secretion by a MyD88/NF-κB-dependent pathway in alveolar macrophages cell line

Luo, M., Hu, L., Li, D., Wang, Y., He, Y., Zhu, L., & Ren, W. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.06.035 · Cited by 59

Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1β secretion in human trophoblasts

Tamura, K., Ishikawa, G., Yoshie, M., Ohneda, W., Nakai, A., Takeshita, T., & Tachikawa, E. (2017) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2017.09.032 · Cited by 59

The rOX‐stars of inflammation: links between the inflammasome and mitochondrial meltdown

Holley, C. L., & Schroder, K. (2020) · Clinical & Translational Immunology · doi:10.1002/cti2.1109 · Cited by 61

Neuroprotective Effect of Oridonin on Traumatic Brain Injury via Inhibiting NLRP3 Inflammasome in Experimental Mice

Yan, C., Yan, H., Mao, J., Liu, Y., Li, X., Zhao, H., Shen, J., Cao, Y. W., Gao, Y., Li, K., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.557170 · Cited by 58

The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3

Tang, T., Li, P., Zhou, X., Wang, R., Fan, X., Yang, M., & Qi, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.741839 · Cited by 61

A review: Pharmacology and pharmacokinetics of Schisandrin A

Fu, K., Zhou, H., Wang, C., Gong, L., Ma, C., Zhang, Y., & Li, Y. (2022) · Phytotherapy Research · doi:10.1002/ptr.7456 · Cited by 60

Interaction between autophagy and the NLRP3 inflammasome in Alzheimer’s and Parkinson’s disease

Lu, R., Zhang, L., & Yang, X. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1018848 · Cited by 58

MCC950 attenuated early brain injury by suppressing NLRP3 inflammasome after experimental SAH in rats

Luo, Y., Lü, J., Ruan, W., Guo, X., & Chen, S. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.01.027 · Cited by 58

The Mechanosensitive Ion Channel PIEZO1 in Intestinal Epithelial Cells Mediates Inflammation through the NOD-Like Receptor 3 Pathway in Crohn’s Disease

Liu, Q., Didi, W., Yang, X., Ma, F., Han, W., Hu, J., & Mei, Q. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izac152 · Cited by 58

Activation of the NLRP3 Inflammasome Pathway by Uropathogenic Escherichia coli Is Virulence Factor-Dependent and Influences Colonization of Bladder Epithelial Cells

Demirel, I., Persson, A., Brauner, A., Särndahl, E., Kruse, R. L., & Persson, K. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00081 · Cited by 57

1,25-Dihydroxy Vitamin D3 Attenuates the Oxidative Stress-Mediated Inflammation Induced by PM2.5via the p38/NF-κB/NLRP3 Pathway

Xin, L., Che, B., Zhai, B., Luo, Q., Zhang, C., Wang, J., Wang, S., Fan, G., Liu, Z., Feng, J., et al. (2018) · Inflammation · doi:10.1007/s10753-018-0928-y · Cited by 57

The involvement of NLRP3 inflammasome in the treatment of neurodegenerative diseases

Feng, Y.-S., Tan, Z., Wu, L., Dong, F., & Zhang, F. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111428 · Cited by 59

NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle

Jorquera, G., Russell‐Guzmán, J., Monsalves‐Álvarez, M., Cruz, G., Valladares-Ide, D., Basualto-Alarcón, C., Barrientos, G. C., Estrada, M., & Llanos, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063254 · Cited by 61

Medicinal plants and bioactive natural products as inhibitors of NLRP3 inflammasome

Bagherniya, M., Khedmatgozar, H., Fakheran, O., Xu, S., Johnston, T. P., & Sahebkar, A. (2021) · Phytotherapy Research · doi:10.1002/ptr.7118 · Cited by 60

Cell death in skin function, inflammation, and disease

Anderton, H., & Alqudah, S. (2022) · Biochemical Journal · doi:10.1042/bcj20210606 · Cited by 64

Microglial NLRP3 inflammasome activation mediates diabetes-induced depression-like behavior via triggering neuroinflammation

Su, W., Li, J.-M., Zhang, T., Cao, Z., Hu, T., Zhong, S.-Y., Xu, Z.-Y., Gong, H., & Jiang, C. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110796 · Cited by 57

Ginsenosides for therapeutically targeting inflammation through modulation of oxidative stress

Paik, S., Song, G., & Jo, E. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110461 · Cited by 58

The NLRP 3 inflammasome contributes to host protection during Sporothrix schenckii infection

Gonçalves, A. C., Ferreira, L. S., Manente, F. A., de Faria, C. M. Q. G., Polesi, M. C., de Andrade, C. R., Zamboni, D. S., & Carlos, I. Z. (2017) · Immunology · doi:10.1111/imm.12719 · Cited by 55

Acrylamide induces NLRP3 inflammasome activation via oxidative stress- and endoplasmic reticulum stress-mediated MAPK pathway in HepG2 cells.

Nan, B., Hong, Y.-L., Yang, C., Li, L., & Yuan, Y. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111679 · Cited by 50

Cathepsin B regulates non‐canonical NLRP 3 inflammasome pathway by modulating activation of caspase‐11 in Kupffer cells

Chen, N., Ou, Z.-B., Zhang, W., Zhu, X., Li, P., & Gong, J. (2018) · Cell Proliferation · doi:10.1111/cpr.12487 · Cited by 55

Innate immunity and HPV: friends or foes

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Hepatic nuclear factor kappa B signaling pathway and NLR family pyrin domain containing 3 inflammasome is over-activated in ketotic dairy cows

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The NLRP3 Inflammasome and Its Role in T1DM

Sun, X., Pang, H., Li, J., Luo, S., Huang, G., Li, X., Xie, Z., & Zhou, Z. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01595 · Cited by 57

Dopamine activates NF-κB and primes the NLRP3 inflammasome in primary human macrophages

Nolan, R. A., Reeb, K. L., Rong, Y., Matt, S. M., Johnson, H. S., Runner, K., & Gaskill, P. J. (2019) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2019.100030 · Cited by 54

COVID‐19 immunopathology: From acute diseases to chronic sequelae

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Inflammasomes: Emerging Central Players in Cancer Immunology and Immunotherapy

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