The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Acute inflammation stimulates a regenerative response in the neonatal mouse heart
Open accessAbstract
Cardiac injury in neonatal 1-day-old mice stimulates a regenerative response characterized by reactive cardiomyocyte proliferation, which is distinguished from the fibrotic repair process in adults. Acute inflammation occurs immediately after heart injury and has generally been believed to exert a negative effect on heart regeneration by promoting scar formation in adults; however, little is known about the role of acute inflammation in the cardiac regenerative response in neonatal mice. Here, we show that acute inflammation induced cardiomyocyte proliferation after apical intramyocardial microinjection of immunogenic zymosan A particles into the neonatal mouse heart. We also found that cardiac injury-induced regenerative response was suspended after immunosuppression in neonatal mice, and that cardiomyocytes could not be reactivated to proliferate after neonatal heart injury in the absence of interleukin-6 (IL-6). Furthermore, cardiomyocyte-specific deletion of signal transducer and activator of transcription 3 (STAT3), the major downstream effector of IL-6 signaling, decreased reactive cardiomyocyte proliferation after apical resection. Our results indicate that acute inflammation stimulates the regenerative response in neonatal mouse heart, and suggest that modulation of inflammatory signals might have important implications in cardiac regenerative medicine.
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Cahill, T. J., Choudhury, R. P., & Riley, P. R. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.106 · Cited by 312
Mechanisms of Cardiac Regeneration
Uygur, A., & Lee, R. T. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.01.018 · Cited by 286
Cell-cell interactions in the heart: advanced cardiac models and omics technologies
Tan, S., Yang, J., Hu, S., & Lei, W. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03982-z · Cited by 30
Self-citation
Metadata
- Authors
- Han, C., Nie, Y., Lian, H., Liu, R., He, F., Huang, H., & Hu, S.
- Venue
- Cell Research
- Published
- 2015-09-11
- Volume
- 25
- Issue
- 10
- Pages
- 1137-1151
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- OpenAlex
- W2132272306
- Cited by
- 172
- References
- 17
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Han, C., Nie, Y., Lian, H., Liu, R., He, F., Huang, H., & Hu, S. (2015). Acute inflammation stimulates a regenerative response in the neonatal mouse heart. Cell Research. https://doi.org/10.1038/cr.2015.110
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