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Mitotic and mitogenic Wnt signalling
Open accessAbstract
Canonical Wnt signalling plays an important role in development, tissue homeostasis, and cancer. At the cellular level, canonical Wnt signalling acts by regulating cell fate, cell growth, and cell proliferation. With regard to proliferation, there is increasing evidence for a complex interaction between canonical Wnt signalling and the cell cycle. Mitogenic Wnt signalling regulates cell proliferation by promoting G1 phase. In mitosis, components of the Wnt signalling cascade function directly in spindle formation. Moreover, Wnt signalling is strongly activated in mitosis, suggesting that 'mitotic Wnt signalling' plays an important role to orchestrate a cell division program. Here, we review the complex interplay between Wnt signalling and the cell cycle.
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“A role for Wnt signaling during M phase has also been suggested based on high Wnt/β-catenin signaling activity during cell division, through an unknown mechanism (39, 40).”
From Wnt signaling regulates hepatocyte cell division by a transcriptional repressor cascade (2022) · cites this paper as [39]
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“High Wnt/βcatenin signaling activity during cell division has suggested a link between Wnt signaling and mitosis through unknown mechanisms (Benham-Pyle et al. 2016;Niehrs and Acebron 2012).”
From Hepatocyte Cell Cycle Progression Depends on a Transcriptional Repressor Cascade Downstream of Wnt Signaling (2021) · cites this paper as Niehrs and Acebron 2012
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Metadata
- Authors
- Niehrs, C., & Acebron, S. P.
- Affiliations
- German Cancer Research Center (DE)
- Corresponding author
- Niehrs, Christof
- ORCID
- Niehrs, Christof
- Venue
- The EMBO Journal
- Published
- 2012-05-22
- Volume
- 31
- Issue
- 12
- Pages
- 2705-2713
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC3380213
- OpenAlex
- W1880424969
- Cited by
- 305
- References
- 137
- Citations by year
- 2026: 6 · 2025: 20 · 2024: 21 · 2023: 22 · 2022: 18 · 2021: 33 · 2020: 25 · 2019: 16 · 2018: 25 · 2017: 32 · 2016: 18 · 2015: 25 · 2014: 21 · 2013: 17 · 2012: 6
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Wnt signaling, cell cycle, cell proliferation, G1 phase, mitosis, spindle assembly, cell division, cell fate
- MeSH terms
- Animals, Cell Differentiation, Gene Expression Regulation, Humans, Mitosis, Models, Biological, Neoplasms, Cell Proliferation, Wnt Proteins, Wnt Signaling Pathway
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