Mitotic and mitogenic Wnt signalling

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

MacDonald, B. T., Tamai, K., & He, X. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.016 · Cited by 5,583

Wnt/β-Catenin Signaling in Development and Disease

Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568

Identification of c- MYC as a Target of the APC Pathway

He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

Morin, P. J., Sparks, A. B., Kořínek, V., Barker, N., Clevers, H. C., Vogelstein, B., & Kinzler, K. W. (1997) · Science · doi:10.1126/science.275.5307.1787 · Cited by 4,000

Cell cycle, CDKs and cancer: a changing paradigm

Malumbres, M., & Barbacid, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2602 · Cited by 3,957 · cited 5×

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Grundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M., Wisniewski, H. M., & Binder, L. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4913 · Cited by 3,676

Wnt signalling in stem cells and cancer

Reya, T., & Clevers, H. (2005) · Nature · doi:10.1038/nature03319 · Cited by 3,666

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

Tetsu, O., & McCormick, F. (1999) · Nature · doi:10.1038/18884 · Cited by 3,601

The ground state of embryonic stem cell self-renewal

Ying, Q.-L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., & Smith, A. (2008) · Nature · doi:10.1038/nature06968 · Cited by 3,442

β‐catenin is a target for the ubiquitin–proteasome pathway

Aberle, H., Bauer, A., Stappert, J., Kispert, A., & Kemler, R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.3797 · Cited by 2,586

Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells

Chen, X., Han, X., Yuan, P., Fang, F., Huss, M., Vega, V. B., Wong, E., Orlov, Y. L., Zhang, W., Jiang, J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.04.043 · Cited by 2,547

The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

Shtutman, M., Zhurinsky, J., Simcha, I., Albanese, C., D’Amico, M., Pestell, R., & Ben-Ze’ev, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5522 · Cited by 2,230

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21.

Toyoshima, H., & Hunter, T. (1994) · Cell · doi:10.1016/0092-8674(94)90573-8 · Cited by 2,208

A role for Wnt signalling in self-renewal of haematopoietic stem cells

Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159

Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

Sato, N., Meijer, L., Skaltsounis, A., Greengard, P., & Brivanlou, A. H. (2003) · Nature Medicine · doi:10.1038/nm979 · Cited by 2,139

Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

Diehl, J. A., Cheng, M., Roussel, M. F., & Sherr, C. J. (1998) · Genes & Development · doi:10.1101/gad.12.22.3499 · Cited by 2,130

MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,030

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A.-P., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01014-0 · Cited by 2,030

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

Nusse, R., & VARMUS, H. E. (1982) · Cell · doi:10.1016/0092-8674(82)90409-3 · Cited by 1,864

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

Kořínek, V., Barker, N., Moerer, P., van Donselaar, E. V., Huls, G., Peters, P., & Clevers, H. (1998) · Nature Genetics · doi:10.1038/1270 · Cited by 1,704

Cyclin D1 is a nuclear protein required for cell cycle progression in G1

Baldin, V, Lukas, J., Marcote, M. J., Pagano, M., & Draetta, G. (1993) · Genes & Development · doi:10.1101/gad.7.5.812 · Cited by 1,614

Linking Colorectal Cancer to Wnt Signaling

Bienz, M., & Clevers, H. C. (2000) · Cell · doi:10.1016/s0092-8674(00)00122-7 · Cited by 1,518

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

Chen, B., Dodge, M. E., Tang, W., Lü, J., Ma, Z., Fan, C.-W., Wei, S., Hao, W., Kilgore, J. A., Williams, N. S., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.137 · Cited by 1,402

TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth

Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Zhang, X., Yang, Q., Bennett, C., Harada, Y., Stankunas, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.055 · Cited by 1,377

Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1

Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., & Elledge, S. J. (1997) · Science · doi:10.1126/science.277.5331.1497 · Cited by 1,320

Epidermal homeostasis: a balancing act of stem cells in the skin

Blanpain, C., & Fuchs, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2636 · Cited by 1,270

G1 cell-cycle control and cancer

Massagué, J. (2004) · Nature · doi:10.1038/nature03094 · Cited by 1,251

Towards an integrated view of Wnt signaling in development

van Amerongen, R., & Nusse, R. (2009) · Development · doi:10.1242/dev.033910 · Cited by 1,213

c-MYC: more than just a matter of life and death

Pelengaris, S., Khan, M., & Evan, G. I. (2002) · Nature reviews. Cancer · doi:10.1038/nrc904 · Cited by 1,192

LDL-receptor-related proteins in Wnt signal transduction

Tamai, K., Semenov, M., Kato, Y., Spokony, R., Liu, C., Katsuyama, Y., Hess, F., Saint-Jeannet, J.-P., & He, X. (2000) · Nature · doi:10.1038/35035117 · Cited by 1,128

WNT Signals Are Required for the Initiation of Hair Follicle Development

Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00167-3 · Cited by 1,088

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.

Drechsel, D. N., Hyman, A. A., Cobb, M. H., & Kirschner, M. W. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.10.1141 · Cited by 1,011

Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

DasGupta, R., & Fuchs, E. V. (1999) · Development · doi:10.1242/dev.126.20.4557 · Cited by 995

Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation

Bilić, J., Huang, Y., Davidson, G. R., Zimmermann, T., Cruciat, C., Bienz, M., & Niehrs, C. (2007) · Science · doi:10.1126/science.1137065 · Cited by 954

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

Welcker, M., Orian, A., Jin, J., Grim, J. A., Harper, J. W., Eisenman, R. N., & Clurman, B. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402770101 · Cited by 942

Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding

Bramblett, G. T., Goedert, M., Jakes, R., Merrick, S. E., Trojanowski, J. Q., & Lee, V. M. Y. (1993) · Neuron · doi:10.1016/0896-6273(93)90057-x · Cited by 903

Inactivation of glycogen synthase kinase-3 β by phosphorylation: new kinase connections in insulin and growth-factor signalling

Sutherland, C., Leighton, I. A., & Cohen, P. (1993) · Biochemical Journal · doi:10.1042/bj2960015 · Cited by 903

Association of human cyclin E with a periodic G1-S phase protein kinase

Dulić, V., Lees, E. M., & Reed, S. I. (1992) · Science · doi:10.1126/science.1329201 · Cited by 884

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

Zeng, X., Tamai, K., Doble, B. W., Li, S., Huang, H., Habas, R., Okamura, H., Woodgett, J. R., & He, X. (2005) · Nature · doi:10.1038/nature04185 · Cited by 872

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

Wehrli, M., Dougan, S. T., Caldwell, K. A., O’Keefe, L. V., Schwartz, S. L., Vaizel-Ohayon, D., Schejter, E. D., Tomlinson, A., & DiNardo, S. (2000) · Nature · doi:10.1038/35035110 · Cited by 871

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphomaPreprint

Weng, A. P., Millholland, J. M., Yashiro–Ohtani, Y., Arcangeli, M.-L., Lau, A. N., Wai, C., Bianco, C. D., Rodríguez, C. G., Sai, H., Tobias, J. W., et al. (2006) · Genes & Development · doi:10.1101/gad.1450406 · Cited by 863

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

Orford, K. W., & Scadden, D. T. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2269 · Cited by 851

A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration

Greco, V., Chen, T., Rendl, M., Schober, M., Pasolli, H. A., Stokes, N., dela Cruz-Racelis, J., & Fuchs, E. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2008.12.009 · Cited by 800

LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism

Cartwright, P., McLean, C. A., Sheppard, A. M., Rivett, D., Jones, K., & Dalton, S. (2005) · Development · doi:10.1242/dev.01670 · Cited by 790

Mining the Wnt pathway for cancer therapeutics

Barker, N., & Clevers, H. C. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2154 · Cited by 752

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase

Hanger, D. P., Hughes, K., Woodgett, J. R., Brion, J.-P., & Anderton, B. H. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90774-2 · Cited by 737

Signalling, cell cycle and pluripotency in embryonic stem cells

Burdon, T., Smith, A. T., & Savatier, P. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02352-8 · Cited by 727

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

Michel, L. S., Liberal, V., Chatterjee, A., Kirchwegger, R., Pasche, B., Gerald, W. L., Dobles, M., Sorger, P. K., Murty, V. V. V. S., & Benezra, R. (2001) · Nature · doi:10.1038/35053094 · Cited by 725

Mutations in the APC tumour suppressor gene cause chromosomal instability

Fodde, R., Kuipers, J., Rosenberg, C., Smits, R., Kielman, M. F., Gaspar, C., van Es, J. H., Breukel, C., Wiegant, J. C. A. G., Giles, R. H., et al. (2001) · Nature Cell Biology · doi:10.1038/35070129 · Cited by 722

Axonal Remodeling and Synaptic Differentiation in the Cerebellum Is Regulated by WNT-7a Signaling

Hall, A. C., Lucas, F. R., & Salinas, P. C. (2000) · Cell · doi:10.1016/s0092-8674(00)80689-3 · Cited by 699

A mitogen gradient of dorsal midline Wnts organizes growth in the CNS

Megason, S. G., & McMahon, A. P. (2002) · Development · doi:10.1242/dev.129.9.2087 · Cited by 681

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

Taelman, V. F., Dobrowolski, R., Plouhinec, J.-L., Fuentealba, L. C., Vorwald, P. P., Gumper, I., Sabatini, D. D., & De Robertis, E. M. (2010) · Cell · doi:10.1016/j.cell.2010.11.034 · Cited by 676

Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1

Kuhnert, F., Davis, C. R., Wang, H.-T., Chu, P., Lee, M., Yuan, J., Nusse, R., & Kuo, C. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536800100 · Cited by 669

Myc deletion rescues Apc deficiency in the small intestine

Sansom, O. J., Méniel, V. S., Muncan, V., Phesse, T. J., Wilkins, J. A., Reed, K. R., Vass, J. K., Athineos, D., Clevers, H. C., & Clarke, A. R. (2007) · Nature · doi:10.1038/nature05674 · Cited by 618

Active cyclin B1–Cdk1 first appears on centrosomes in prophase

Jackman, M. R., Lindon, C., Nigg, E. A., & Pines, J. (2003) · Nature Cell Biology · doi:10.1038/ncb918 · Cited by 614

A common human skin tumour is caused by activating mutations in β-catenin

Chan, E., Gat, U., McNiff, J. M., & Fuchs, E. (1999) · Nature Genetics · doi:10.1038/7747 · Cited by 612

Nanog and transcriptional networks in embryonic stem cell pluripotency

Pan, G., & Thomson, J. A. (2007) · Cell Research · doi:10.1038/sj.cr.7310125 · Cited by 606

Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction

Davidson, G. R., Wu, W., Shen, J., Bilić, J., Fenger, U., Stannek, P., Glinka, A., & Niehrs, C. (2005) · Nature · doi:10.1038/nature04170 · Cited by 600

Genes involved in sister chromatid separation are needed for b-type cyclin proteolysis in budding yeast

Irniger, S., Piatti, S., Michaelis, C., & Nasmyth, K. (1995) · Cell · doi:10.1016/0092-8674(95)90337-2 · Cited by 560

Apc Tumor Suppressor Gene Is the “Zonation-Keeper” of Mouse Liver

Benhamouche, S., Decaens, T., Godard, C., Chambrey, R., Rickman, D. S., Moinard, C., Vasseur-Cognet, M., Kuo, C. J., Kahn, A., Perret, C., et al. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.03.015 · Cited by 543

Distinct Wnt signaling pathways have opposing roles in appendage regeneration

Stoick-Cooper, C. L., Weidinger, G., Riehle, K. J., Hubbert, C. C., Major, M. B., Fausto, N., & Moon, R. T. (2006) · Development · doi:10.1242/dev.001123 · Cited by 533

Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation

Wray, J. P., Kalkan, T., Gómez‐López, S., Eckardt, D., Cook, A. S., Kemler, R., & Smith, A. G. (2011) · Nature Cell Biology · doi:10.1038/ncb2267 · Cited by 525

Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cellsPreprint

Cole, M. F., Johnstone, S. E., Newman, J. J., Kagey, M. H., & Young, R. A. (2008) · Genes & Development · doi:10.1101/gad.1642408 · Cited by 524

Requirement of Prorenin Receptor and Vacuolar H + -ATPase–Mediated Acidification for Wnt Signaling

Cruciat, C.-M., Ohkawara, B., Acebron, S. P., Karaulanov, E., Reinhard, C., Ingelfinger, D., Boutros, M., & Niehrs, C. (2010) · Science · doi:10.1126/science.1179802 · Cited by 516

Control of Cyclin Ubiquitination by CDK-Regulated Binding of Hct1 to the Anaphase Promoting Complex

Zachariae, W., Schwab, M., Nasmyth, K., & Seufert, W. (1998) · Science · doi:10.1126/science.282.5394.1721 · Cited by 511

Synthesis of RNA and protein during mitosis in mammalian tissue culture cells

Prescott, D. M., & Bender, M. A. (1962) · Experimental Cell Research · doi:10.1016/0014-4827(62)90176-3 · Cited by 499

Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells

ten Berge, D., Kurek, D., Blauwkamp, T. A., Koole, W., Maas, A., Eroğlu, E., Siu, R. K., & Nusse, R. (2011) · Nature Cell Biology · doi:10.1038/ncb2314 · Cited by 481

Self‐renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase

Becker, K. A., Ghule, P. N., Therrien, J. A., Lian, J. B., Stein, J. L., van Wijnen, A. J., & Stein, G. S. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20776 · Cited by 460

Translation of cyclin mRNA is necessary for extracts of activated Xenopus eggs to enter mitosis

Minshull, J., Blow, J. J., & Hunt, T. (1989) · Cell · doi:10.1016/0092-8674(89)90628-4 · Cited by 440

The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization

Schwarz, T., Fiedler, M., Shibata, N., Butler, P. J. G., Kikuchi, A., Higuchi, Y., & Bienz, M. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1247 · Cited by 429

Myc represses the p21 (WAF1/CIP1) promoter and interacts with Sp1/Sp3

Gartel, A. L., Ye, X., Goufman, E., Shiyanov, P. A., Hay, N., Najmabadi, F., & Tyner, A. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081074898 · Cited by 416

Wnt5aandWnt5bexhibit distinct activities in coordinating chondrocyte proliferation and differentiation

Yang, Y., Topol, L. Z., Lee, H., & Wu, J. (2003) · Development · doi:10.1242/dev.00324 · Cited by 398

Control of mitosis by changes in the subcellular location of cyclin-B1–Cdk1 and Cdc25C

Takizawa, C. G., & Morgan, D. O. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00149-6 · Cited by 390

Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities

Stead, E., White, J., Faast, R., Conn, S. J., Goldstone, S. D., Rathjen, J., Dhingra, U., Rathjen, P. D., Walker, D., & Dalton, S. (2002) · Oncogene · doi:10.1038/sj.onc.1206015 · Cited by 389

Proteolysis of the Hedgehog Signaling Effector Cubitus interruptus Requires Phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1

Price, M. A., & Kalderon, D. (2002) · Cell · doi:10.1016/s0092-8674(02)00664-5 · Cited by 381

Regulation of cyclin E transcription by E2Fs and retinoblastoma protein.

Geng, Y., Eaton, E. N., Picón, M., Roberts, J. M., Lundberg, A. S., Gifford, A. M., Sardet, C., & Weinberg, R. A. (1996) · PubMed · Cited by 378

Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin

Haegebarth, A., & Clevers, H. C. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080758 · Cited by 376

Multisite Phosphorylation by Cdk2 and GSK3 Controls Cyclin E Degradation

Welcker, M., Singer, J. D., Loeb, K. R., Grim, J. A., Bloecher, A., Gurian-West, M., Clurman, B. E., & Roberts, J. M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00287-9 · Cited by 369

Mitotic repression of the transcriptional machinery

Gottesfeld, J. M. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01045-1 · Cited by 368

Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling

Kielman, M. F., Rindapää, M., Gaspar, C., van Poppel, N., Breukel, C., van Leeuwen, S., Taketo, M. M., Roberts, S., Smits, R., & Fodde, R. (2002) · Nature Genetics · doi:10.1038/ng1045 · Cited by 362

β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis

Cobas, M., Wilson, A., Ernst, B., Mancini, S. J. C., MacDonald, H. R., Kemler, R., & Radtke, F. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031615 · Cited by 358

Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation

Reddy, S., Rapé, M., Marganski, W. A., & Kirschner, M. W. (2007) · Nature · doi:10.1038/nature05734 · Cited by 356

TERT Promotes Epithelial Proliferation through Transcriptional Control of a Myc- and Wnt-Related Developmental Program

Choi, J., Southworth, L. K., Sarin, K. Y., Venteicher, A. S., Ma, W., Chang, W., Cheung, P., Jun, S., Artandi, M. K., Shah, N., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040010 · Cited by 336

Canonical Wnt Signaling Regulates Hematopoiesis in a Dosage-Dependent Fashion

Luis, T. C., Naber, B. A. E., Roozen, P. P. C., Brugman, M. H., de Haas, E. F. E., Ghazvini, M., Fibbe, W. E., van Dongen, J. J. M., Fodde, R., & Staal, F. J. T. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.07.017 · Cited by 330

Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

Rabbani, P. S., Takeo, M., Chou, W. C., Myung, P. S., Bosenberg, M., Chin, L., Taketo, M. M., & Ito, M. (2011) · Cell · doi:10.1016/j.cell.2011.05.004 · Cited by 322

Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency

Miyabayashi, T., Teo, J.-L., Yamamoto, M., McMillan, M., Nguyen, C., & Kahn, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701331104 · Cited by 310

Advances in signaling in vertebrate regeneration as a prelude to regenerative medicinePreprint

Stoick-Cooper, C. L., Moon, R. T., & Weidinger, G. (2007) · Genes & Development · doi:10.1101/gad.1540507 · Cited by 309

Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal

Yi, F., Pereira, L., Hoffman, J. A., Shy, B. R., Yuen, C. M., Liu, D. R., & Merrill, B. J. (2011) · Nature Cell Biology · doi:10.1038/ncb2283 · Cited by 303

Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase‐3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin

Welsh, G. I., Miller, C. M., Loughlin, A. J., & Price, N. T. (1998) · FEBS Letters · doi:10.1016/s0014-5793(97)01548-2 · Cited by 298

WNT/β-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells

Hao, J., Li, T.-G., Qi, X., Zhao, D., & Zhao, G.-Q. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.11.011 · Cited by 295

Cell Cycle Control of Wnt Receptor Activation

Davidson, G. R., Shen, J., Huang, Y., Su, Y., Karaulanov, E., Bartscherer, K., Hassler, C., Stannek, P., Boutros, M., & Niehrs, C. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.11.006 · Cited by 284

Repression of transcription of the p27Kip1 cyclin-dependent kinase inhibitor gene by c-Myc

Yang, W. E., Shen, J., Wu, M., Arsura, M., Fitzgerald, M. J., Suldan, Z., Kim, D. W., Hofmann, C. S., Pianetti, S., Romieu, R., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204245 · Cited by 277

Exogenous Expression of β-Catenin Regulates Contact Inhibition, Anchorage-Independent Growth, Anoikis, and Radiation-Induced Cell Cycle Arrest

Orford, K. W., Orford, C. C., & Byers, S. W. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.4.855 · Cited by 276

New Insights into the Mechanism of Wnt Signaling Pathway Activation

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Wnt signaling in neural circuit assembly

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