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Bace1 and Neuregulin‐1 cooperate to control formation and maintenance of muscle spindles

Cheret, Cyril, Willem, Michael, Fricker, Florence R, Wende, Hagen, Wulf‐Goldenberg, Annika, Tahirovic, Sabina, Nave, Klaus‐Armin, Saftig, Paul, Haass, Christian, Garratt, Alistair N, Bennett, David L, Birchmeier, Carmen·2013·The EMBO Journal
DOI 10.1038/emboj.2013.146PMC PMC3715864
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Crossref · 10.1038/emboj.2013.146

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  • BACE1 is highly expressed in the nervous system and contributes to additional physiological processes besides its role in AD, e.g., through neuregulin-1 cleavage in myelination and CHL1 cleavage in axon targeting.

    “BACE1 is highly expressed in the nervous system and contributes to additional physiological processes besides its role in AD, e.g. through neuregulin-1 cleavage in myelination and CHL1 cleavage in axon targeting [7–12].”

    From Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons (2016) · cites this paper as [10]

    The Introduction reports that Bace1-dependent shedding of neuregulin-1 is implicated in peripheral nervous system myelination, and the Results say Bace1 is broadly expressed in sensory neurons. The copy does not establish high expression throughout the nervous system. Its References list a study of CHL1 cleavage by Bace1, but no passage links that cleavage to axon targeting. (LLM, conf=0.88)

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Metadata

Authors
Cheret, C., Willem, M., Fricker, F. R., Wende, H., Wulf‐Goldenberg, A., Tahirovic, S., Nave, K., Saftig, P., Haass, C., Garratt, A. N., Bennett, D. L., & Birchmeier, C.
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
2013-06-21
Volume
32
Issue
14
Pages
2015-2028
ISSN
  • 0261-4189
  • 1460-2075
DOI
10.1038/emboj.2013.146
PMC
PMC3715864
Cited by
124
References
2
Language
en
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