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Cited by 140Retinal Diseases and TreatmentsRetinal and Macular SurgeryOcular Diseases and Behçet’s Syndrome

Morphology of early choroidal neovascularisation in age-related macular degeneration: Correlation with activity

Sarks, J P, Sarks, S H, Killingsworth, M C·1997·Eye
DOI 10.1038/eye.1997.137
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Abstract

The purpose of this study was to describe the morphology of early choroidal neovascularisation (CNV) and compare the findings in two patients, in the first of whom the vessels appeared inactive and in the second progressive. Changes common to both included a diffuse deposition of membrane coils external to the basement membrane (BsM) of the retinal pigment epithelium (RPE), and macrophages and foreign body giant cells beneath thinned segments of Bruch's membrane (BrM). In the first patient small activated vessels surrounded by enlarged pericytes were found in the choroid beneath these areas and pursued a convoluted course, bulging into or through BrM, but without spreading in the sub-RPE space. This choroidal phase of CNV may be common and unrecognised. In the second patient there was spread of CNV in the sub-RPE space with extravasation of red cells and fibrin. The tips leaking fibrin were covered by a thick BsM-like material and naked endothelial cells were not seen. Pericytes were absent here but were observed at the non-leaking edge. The difference in activity of CNV in the two patients appeared to correlate with the quantity of membranous debris present.

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Crossref · 10.1038/eye.1997.137

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  • Choroidal neovascularization refers to the growth of new blood vessels from the choroid through Bruch's membrane and under the RPE.

    “CNV refers to the growth of new blood vessels from the choroid through Bruch’s membrane and under the RPE (125).”

    From Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration (2009) · cites this paper as [125]

  • Early choroidal neovascularisation occurs under the retinal pigment epithelium, eventually breaking through to develop exudative, haemorrhagic, or disciform age-related macular degeneration.

    “Early choroidal neovascularisation occurs under the retinal pigment epithelium,133,134 eventually breaking through135 to develop exudative, haemorrhagic, or disciform age-related macular degeneration (figure 6).”

    From Age-related macular degeneration (2008) · cites this paper as [133]

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Related

Authors
Sarks, J. P., Sarks, S. H., & Killingsworth, M. C.
Affiliations
UNSW Sydney (AU)
ORCID
Killingsworth, M C
Venue
Eye
Publisher
Springer Science and Business Media LLC
Published
1997-07
Volume
11
Issue
4
Pages
515-522
ISSN
  • 0078-5334 (ISSN-L)
  • 0950-222X
  • 1476-5454
DOI
10.1038/eye.1997.137
OpenAlex
W1976540988
Cited by
140
References
33
Citations by year
2026: 3 · 2025: 5 · 2024: 9 · 2023: 2 · 2022: 9 · 2021: 10 · 2020: 12 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 12 · 2014: 3 · 2013: 4 · 2012: 4
FWCI
4.47
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Eye (publishedVersion)
  • PubMed (publishedVersion)
Funders
Retina Research Foundation
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal and Macular Surgery
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords
choroidal neovascularization, age-related macular degeneration, choroid, Bruch's membrane, retinal pigment epithelium, basement membrane, pericytes, macrophages, foreign body giant cells, choroidal morphology
MeSH terms
Aged, Aged, 80 and over, Choroid, Humans, Macular Degeneration, Male, Microscopy, Electron, Neovascularization, Pathologic, Pigment Epithelium of Eye, Bruch Membrane, Disease Progression

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