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The effect of a low-fat, high-protein or high-carbohydrate ad libitum diet on weight loss maintenance and metabolic risk factors
Abstract
Background High-protein (HP) diets are often advocated for weight reduction and weight loss maintenance. Objective The aim was to compare the effect of low-fat, high-carbohydrate (HC) and low-fat, HP ad libitum diets on weight maintenance after weight loss induced by a very low-calorie diet, and on metabolic and cardiovascular risk factors in healthy obese subjects. Design Forty-eight subjects completed the study that consisted of an energy restriction period of 5-6 weeks followed by a weight maintenance period of 12 weeks. During weight maintenance subjects received maltodextrin (HC group) or protein (HP group) (casein (HPC subgroup) or whey (HPW subgroup)) supplements (2 x 25 g per day), respectively and consumed a low-fat diet. Results Subjects in the HP diet group showed significantly better weight maintenance after weight loss (2.3 kg difference, P=0.04) and fat mass reduction (2.2 kg difference, P=0.02) than subjects in the HC group. Triglyceride (0.6 mM difference, P=0.01) and glucagon (9.6 pg ml(-1) difference, P=0.02) concentrations increased more in the HC diet group, while glucose (0.3 mM difference, P=0.02) concentration increased more in the HP diet group. Changes in total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, insulin, HOMAir index, HbA1c, leptin and adiponectin concentrations did not differ between the diets. No differences were found between the casein- or whey-supplemented HP groups. Conclusions These results s…
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“It has been claimed that high-protein diets may help promote weight loss, maintain lean body mass, and improve lipid and plasma glucose profiles in obese subjects with our without T2DM15, 16, 17, 18 and prevent hepatic steatosis in obese animal models.19”
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Metadata
- Authors
- Claessens, M., van Baak, M. A., Monsheimer, S., & Saris, W. H. M.
- Venue
- International Journal of Obesity
- Published
- 2009-01-20
- Volume
- 33
- Issue
- 3
- Pages
- 296-304
- ISSN
- 0307-0565
- 1476-5497
- Cited by
- 132
- References
- 9
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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