The role of higher protein diets in weight control and obesity-related comorbidities
Open accessAbstract
The importance of the relative dietary content of protein, carbohydrate and the type of carbohydrate (that is, glycemic index (GI)) for weight control under ad libitum conditions has been controversial owing to the lack of large scale studies with high diet adherence. The Diet, Obesity and Genes (DioGenes) European multicentre trial examined the importance of a slight increase in dietary protein content, reduction in carbohydrate and the importance of choosing low (LGI) vs high GI (HGI) carbohydrates for weight control in 932 obese families. Only the adults underwent a diet of 800 kcal per day for 8 weeks, and after losing ~11kg they were randomized to one of five energy ad libitum diets for 6 months. The diets differed in protein content and GI. The high-protein (HP) diet groups consumed 5.4% points more energy from protein than the normal protein (NP) groups, and the LGI diet groups achieved 5.1% lower GI than the HGI groups. The effect of HP and LGI was additive on weight loss and maintenance, and the combination was successful in preventing weight regain and reducing drop-out rate among the adults after the 11kg weight loss. This diet also reduced body fatness and prevalence of overweight and obesity among their children and had consistent beneficial effects on blood pressure, blood lipids and inflammation in both parents and children. After 1 year, mainly the HP effects were maintained. Putative genes have been identified that suggest this diet to be particularly effective in 67% of the population. In conclusion, the DioGenes diet has shown to be effective for prevention of weight regain and for weight reduction in overweight children under ad libitum conditions. The less-restrictive dietary approach fits into a normal food culture, and has been translated into popular diet and cook books in several languages.
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Positive effects of dietary protein on body weight management have been observed in large long-term randomized controlled trials.
“The positive effects of dietary protein on body weight management have been observed in large long-term randomized controlled trials [15].”
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Cites
Diets with high or low protein content and glycemic index for weight-loss maintenance
Larsen, T. M., Dalskov, S.-M., van Baak, M., Jebb, S. A., Papadaki, A., Pfeiffer, A. F. H., Martinez, J. A., Handjieva-Darlenska, T., Kunešová, M., Pihlsgård, M., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1007137 · Cited by 843 · see citing works
Self-citationWycherley, T. P., Moran, L. J., Clifton, P. M., Noakes, M., & Brinkworth, G. D. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.044321 · Cited by 606 · see citing works
Protein, weight management, and satiety
Paddon-Jones, D., Westman, E., Mattes, R. D., Wolfe, R. R., Astrup, A., & Westerterp-Plantenga, M. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1558s · Cited by 549 · see citing works
Self-citationKrieger, J. W., Sitren, H. S., Daniels, M. J., & Langkamp-Henken, B. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.260 · Cited by 466 · see citing works
Myths, Presumptions, and Facts about Obesity
Casazza, K., Fontaine, K. R., Astrup, A., Birch, L. L., Brown, A. W., Bohan Brown, M. M., Durant, N., Dutton, G., Foster, E. M., Heymsfield, S. B., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmsa1208051 · Cited by 442 · see citing works
Self-citationSantos, F. L., Esteves, S. S., da Costa Pereira, A., Yancy Jr, W. S., & Nunes, J. P. L. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01021.x · Cited by 318 · see citing works
Mikkelsen, P. B., Toubro, S., & Astrup, A. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.5.1135 · Cited by 293 · see citing works
Self-citationAstrup, A. V. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.073015 · Cited by 249 · see citing works
Self-citationBendtsen, L. Q., Lorenzen, J. K., Bendsen, N. T., Rasmussen, C., & Astrup, A. V. (2013) · Advances in Nutrition · doi:10.3945/an.113.003723 · Cited by 247 · see citing works
Self-citationLarsen, T. M., Dalskov, S., van Baak, M. A., Jebb, S. A., Kafatos, A., Pfeiffer, A. F. H., Martínez, J. A., Handjieva‐Darlenska, T., Kunešová, M., Holst, J. J., et al. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00603.x · Cited by 206 · see citing works
Self-citationGögebakan, Ö., Kohl, A., Osterhoff, M. A., van Baak, M. A., Jebb, S. A., Papadaki, A., Martinez, J. A., Handjieva-Darlenska, T., Hlavaty, P., Weickert, M. O., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.033274 · Cited by 180 · see citing works
Self-citationContribution of gastroenteropancreatic appetite hormones to protein-induced satiety
Belza, A., Ritz, C., Sørensen, M. Q., Holst, J. J., Rehfeld, J. F., & Astrup, A. V. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.047563 · Cited by 171 · see citing works
Self-citationClifton, P. M., Condo, D., & Keogh, J. B. (2013) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2013.11.006 · Cited by 158 · see citing works
Effects of PYY3–36 and GLP-1 on energy intake, energy expenditure, and appetite in overweight men
Schmidt, J. B., Gregersen, N. T., Pedersen, S. D., Arentoft, J. L., Ritz, C., Schwartz, T. W., Holst, J. J., Astrup, A. V., & Sjödin, A. M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00569.2013 · Cited by 147 · see citing works
Self-citationMaersk, M., Belza, A., Holst, J. J., Fenger‐Grøn, M., Pedersen, S. B., Astrup, A. V., & Richelsen, B. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.223 · Cited by 124 · see citing works
Self-citationAller, E. E. J. G., Larsen, T. M., Claus, H., Lindroos, A. K., Kafatos, A., Pfeiffer, A., Martinez, J. A., Handjieva-Darlenska, T., Kunesova, M., Stender, S., et al. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.52 · Cited by 121 · see citing works
Self-citationPapadaki, A., Linardakis, M. K., Larsen, T. M., van Baak, M. A., Lindroos, A. K., Pfeiffer, A. F. H., Martínez, J. A., Handjieva‐Darlenska, T., Kunešová, M., Holst, C., et al. (2010) · PEDIATRICS · doi:10.1542/peds.2009-3633 · Cited by 92 · see citing works
Self-citationMoore, C. S., Lindroos, A. K., Kreutzer, M., Larsen, T. M., Astrup, A. V., van Baak, M. A., Handjieva‐Darlenska, T., Hlavatý, P., Kafatos, A., Kohl, A., et al. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00602.x · Cited by 66 · see citing works
Self-citationDamsgaard, C. T., Papadaki, A., Jensen, S. M., Ritz, C., Dalskov, S., Hlavatý, P., Saris, W. H. M., Martínez, J. A., Handjieva‐Darlenska, T., Andersen, M. R., et al. (2013) · Journal of Nutrition · doi:10.3945/jn.112.173427 · Cited by 52 · see citing works
Self-citationLarsen, L. H., Ängquist, L. H., Vimaleswaran, K. S., Hager, J., Viguerie, N., Loos, R. J. F., Handjieva‐Darlenska, T., Jebb, S. A., Kunešová, M., Larsen, T. M., et al. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.016543 · Cited by 49 · see citing works
Self-citationWang, P., Holst, C., Andersen, M. R., Astrup, A. V., Bouwman, F. G., van Otterdijk, S. D., Wodzig, W. K. W. H., van Baak, M. A., Larsen, T. M., Jebb, S. A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016773 · Cited by 46 · see citing works
Self-citationKunešová, M., Hlavatý, P., TVRZICKÁ, E., Staňková, B., Kalousková, P., Viguerie, N., Larsen, T. M., van Baak, M. A., Jebb, S. A., Martínez, J. A., et al. (2012) · Physiological Research · doi:10.33549/physiolres.932414 · Cited by 40 · see citing works
Self-citationSkov, A. R., Toubro, S., Raben, A., & Astrup, A. V. (1997) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600459 · Cited by 39 · see citing works
Self-citationStocks, T., Ängquist, L., Hager, J., Charon, C., Holst, C., Martinez, J. A., Saris, W. H. M., Astrup, A., Sørensen, T. I. A., & Larsen, L. H. (2013) · Human Heredity · doi:10.1159/000353591 · Cited by 29 · see citing works
Self-citationWang, P., Menheere, P. P. C. A., Astrup, A. V., Andersen, M. R., van Baak, M. A., Larsen, T. M., Jebb, S. A., Kafatos, A., Pfeiffer, A. F. H., Martínez, J. A., et al. (2013) · Obesity · doi:10.1002/oby.20311 · Cited by 28 · see citing works
Self-citationGoyenechea, E., Holst, C., van Baak, M. A., Saris, W. H. M., Jebb, S. A., Kafatos, A., Pfeiffer, A. F. H., Handjiev, S., Hlavatý, P., Stender, S., et al. (2011) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1218 · Cited by 28 · see citing works
Self-citationWang, P., Holst, C., Astrup, A. V., Bouwman, F. G., van Otterdijk, S. D., Wodzig, W. K. W. H., Andersen, M. R., van Baak, M. A., Rasmussen, L. G., Martínez, J. A., et al. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511002583 · Cited by 24 · see citing works
Self-citationBrahe, L. K., Ängquist, L. H., Larsen, L. H., Vimaleswaran, K. S., Hager, J., Viguerie, N., Loos, R. J. F., Handjieva‐Darlenska, T., Jebb, S. A., Hlavatý, P., et al. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114512006058 · Cited by 21 · see citing works
Self-citationEngberink, M. F., Geleijnse, J. M., Bakker, S. J. L., Larsen, T. M., Handjieva-Darlesnka, T., Kafatos, A., Martínez, J. A., Pfeiffer, A. F. H., Kunešová, M., Jebb, S. A., et al. (2014) · Journal of Human Hypertension · doi:10.1038/jhh.2014.30 · Cited by 21 · see citing works
Self-citationMechanisms of weight maintenance under high‐ and low‐protein, low‐glycaemic index diets
Rubio‐Aliaga, I., Marvin, L., Wang, P., Wagnière, S., Mansourian, R., Fuerholz, A., Saris, W. H. M., Astrup, A. V., Mariman, E. C. M., & Kussmann, M. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100081 · Cited by 18 · see citing works
Self-citationMcConnon, Á., Horgan, G. W., Lawton, C. L., Stubbs, R. J., Shepherd, R., Astrup, A. V., Handjieva‐Darlenska, T., Kunešová, M., Larsen, T. M., Lindroos, A. K., et al. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.99 · Cited by 17 · see citing works
Self-citationPapadaki, A., Linardakis, M. K., Plada, M., Larsen, T. M., Damsgaard, C. T., van Baak, M. A., Jebb, S. A., Pfeiffer, A. F. H., Martínez, J. A., Handjieva‐Darlenska, T., et al. (2013) · Nutrition · doi:10.1016/j.nut.2013.09.001 · Cited by 16 · see citing works
Self-citationAstrup, A. V., & Geiker, N. R. W. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.02.003 · Cited by 12 · see citing works
Self-citationBendtsen, L. Q., Lorenzen, J. K., Larsen, T. M., van Baak, M. A., Papadaki, A., Martínez, J. A., Handjieva‐Darlenska, T., Jebb, S. A., Kunešová, M., Pfeiffer, A. F. H., et al. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513003322 · Cited by 12 · see citing works
Self-citationHave new guidelines overlooked the role of diet composition?
Astrup, A. V., & Brand-Miller, J. C. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.271 · Cited by 7 · see citing works
Self-citationEffects of dietary protein and glycaemic index on biomarkers of bone turnover in children
Dalskov, S., Müller, M., Ritz, C., Damsgaard, C. T., Papadaki, A., Saris, W. H. M., Astrup, A. V., Michaelsen, K. F., & Mølgaard, C. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114513003760 · Cited by 7 · see citing works
Self-citationBrand-Miller, J. C., Colagiuri, S., Fogelholm, M., Feskens, E. J. M., Westerterp‐Plantenga, M. S., Schlicht, W. M., & Raben, A. (2013) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2013.12.676 · Cited by 6 · see citing works
Self-citationTotality of evidence needed for nutrition recommendations
Astrup, A. V., & Brand-Miller, J. C. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.271-c2 · Cited by 2 · see citing works
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Self-citationMarangoni, F., Corsello, G., Cricelli, C. A., Ferrara, N., Ghiselli, A., Lucchin, L., & Poli, A. (2015) · Food & Nutrition Research · doi:10.3402/fnr.v59.27606 · Cited by 439 · see citing works
Valerio, G., Maffeis, C., Saggese, G., Ambruzzi, M. A., Balsamo, A., Bellone, S., Bergamini, M., Bernasconi, S., Bona, G., Calcaterra, V., et al. (2018) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-018-0525-6 · Cited by 228 · see citing works
Wernimont, S. M., Radosevich, J., Jackson, M. I., Ephraim, E., Badri, D. V., MacLeay, J. M., Jewell, D. E., & Suchodolski, J. S. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01266 · Cited by 220 · see citing works
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Rolls, B. J. (2017) · Nutrition Bulletin · doi:10.1111/nbu.12280 · Cited by 165 · see citing works
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Protein, amino acids and obesity treatment
Simonson, M., Boirie, Y., & Guillet, C. (2020) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09574-5 · Cited by 128 · see citing works
Kralik, G., Kralik, Z., Grčević, M., & Hanžek, D. (2018) · InTech eBooks · doi:10.5772/intechopen.72865 · Cited by 134 · see citing works
Diet, microbiota, and the mucus layer: The guardians of our health
Suriano, F., Nyström, E. E. L., Sergi, D., & Gustafsson, J. K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.953196 · Cited by 120 · see citing works
Links between Dietary Protein Sources, the Gut Microbiota, and Obesity
Madsen, L., Myrmel, L. S., Fjære, E., Liaset, B., & Kristiansen, K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01047 · Cited by 110 · see citing works
Fogelholm, M., Larsen, T. M., Westerterp‐Plantenga, M. S., Macdonald, I. A., Martínez, J. A., Boyadjieva, N. I., Poppitt, S. D., Schlicht, W. M., Stratton, G., Sundvall, J., et al. (2017) · Nutrients · doi:10.3390/nu9060632 · Cited by 104 · see citing works
Self-citationBawa, M., Songsermpong, S., Kaewtapee, C., & Chanput, W. P. (2020) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.14601 · Cited by 89 · see citing works
Sustainable food protein supply reconciling human and ecosystem health: A Leibniz Position
Weindl, I., Ost, M., Wiedmer, P., Schreiner, M., Neugart, S., Klopsch, R., Kühnhold, H., Kloas, W., Henkel, I. M., Schlüter, O., et al. (2020) · Global Food Security · doi:10.1016/j.gfs.2020.100367 · Cited by 88 · see citing works
Crujeiras, A. B., Gómez-Arbeláez, D., Zulet, M. Á., Carreira, M. C., Sajoux, I., de Luis, D. A., Castro, A. I., Baltar, J., de la Torre, I. B., Sueiro, A. M., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.138 · Cited by 82 · see citing works
Egg consumption, cardiovascular diseases and type 2 diabetes
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Self-citationHansen, T. T., Astrup, A., & Sjödin, A. (2021) · Nutrients · doi:10.3390/nu13093193 · Cited by 77 · see citing works
“The positive effects of dietary protein on body weight management have been observed in large long-term randomized controlled trials [15].”
BackgroundSelf-citationTettamanzi, F., Bagnardi, V., Louca, P., Nogal, A., Monti, G. S., Mambrini, S. P., Lucchetti, E., Maestrini, S., Mazza, S., Rodriguez‐Mateos, A., et al. (2021) · Nutrients · doi:10.3390/nu13124380 · Cited by 79 · see citing works
Akhlaghi, M., Zare, M., & Nouripour, F. (2017) · Advances in Nutrition · doi:10.3945/an.117.015370 · Cited by 71 · see citing works
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High Protein Diet Induces Oxidative Stress in Rat Cerebral Cortex and Hypothalamus
Żebrowska, E., Maciejczyk, M., Żendzian‐Piotrowska, M., Zalewska, A., & Chabowski, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071547 · Cited by 57 · see citing works
Crujeiras, A. B., Zulet, M. Á., Abete, I., Amil, M., Carreira, M. C., Martínez, J. A., & Casanueva, F. F. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.206 · Cited by 51 · see citing works
Efficacy of Dietary and Supplementation Interventions for Individuals with Type 2 Diabetes
Lewgood, J., Oliveira, B., Korzepa, M., Forbes, S. C., Little, J. P., Breen, L., Bailie, R., & Candow, D. G. (2021) · Nutrients · doi:10.3390/nu13072378 · Cited by 49 · see citing works
Smith, G. I., Commean, P. K., Reeds, D. N., Klein, S., & Mittendorfer, B. (2018) · Obesity · doi:10.1002/oby.22169 · Cited by 42 · see citing works
Causal inference in obesity research
Franks, P. W., & Atabaki‐Pasdar, N. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12577 · Cited by 42 · see citing works
Nadar, C. G., Fletcher, A., Moreira, B. R. D. A., Hine, D. C., & Yadav, S. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13375 · Cited by 44 · see citing works
Arciero, P. J., Edmonds, R., He, F. J., Ward, E. G., Gumpricht, E., Mohr, A. E., Ormsbee, M. J., & Astrup, A. V. (2016) · Nutrients · doi:10.3390/nu8080476 · Cited by 41 · see citing works
Self-citationKroeger, C. M., Trepanowski, J. F., Klempel, M. C., Barnosky, A., Bhutani, S., Gabel, K., & Varady, K. A. (2018) · Nutrition and Health · doi:10.1177/0260106017753487 · Cited by 37 · see citing works
Freuer, D., Meisinger, C., & Linseisen, J. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.01.047 · Cited by 35 · see citing works
de Carvalho, K. M. B., Pizato, N., Botelho, P. B., Dutra, E. S., & Gonçalves, V. S. S. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02321-1 · Cited by 32 · see citing works
Nicolaisen, T. S., Lyster, A. E., Sjøberg, K. A., Haas, D. T., Voldstedlund, C. T., Lundsgaard, A., Jensen, J. K., Madsen, E. M., Nielsen, C. K., Bloch‐Ibenfeldt, M., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01236-7 · Cited by 36 · see citing works
Dominique, M., Breton, J., Guérin, C., Bôle‐Feysot, C., Lambert, G., Déchelotte, P., & Fetissov, S. O. (2019) · Nutrients · doi:10.3390/nu11092115 · Cited by 33 · see citing works
Starr, K. N. P., Orenduff, M. C., McDonald, S. R., Mulder, H. S., Sloane, R. J., Pieper, C. F., & Bales, C. W. (2019) · Journal of Nutrition in Gerontology and Geriatrics · doi:10.1080/21551197.2018.1564200 · Cited by 30 · see citing works
Foscolou, A., Magriplis, E., Tyrovolas, S., Chrysohoou, C. A., Sidossis, L. S., Matalas, A., Rallidis, L. S., & Panagiotakos, D. B. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1693-2 · Cited by 26 · see citing works
A scientific transition to support the 21st century dietary transition
Tufford, A., Brennan, L., van Trijp, J. C. M., D’Auria, S., Feskens, E. J. M., Finglas, P. M., Kok, F. J., Kolesárová, A., Poppe, K. J., Zimmermann, K. L., et al. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.11.021 · Cited by 28 · see citing works
Outcomes of a Mobile Health Coaching Platform: 12-Week Results of a Single-Arm Longitudinal Study
Willey, S., & Walsh, J. K. (2016) · JMIR mhealth and uhealth · doi:10.2196/mhealth.4933 · Cited by 26 · see citing works
Chang, H., Gan, W., Liao, X., Wei, J., Lu, M., Chen, H., Wang, S., Ma, Y., Wu, Q., Yu, Y., et al. (2020) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.05.029 · Cited by 25 · see citing works
Lesgards, J. (2023) · Nutrients · doi:10.3390/nu15051294 · Cited by 27 · see citing works
Weight loss relapse associated with exposure to perfluorinated alkylate substances
Grandjean, P., Meddis, A., Nielsen, F., Sjödin, A. M., Hjorth, M. F., Astrup, A. V., & Budtz–Jørgensen, E. (2023) · Obesity · doi:10.1002/oby.23755 · Cited by 26 · see citing works
Self-citationAnjom-Shoae, J., Feinle‐Bisset, C., & Horowitz, M. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1412182 · Cited by 28 · see citing works
Li, K., Xiao, X., Li, Y., Lu, S., Zi, J., Sun, X., Xu, J., Liu, H., Li, X., Song, T., et al. (2024) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-024-01073-w · Cited by 23 · see citing works
Effects of low-calorie and different weight-maintenance diets on IgG glycome composition
Deriš, H., Tominac, P., Vučković, F., Briški, N. Š., Astrup, A. V., Blaak, E. E., Lauc, G., & Gudelj, I. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.995186 · Cited by 23 · see citing works
Self-citationCurrenti, W., Losavio, F., Quiete, S., Alanazi, A. M., Messina, G., Polito, R., Ciolli, F., Zappalà, R. S., Galvano, F., & Cincione, R. I. (2023) · Nutrients · doi:10.3390/nu16010095 · Cited by 23 · see citing works
Impact of carbohydrates on weight regain
Bosy‐Westphal, A., & Müller, M. J. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000193 · Cited by 21 · see citing works
Dietary lactalbumin and lactoferrin interact with inulin to modulate energy balance in obese rats
Singh, A., Zapata, R. C., Pezeshki, A., & Chelikani, P. K. (2017) · Obesity · doi:10.1002/oby.21840 · Cited by 20 · see citing works
Tebeje, N. B., Bikes, G. A., Abebe, S. M., & Yesuf, M. E. (2017) · Journal of Childhood Obesity · doi:10.21767/2572-5394.100037 · Cited by 20 · see citing works
Kruseman, M., Schmutz, N., & Carrard, I. (2017) · Obesity Facts · doi:10.1159/000478096 · Cited by 20 · see citing works
Castaldo, G., Palmieri, V., Galdo, G., Castaldo, L., Molettieri, P., Vitale, A., & Monaco, L. (2015) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2015.05.001 · Cited by 18 · see citing works
Guanylyl Cyclase C Hormone Axis at the Intersection of Obesity and Colorectal Cancer
Blomain, E. S., Merlino, D. J., Pattison, A. M., Snook, A. E., & Waldman, S. A. (2016) · Molecular Pharmacology · doi:10.1124/mol.115.103192 · Cited by 16 · see citing works
Waliłko, E., Napierała, M., Bryśkiewicz, M., Fronczyk, A., & Majkowska, L. (2021) · Nutrients · doi:10.3390/nu13041086 · Cited by 16 · see citing works
Mitra, S. R., & Tan, P. Y. (2019) · British Journal Of Nutrition · doi:10.1017/s0007114519000345 · Cited by 15 · see citing works
Noer, E. R., Dewi, L., & Kuo, C. (2021) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2021.06.005 · Cited by 16 · see citing works
Qu, Y., Xu, W., Guo, S., & Wu, H. (2024) · BMC Public Health · doi:10.1186/s12889-024-19637-w · Cited by 19 · see citing works
High protein diet promotes body weight loss among Brazilian postpartum women.
de Castro, M. B. T., Cunha, D., Araújo, M. C., Bezerra, I. N., Adegboye, A., Kac, G., & Sichieri, R. (2018) · Maternal and Child Nutrition · doi:10.1111/mcn.12746 · Cited by 15 · see citing works
Röhling, M., Stensitzky-Thielemanns, A., Oliveira, C. L. P., Beck, A., Braumann, K. M., Halle, M., Führer‐Sakel, D., Kempf, K., McCarthy, H. D., Predel, H. G., et al. (2021) · Nutrients · doi:10.3390/nu13020376 · Cited by 15 · see citing works
Riseberg, E., Lopez‐Cepero, A. A., Mangano, K. M., Tucker, K. L., & Mattei, J. (2021) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2021.05.020 · Cited by 14 · see citing works
Schmedes, M. S., Bendtsen, L. Q., Gomes, S., Liaset, B., Holst, J. J., Ritz, C., Reitelseder, S., Sjödin, A. M., Astrup, A. V., Young, J. F., et al. (2018) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9103 · Cited by 13 · see citing works
Self-citationRichter, M. M., Thomsen, M. N., Skytte, M. J., Kjeldsen, S. A. S., Samkani, A., Frystyk, J., Magkos, F., Holst, J. J., Madsbad, S., Krarup, T., et al. (2024) · Journal of the Endocrine Society · doi:10.1210/jendso/bvae008 · Cited by 12 · see citing works
Luppino, G., Wasniewska, M. G., Casto, C., Ferraloro, C., Pomi, A. L., Pepe, G., Morabito, L. A., Alibrandi, A., Corica, D., & Aversa, T. (2024) · Children · doi:10.3390/children11020205 · Cited by 12 · see citing works
Ma, Y., Sun, L., & Mu, Z. (2023) · Medicine · doi:10.1097/md.0000000000033254 · Cited by 11 · see citing works
Foscolou, A., Critselis, E., Tyrovolas, S., Chrysohoou, C. A., Naumovski, N., Sidossis, L. S., Rallidis, L. S., Matalas, A., & Panagiotakos, D. B. (2020) · Public Health Nutrition · doi:10.1017/s1368980020000427 · Cited by 11 · see citing works
Duhita, M. R., Schütz, Y., Montani, J., Dulloo, A. G., & Miles-Chan, J. L. (2019) · Nutrients · doi:10.3390/nu11071599 · Cited by 10 · see citing works
Ketogenic Diets for Fat Loss and Exercise Performance
Kiens, B., & Astrup, A. V. (2015) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000053 · Cited by 9 · see citing works
Self-citationLiu, X., Gan, W., Gao, C., Qi, X., Liao, X., Lin, J., & Zhao, Y. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1751-9 · Cited by 9 · see citing works
Do gluten peptides stimulate weight gain in humans?
Brouns, F. J. P. H., & Shewry, P. R. (2022) · Nutrition Bulletin · doi:10.1111/nbu.12558 · Cited by 9 · see citing works
Review on quality attributes of milk and commonly produced dairy products in Ethiopia
Assen, K. A., & Abegaz, M. A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e40089 · Cited by 8 · see citing works
High-protein diet with excess leucine prevents inactivity-induced insulin resistance in women
Mangogna, A., Girolamo, F. G. D., Fiotti, N., Vinci, P., Landolfo, M., Mearelli, F., & Biolo, G. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.10.028 · Cited by 8 · see citing works
Kotopoulea‐Nikolaidi, M., Watkins, E., & Giannopoulou, I. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00141 · Cited by 8 · see citing works
Ji, X. N., Huang, M., Yao, S. H., Qi, J. Y., Onwuka, J. U., Wang, Y., Wang, X. M., Chen, Y., Wu, X. Y., Liu, L. Y., et al. (2020) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2020.1746956 · Cited by 8 · see citing works
Nutrition, Lifestyle, and Hypertension
Lin, P., Tyson, C. C., Batch, B. C., & Svetkey, L. P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802928-2.00028-x · Cited by 11 · see citing works
Role of Meal Replacements on Weight Management, Health and Nutrition
Shao, A. E. (2017) · InTech eBooks · doi:10.5772/66331 · Cited by 7 · see citing works
Ajuogu, P. K., Wolden, M., McFarlane, J. R., Hart, R. A. D. J., Carlson, D. J., van der Touw, T., & Smart, N. A. (2019) · Journal of Animal Science · doi:10.1093/jas/skz380 · Cited by 7 · see citing works
Evaluation of an 18‐month commercial multidisciplinary obesity treatment programme
Aller, E. E. J. G., & van Baak, M. A. (2015) · Clinical Obesity · doi:10.1111/cob.12122 · Cited by 7 · see citing works
Andreoli, M. F., Stoker, C., Lazzarino, G. P., Canesini, G., Luque, E. H., & Ramos, J. G. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516002865 · Cited by 7 · see citing works
The role of diet in chronic disease
Tucker, K. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818460-8.00018-6 · Cited by 6 · see citing works
Milk intake and IGF-1 rs6214 polymorphism as protective factors to obesity
Grijalva, J. C. Á., Villanueva‐Fierro, I., Lares‐Asseff, I., Chairez‐Hernández, I., Rivera, G., Martínez-Estrada, S. C., Martínez-Rivera, I., Quiñones, L. A., & Loera‐Castañeda, V. (2019) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2019.1666805 · Cited by 6 · see citing works
Zhu, Q., Xue, K., Guo, H., Deng, F. F., & Yang, Y. H. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17051515 · Cited by 6 · see citing works
Dietary amino acids and anthropometric indices: Tehran Lipid and Glucose Study
Teymoori, F., Asghari, G., Hosseinpour, S., Roosta, S., Bordbar, M. R. F., Mirmiran, P., Sarbazi, N., & Azizi, F. (2023) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000646 · Cited by 5 · see citing works
Saudi Adults’ Understanding and Views of Weight Management Practices and Obesity
Alshehri, F. S., & Alorfi, N. M. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s433721 · Cited by 5 · see citing works
Rajta, P., Bajaj, A., Sharma, S., Regassa, H., & Gudeta, K. (2023) · International Journal of Agricultural Sciences and Technology · doi:10.51483/ijagst.3.2.2023.18-38 · Cited by 4 · see citing works
The Importance of Poultry Meat in Medicine: A Review
Jilo, S. A., & Hasan, L. A. (2022) · Journal of World s Poultry Research · doi:10.36380/jwpr.2022.28 · Cited by 6 · see citing works
Minderis, P., Fokin, A., Povilonis, T., Kvedaras, M., & Ratkevičius, A. (2023) · Nutrients · doi:10.3390/nu15224836 · Cited by 4 · see citing works
Petrovic, A., Jovičić, S. Ž., Dodevska, M. S., Djordjevic, B. I., Milinković, N., & Ivanović, N. (2024) · Nutrients · doi:10.3390/nu16203453 · Cited by 4 · see citing works
de Maredsous, C. D., Carlin, G., Oosting, A., Delteil, C., Azzout‐Marniche, D., Chaumontet, C., Blachier, F., Barbillon, P., Mary‐Huard, T., Tomé, D., et al. (2020) · Nutrients · doi:10.3390/nu12020315 · Cited by 4 · see citing works
Dietary Patterns and Insulin Resistance
Torsoni, A. S., Milanski, M., & Torsoni, M. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801585-8.00002-6 · Cited by 4 · see citing works
Somogyi, E., Hoornenborg, C. W., Bruggink, J. E., Nyakas, C. J., van Beek, A. P., & van Dijk, G. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.112844 · Cited by 3 · see citing works
Factors Affecting Quality Milk Productivity in Dairy Farming
N.A., J. P. S. (2023) · Salud Ciencia y Tecnología - Serie de Conferencias · doi:10.56294/sctconf2023579 · Cited by 3 · see citing works
Park, J. S., & Kim, K. Y. (2017) · Journal of Nutrition and Health · doi:10.4163/jnh.2017.50.5.447 · Cited by 3 · see citing works
PET/CT Imaging and Physiology of Mice on High Protein Diet
Sijbesma, J. W. A., van Waarde, A., Stegger, L., Dierckx, R. A. J. O., Boersma, H. H., & Slart, R. H. J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063236 · Cited by 3 · see citing works
Ecology, Protein Leverage, and Public Health
Raubenheimer, D., & Simpson, S. J. (2022) · doi:10.1002/9781119695257.ch6 · Cited by 3 · see citing works
Fajardo-Espinoza, F. S., Alvarez-Altamirano, K., Mendoza-Hernández, A. N., Garibay-Nieto, N., Falcón-Álvarez, T., Rosales, M. B., Raya-Hernández, A., Feferbaum, R., & Fuchs‐Tarlovsky, V. (2023) · Clinical Nutrition Open Science · doi:10.1016/j.nutos.2023.10.008 · Cited by 2 · see citing works
Fotros, D., Rohani, P., Prabahar, K., Fatahi, S., Sohouli, M. H., & Guimarães, N. S. (2025) · Clinical Hypertension · doi:10.5646/ch.2025.31.e17 · Cited by 2 · see citing works
Corbalan, J. J., Jagadeesan, P., & Nickels, J. T. (2025) · PLoS ONE · doi:10.1371/journal.pone.0334213 · Cited by 2 · see citing works
Yang, X., Hua, L., Gao, D., Wu, Y., Yang, Y., Jin, X., Jiang, X., Jin, C., Feng, B., Che, L., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102306 · Cited by 2 · see citing works
Association Between Dietary Intake of Phosphorus and Measures of Obesity in the Jackson Heart Study
Duong, C. N., Akinlawon, O. J., Noel, S. E., & Tucker, K. L. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.05.014 · Cited by 2 · see citing works
Obesity and Metabolic Syndrome
Ettinger, S. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803013-4.00001-6 · Cited by 2 · see citing works
Kim, S., & Ha, K. (2023) · Journal of Nutrition and Health · doi:10.4163/jnh.2023.56.1.54 · Cited by 2 · see citing works
The Role of Meat in a Healthful Dietary Pattern: Evidence from Menu Modeling
Cochran, B. H. N. (2015) · Journal of Nutrition & Food Sciences · doi:10.4172/2155-9600.1000404 · Cited by 2 · see citing works
- Authors
- Astrup, A., Raben, A., & Geiker, N.
- Affiliations
- University of Copenhagen (DK)
- Herlev Hospital (DK)
- Corresponding author
- Astrup, A
- Venue
- International Journal of Obesity
- Published
- 2014-12-26
- Volume
- 39
- Issue
- 5
- Pages
- 721-726
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- PMC
- PMC4424378
- OpenAlex
- W2045725181
- Cited by
- 137
- References
- 38
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 14 · 2023: 15 · 2022: 6 · 2021: 12 · 2020: 17 · 2019: 12 · 2018: 11 · 2017: 19 · 2016: 11 · 2015: 8 · 2012: 1
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- International Journal of Obesity (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- high-protein diet, weight management, obesity, weight regain prevention, glycemic index, low glycemic index carbohydrates, ad libitum feeding, weight loss maintenance, obesity-related comorbidities, blood pressure, serum lipids, inflammation, gene-diet interaction
- MeSH terms
- Diabetes Mellitus, Type 2, Diet, Reducing, Dietary Carbohydrates, Dietary Proteins, Humans, Obesity, Patient Compliance, Weight Loss, Comorbidity, Randomized Controlled Trials as Topic, Genetic Predisposition to Disease, Glycemic Index, Evidence-Based Practice, Weight Reduction Programs
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