Brain perfusion SPECT: age- and sex-related effects correlated with voxel-based morphometric findings in healthy adults
Abstract
PURPOSE: To investigate brain perfusion at single photon emission computed tomography (SPECT) as a function of age and sex in healthy adult volunteers and to correlate perfusion with gray matter concentration determined by using voxel-based morphometry (VBM). MATERIALS AND METHODS: Eighty-one healthy volunteers underwent both technetium 99m ethylene cysteine dimer SPECT and three-dimensional magnetization preparation rapid acquisition gradient-echo magnetic resonance (MR) imaging. Statistical parametric mapping was used to conduct VBM analysis of the morphologic data, which were compared voxel by voxel with the results of a similar analysis of the perfusion data and more specifically in brain areas showing significant perfusion changes. RESULTS: VBM data, as compared with perfusion changes, indicated a more symmetric age-related gray matter volume decrease along the Sylvian fissure and in subcortical regions (P < .001). The combination of functional and structural changes indicated a relatively lower functional decrease with aging, as compared with the structural atrophy in the visual, parietal, sensorimotor, and right prefrontal cortices. Significant relative morphologic sex-based differences were found in the cerebellar and temporal cortices, but the comparison did not reveal significant differences between the functional and morphometric data. CONCLUSION: Age-related perfusion changes are paralleled by similar more symmetric changes in gray matter concentration, which are more prominent than the perfusion changes in some regions. No sex-based differences between perfusion and gray matter concentration were found.
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Studies using ROI or VBM have yielded contradictory results regarding whether the hippocampus is preserved or deteriorates with aging.
“In spite of the objectivity of this method, studies led to somewhat contradictory results regarding the hippocampus: some authors have found this structure to be preserved with aging [29,31], whereas others have reported structural deterioration [38,81,84,87].”
From Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging (2009) · cites this paper as [84]
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- Authors
- Van Laere, K. J., & Dierckx, R. A.
- Venue
- Radiology
- Published
- 2001-12
- Volume
- 221
- Issue
- 3
- Pages
- 810-817
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2134145461
- Cited by
- 67
- References
- 50
- Citations by year
- 2021: 1 · 2020: 2 · 2018: 2 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiology (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- cerebral perfusion, aging, sex differences, gray matter volume, gray matter concentration, brain atrophy, voxel-based morphometry, SPECT, healthy adults, cerebellum, temporal cortex, prefrontal cortex
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Brain, Cerebrovascular Circulation, Cysteine, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Sex Characteristics, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Radiopharmaceuticals
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