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Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained with the Kety-Schmidt technique

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Madsen, Peter Lund, Hasselbalch, Steen G., Hagemann, Lars P., Olsen, Karsten Skovgaard, Bülow, Jens, Holm, Søren, Wildschiødtz, Gordon, Paulson, Olaf B. +1 more·1995·Journal of Cerebral Blood Flow & Metabolism
DOI 10.1038/jcbfm.1995.60
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Abstract

Global cerebral blood flow (CBF), global cerebral metabolic rates for oxygen (CMRO 2 ), and for glucose (CMR glc ), and lactate efflux were measured during rest and during cerebral activation induced by the Wisconsin card sorting test. Measurements were performed in healthy volunteers using the Kety–Schmidt technique. Global CMRO 2 was unchanged during cerebral activation, whereas global CBF and global CMR glc both increased by 12%, reducing the molar ratio of oxygen to glucose consumption from 6.0 during baseline conditions to 5.4 during activation. Data obtained in the period following cerebral activation showed that the activation-induced resetting of the relation between CMR glc and CMRO 2 persisted virtually unaltered for ≥40 min after the mental activation task was terminated. The activation-induced increase in cerebral lactate efflux measured over the same time period accounted for only a small fraction of the activation-induced excess glucose uptake. These data confirm earlier reports that brain activation can induce resetting of the cerebral oxygen/glucose consumption ratio, and indicate that the resetting persists for a long period after cerebral activation has been terminated and physiologic stress indicators returned to baseline values. Activation-induced resetting of the cerebral oxygen/glucose uptake ratio is not necessarily accounted for by increased lactate production from nonoxidative glucose metabolism.

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  • Aerobic glycolysis (AG), the non-oxidative metabolism of glucose despite abundant oxygen, accounts for approximately 10-12% of the glucose consumed by the normal adult human brain.

    “Aerobic glycolysis (AG), i.e., non-oxidative metabolism of glucose despite the presence of abundant oxygen, accounts for 10–12% of glucose used by the adult human brain.”

    From Aerobic glycolysis in the human brain is associated with development and neotenous gene expression (2014) · cites this paper as Madsen et al., 1995

    In “Global metabolism before and during mental activation” (page unavailable), the paper reports a 12% increase in glucose uptake during activation, not that aerobic glycolysis accounts for 10–12% of glucose use in the normal resting adult brain. Its baseline lactate/glucose index was 6%, and the Concluding remarks say the data do not establish the nature of the metabolic processes behind the altered oxygen/glucose ratio. (LLM, conf=0.87)

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  • Aerobic glycolysis persists for at least 40 minutes following cognitively demanding task performance, despite the return of blood flow and lactate production to control levels.

    “Curiously, AG persists for at least 40 minutes following cognitive demanding task performance, despite the return of blood flow and lactate production to control levels”

    From Aerobic glycolysis in the human brain is associated with development and neotenous gene expression (2014) · cites this paper as Madsen et al., 1995

    The Global metabolism section (page unavailable) reports that glucose uptake remained elevated relative to oxygen uptake for about 40 minutes after the mental task. The Relation between excess CMRglc and CMRlac section says lactate measures returned to baseline within 20 minutes. But the Concluding remarks (page unavailable) say the study cannot identify the metabolic process behind the persistent uptake-ratio change, so it does not establish persistent aerobic glycolysis; the passages also do not establish that blood flow returned to control levels after the task. (LLM, conf=0.88)

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Authors
Madsen, P. L., Hasselbalch, S. G., Hagemann, L. P., Olsen, K. S., Bülow, J., Holm, S., Wildschiødtz, G., Paulson, O. B., & Lassen, N. A.
Affiliations
  • Bispebjerg Hospital (DK)
  • Department of Neurology, Copenhagen, Denmark
  • Department of Anesthesia, Copenhagen, Denmark
  • Department of Clinical Physiology and Nuclear Medicine, Copenhagen, Denmark
  • Rigshospitalet (DK)
ORCID
Venue
Journal of Cerebral Blood Flow & Metabolism
Publisher
SAGE Publications
Published
1995-05
Volume
15
Issue
3
Pages
485-491
ISSN
  • 0271-678X (ISSN-L)
  • 1559-7016
DOI
10.1038/jcbfm.1995.60
OpenAlex
W2005536744
Cited by
264
References
22
Citations by year
2026: 6 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 12 · 2016: 9 · 2015: 8 · 2014: 20 · 2013: 11 · 2012: 13
FWCI
8.07
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
cerebral blood flow, cerebral oxygen consumption, cerebral metabolic rate of glucose, lactate efflux, brain activation, Wisconsin Card Sorting Test, nonoxidative glucose metabolism, brain glucose metabolism
MeSH terms
Adult, Brain, Cerebrovascular Circulation, Female, Glucose, Humans, Male, Methods, Neuropsychological Tests, Oxygen Consumption

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