The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Role of Spleen-Derived Monocytes/Macrophages in Acute Ischemic Brain Injury
Open accessAbstract
Monocytes/macrophages (MMs), mononuclear phagocytes, have been implicated in stroke-induced inflammation and injury. However, the presence of pro-inflammatory Ly-6C high and antiinflammatory Ly-6C low monocyte subsets raises uncertainty regarding their role in stroke pathologic assessment. With recent identification of the spleen as an immediate reservoir of MMs, this current study addresses whether the spleen-derived MMs are required for stroke pathologic assessment. We observed that the spleen was contracted in poststroke animals and the contraction was accompanied by decreased number of Ly-6C high and Ly-6C low subsets in the spleen. The deployment of these subsets from the spleen temporally coincided with respective increases in the ischemic brain. Compared to mice with the spleen, mice receiving a splenectomy just before the stroke displayed less accumulation of Ly-6C high and Ly-6C low MMs in the brain. Despite the reduced accumulation of both subsets, infarct size and swelling were not reduced in the asplenic mice. The dissociative findings of infarct size and extent of MM infiltration in the postischemic brain indicate minimal involvement of spleen-derived total MMs in acute infarct development. Selective Ly-6C high or Ly-6C low MM targeting is suggested to address the contribution of the individual subset to acute stroke pathologic assessment.
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Cites
Monocyte recruitment during infection and inflammation
Shi, C., & Pamer, E. G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3070 · Cited by 3,015
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Identification of splenic reservoir monocytes and their deployment to inflammatory sites
Swirski, F. K., Nahrendorf, M., Etzrodt, M., Wildgruber, M., Cortez-Retamozo, V., Panizzi, P., Figueiredo, J.-L., Kohler, R. H., Chudnovskiy, A., Waterman, P., et al. (2009) · Science · doi:10.1126/science.1175202 · Cited by 2,221
Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior
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Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke
Gelderblom, M., Leypoldt, F., Steinbach, K., Behrens, D., Choe, C.-U., Siler, D. A., Arumugam, T. V., Orthey, E., Gerloff, C., Tolosa, E., et al. (2009) · Stroke · doi:10.1161/strokeaha.108.534503 · Cited by 1,066
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
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Absence of the Chemokine Receptor CCR2 Protects Against Cerebral Ischemia/Reperfusion Injury in Mice
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Cited by
Immune responses to stroke: mechanisms, modulation, and therapeutic potential.
Iadecola, C., Buckwalter, M. S., & Anrather, J. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135530 · Cited by 853
Dabrowska, S., Andrzejewska, A., Lukomska, B., & Janowski, M. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1571-8 · Cited by 298
Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients
Bolayir, A., Gokce, S. F., Cigdem, B., Bolayir, H. A., Yildiz, O. K., Bolayir, E., & Topaktas, S. A. (2018) · Neurologia i Neurochirurgia Polska · doi:10.1016/j.pjnns.2017.08.011 · Cited by 98
The Translational Potential of Microglia and Monocyte-Derived Macrophages in Ischemic Stroke
Wicks, E. E., Ran, K. R., Kim, J. E., Xu, R., Lee, R. P., & Jackson, C. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.897022 · Cited by 92
Protective features of peripheral monocytes/macrophages in stroke
Gliem, M., Schwaninger, M., & Jander, S. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.004 · Cited by 88
Metadata
- Authors
- Kim, E., Yang, J., Beltran, C. D., & Cho, S.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2014-05-28
- Volume
- 34
- Issue
- 8
- Pages
- 1411-1419
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W1986677588
- Cited by
- 186
- References
- 16
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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