The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Is L-Lactate a Novel Signaling Molecule in the Brain?
Open accessAbstract
In the brain, L-lactate is produced by both neurons and astrocytes. There is no doubt that neurons use L-lactate as a supplementary fuel although the importance of this energy source is disputed. Irrespective of its caloric value, L-lactate might also have a signaling role in the brain. Here, we review several current hypotheses of L-lactate mediated signaling. Some proposed mechanisms require L-lactate entry into the neurons leading to a shift in ATP/ADP ratio or redox state. Others postulate interaction with either known receptor HCA1 (GPR81) or a novel, yet unidentified receptor. We argue that the sensitivity of any such mechanism has to match the concentration range of extracellular L-lactate, which is less than ~ 1.5 mmol/L under physiologic conditions. From that point of view, some of the proposed mechanisms require supraphysiologic levels of L-lactate and could be engaged during ischemia or seizures when L-lactate concentration rises dramatically. Currently, we do not know whether L-lactate production in the brain occurs in microdomains, which might create higher than average local concentrations. Nevertheless, it is clear that in the brain, as in the peripheral tissues, L-lactate is not only used as a source of energy but also acts as a signaling molecule.
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Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
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Cited by
Lactate in the brain: from metabolic end-product to signalling molecule
Magistretti, P. J., & Allaman, I. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.19 · Cited by 1,298
Brain Glucose Metabolism: Integration of Energetics with Function
Dienel, G. A. (2019) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 865
Astrocyte-neuron metabolic cooperation shapes brain activity
Bonvento, G., & Bolaños, J. P. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.006 · Cited by 580
In vivo evidence for a lactate gradient from astrocytes to neurons
Mächler, P., Wyss, M. T., Elsayed, M., Stobart, J., Gutierrez, R., von Faber-Castell, A., Kaelin, V., Zuend, M., San Martín, A., Romero-Gómez, I., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.010 · Cited by 571
Romero-Garcia, S., Moreno-Altamirano, M. M. B., Prado-Garcia, H., & Sánchez-García, F. J. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00052 · Cited by 506
Metadata
- Authors
- Mosienko, V., Teschemacher, A. G., & Kasparov, S.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2015-04-29
- Volume
- 35
- Issue
- 7
- Pages
- 1069-1075
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2029205073
- Cited by
- 176
- References
- 10
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
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