Cited by 298Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyDermatology and Skin Diseases

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Skin-Resident T Cells: The Ups and Downs of On Site Immunity

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Clark, Rachael A.·2010·Journal of Investigative Dermatology

DOI 10.1038/jid.2009.247PMC PMC2922675

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Abstract

The cutaneous surface of a normal adult individual contains approximately 20 billion T cells, nearly twice the number present in the entire circulation. Recent studies have shown a role for these cells in both normal immunity and in inflammatory skin diseases such as psoriasis. Regulatory T cells protect against autoimmune reactions to self antigens and assist in the resolution of cutaneous inflammation. However, they can also shield tumors from immune detection, allow latent infections to persist and can dysfunction under the conditions present in inflammatory skin diseases. Th17 T cells protect organisms against extracellular pathogens but also have a key role in the pathogenesis of psoriasis. Evidence suggests that effector memory T cells produced during immune reactions survive and persist long term within the skin, providing local and rapid protection against pathogen reexposure. This review summarizes the current understanding of how skin-resident T cells contribute to normal and aberrant immunity in the skin.

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Authors: Clark, R. A.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Clark, Rachael A.
ORCID: Clark, Rachael A.
Venue: Journal of Investigative Dermatology
Publisher: Elsevier BV
Published: 2010-02
Volume: 130
Issue: 2
Pages: 362-370
ISSN: 0022-202X (ISSN-L)
DOI: 10.1038/jid.2009.247
PMC: PMC2922675
OpenAlex: W2074644098
Cited by: 298
References: 97
Citations by year: 2026: 10 · 2025: 4 · 2024: 16 · 2023: 8 · 2022: 16 · 2021: 13 · 2020: 21 · 2019: 20 · 2018: 15 · 2017: 20 · 2016: 18 · 2015: 24 · 2014: 35 · 2013: 21 · 2012: 28
FWCI: 1.49
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2130 d)
Locations: Journal of Investigative Dermatology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Scleroderma Foundation
Leukemia and Lymphoma Society
National Institutes of Health (1K08AI060890-01A1, 1R01AR056720-01A1, 1R01CA122569-01A)
Damon Runyon Cancer Research Foundation
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords: skin-resident T cells, skin immunity, regulatory T cells, Th17 cells, effector memory T cells, psoriasis, skin inflammation, autoimmune tolerance, tumor immune evasion, viral latency, T cell dysfunction
MeSH terms: Animals, Endocytosis, Humans, Immune System, Immunologic Memory, Inflammation, Models, Biological, Psoriasis, Skin, Skin Physiological Phenomena, T-Lymphocytes, Autoimmunity, T-Lymphocyte Subsets, Interleukin-17, Mice

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Skin-Resident T Cells: The Ups and Downs of On Site Immunity

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