Cited by 241T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisDermatology and Skin Diseases

T cells and the skin: from protective immunity to inflammatory skin disorders

Ho, Allen W., Kupper, Thomas S.·2019·Nature Reviews Immunology

Abstract

Skin is our primary interface with the environment, and T cells are crucial for orchestrating host immune responses against pathogenic microorganisms at this site. Effective skin immune responses require the generation of antigen-specific effector T cells, which home to cutaneous sites of injury or infection. Long-lasting immunity against future immune challenges is mediated by memory T cells. Among the memory T cells found in skin are both recirculating cells that transit between skin and blood and tissue-resident memory T (T RM ) cells, which remain in skin for long periods of time and mediate durable protective immunity. These T RM cells also appear to drive many inflammatory diseases of skin. Here, we consider how a better understanding of cutaneous T cell responses can aid in the development of effective new therapies for immune-mediated cutaneous diseases.

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Crossref · 10.1038/s41577-019-0162-3

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204 of 204 references verified0 citation errors · 0 not checkable

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Authors
Ho, A. W., & Kupper, T. S.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Kupper, Thomas S.
Venue
Nature Reviews Immunology
Published
2019-04-16
Volume
19
Issue
8
Pages
490-502
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W2936645459
Cited by
241
References
207
Citations by year
2026: 17 · 2025: 28 · 2024: 39 · 2023: 41 · 2022: 38 · 2021: 42 · 2020: 28 · 2019: 8
FWCI
2.50
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Dermatology Foundation
  • National Institutes of Health (5r01ca120372-05)
  • National Cancer Institute (R01 CA120372)
  • National Institute of Allergy and Infectious Diseases (R01AI127654)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR065807, T32AR007098)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
skin immunity, tissue-resident memory T cells, memory T cells, effector T cells, skin inflammation, immune-mediated skin disease, innate-like T cells, protective immunity, T cell homing, skin immune response
MeSH terms
Animals, Humans, Immunologic Memory, Inflammation, Skin, Skin Diseases, T-Lymphocytes

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