T cells and the skin: from protective immunity to inflammatory skin disorders
Abstract
Skin is our primary interface with the environment, and T cells are crucial for orchestrating host immune responses against pathogenic microorganisms at this site. Effective skin immune responses require the generation of antigen-specific effector T cells, which home to cutaneous sites of injury or infection. Long-lasting immunity against future immune challenges is mediated by memory T cells. Among the memory T cells found in skin are both recirculating cells that transit between skin and blood and tissue-resident memory T (T RM ) cells, which remain in skin for long periods of time and mediate durable protective immunity. These T RM cells also appear to drive many inflammatory diseases of skin. Here, we consider how a better understanding of cutaneous T cell responses can aid in the development of effective new therapies for immune-mediated cutaneous diseases.
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The immune response and inflammatory processes involved in wound healing can vary between mice and humans.
“Additionally, the immune response and inflammatory processes involved in wound healing can vary between mice and humans.”
From Anti-Inflammatory and Histological Analysis of Skin Wound Healing through Topical Application of Mexican Propolis (2023) · cites this paper as [92]
Mice may exhibit a more robust or different immune response compared to humans, so the effects of propolis on immune modulation and inflammation observed in mice may not directly translate to humans.
“Mice may exhibit a more robust or different immune response compared to humans, meaning that the effects of propolis on immune modulation and inflammation observed in mice may not directly translate to humans [91,92].”
From Anti-Inflammatory and Histological Analysis of Skin Wound Healing through Topical Application of Mexican Propolis (2023) · cites this paper as [92]
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- Authors
- Ho, A. W., & Kupper, T. S.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Kupper, Thomas S.
- Venue
- Nature Reviews Immunology
- Published
- 2019-04-16
- Volume
- 19
- Issue
- 8
- Pages
- 490-502
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2936645459
- Cited by
- 241
- References
- 207
- Citations by year
- 2026: 17 · 2025: 28 · 2024: 39 · 2023: 41 · 2022: 38 · 2021: 42 · 2020: 28 · 2019: 8
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dermatology Foundation
- National Institutes of Health (5r01ca120372-05)
- National Cancer Institute (R01 CA120372)
- National Institute of Allergy and Infectious Diseases (R01AI127654)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR065807, T32AR007098)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- skin immunity, tissue-resident memory T cells, memory T cells, effector T cells, skin inflammation, immune-mediated skin disease, innate-like T cells, protective immunity, T cell homing, skin immune response
- MeSH terms
- Animals, Humans, Immunologic Memory, Inflammation, Skin, Skin Diseases, T-Lymphocytes
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