The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients
Open accessAbstract
Reports of cognitive decline, symptom worsening and brain atrophy in bipolar disorder (BD) suggest that the disease progresses over time. The worsening neuropathology may involve excitotoxicity and neuroinflammation. We determined protein and mRNA levels of excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from 10 BD patients and 10 age-matched controls. The brain tissue was matched for age, postmortem interval and pH. The results indicated statistically significant lower protein and mRNA levels of the N-methyl-D-aspartate receptors, NR-1 and NR-3A, but significantly higher protein and mRNA levels of interleukin (IL)-1beta, the IL-1 receptor (IL-1R), myeloid differentiation factor 88, nuclear factor-kappa B subunits, and astroglial and microglial markers (glial fibrillary acidic protein, inducible nitric oxide synthase, c-fos and CD11b) in postmortem frontal cortex from BD compared with control subjects. There was no significant difference in mRNA levels of tumor necrosis factor alpha or neuronal nitric oxide synthase in the same region. These data show the presence of excitotoxicity and neuroinflammation in BD frontal cortex, with particular activation of the IL-R cascade. The changes may account for reported evidence of disease progression in BD and be a target for future therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“evidence of microglial and astroglial activation in several brain regions including frontal cortex, anterior cingulate cortex (ACC) and thalamus in post-mortem studies of patients with depression have been described57–59,60.”
From The role of inflammation in depression: from evolutionary imperative to modern treatment target (2016) · cites this paper as [57]
Experimental — accuracy not yet measuredIn the citing paper
“Previous work has identified differential activation of glial and neural-immune processes in brain from patients with psychiatric disorders (16, 52, 57, 66–69)”
From Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder (2018) · cites this paper as [69]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
3 retracted
Rao, J. S., Ertley, R. N., Rapoport, S. I., Bazinet, R. P., & Lee, H. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04648.x · Cited by 59
Self-citationRetractedRao, J. S., Ertley, R. N., Lee, H.-J., Rapoport, S. I., & Bazinet, R. P. (2006) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500391 · Cited by 40
Self-citationRetractedDecreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients
Rao, J. S., Rapoport, S. I., & Kim, H. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114570900025x · Cited by 22
Self-citationRetractedAnalysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Structure, Regulation and Function of NF-kappaB
Siebenlist, U. K., Franzoso, G., & Brown, K. D. (1994) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.10.110194.002201 · Cited by 2,086
TRAF6 is a signal transducer for interleukin-1
Cao, Z., Xiong, J., Takeuchi, M., Kurama, T., & Goeddel, D. V. (1996) · Nature · doi:10.1038/383443a0 · Cited by 1,305
Ciabarra, A., Sullivan, J., Gahn, L. G., Pecht, G., Heinemann, S., & Sevarino, K. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06498.1995 · Cited by 1,260
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.
Wesche, H., Henzel, W., Shillinglaw, W., Li, S., & Cao, Z.-D. (1997) · Immunity · doi:10.1016/s1074-7613(00)80402-1 · Cited by 1,247
Ninomiya‐Tsuji, J., Kishimoto, K., Hiyama, A., Inoue, J., Cao, Z., & Matsumoto, K. (1999) · Nature · doi:10.1038/18465 · Cited by 1,187
IRAK: A Kinase Associated with the Interleukin-1 Receptor
Cao, Z., Henzel, W. J., & Gao, X. (1996) · Science · doi:10.1126/science.271.5252.1128 · Cited by 898
Flagged first, then by citations
Cited by
Sorted by citations
The role of inflammation in depression: from evolutionary imperative to modern treatment target
Miller, A. H., & Raison, C. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.5 · Cited by 3,942
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
Gandal, M. J., Zhang, P., Hadjimichael, E., Walker, R. L., Chen, C., Liu, S., Won, H., van Bakel, H., Varghese, M., Wang, Y., et al. (2018) · Science · doi:10.1126/science.aat8127 · Cited by 1,247
Berk, M., Kapczinski, F., Andreazza, A. C., Dean, O. M., Giorlando, F., Maes, M., Yücel, M., Gama, C. S., Dodd, S., Dean, B., et al. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.001 · Cited by 1,178
Neuroinflammation and psychiatric illness
Najjar, S., Pearlman, D. M., Alper, K., Najjar, A., & Devinsky, O. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-43 · Cited by 733
The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders
Réus, G. Z., Fries, G. R., Stertz, L., Badawy, M., Passos, I. C., Barichello, T., Kapczinski, F., & Quevedo, J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.018 · Cited by 594
Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.165 · Cited by 555
Goldstein, B. I., Carnethon, M. R., Matthews, K. A., McIntyre, R. S., Miller, G. E., Raghuveer, G., Stoney, C. M., Wasiak, H., & McCrindle, B. W. (2015) · Circulation · doi:10.1161/cir.0000000000000229 · Cited by 519
Sex differences in depression: Insights from clinical and preclinical studies
Eid, R. S., Gobinath, A. R., & Galea, L. A. M. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.01.006 · Cited by 486
Bidirectional Microglia–Neuron Communication in Health and Disease
Szepesi, Z., Manouchehrian, O., Bachiller, S., & Deierborg, T. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00323 · Cited by 459
Cytokines in bipolar disorder vs. healthy control subjects: A systematic review and meta-analysis
Munkholm, K., Braüner, J. V., Kessing, L. V., & Vinberg, M. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.018 · Cited by 402
Implications of glial nitric oxide in neurodegenerative diseases
Yuste, J. E., Tarragon, E., Campuzano, C. M., & Ros-Bernal, F. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00322 · Cited by 356
Holmes, S. E., Hinz, R., Conen, S., Gregory, C. J., Matthews, J. C., Anton-Rodriguez, J. M., Gerhard, A., & Talbot, P. S. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.005 · Cited by 346
Features of Microglia and Neuroinflammation Relevant to Environmental Exposure and Neurotoxicity
Kraft, A. D., & Harry, G. J. (2011) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph8072980 · Cited by 340
Self-citationNeutrophil/lymphocyte ratio and platelet/lymphocyte ratio in mood disorders: A meta-analysis
Mazza, M. G., Lucchi, S., Tringali, A. G. M., Rossetti, A., Botti, E. R., & Clerici, M. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.03.012 · Cited by 326
Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients
Rao, J. S., Keleshian, V. L., Klein, S. L., & Рапопорт, С. И. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.55 · Cited by 305
Self-citationNeuroinflammation and Synaptic Loss
Rao, J. S., Kellom, M., Kim, H., Rapoport, S. I., & Reese, E. A. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0708-2 · Cited by 271
Self-citationThe kynurenine pathway in schizophrenia and bipolar disorder
Erhardt, S., Schwieler, L., Imbeault, S., & Engberg, G. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.05.020 · Cited by 265
Costello, H., Gould, R. L., Abrol, E., & Howard, R. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-027925 · Cited by 248
Biological hypotheses and biomarkers of bipolar disorder
Sigitova, E., Fišar, Z., Hroudová, J., Cikánková, T., & Raboch, J. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12476 · Cited by 257
Fillman, S. G., Sinclair, D., Fung, S. J., Webster, M. J., & Shannon Weickert, C. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.8 · Cited by 226
Matosin, N., Halldorsdottir, T., & Binder, E. B. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.021 · Cited by 226
Gigante, A. D., Bond, D. J., Lafer, B., Lam, R. W., Young, L. T., & Yatham, L. N. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2012.01033.x · Cited by 226
The microglial ATP‐gated ion channel P2X7 as a CNS drug target
Bhattacharya, A., & Biber, K. (2016) · Glia · doi:10.1002/glia.23001 · Cited by 221
Diversity and plasticity of microglial cells in psychiatric and neurological disorders
Nakagawa, Y., & Chiba, K. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.010 · Cited by 208
Effects of Lithium on Inflammation
Nassar, A., & Azab, A. N. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500038f · Cited by 230
Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan
Tay, T. L., Béchade, C., D’Andrea, I., St‐Pierre, M., Henry, M. S., Roumier, A., & Tremblay, M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00421 · Cited by 217
Emerging roles of GluN3-containing NMDA receptors in the CNS
Pérez-Otaño, I., Larsen, R. S., & Wesseling, J. F. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.92 · Cited by 214
Kim, H., Rapoport, S. I., & Rao, J. S. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.010 · Cited by 211
Self-citationBhattacharya, A., Wang, Q., Ao, H., Shoblock, J. R., Lord, B., Aluisio, L. E., Fraser, I. C., Nepomuceno, D. H., Neff, R. A., Welty, N., et al. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12314 · Cited by 204
Igarashi, M., Ma, K., Gao, F., Kim, H., Rapoport, S. I., & Rao, J. S. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101608 · Cited by 208
Self-citationKhan, A. A., Plana‐Ripoll, O., Antonsen, S., Brandt, J. G., Geels, C., Landecker, H. L., Sullivan, P. F., Pedersen, C. B., & Rzhetsky, A. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000353 · Cited by 214
Misiak, B., Stańczykiewicz, B., Kotowicz, K., RYBAKOWSKI, J. K., Samochowiec, J., & Frydecka, D. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.04.015 · Cited by 209
Novel therapeutic targets in depression: Minocycline as a candidate treatment
Soczynska, J. K., Mansur, R. B., Brietzke, E. M., Swardfager, W., Kennedy, S. H., Woldeyohannes, H. O., Powell, A. M., Manierka, M. S., & McIntyre, R. S. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.026 · Cited by 192
A systematic review of evidence for the role of inflammatory biomarkers in bipolar patients
Sayana, P., Colpo, G. D., Simões, L. R., Giridharan, V. V., Teixeira, A. L., Quevedo, J., & Barichello, T. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.03.018 · Cited by 196
Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders
Kim, Y., Vadodaria, K. C., Lenkei, Z., Kato, T., Gage, F. H., Marchetto, M. C., & Santos, R. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7606 · Cited by 193
Is bipolar disorder an inflammatory condition? The relevance of microglial activation
Stertz, L., Magalhães, P. V. D. S., & Kapczinski, F. P. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32835aa4b4 · Cited by 184
Elevation of cerebrospinal fluid interleukin-1β in bipolar disorder
Söderlund, J., Olsson, S. K., Samuelsson, M., Walther–Jallow, L., Johansson, C., Erhardt, S., Landén, M., & Engberg, G. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100080 · Cited by 182
Bipolar Disorder and Inflammation
Rosenblat, J. D., & McIntyre, R. S. (2016) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2015.09.006 · Cited by 186
Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders
Kalkman, H. O., & Feuerbach, D. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2175-4 · Cited by 191
Scaini, G., Rezin, G. T., Carvalho, A. F., STRECK, E. L., Berk, M., & Quevedo, J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.040 · Cited by 187
Davis, M. T., Holmes, S. E., Pietrzak, R. H., & Esterlis, I. (2017) · Chronic Stress · doi:10.1177/2470547017710916 · Cited by 194
Husain, M. I., Chaudhry, I. B., Khoso, A. B., Husain, M. O., Hodsoll, J., Ansari, M. A., Naqvi, H. A., Minhas, F. A., Carvalho, A. F., Meyer, J. H., et al. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30138-3 · Cited by 167
Neuropathology of mood disorders: Do we see the stigmata of inflammation?
Mechawar, N., & Savitz, J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.212 · Cited by 165
Hope, S., Dieset, I., Agartz, I., Steen, N. E., Ueland, T., Melle, I., Aukrust, P., & Andreassen, O. A. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.08.003 · Cited by 164
The P2X7 Receptor: Central Hub of Brain Diseases
Andrejew, R., Oliveira-Giacomelli, Á., Ribeiro, D. E., Glaser, T., Arnaud-Sampaio, V. F., Lameu, C., & Ulrich, H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00124 · Cited by 162
Gamazon, E. R., Badner, J. A., Cheng, L., Zhang, C., Zhang, D., Cox, N. J., Gershon, E. S., Kelsoe, J. R., Greenwood, T. A., Nievergelt, C. M., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.174 · Cited by 158
Bipolar disorder and mechanisms of action of mood stabilizers
Rapoport, S. I., Basselin, M., Kim, H., & Rao, J. S. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.06.003 · Cited by 159
Self-citationMedical comorbidity in bipolar disorder: The link with metabolic-inflammatory systems
SayuriYamagata, A., Brietzke, E. M., Rosenblat, J. D., Kakar, R., & McIntyre, R. S. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.12.059 · Cited by 160
Revisiting inflammation in bipolar disorder
Fries, G. R., Walss-Bass, C., Bauer, M. E., & Teixeira, A. L. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.12.006 · Cited by 147
Cytokines in Bipolar Disorder: Paving the Way for Neuroprogression
Barbosa, I. G., Bauer, M. E., Machado‐Vieira, R., & Teixeira, A. L. (2014) · Neural Plasticity · doi:10.1155/2014/360481 · Cited by 154
Konradi, C. L., Daws, S. E., & Clay, H. B. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.025 · Cited by 148
Gigante, A. D., Young, L. T., Yatham, L. N., Andreazza, A. C., Nery, F. G., Grinberg, L. T., Heinsen, H., & Lafer, B. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571000146x · Cited by 145
The Immunology of Bipolar Disorder
Barbosa, I. G., Machado‐Vieira, R., Soares, J. C., & Teixeira, A. L. (2014) · NeuroImmunoModulation · doi:10.1159/000356539 · Cited by 146
Inflammatory signaling mechanisms in bipolar disorder
Jones, G. H., Vecera, C. M., Pinjari, O. F., & Machado‐Vieira, R. (2021) · Journal of Biomedical Science · doi:10.1186/s12929-021-00742-6 · Cited by 148
Inflammation‐driven brain and gut barrier dysfunction in stress and mood disorders
Doney, E., Cadoret, A., Dion‐Albert, L., Lebel, M., & Ménard, C. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15239 · Cited by 134
Kim, H. K., Andreazza, A. C., Elmi, N., Chen, W., & Young, L. T. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.10.015 · Cited by 128
Self-citationChitty, K. M., Lagopoulos, J., Lee, R. S. C., Hickie, I. B., & Hermens, D. F. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.07.007 · Cited by 133
The role of NMDA receptors in the pathophysiology and treatment of mood disorders
Ghasemi, M., Phillips, C., Trillo, L., Miguel, Z. D., Das, D., & Salehi, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.017 · Cited by 132
Neuroprogression and illness trajectories in bipolar disorder
Kapczinski, N. S., Mwangi, B., Cassidy, R. M., Librenza‐Garcia, D., Bermúdez, M. B., Kauer‐Sant’Anna, M., Kapczinski, F. P., & Passos, I. C. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1240615 · Cited by 132
Principles of inflammasome priming and inhibition: implications for psychiatric disorders
Herman, F. J., & Pasinetti, G. M. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.06.010 · Cited by 115
Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology
Parrott, J. M., & O’Connor, J. C. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00116 · Cited by 125
Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients
Kim, H., Рапопорт, С. И., & Rao, J. S. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.137 · Cited by 122
Self-citationPostmortem evidence of brain inflammatory markers in bipolar disorder: a systematic review
Giridharan, V. V., Sayana, P., Pinjari, O. F., Ahmad, N., da Rosa, M. I., Quevedo, J., & Barichello, T. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0448-7 · Cited by 120
Molecular Mechanisms of Bipolar Disorder: Progress Made and Future Challenges
Kim, Y., Santos, R., Gage, F. H., & Marchetto, M. C. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00030 · Cited by 127
Goldstein, B. I., Baune, B. T., Bond, D. J., Chen, P., Eyler, L. T., Fagiolini, A. M., Gomes, F. A., Hájek, T., Hatch, J. K., McElroy, S. L., et al. (2020) · Bipolar Disorders · doi:10.1111/bdi.12921 · Cited by 116
Interleukin-1β Causes Anxiety by Interacting with the Endocannabinoid System
Rossi, S., Sacchetti, L., Napolitano, F., Chiara, V. D., Motta, C., Studer, V., Musella, A., Barbieri, F. R., Bari, M., Bernardi, G., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1515-12.2012 · Cited by 118
Altamura, A. C., Buoli, M., & Pozzoli, S. M. (2013) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12089 · Cited by 113
Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target?
McNamara, R. K., & Lotrich, F. E. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.98 · Cited by 112
Kim, H. K., Nunes, P. V., de Oliveira, K. C., Young, L. T., & Lafer, B. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.01.008 · Cited by 112
Self-citationRao, J. S., Kim, H.-W., Harry, G. J., Rapoport, S. I., & Reese, E. A. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.02.017 · Cited by 106
Self-citationRetractedAnti-TNF-α Compounds as a Treatment for Depression
Uzzan, S., & Azab, A. N. (2021) · Molecules · doi:10.3390/molecules26082368 · Cited by 112
Altered fatty acid concentrations in prefrontal cortex of schizophrenic patients
Taha, A. Y., Cheon, Y., Ma, K., Rapoport, S. I., & Rao, J. S. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.01.016 · Cited by 105
Self-citationImmunity, Inflammation, and Bipolar Disorder: Diagnostic and Therapeutic Implications
Hamdani, N., Doukhan, R., Kurtlucan, O., Tamouza, R., & Leboyer, M. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0387-y · Cited by 107
Tsai, S., Chung, K., Wu, J.-Y., Kuo, C., Lee, H., & Huang, S. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.022 · Cited by 103
Rao, J. S., Kellom, M., Reese, E. A., Rapoport, S. I., & Kim, H. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.017 · Cited by 101
Self-citationRetractedMuszyński, P., Groblewska, M., Kulczyńska‐Przybik, A., Kułakowska, A., & Mroczko, B. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170208124324 · Cited by 104
Brain lipid concentrations in bipolar disorder
Igarashi, M., Ma, K., Gao, F., Kim, H., GREENSTEIN, D. K., Rapoport, S. I., & Rao, J. S. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.08.001 · Cited by 101
Self-citationMonocyte and microglial activation in patients with mood-stabilized bipolar disorder
Jakobsson, J., Bjerke, M., Sahebi, S., Isgren, A., Ekman, C. J., Sellgren, C. M., Olsson, B., Zetterberg, H., Blennow, K., Pålsson, E., et al. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140183 · Cited by 99
Dean, B., Gibbons, A. S., Tawadros, N., Brooks, L., Everall, I., & Scarr, E. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.95 · Cited by 99
Tsai, S.-J. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.06.001 · Cited by 98
Fusar-Poli, L., Natale, A., Amerio, A., Cimpoesu, P., Grimaldi Filioli, P., Aguglia, E., Amore, M., Serafini, G., & Aguglia, A. (2021) · Brain Sciences · doi:10.3390/brainsci11010058 · Cited by 93
Goldstein, B. I., Collinger, K. A., Lotrich, F. E., Marsland, A. L., Gill, M., Axelson, D., & Birmaher, B. B. (2011) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2011.0009 · Cited by 97
Are medical comorbid conditions of bipolar disorder due to immune dysfunction?
Rosenblat, J. D., & McIntyre, R. S. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12414 · Cited by 97
Brand, S., Moller, M., & Harvey, B. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150307004545 · Cited by 95
Is it time for immunopsychiatry in psychotic disorders?
Leboyer, M., Oliveira, J., Tamouza, R., & Groc, L. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4266-1 · Cited by 98
Applications of blood-based protein biomarker strategies in the study of psychiatric disorders
Chan, M. K., Gottschalk, M. G., Haenisch, F., Tomasik, J., Ruland, T., Rahmoune, H., Guest, P. C., & Bahn, S. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.08.002 · Cited by 98
Draper, A., Koch, R. M., van der Meer, J. W., Apps, M. A. J., Pickkers, P., Husain, M., & van der Schaaf, M. E. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.231 · Cited by 94
Kadriu, B., Farmer, C., Yuan, P., Park, L. T., Deng, Z., Moaddel, R., Henter, I. D., Shovestul, B. J., Ballard, E. D., Kraus, C., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0589-8 · Cited by 93
Rege, S., & Hodgkinson, S. J. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413499077 · Cited by 90
The emerging tale of microglia in psychiatric disorders
Rahimian, R., Wakid, M., O’Leary, L. A., & Mechawar, N. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.023 · Cited by 96
Young, K. D., Drevets, W. C., Dantzer, R., Teague, T. K., Bodurka, J., & Savitz, J. B. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.04.007 · Cited by 91
Immune-based strategies for mood disorders: facts and challenges
Colpo, G. D., Leboyer, M., Dantzer, R., Trivedi, M. H., & Teixeira, A. L. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1407242 · Cited by 93
Sex differences in the blood–brain barrier: Implications for mental health
Dion‐Albert, L., Binder, L. B., Daigle, B., Hong-Minh, A., Lebel, M., & Ménard, C. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100989 · Cited by 93
Improving Lithium Therapeutics by Crystal Engineering of Novel Ionic Cocrystals
Smith, A. J., Kim, S.-H., Duggirala, N. K., Jin, J., Wojtas, Ł., Ehrhart, J. C., Giunta, B. N., Tan, J., Zaworotko, M. J., & Shytle, R. D. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400571a · Cited by 90
Bélarbi, K., Arellano, C., Ferguson, R. A., Jopson, T. D., & Rosi, S. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.07.225 · Cited by 90
Rao, J. S., Rapoport, S. I., & Kim, H. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.27 · Cited by 86
Self-citationRetractedSethi, R., Gómez‐Coronado, N., Walker, A. J., Robertson, O. D., Agustini, B., Berk, M., & Dodd, S. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00605 · Cited by 90
Goldstein, B. I., & Young, L. T. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0425-9 · Cited by 88
Resilience and Vulnerability to Pain and Inflammation in the Hippocampus
Vasić, V., & Schmidt, M. H. H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040739 · Cited by 88
Munkholm, K., Weikop, P., Kessing, L. V., & Vinberg, M. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.09.021 · Cited by 83
Metadata
- Authors
- Rao, J. S., Harry, G. J., Rapoport, S. I., & Kim, H. W.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Rao, J S
- ORCID
- Venue
- Molecular Psychiatry
- Published
- 2009-06-02
- Volume
- 15
- Issue
- 4
- Pages
- 384-392
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC2844920
- OpenAlex
- W2014858274
- Cited by
- 432
- References
- 54
- Citations by year
- 2026: 12 · 2025: 10 · 2024: 18 · 2023: 20 · 2022: 23 · 2021: 35 · 2020: 31 · 2019: 26 · 2018: 26 · 2017: 29 · 2016: 38 · 2015: 48 · 2014: 25 · 2013: 25 · 2012: 26
- FWCI
- 13.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 AG999999)
- National Institute on Aging
- National Institute of Mental Health (R24MH068855)
- National Cancer Institute
- National Institute of Environmental Health Sciences
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- bipolar disorder, excitotoxicity, neuroinflammation, frontal cortex, NMDA receptor, NR1, IL-1β, IL-1 receptor, myeloid differentiation factor 88, NF-κB, microglia, astrocytes, glial fibrillary acidic protein, inducible nitric oxide synthase, c-fos, CD11b, disease progression, postmortem brain
- MeSH terms
- Adult, Bipolar Disorder, Female, Frontal Lobe, Gene Expression Regulation, Humans, Male, Middle Aged, Nerve Tissue Proteins, Nuclear Proteins, Postmortem Changes, RNA, Messenger, Statistics as Topic, Case-Control Studies, Receptors, N-Methyl-D-Aspartate, Proto-Oncogene Proteins c-fos, Receptors, Interleukin-1, Inflammation Mediators, CD11b Antigen, Interleukin-1beta, Myeloid Differentiation Factor 88
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
