Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder

Fillman, S G; Sinclair, D; Fung, S J; Webster, M J; Shannon Weickert, C

doi:10.1038/tp.2014.8

Cited by 226Tryptophan and brain disordersSchizophrenia research and treatmentStress Responses and Cortisol

Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder

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Fillman, S G, Sinclair, D, Fung, S J, Webster, M J, Shannon Weickert, C·2014·Translational Psychiatry

DOI 10.1038/tp.2014.8PMC PMC3944638

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Abstract

Schizophrenia and bipolar disorder share a number of common features, both symptomatically and biologically. Abnormalities in the neuroimmune and the stress-signaling pathways have been previously identified in brains of individuals with both diseases. However, the possible relationship between abnormalities in stress and neuroimmune signaling within the cortex of people with psychotic illness has not been defined. To test the hypothesis that combined alterations in brain stress responsiveness and neuroimmune/inflammatory status are characteristic of some individuals suffering from major mental illness, we examined gene expression in the Stanley Array Cohort of 35 controls, 35 individuals with schizophrenia and 34 individuals with bipolar disorder. We used levels of 8 inflammatory-related transcripts, of which SERPINA3 was significantly elevated in individuals with schizophrenia (F(2,88)=4.137, P<0.05), and 12 glucocorticoid receptor signaling (stress) pathway transcripts previously examined, to identify two clusters of individuals: a high inflammation/stress group (n=32) and a low (n=68) inflammation/stress group. The high inflammation/stress group has a significantly greater number of individuals with schizophrenia (n=15), and a trend toward having more bipolar disorder individuals (n=11), when compared with controls (n=6). Using these subgroups, we tested which microarray-assessed transcriptional changes may be associated with high inflammatory/stress groups using ingenuity analysis and found that an extended network of gene expression changes involving immune, growth factors, inhibitory signaling and cell death factors also distinguished these groups. Our work demonstrates that some of the heterogeneity in schizophrenia and bipolar disorder may be partially explained by inflammation/stress interactions, and that this biological subtype cuts across Diagnostic and Statistical Manual of Mental Disorders (DSM)-defined categories.

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Stress and immune responses markedly affect PNN integrity and metalloprotease expression.
“Second, PNN integrity and expression of metalloproteases are markedly affected by stress and immune responses (Fillman et al., 2014; Franklin et al., 2008; Gray et al., 2008; Medina-Flores et al., 2004).”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Fillman et al., 2014

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Liu, L., Jia, F., Yuan, G., Chen, Z., Yao, J., Li, H., & Fang, C. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2008.10.024 · Cited by 57 · see citing works
Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease
Ramaswamy, S., McBride, J. L., Han, I., Berry‐Kravis, E., Zhou, L., Herzog, C. D., Gasmi, M., Bartus, R. T., & Kordower, J. H. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.12.005 · Cited by 57 · see citing works
Glucocorticoid-independent Repression of Tumor Necrosis Factor (TNF) α-stimulated Interleukin (IL)-6 Expression by the Glucocorticoid Receptor
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Odor Hedonic Capacity and Anhedonia in Schizophrenia and Unaffected First-Degree Relatives of Schizophrenia Patients
Kamath, V. J., Moberg, P. J., Kohler, C. G., Gur, R. C., & Turetsky, B. I. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr050 · Cited by 55 · see citing works
Identification of Lysines within α1-Antichymotrypsin Important for DNA Binding. AN UNUSUAL COMBINATION OF DNA-BINDING ELEMENTS
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Investigation of linkage and association/linkage disequilibrium of HLA A‐, DQA1‐, DQB1‐, and DRB1‐alleles in 69 sib‐pair‐ and 89 trio‐families with schizophrenia
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Gene Expression Analysis Implicates a Death Receptor Pathway in Schizophrenia Pathology
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Area-specific effects of brain-derived neurotrophic factor (BDNF) genetic ablation on various neuronal subtypes of the mouse brain
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CHRONIC STIMULATION OF THE HYPOTHALAMUS–PITUITARY–ADRENAL AXIS IN RATS BY INTERLEUKIN 1β: CENTRAL AND PERIPHERAL MECHANISMS
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Effects of antenatal dexamethasone treatment on glucocorticoid receptor and calcyon gene expression in the prefrontal cortex of neonatal and adult common marmoset monkeys
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Immune activation, steroid resistancy and bipolar disorder
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Glucocorticoid receptor mRNA in human frontal cortex
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Self-citation
Increases in [3H]Muscimol and [3H]Flumazenil Binding in the Dorsolateral Prefrontal Cortex in Schizophrenia Are Linked to α4 and γ2S mRNA Levels Respectively
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Self-citation
Successful intracerebral allotransplantation of pancreatic endocrine cells in spontaneous diabetic BB rats without immunosuppression
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The Editors' Choice
Leung, D. Y. M., Nelson, H. S., Szefler, S. J., & Busse, W. W. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(03)80111-2 · Cited by 18 · see citing works
Glucocorticoid inhibits the human pro-interleukin lβ gene (ILIB) by decreasing DNA binding of transactivators to the signal-responsive enhancer
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Effects of Alzheimer's peptide and α1-antichymotrypsin on astrocyte gene expression
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Schizophrenia
Kahn, R. S., Sommer, I. E., Murray, R. M., Meyer‐Lindenberg, A., Weinberger, D. R., Cannon, T. D., O’Donovan, M. C., Correll, C. U., Kane, J. M., van Os, J., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.67 · Cited by 1,132 · see citing works
Inflammation Effects on Motivation and Motor Activity: Role of Dopamine
Felger, J. C., & Treadway, M. T. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.143 · Cited by 453 · see citing works
Imaging the Role of Inflammation in Mood and Anxiety-related Disorders
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Immune involvement in the pathogenesis of schizophrenia: a meta-analysis on postmortem brain studies
van Kesteren, C. F. M. G., Gremmels, H., de Witte, L. D., Hol, E. M., Gool, A. R. V., Falkai, P., Kahn, R. S., & Sommer, I. E. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.4 · Cited by 368 · see citing works
Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review
Trépanier, M. O., Hopperton, K. E., Mizrahi, R., Mechawar, N., & Bazinet, R. P. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.90 · Cited by 360 · see citing works
The neural diathesis-stress model of schizophrenia revisited: an update on recent findings considering illness stage and neurobiological and methodological complexities
Pruessner, M., Cullen, A. E., Aas, M., & Walker, E. F. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.013 · Cited by 315 · see citing works
Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia
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Elevated peripheral cytokines characterize a subgroup of people with schizophrenia displaying poor verbal fluency and reduced Broca’s area volume
Fillman, S. G., Weickert, T. W., Lenroot, R. K., Catts, S. V., Bruggemann, J. M., Catts, V. S., & Weickert, C. S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.90 · Cited by 270 · see citing works
Self-citation
The microbiome, immunity, and schizophrenia and bipolar disorder.
Dickerson, F., Severance, E., & Yolken, R. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.12.010 · Cited by 268 · see citing works
“In schizophrenia and bipolar disorder, a low-grade inflammatory state is prevalent in a subset of individuals (Bechter, 2013; Fillman et al., 2014; Miller et al., 2011).”
Background
Increased macrophages and changed brain endothelial cell gene expression in the frontal cortex of people with schizophrenia displaying inflammation
Cai, H. Q., Catts, V. S., Webster, M. J., Galletly, C. A., Liu, D., O׳Donnell, M., Weickert, T. W., & Weickert, C. S. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0235-x · Cited by 229 · see citing works
Self-citation
Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming Stimulus of Microglia and the NLRP3 Inflammasome
Weber, M. D., Frank, M. G., Tracey, K. J., Watkins, L. R., & Maier, S. F. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3561-14.2015 · Cited by 215 · see citing works
Translational evaluation of translocator protein as a marker of neuroinflammation in schizophrenia
Notter, T., Coughlin, J. M., Gschwind, T., Weber-Stadlbauer, U., Wang, Y.-C., Kassiou, M., Vernon, A., Benke, D., Pomper, M., Sawa, A., et al. (2018) · Molecular Psychiatry · doi:10.1038/mp.2016.248 · Cited by 195 · see citing works
A systematic review of evidence for the role of inflammatory biomarkers in bipolar patients
Sayana, P., Colpo, G. D., Simões, L. R., Giridharan, V. V., Teixeira, A. L., Quevedo, J., & Barichello, T. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.03.018 · Cited by 188 · see citing works
Immune System Abnormalities in Schizophrenia: An Integrative View and Translational Perspectives
Ermakov, E. A., Melamud, M. M., Buneva, V. N., & Ivanova, S. А. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.880568 · Cited by 192 · see citing works
Inflammation in schizophrenia: A question of balance
Leza, J. C., García‐Bueno, B., Bioque, M., Arango, C., Parellada, M., Kim, Q., O’Donnell, P., & Bernardo, M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.014 · Cited by 183 · see citing works
Epidemiology, neurobiology and pharmacological interventions related to suicide deaths and suicide attempts in bipolar disorder: Part I of a report of the International Society for Bipolar Disorders Task Force on Suicide in Bipolar Disorder
Schaffer, A., Isometsä, E. T., Tondo, L., Moreno, D. H., Sinyor, M., Kessing, L. V., Turecki, G., Weizman, A., Azorin, J.-M., Ha, K., et al. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415594427 · Cited by 175 · see citing works
Cortical grey matter volume reduction in people with schizophrenia is associated with neuro-inflammation
Zhang, Y.-Q., Catts, V. S., Sheedy, D. L., McCrossin, T., Kril, J. J., & Weickert, C. S. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.238 · Cited by 176 · see citing works
Using blood cytokine measures to define high inflammatory biotype of schizophrenia and schizoaffective disorder
Boerrigter, D., Weickert, T. W., Lenroot, R., O׳Donnell, M., Galletly, C. A., Liu, D., Burgess, M., Cadiz, R., Jacomb, I., Catts, V. S., et al. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0962-y · Cited by 171 · see citing works
Self-citation
Inflammation in first‐episode psychosis: The contribution of inflammatory biomarkers to the emergence of negative symptoms, a systematic review and meta‐analysis
Dunleavy, C., Elsworthy, R. J., Upthegrove, R., Wood, S. J., & Aldred, S. (2022) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13416 · Cited by 169 · see citing works
Neuropathology of mood disorders: Do we see the stigmata of inflammation?
Mechawar, N., & Savitz, J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.212 · Cited by 165 · see citing works
Neuroimmune biomarkers in schizophrenia
Tomasik, J., Rahmoune, H., Guest, P. C., & Bahn, S. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.07.025 · Cited by 158 · see citing works
Peripheral blood brain-derived neurotrophic factor in bipolar disorder: a comprehensive systematic review and meta-analysis
Munkholm, K., Vinberg, M., & Kessing, L. V. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.54 · Cited by 157 · see citing works
Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia
Berretta, S., Pantazopoulos, H., Markota, M., Brown, C., & Batzianouli, E. T. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.12.040 · Cited by 152 · see citing works
A comparison of the neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratios in schizophrenia and bipolar disorder patients – a retrospective file review
Özdin, S., Sarisoy, G., & Böke, Ö. (2017) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2017.1340517 · Cited by 148 · see citing works
Inflammatory signaling mechanisms in bipolar disorder
Jones, G. H., Vecera, C. M., Pinjari, O. F., & Machado‐Vieira, R. (2021) · Journal of Biomedical Science · doi:10.1186/s12929-021-00742-6 · Cited by 141 · see citing works
Molecular Mechanisms and Timing of Cortical Immune Activation in Schizophrenia
Volk, D. W., Chitrapu, A., Edelson, J. R., Roman, K. M., Moroco, A. E., & Lewis, D. A. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15010019 · Cited by 137 · see citing works
Behavioral, neuroanatomical, and molecular correlates of resilience and susceptibility to maternal immune activation
Mueller, F. S., Scarborough, J., Schalbetter, S. M., Richetto, J., Kim, E., Couch, A. C. M., Yee, Y., Lerch, J. P., Vernon, A. C., Weber‐Stadlbauer, U., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00952-8 · Cited by 128 · see citing works
Increased levels of midbrain immune-related transcripts in schizophrenia and in murine offspring after maternal immune activation
Purves-Tyson, T. D., Weber‐Stadlbauer, U., Richetto, J., Rothmond, D. A., Labouesse, M. A., Polesel, M., Robinson, K., Weickert, C. S., & Meyer, U. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0434-0 · Cited by 125 · see citing works
Neuroinflammation in schizophrenia: the role of nuclear factor kappa B
Murphy, C. E., Walker, A. K., & Weickert, C. S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01607-0 · Cited by 128 · see citing works
Multivariate relationships between peripheral inflammatory marker subtypes and cognitive and brain structural measures in psychosis
Lizano, P. L., Lutz, O., Xu, Y., Rubin, L. H., Paskowitz, L., Lee, A. M., Eum, S., Keedy, S., Hill, S. K., Reilly, J. L., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00914-0 · Cited by 126 · see citing works
Postmortem evidence of brain inflammatory markers in bipolar disorder: a systematic review
Giridharan, V. V., Sayana, P., Pinjari, O. F., Ahmad, N., da Rosa, M. I., Quevedo, J., & Barichello, T. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0448-7 · Cited by 120 · see citing works
Prenatal exposure to environmental insults and enhanced risk of developing Schizophrenia and Autism Spectrum Disorder: focus on biological pathways and epigenetic mechanisms
Cattane, N., Richetto, J., & Cattaneo, A. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.001 · Cited by 118 · see citing works
Bifidobacterium and Lactobacillus Counts in the Gut Microbiota of Patients With Bipolar Disorder and Healthy Controls
Aizawa, E., Tsuji, H., Asahara, T., Takahashi, T., Teraishi, T., Yoshida, S., Koga, N., Hattori, K., Ota, M., & Kunugi, H. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00730 · Cited by 110 · see citing works
Cortisol awakening response in patients with psychosis: systematic review and meta-analysis
Berger, M., Kraeuter, A. K., Romanik, D., Malouf, P., Amminger, G. P., & Sarnyai, Z. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.027 · Cited by 109 · see citing works
Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia
Purves-Tyson, T. D., Robinson, K., Brown, A. M., Boerrigter, D., Cai, H. Q., Weissleder, C., Owens, S. J., Rothmond, D. A., & Weickert, C. S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02002 · Cited by 112 · see citing works
Oxidative Stress and Inflammation in Early Onset First Episode Psychosis: A Systematic Review and Meta-Analysis
Fraguas, D., Díaz‐Caneja, C. M., Rodríguez-Quiroga, A., & Arango, C. (2017) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx015 · Cited by 106 · see citing works
Applications of blood-based protein biomarker strategies in the study of psychiatric disorders
Chan, M. K., Gottschalk, M. G., Haenisch, F., Tomasik, J., Ruland, T., Rahmoune, H., Guest, P. C., & Bahn, S. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.08.002 · Cited by 94 · see citing works
The Role of the Nuclear Factor-κB Transcriptional Complex in Cortical Immune Activation in Schizophrenia
Volk, D. W., Moroco, A. E., Roman, K. M., Edelson, J. R., & Lewis, D. A. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.06.015 · Cited by 92 · see citing works
Exosomal secretion of a psychosis-altered miRNA that regulates glutamate receptor expression is affected by antipsychotics
Amoah, S. K., Rodriguez, B. A., Logothetis, C., Chander, P. N., Sellgren, C. M., Weick, J. P., Sheridan, S. D., Jantzie, L. L., Webster, M. J., & Mellios, N. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0579-1 · Cited by 94 · see citing works
Self-citation
Constructing the Immune Signature of Schizophrenia for Clinical Use and Research; An Integrative Review Translating Descriptives Into Diagnostics
Kroken, R. A., Sommer, I. E., Steen, V. M., Dieset, I., & Johnsen, E. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00753 · Cited by 94 · see citing works
Inflammation Subtypes and Translating Inflammation-Related Genetic Findings in Schizophrenia and Related Psychoses: A Perspective on Pathways for Treatment Stratification and Novel Therapies
Bishop, J. R., Zhang, L., & Lizano, P. L. (2022) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000321 · Cited by 90 · see citing works
Translational potential of olfactory mucosa for the study of neuropsychiatric illness
Borgmann‐Winter, K. E., Willard, S. L., Sinclair, D., Mirza, N. A., Turetsky, B. I., Berretta, S., & Hahn, C.-G. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.141 · Cited by 89 · see citing works
Self-citation
Impaired regulatory T cell control of astroglial overdrive and microglial pruning in schizophrenia
Zuelli, F. M. D. G. C., & Deakin, J. F. W. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.03.004 · Cited by 85 · see citing works
Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses
Aas, M., Dieset, I., Hope, S., Hoseth, E. Z., Mørch, R. H., Reponen, E. J., Steen, N. E., Laskemoen, J. F., Ueland, T., Aukrust, P., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.06.005 · Cited by 84 · see citing works
Chemokine Dysregulation and Neuroinflammation in Schizophrenia: A Systematic Review
Ermakov, E. A., Mednova, I. A., Boiko, A. S., Buneva, V. N., & Ivanova, S. А. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032215 · Cited by 79 · see citing works
A schizophrenia subgroup with elevated inflammation displays reduced microglia, increased peripheral immune cell and altered neurogenesis marker gene expression in the subependymal zone
North, H. F., Weissleder, C., Fullerton, J. M., Sager, R., Webster, M. J., & Weickert, C. S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01742-8 · Cited by 75 · see citing works
Self-citation
Neuroimmune transcriptome changes in patient brains of psychiatric and neurological disorders
Chen, Y., Dai, R., Tang, L., Mikhailova, T., Liang, Q., Li, M., Zhou, J., Kopp, R. F., Weickert, C. S., Chen, C., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01854-7 · Cited by 69 · see citing works
Transcriptome sequencing of the choroid plexus in schizophrenia
Kim, S., Hwang, Y., Lee, D., & Webster, M. J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.229 · Cited by 67 · see citing works
Self-citation
Genetics of Schizophrenia
van de Leemput, J., Hess, J., Glatt, S. J., & Tsuang, M. T. (2016) · Advances in genetics · doi:10.1016/bs.adgen.2016.08.001 · Cited by 68 · see citing works
Allostatic load is associated with psychotic symptoms and decreases with antipsychotic treatment in patients with schizophrenia and first-episode psychosis
Berger, M., Juster, R., Westphal, S., Amminger, G. P., Bogerts, B., Schiltz, K., Bahn, S., Steiner, J. H., & Sarnyai, Z. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.02.001 · Cited by 74 · see citing works
Biological subtyping of psychiatric syndromes as a pathway for advances in drug discovery and personalized medicine
Zhang, W., Sweeney, J. A., Bishop, J. R., Gong, Q., & Lui, S. (2023) · Nature Mental Health · doi:10.1038/s44220-023-00019-x · Cited by 67 · see citing works
Decreased Numbers of Somatostatin-Expressing Neurons in the Amygdala of Subjects With Bipolar Disorder or Schizophrenia: Relationship to Circadian Rhythms
Pantazopoulos, H., Wiseman, J. T., Markota, M., Ehrenfeld, L., & Berretta, S. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.04.006 · Cited by 64 · see citing works
The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines
Boczek, T., Mackiewicz, J., Sobolczyk, M., Wawrzyniak, J., Lisek, M., Ferenc, B., Guo, F., & Żylińska, L. (2021) · Cells · doi:10.3390/cells10051228 · Cited by 61 · see citing works
Inflammation and cognition in severe mental illness: patterns of covariation and subgroups
Sæther, L. S., Ueland, T., Haatveit, B. C., Maglanoc, L. A., Szabó, A., Djurovic, S., Aukrust, P., Roelfs, D., Mohn, C., Ormerod, M. B. E. G., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01924-w · Cited by 60 · see citing works
IgG dynamics of dietary antigens point to cerebrospinal fluid barrier or flow dysfunction in first-episode schizophrenia
Severance, E. G., Gressitt, K. L., Alaedini, A., Rohleder, C., Enning, F., Bumb, J. M., Müller, J. K., Schwarz, E., Yolken, R. H., & Leweke, F. M. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.09.009 · Cited by 59 · see citing works
Inflammatory Subtypes in Antipsychotic-Naïve First-Episode Schizophrenia are Associated with Altered Brain Morphology and Topological Organization
Hoang, D. T., Xu, Y., Lutz, O., Bannai, D., Zeng, V., Bishop, J. R., Keshavan, M. S., & Lizano, P. L. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.11.019 · Cited by 58 · see citing works
White matter neuron biology and neuropathology in schizophrenia
Duchatel, R. J., Weickert, C. S., & Tooney, P. A. (2019) · Schizophrenia · doi:10.1038/s41537-019-0078-8 · Cited by 56 · see citing works
Altered polyunsaturated fatty acid levels in relation to proinflammatory cytokines, fatty acid desaturase genotype, and diet in bipolar disorder
Koga, N., Ogura, J., Yoshida, F., Hattori, K., Hori, H., Aizawa, E., Ishida, I., & Kunugi, H. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0536-0 · Cited by 54 · see citing works
Interaction between TNF-α and oxidative stress status in first-episode drug-naïve schizophrenia
Zhu, S., Zhao, L., Fan, Y., Lv, Q., Wu, K., Lang, X., Li, Z., Yi, Z., & Geng, D. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104595 · Cited by 56 · see citing works
Brain-Derived Neurotrophic Factor: A Novel Dynamically Regulated Therapeutic Modulator in Neurological Disorders
Sharma, V., Singh, T. G., Kaur, A., Mannan, A., & Dhiman, S. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03755-1 · Cited by 55 · see citing works
Dopamine activates NF-κB and primes the NLRP3 inflammasome in primary human macrophages
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Authors: Fillman, S. G., Sinclair, D., Fung, S. J., Webster, M. J., & Shannon Weickert, C.
Affiliations: UNSW Sydney (AU)
Stanley Medical Research Institute (US)
ORCID: Sinclair, D
Webster, M J
Venue: Translational Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2014-02-25
Volume: 4
Issue: 2
Pages: e365-e365
ISSN: 2158-3188 (ISSN-L)
DOI: 10.1038/tp.2014.8
PMC: PMC3944638
OpenAlex: W2081664670
Semantic Scholar: ad5a7f3a0267bb987ce8be600524c011af4859b1
Cited by: 226
References: 96
Citations by year: 2026: 15 · 2025: 15 · 2024: 13 · 2023: 16 · 2022: 23 · 2021: 22 · 2020: 18 · 2019: 25 · 2018: 12 · 2017: 18 · 2016: 25 · 2015: 16 · 2014: 7
FWCI: 6.71
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-sa
www.springer.com/tdm (unspecified)
Locations: Translational Psychiatry (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
Figshare (submittedVersion, cc-by-nc-sa)
Funders: Stanley Medical Research Institute
Neuroscience Research Australia
University of New South Wales
NSW Ministry of Health
Macquarie Group Foundation
Medical Research Council
National Health and Medical Research Council (1021970)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: schizophrenia, bipolar disorder, neuroinflammation, stress response, glucocorticoid receptor signaling, alpha-1-antichymotrypsin, gene expression, transcriptome, neuroimmune signaling, psychosis, biotypes
MeSH terms: Adult, Bipolar Disorder, Cerebral Cortex, Female, Humans, Inflammation, Male, Middle Aged, Schizophrenia, Stress, Psychological, Cohort Studies, Biomarkers, Gene Expression, Young Adult

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Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder

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