The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Schizophrenia is associated with an increase in cortical microRNA biogenesis
Open accessAbstract
MicroRNA expression profiling and quantitative reverse transcription-PCR analysis of the superior temporal gyrus and the dorsolateral prefrontal cortex revealed a significant schizophrenia-associated increase in global microRNA expression. This change was associated with an elevation of primary microRNA processing and corresponded with an increase in the microprocessor component DGCR8. The biological implications for this extensive increase in gene silencing are profound, and were exemplified by members of the miR-15 family and other related microRNA, which were significantly upregulated in both brain regions. This functionally convergent influence is overrepresented in pathways involved in synaptic plasticity and includes many genes and pathways associated with schizophrenia, some of which were substantiated in vitro by reporter gene assay. Given the magnitude of microRNA changes and their wide sphere of influence, this phenomenon could represent an important dimension in the pathogenesis of schizophrenia.
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Cited by
McDonald-McGinn, D. M., Sullivan, K. E., Marino, B., Philip, N., Swillen, A., Vorstman, J. A. S., Zackai, E. H., Emanuel, B. S., Vermeesch, J. R., Morrow, B. E., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.71 · Cited by 2,236
MicroRNAs in Development and Disease
Sayed, D., & Abdellatif, M. (2011) · Physiological Reviews · doi:10.1152/physrev.00006.2010 · Cited by 1,078
Identifying miRNAs, targets and functions
Liu, B., Li, J., & Cairns, M. J. (2014) · Briefings in Bioinformatics · doi:10.1093/bib/bbs075 · Cited by 563
Self-citationBarry, G., Briggs, J. A., Vanichkina, D. P., Poth, E. M., Beveridge, N. J., Ratnu, V. S., Nayler, S. P., Nones, K., Hu, J., Bredy, T. W., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.45 · Cited by 394
Self-citationMicroRNAs in neuronal function and dysfunction
Im, H.-I., & Kenny, P. J. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.01.004 · Cited by 399
Metadata
- Authors
- Beveridge, N. J., Gardiner, E., Carroll, A. P., Tooney, P. A., & Cairns, M. J.
- Venue
- Molecular Psychiatry
- Published
- 2009-09-01
- Volume
- 15
- Issue
- 12
- Pages
- 1176-1189
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W1964520813
- Cited by
- 432
- References
- 13
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
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