Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

Mitochondria and Apoptosis

Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 9,051

The biochemistry of apoptosis

Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 5,779

The Bcl2 family: regulators of the cellular life-or-death switch

Cory, S., & Adams, J. M. (2002) · Nature Reviews Cancer · doi:10.1038/nrc883 · Cited by 4,032

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., et al. (1995) · Nature · doi:10.1038/376037a0 · Cited by 3,980

BCL-2 family members and the mitochondria in apoptosisPreprint

Gross, A., McDonnell, J. M., & Korsmeyer, S. J. (1999) · Genes & Development · doi:10.1101/gad.13.15.1899 · Cited by 3,642

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., & Nagata, S. (1998) · Nature · doi:10.1038/34112 · Cited by 3,239

Untitled work

(2001) · PubMed · Cited by 2,381

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

Liu, X., Zou, H., Slaughter, C. A., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80197-x · Cited by 1,835

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

Kuida, K., Haydar, T. F., Kuan, C.-Y., Gu, Y., Taya, C., Karasuyama, H., Su, M. S.-S., Rakic, P., & Flavell, R. A. (1998) · Cell · doi:10.1016/s0092-8674(00)81476-2 · Cited by 1,643

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

Bouillet, P., Metcalf, D., Huang, D. C. S., Tarlinton, D. M., Kay, T. W. H., Köntgen, F., Adams, J. M., & Strasser, A. (1999) · Science · doi:10.1126/science.286.5445.1735 · Cited by 1,504

Neuroprotective actions of ovarian hormones without insult in the raphe region of rhesus macaques

Tokuyama, Y., Reddy, A. P., & Bethea, C. L. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.056 · Cited by 28

Increased Expression of Hypoxia-Inducible Factor-1alpha and Bcl-2 in Varicocele and Varicose Veins

Lee, J.-D., Yang, W., & Lee, T. (2012) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2011.12.014 · Cited by 28

Apaf-1- and Caspase-8-independent apoptosis

Imao, T., & Nagata, S. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.149 · Cited by 28

Gli-1 siRNA induced apoptosis in Huh7 cells

Chen, X., Cao, L., She, M., Wang, Q., Huang, X., & Fu, X. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.582 · Cited by 28

Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death

Marsden, V. S., Kaufmann, T., O’Reilly, L. A., Adams, J. M., & Strasser, A. (2005) · Blood · doi:10.1182/blood-2005-05-2160 · Cited by 28

Outer mitochondrial membrane permeabilization: an open-and-shut case?

Robertson, J. D., Zhivotovsky, B., Gogvadze, V. G., & Orrenius, S. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401218 · Cited by 28

Clausenidin induces caspase-dependent apoptosis in colon cancer

Waziri, P. M., Abdullah, R., Yeap, S. K., Omar, A. R., Kassim, N. K., Malami, I., How, C. W., Etti, I. C., & Abu, M. L. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1247-1 · Cited by 27

The NS1 protein of avian influenza virus H9N2 induces oxidative-stress-mediated chicken oviduct epithelial cells apoptosis

Qi, X., Zhang, H., Wang, Q., & Wang, J. (2016) · Journal of General Virology · doi:10.1099/jgv.0.000625 · Cited by 27

Resveratrol inhibits Extranodal NK/T cell lymphoma through activation of DNA damage response pathway

Sui, X., Zhang, C.-J., Zhou, J., Cao, S., Xu, C., Tang, F., Zhi, X., Chen, B., Wang, S., & Yin, L. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0601-6 · Cited by 28

Morphology of Mitochondria During Apoptosis: Worms-to-Beetles in Worms

Youle, R. J. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.003 · Cited by 27

Bacillomycin D-C16 triggers apoptosis of gastric cancer cells through the PI3K/Akt and FoxO3a signaling pathways

Lin, F., Yang, J., Umair, M., Sun, J. Y., Huang, Z., Li, W., Lv, F., & Lu, Z. (2018) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000688 · Cited by 26

Inhibitory effects of Lang-du extract on the in vitro and in vivo growth of melanoma cells and its molecular mechanisms of action

Wang, L., Duan, H., Wang, Y., Liu, K., Jiang, P., Qu, Z., Yagasaki, K., & Zhang, G. (2010) · Cytotechnology · doi:10.1007/s10616-010-9283-z · Cited by 26

Promoter methylation of cancer-related genes in gastric carcinoma.

Popławski, T., Tomaszewska, K., Galicki, M., Morawiec, Z., & Błasiak, J. (2008) · PubMed · Cited by 26

Bishydroquinone Renieramycin M Induces Apoptosis of Human Lung Cancer Cells Through a Mitochondria-dependent Pathway

Pinkhien, T., Maiuthed, A., Chamni, S., Suwanborirux, K., Saito, N., & Pithi Chanvorachote, B. (2016) · Anticancer Research · doi:10.21873/anticanres.11229 · Cited by 26

Text mining-based in silico drug discovery in oral mucositis caused by high-dose cancer therapy

Kirk, J., Shah, N. P., Noll, B. D., Stevens, C. B., Lawler, M., Mougeot, F. B., & Mougeot, J.-L. (2018) · Supportive Care in Cancer · doi:10.1007/s00520-018-4096-2 · Cited by 26

Anticancer drug development based on modulation of the Bcl-2 family core apoptosis mechanism

Gardner, C. R. (2004) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.4.6.1157 · Cited by 26

The PYRIN Domain in Signal Transduction

Stehlik, C. (2007) · Current Protein and Peptide Science · doi:10.2174/138920307780831857 · Cited by 26

Hybrid Nanoparticles of Extracellular Vesicles and Gemcitabine Prodrug-Loaded Liposomes with Enhanced Targeting Ability for Effective PDAC Treatment

Kim, B., Park, H., Liu, H., Kim, S., Lee, Y.-K., & Kim, Y. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c00658 · Cited by 28

An iPSC-Derived Neuron Model of CLN3 Disease Facilitates Small Molecule Phenotypic Screening

Kinarivala, N., Morsy, A., Patel, R., Carmona, A. V., Sajib, M. S., Raut, S., Mikelis, C. M., Al-Ahmad, A. J., & Trippier, P. C. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00077 · Cited by 25

Toxicological mechanism of ammonia-N on haematopoiesis and apoptosis of haemocytes in Litopenaeus vannamei

Li, Y., Tong, R., Li, Z., Zhang, X., Pan, L., Li, Y., & Zhang, N. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.163039 · Cited by 25

Downregulation of Apaf-1 and caspase-3 by RNA interference in human glioma cells: Consequences for erucylphosphocholine-induced apoptosis

Kugler, W., Buchholz, F., Köhler, F., Eibl, H., Lakomek, M., & Erdlenbruch, B. (2005) · APOPTOSIS · doi:10.1007/s10495-005-1190-y · Cited by 25

The Role of Apaf-1 in Programmed Cell Death: From Worm to Tumor.

Yoshida, H. (2003) · Cell Structure and Function · doi:10.1247/csf.28.3 · Cited by 25

Role of Caspases in Death and Survival of the Plaque Macrophage

Nhan, T. Q., Liles, W. C., & Schwartz, S. M. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000159519.07181.33 · Cited by 25

Dopaminergic neurons lacking Caspase-3 avoid apoptosis but undergo necrosis after MPTP treatment inducing a Galectin-3-dependent selective microglial phagocytic response

García‐Revilla, J., Ruiz, R., Espinosa‐Oliva, A. M., Santiago, M., García-Domínguez, I., Camprubí-Ferrer, L., Bachiller, S., Deierborg, T., Joseph, B., de Pablos, R. M., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07014-9 · Cited by 25

Involved Intrinsic Apoptotic Pathway in the Varicocele and Varicose Veins

Lee, J.-D., Yang, W., & Lai, C. (2010) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2010.02.018 · Cited by 24

Clausenidin from Clausena excavata induces apoptosis in hepG2 cells via the mitochondrial pathway

Waziri, P. M., Abdullah, R., Yeap, S. K., Omar, A. R., Abdul, A. B., Kassim, N. K., Malami, I., Karunakaran, T., & Imam, M. U. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.10.030 · Cited by 24

Layer‐by‐Layer Assembly of Functional Nanoparticles for Hepatocellular Carcinoma Therapy

Gao, X., He, Z., Ni, W., Jian, X., Hu, C., Zhao, Y., Yan, Y., & Wei, X. C. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201904246 · Cited by 24

Alkylphosphocholine-induced glioma cell death is BCL-XL-sensitive, caspase-independent and characterized by massive cytoplasmic vacuole formation

Naumann, U., Wischhusen, J., Weit, S., Rieger, J., Wolburg, H., Massing, U., & Weller, M. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401503 · Cited by 24

Differential regulation of the intrinsic pathway of apoptosis in brain and liver during ageing

Stoka, V., Türk, V., & Bredesen, D. E. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.05.066 · Cited by 25

Microarray Analysis Reveals Differences in Gene Expression of Circulating CD8+ T Cells in Melanoma Patients and Healthy Donors

Xu, T., Shu, C.-T., Purdom, E. A., Dang, D., Ilsley, D. D., Guo, Y., Weber, J. S., Holmes, S., & Lee, P. P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3396 · Cited by 24

Targeting caspase-8: a new strategy for combating hepatocellular carcinoma

Chen, H., Lin, Y., Chen, J., Luo, X., Kan, Y., He, Y., Zhu, R., Jin, J., Li, D., Wang, Y., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1501659 · Cited by 23

Cucurbitacin B reverses multidrug resistance by targeting CIP2A to reactivate protein phosphatase 2A in MCF-7/Adriamycin cells

Cai, F., Zhang, L., Xiao, X., Duan, C., Huang, Q., Fan, C., Li, J., Liu, X., Li, S., & Liu, Y. (2016) · Oncology Reports · doi:10.3892/or.2016.4892 · Cited by 23

Aqueous Extract of Pepino Leaves Ameliorates Palmitic Acid-Induced Hepatocellular Lipotoxicity via Inhibition of Endoplasmic Reticulum Stress and Apoptosis

Hsu, J., Lin, H., Chyau, C.-C., Wang, Z.-H., & Chen, J. (2021) · Antioxidants · doi:10.3390/antiox10060903 · Cited by 23

Role of Smac in cephalostatin-induced cell death

Rudy, A., López-Antón, N., Barth, N. D., Pettit, G. R., Dirsch, V. M., Schulze‐Osthoff, K., Rehm, M., Prehn, J. H. M., Vogler, M., Fulda, S., et al. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.125 · Cited by 23

Apaf-1-deficient fog mouse cell apoptosis involves hypo-polarization of the mitochondrial inner membrane, ATP depletion and citrate accumulation

Katoh, I., Sato, S., Fukunishi, N., Yoshida, H., Imai, T., & Kurata, S. (2008) · Cell Research · doi:10.1038/cr.2008.87 · Cited by 23

Differential roles of protease isoforms in the tumor microenvironment

Liyanage, C. D. K., Fernando, A., & Batra, J. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09816-2 · Cited by 23

Inhalation of ammonia promotes apoptosis and induces autophagy in hepatocytes via Bax/BCl-2 and m-TOR/ATG5/LC-3bII axes

Chen, B., Liu, X., Wu, S., Hou, J., Shang, P., Chamba, Y., Mehmood, K., Fouad, D., Li, Y., & Zhang, H. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.169036 · Cited by 22

The mechanism of reactive oxygen species generation, DNA damage and apoptosis in hemocytes of Litopenaeus vannamei under ammonia nitrogen exposure

Tong, R., Li, Y., Yu, X., Zhang, N., Liao, Q., & Pan, L. (2024) · Aquatic Toxicology · doi:10.1016/j.aquatox.2024.106958 · Cited by 22

Ligand-dependent corepressor contributes to transcriptional repression by C2H2 zinc-finger transcription factor ZBRK1 through association with KRAB-associated protein-1

Calderon, M. R., Verway, M. J., Benslama, R. O., Birlea, M., Bouttier, M., Dimitrov, V., Mader, S., & White, J. H. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku413 · Cited by 23

Isolation and prevention of calcium oxalate-induced apoptotic death and oxidative stress in MDCK cells by diosgenin

Saha, S., Goswami, G., & Anupama, P. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.09.016 · Cited by 22

Apoptosis, airway inflammation and anti‐asthma therapy: From immunobiology to clinical application

Spinozzi, F., de Benedictis, D., & Fm, D. B. (2008) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2007.00668.x · Cited by 22

Efficient T cell receptor–mediated apoptosis in nonobese diabetic mouse thymocytes

Villunger, A., Marsden, V. S., & Strasser, A. (2003) · Nature Immunology · doi:10.1038/ni0803-717 · Cited by 22

Potential mechanism of mycelium polysaccharide from Pholiota dinghuensis Bi in regulating the proliferation and apoptosis of human breast cancer MCF-7 cells through p38/MAPK pathway

Gan, D., Zeng, X., Liu, R. H., & Ye, H. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.12.008 · Cited by 21

Effect of yellowing time on bioactive compounds in yellow tea and their antiproliferative capacity in HepG2 cells

An, R., Sun, L., Xiang, L., Zhang, W., Li, Q., Lai, X., Wen, S., Huo, M., Li, D., & Sun, S. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.1036 · Cited by 21

Postmortem expression of apoptosis-related genes in the liver of mice and their use for estimation of the time of death

Noshy, P. A. (2020) · International Journal of Legal Medicine · doi:10.1007/s00414-020-02419-5 · Cited by 21

Rationales for expression and altered expression of apoptotic protease activating factor-1 gene in gastric cancer

Wang, H. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i38.5060 · Cited by 21

Perforin‐dependent activation‐induced cell death acts through caspase 3 but not through caspases 8 or 9

Chen, L., Woo, M., Hakem, R., & Miller, R. G. (2003) · European Journal of Immunology · doi:10.1002/eji.200323783 · Cited by 21

Oncogenes as Novel Targets for Cancer Therapy (Part IV)

Zhang, Z., Li, M., Rayburn, E. R., Hill, D. L., Zhang, R., & Wang, H. (2005) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200505060-00006 · Cited by 21

Chemopreventive Effects of Non-steroidal Anti-inflammatory Drugs in Early Neoplasm of Experimental Colorectal Cancer: an Apoptosome Study

Vaish, V., Tanwar, L., Kaur, J., & Sanyal, S. N. (2010) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-010-9188-2 · Cited by 20

The better effects of microbubble ultrasound transfection of miR-940 on cell proliferation inhibition and apoptosis promotion in human cervical cancer cells

Xiao, X., Zhang, Y., Qi, L., & Zhong, K. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s209692 · Cited by 20

Activation of Extrinsic Apoptotic Pathway From Bladder Biopsy in Patients With Interstitial Cystitis/Painful Bladder Syndrome

Lee, J.-D., & Lee, M. (2013) · Urology · doi:10.1016/j.urology.2013.08.042 · Cited by 20

Cytotoxic effects and pro-apoptotic mechanism of TBIDOM, a novel dehydroabietylamine derivative, on human hepatocellular carcinoma SMMC-7721 cells

Fu, L., He, L., Song, Z., Yao, J.-C., Rao, X., & Li, H. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.2.0009 · Cited by 20

Synthesis of breast cancer targeting conjugate of temporin-SHa analog and its effect on pro- and anti-apoptotic protein expression in MCF-7 cells

Shaheen, F., Nadeem-Ul-Haque, M., Ahmed, A., Sımjee, S. U., Ganesan, A., Jabeen, A., Shah, Z. A., & Choudhary, M. I. (2018) · Peptides · doi:10.1016/j.peptides.2018.07.002 · Cited by 20

Cell death in the thymus—it's all a matter of contacts

Minter, L. M. (2003) · Seminars in Immunology · doi:10.1016/s1044-5323(03)00029-0 · Cited by 20

Cell differentiation

Lindholm, D., & Arumäe, U. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200409171 · Cited by 20

Verrucarin A alters cell-cycle regulatory proteins and induces apoptosis through reactive oxygen species-dependent p38MAPK activation in the human breast cancer cell line MCF-7

Kandasamy, P., Kanimozhi, V., & Kadalmani, B. (2014) · Tumor Biology · doi:10.1007/s13277-014-2286-1 · Cited by 20

Integration of Apoptosis and MetabolismPreprint

Yi, C., Vakifahmetoglu-Norberg, H., & Yuan, J. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010777 · Cited by 20

Molecular Pathways and Druggable Targets in Head and Neck Squamous Cell Carcinoma

Kordbacheh, F., & Farah, C. S. (2021) · Cancers · doi:10.3390/cancers13143453 · Cited by 19

Effects of Dietary Ferulic Acid Supplementation on Hepatic Injuries in Tianfu Broilers Challenged with Lipopolysaccharide

Shu, G., Tang, Z., Du, H., Zheng, Y., Chang, L., Li, H., Xu, F., Fu, H., Zhang, W., & Lin, J. (2022) · Toxins · doi:10.3390/toxins14030227 · Cited by 19

miR‑98 inhibits cell proliferation and induces cell apoptosis by targeting MAPK6 in HUVECs

Hu, C., Su, H. W., Wu, F., & Ding, H. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.5735 · Cited by 19

siRNA-Mediated Silencing of c-kit in Mouse Primary Spermatogonial Cells Induces Cell Cycle Arrest

Sikarwar, A. P., & Reddy, K. V. R. (2008) · Oligonucleotides · doi:10.1089/oli.2008.0108 · Cited by 19

Mitochondria, Cell Death, and B Cell Tolerance

Deming, P. B., & Rathmell, J. C. (2005) · KARGER eBooks · doi:10.1159/000090774 · Cited by 19

Migrate, Differentiate, Proliferate, or Die: Pleiotropic Functions of an Apical "Apoptotic Caspase"

Kumar, S. (2004) · Science s STKE · doi:10.1126/stke.2542004pe49 · Cited by 19

Histological analyses of normally grown, fertile Apaf1-deficient mice

Okamoto, H., Shiraishi, H., & Yoshida, H. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401806 · Cited by 19

Gene expression profiles of U937 human macrophages exposed to Chlamydophila pneumoniae and/or low density lipoprotein in five study models using differential display and real-time RT-PCR

Lim, W., & Chow, V. T. K. (2005) · Biochimie · doi:10.1016/j.biochi.2005.11.001 · Cited by 19

Apoptosis pathways: turned on their heads?

Fulda, S., & Debatin, K. (2003) · Drug Resistance Updates · doi:10.1016/s1368-7646(02)00140-1 · Cited by 19

Effects of Broflanilide on Oxidative Stress and Expression of Apoptotic Genes in Zebrafish (Danio rerio) Gill

Wang, K., Che, W., Duan, M., Wang, C., Li, X., & He, L. (2023) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/s00128-023-03733-5 · Cited by 18

Hypoxia inducible factor-1alpha mediates protection of DL-3-n-butylphthalide in brain microvascular endothelial cells against oxygen glucose deprivation-induced injury.

Yang, W., Li, L., Huang, R., Pei, Z., Liao, S., & Zeng, J. (2012) · PubMed · doi:10.3969/j.issn.1673-5374.2012.12.012 · Cited by 18

Mechanisms of T Cell Death in the Liver: To Bim or Not to Bim?

Holz, L. E., Bowen, D. G., & Bertolino, P. (2010) · Digestive Diseases · doi:10.1159/000282060 · Cited by 19

Recognition and Control of the Progression of Age-Related Hearing Loss

Ren, H., Ren, J., & Liu, W. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1435 · Cited by 18

The Ca2+ channel blocker flunarizine induces caspase-10-dependent apoptosis in Jurkat T-leukemia cells

Conrad, D., Furlong, S. J., Doucette, C. D., West, K. A., & Hoskin, D. W. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0454-3 · Cited by 18

Toxoplasma gondii inhibits cytochrome c-induced caspase activation in its host cell by interference with holo-apoptosome assembly

Graumann, K., Schaumburg, F., Reubold, T. F., Hippe, D., Eschenburg, S., & Lüder, C. G. K. (2015) · Microbial Cell · doi:10.15698/mic2015.05.201 · Cited by 18

Effect of fluvastatin on apoptosis in human CD4+ T cells

Samson, K. T. R., Minoguchi, K., Tanaka, A., Oda, N., Yokoe, T., Okada, S., Yamamoto, Y., Watanabe, Y., Yamamoto, M., Ohta, S., et al. (2005) · Cellular Immunology · doi:10.1016/j.cellimm.2005.08.028 · Cited by 18

Increased hepatic apoptosis during short-term caloric restriction is not associated with an enhancement in caspase levels

Selman, C., Kendaiah, S., Gredilla, R., & Leeuwenburgh, C. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00091-3 · Cited by 18

Caspases and T lymphocytes: a flip of the coin?

Lakhani, S. A., & Flavell, R. A. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00046.x · Cited by 18

Adaptogenic potential of royal jelly in reproductive system of heat stress-exposed male rats.

Mahdivand, N., Shalizar-Jalali, A., Nejati, V., Najafi, G., & Rahmani, F. (2021) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2020.102827 · Cited by 16

Lipopolysaccharide sensitizes the therapeutic response of breast cancer to IAP antagonist

Liu, X. Z., Yao, J. J., Chen, Z., Lei, W., Duan, R., & Yao, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.906357 · Cited by 19

Effect of nutritionally induced hyperlipidaemia on in vitro bovine embryo quality depends on the type of major fatty acid in the diet

Marei, W. F. A., Arias‐Álvarez, M., Hoeck, V. V., Gutiérrez‐Adán, A., Bols, P. E. J., & Leroy, J. (2016) · Reproduction Fertility and Development · doi:10.1071/rd16297 · Cited by 17

Luteolin inhibits multi-heavy metal mixture-induced HL7702 cell apoptosis through downregulation of ROS-activated mitochondrial pathway

Wang, Y., Su, H., Song, X., Kenston, S. S. F., Zhao, J., & Gu, Y. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3219 · Cited by 17

A bioactive polysaccharide TLH-3 isolated from Tricholoma lobayense protects against oxidative stress-induced premature senescence in cells and mice

Pan, W., Ding, Q., Wang, Y., Wang, D., Lu, Y., Yang, W., Cai, Z., Cheng, X.-D., Zhang, W., & Chen, Y. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2017.12.070 · Cited by 17

XIAP Activity Dictates Apaf-1 Dependency for Caspase 9 Activation

Ho, A. T. V., Li, Q. H., Okada, H., Mak, T. W., & Zacksenhaus, E. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00188-07 · Cited by 17

Cell Death is Associated with Reduced Base Excision Repair During Chronic Alcohol Administration in Adult Rat Brain

Sunkesula, S. R. B., Swain, U., & Babu, P. P. (2008) · Neurochemical Research · doi:10.1007/s11064-007-9560-1 · Cited by 17

Is Apaf-1 expression frequently abrogated in melanoma?

Allen, J. D., Zhang, X. D., Scott, C. L., Boyle, G. M., Hersey, P., & Strasser, A. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401634 · Cited by 17

Overexpression of oxidored-nitro domain containing protein 1 induces growth inhibition and apoptosis in human prostate cancer PC3 cells

Shan, Z., Qinglan, H., Zhang, N., Guo, L., ZHANG, X., Yaohui, M., & Zhou, Y. (2014) · Oncology Reports · doi:10.3892/or.2014.3407 · Cited by 16

Heat-shock protein 60 of Porphyromonas gingivalis may induce dysfunction of human umbilical endothelial cells via regulation of endothelial-nitric oxide synthase and vascular endothelial-cadherin

Wu, C., Guo, S., Niu, Y., Yang, L., Liu, B., Jiang, N., Su, M., & Wang, L. (2016) · Biomedical Reports · doi:10.3892/br.2016.693 · Cited by 16

Effects of zinc on programmed cell death of Musca domestica and Drosophila melanogaster blood cells

Filipiak, M., Bilska, E., Tylko, G., & Pyza, E. (2009) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2009.11.010 · Cited by 16

Enhanced suppression of proliferation and migration in highly-metastatic lung cancer cells by combination of valproic acid and coumarin-3-carboxylic acid and its molecular mechanisms of action

Liu, X., Chen, L., Sun, F., & Zhang, G. (2012) · Cytotechnology · doi:10.1007/s10616-012-9513-7 · Cited by 16

TAT‐BH4 counteracts Aβ toxicity on capillary endothelium

Cantara, S., Thorpe, P. E., Ziche, M., & Donnini, S. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.01.037 · Cited by 16

Changes in levels of apoptosis in the walls of different segments of great saphenous varicose veins

Xu, Y., Wei, H., Lei, W., Jianhua, Z., Wang, T., Jinyuan, T., Li, K., & Chu, H. (2015) · Phlebology The Journal of Venous Disease · doi:10.1177/0268355515605670 · Cited by 16

New orally active DNA minor groove binding small molecule CT‐1 acts against breast cancer by targeting tumor DNA damage leading to p53‐dependent apoptosis

Saini, K. S., Hamidullah, Ashraf, R., Mandalapu, D., Das, S., Siddiqui, M. Q., Dwivedi, S., Sarkar, J., Sharma, V. L., & Konwar, R. (2016) · Molecular Carcinogenesis · doi:10.1002/mc.22588 · Cited by 16

Modulation and function of caspase pathways in B lymphocytes

Graves, J. D., Craxton, A., & Clark, E. A. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.0110.x · Cited by 16

Mechanisms of expression of apoptotic protease activating factor-1 (Apaf-1) in nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets

Ashraf, Q. M., Mishra, O. P., & Delivoria‐Papadopoulos, M. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.01.023 · Cited by 16

Proteases, proteasomes and apoptosis: breaking Ub is hard to do

Taylor, R. C., Adrain, C., & Martin, S. J. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401703 · Cited by 17

Mutations dislocate caspase‐12 from the endoplasmatic reticulum to the cytosol

Hoppe, V., & Hoppe, J. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.09.012 · Cited by 15

Tributyltin (TBT) induces ultra-rapid caspase activation independent of apoptosome formation in human platelets

Berg, C. P., Rothbart, A., Lauber, K., Stein, G. M., Engels, I. H., Belka, C., Jänicke, R. U., Schulze‐Osthoff, K., & Wesselborg, S. (2003) · Oncogene · doi:10.1038/sj.onc.1206221 · Cited by 15

A novel copper (II) complex activated both extrinsic and intrinsic apoptotic pathways in liver cancerous cells

Rezaei, A., Mahmoodi, M., Mohammadizadeh, F., Mohamadi, M., Hajizadeh, M. R., Mirzaei, M. R., & Falahati‐pour, S. K. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28491 · Cited by 15

A novel Bcl-2 small molecule inhibitor 4-(3-methoxy-phenylsulfannyl)-7-nitro-benzofurazan-3-oxide (MNB)-induced apoptosis in leukemia cells

Zhang, M., Ling, Y., Yang, C., Liu, H., Wang, R., Wu, X., Ding, K., Zhu, F., Griffith, B. N., Mohammad, R. M., et al. (2007) · Annals of Hematology · doi:10.1007/s00277-007-0288-4 · Cited by 15

Proteasome inhibition activates the mitochondrial pathway of apoptosis in human CD4+ T cells

Berges, C., Haberstock, H., Fuchs, D., Sadeghi, M., Opelz, G., Daniel, V., & Naujokat, C. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22325 · Cited by 17

Cell Stress-Associated Caspase Activation: Intrinsically Complex?

Creagh, E. M., & Martin, S. J. (2003) · Science s STKE · doi:10.1126/stke.2003.175.pe11 · Cited by 15

Ibulocydine sensitizes human cancers to radiotherapy by induction of mitochondria-mediated apoptosis

Park, S. S., Kim, Y.-J., Ju, E. J., Shin, S. H., Choi, J., Park, J., Lee, J. H., Lee, K. J., Park, J. H., Park, H. J., et al. (2014) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2014.07.005 · Cited by 14

Bcl-2–regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

Marsden, V. S., Ekert, P. G., van Delft, M. F., Vaux, D. L., Adams, J. M., & Strasser, A. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312030 · Cited by 100

Bcl-2 regulates amplification of caspase activation by cytochrome c

Cosulich, S. C., Savory, P., & Clarke, P. R. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80068-2 · Cited by 91

Broader role for Bcl-2

Buckland, J. (2002) · Nature reviews. Immunology · doi:10.1038/nri940

Bcl-2 Finds a New Way to Save Cells

(2002) · Science Signaling · doi:10.1126/scisignal.1542002tw373

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

Kluck, R. M., Bossy‐Wetzel, E., Green, D. R., & Newmeyer, D. D. (1997) · Science · doi:10.1126/science.275.5303.1132 · Cited by 4,715