Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

Mitochondria and Apoptosis

Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 9,051

The biochemistry of apoptosis

Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 5,779

The Bcl2 family: regulators of the cellular life-or-death switch

Cory, S., & Adams, J. M. (2002) · Nature Reviews Cancer · doi:10.1038/nrc883 · Cited by 4,032

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., et al. (1995) · Nature · doi:10.1038/376037a0 · Cited by 3,980

BCL-2 family members and the mitochondria in apoptosisPreprint

Gross, A., McDonnell, J. M., & Korsmeyer, S. J. (1999) · Genes & Development · doi:10.1101/gad.13.15.1899 · Cited by 3,642

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., & Nagata, S. (1998) · Nature · doi:10.1038/34112 · Cited by 3,239

Untitled work

(2001) · PubMed · Cited by 2,381

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

Liu, X., Zou, H., Slaughter, C. A., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80197-x · Cited by 1,835

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

Kuida, K., Haydar, T. F., Kuan, C.-Y., Gu, Y., Taya, C., Karasuyama, H., Su, M. S.-S., Rakic, P., & Flavell, R. A. (1998) · Cell · doi:10.1016/s0092-8674(00)81476-2 · Cited by 1,643

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

Bouillet, P., Metcalf, D., Huang, D. C. S., Tarlinton, D. M., Kay, T. W. H., Köntgen, F., Adams, J. M., & Strasser, A. (1999) · Science · doi:10.1126/science.286.5445.1735 · Cited by 1,504

Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-κB signaling

Yu, P., Liu, Q., Liu, K., Yagasaki, K., Wu, E., & Zhang, G. (2009) · Cytotechnology · doi:10.1007/s10616-009-9225-9 · Cited by 110

Human Caspase-7 Activity and Regulation by Its N-terminal Peptide

Denault, J., & Salvesen, G. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305110200 · Cited by 108

MAPK signaling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells

Li, Y., Wang, J., Xiao, H., Wu, W., Wang, Y., & Liu, X. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.11.048 · Cited by 106

Protease signaling in animal and plant‐regulated cell death

Salvesen, G. S., Hempel, A., & Coll, N. S. (2015) · FEBS Journal · doi:10.1111/febs.13616 · Cited by 109

Crystal Structure of Caspase-2, Apical Initiator of the Intrinsic Apoptotic Pathway

Schweizer, A., Briand, C., & Grütter, M. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304895200 · Cited by 106

How apoptosis got the immune system in shape

Feig, C., & Peter, M. E. (2007) · European Journal of Immunology · doi:10.1002/eji.200737462 · Cited by 108

Differential contribution of Puma and Noxa in dual regulation of p53‐mediated apoptotic pathways

Shibue, T., Suzuki, S., Okamoto, H., Yoshida, H., Ohba, Y., Takaoka, A., & Taniguchi, T. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601359 · Cited by 104

The Role of the Apoptotic Machinery in Tumor SuppressionPreprint

Delbridge, A. R. D., Valente, L. J., & Strasser, A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008789 · Cited by 106

Bcl-2–regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

Marsden, V. S., Ekert, P. G., van Delft, M. F., Vaux, D. L., Adams, J. M., & Strasser, A. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312030 · Cited by 100

Apoptosis in human cancer cells

Yu, J., & Zhang, L. (2003) · Current Opinion in Oncology · doi:10.1097/00001622-200401000-00005 · Cited by 99

Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ overexpressing transgenic mice

Delfino, D. V., Agostini, M., Spinicelli, S., Vito, P., & Riccardi, C. (2004) · Blood · doi:10.1182/blood-2004-03-0920 · Cited by 100

In vitro Antiproliferative and Apoptosis Inducing Effect of Allium atroviolaceum Bulb Extract on Breast, Cervical, and Liver Cancer Cells

Khazaei, S., Esa, N. M., Ramachandran, V., Hamid, R. A., Pandurangan, A. K., Etemad, A., & Ismail, P. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00005 · Cited by 97

Chapter 1 Molecular Modes of Action of Cytotoxic Alkaloids: From DNA Intercalation, Spindle Poisoning, Topoisomerase Inhibition to Apoptosis and Multiple Drug Resistance

Wink, M. (2007) · The Alkaloids. Chemistry and biology/The alkaloids. Chemistry and biology · doi:10.1016/s1099-4831(07)64001-2 · Cited by 96

Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase‐9 in the absence of Apaf‐1

Manns, J., Daubrawa, M., Drießen, S., Paasch, F., Hoffmann, N. A., Löffler, A. S., Lauber, K., Dieterle, A. M., Alers, S., Iftner, T., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-177527 · Cited by 99

The Essential Role of Evasion from Cell Death in Cancer

Kelly, G. L., & Strasser, A. (2011) · Advances in cancer research · doi:10.1016/b978-0-12-385524-4.00002-7 · Cited by 101

Neuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins

Pemberton, J. M., Pogmore, J. P., & Andrews, D. W. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00654-2 · Cited by 93

Big wheel keeps on turning: apoptosome regulation and its role in chemoresistance

Fadeel, B., Ottosson, A., & Pervaiz, S. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402265 · Cited by 95

Proapoptotic BH3-Only Protein Bid Is Essential For Death Receptor–Induced Apoptosis of Pancreatic β-Cells

McKenzie, M. D., Carrington, E. M., Kaufmann, T., Strasser, A., Huang, D. C. S., Kay, T. W. H., Allison, J., & Thomas, H. E. (2008) · Diabetes · doi:10.2337/db07-1692 · Cited by 96

Neuroprotective effects of water-soluble Ganoderma lucidum polysaccharides on cerebral ischemic injury in rats

Zhou, Z., Tang, Y., Xiang, J. Y., Wua, P., Jin, H., Wang, Z., Mori, M., & Cai, D. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.06.023 · Cited by 92

Triptolide-induced oxidative stress involved with Nrf2 contribute to cardiomyocyte apoptosis through mitochondrial dependent pathways

Zhou, J., Chen, X., Wang, W., Fu, X., Jinqiang, L., Qiu, Y., Jin, J., Xu, J., & Huang, Z. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.08.017 · Cited by 91

Melatonin and cancer: From the promotion of genomic stability to use in cancer treatment

Farhood, B., Goradel, N. H., Mortezaee, K., Khanlarkhani, N., Najafi, M., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27391 · Cited by 94

Mitochondrial electron transport chain identified as a novel molecular target of SPIO nanoparticles mediated cancer-specific cytotoxicity

He, C., Jiang, S., Jin, H., Chen, S., Lin, G., Yao, H., Wang, X., Mi, P., Ji, Z., Lin, Y., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.010 · Cited by 90

Ammonia inhalation impaired immune function and mitochondrial integrity in the broilers bursa of fabricius: Implication of oxidative stress and apoptosis

Shah, S. W. A., Chen, J., Han, Q., Xu, Y., Ishfaq, M., & Teng, X. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.110078 · Cited by 88

Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery

Leulier, F., Ribeiro, P. S., Palmer, E., Tenev, T., Takahashi, K., Robertson, D. M., Zachariou, A., Franck Pichaud, N., Ueda, R., & Meier, P. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401868 · Cited by 87

miR-29b-3p promotes progression of MDA-MB-231 triple-negative breast cancer cells through downregulating TRAF3

Zhang, B., Shetti, D., Fan, C., & Wei, K. (2019) · Biological Research · doi:10.1186/s40659-019-0245-4 · Cited by 84

Pterostilbene protects vascular endothelial cells against oxidized low-density lipoprotein-induced apoptosis in vitro and in vivo

Zhang, L., Zhou, G., Song, W., Tan, X., Guo, Y., Zhou, B., Jing, H., Zhao, S., & Chen, L. (2011) · APOPTOSIS · doi:10.1007/s10495-011-0653-6 · Cited by 84

Structural and Functional Analysis of Novel Human Cytochrome c Targets in Apoptosis

Martínez‐Fábregas, J., Díaz‐Moreno, I., González‐Arzola, K., Janocha, S., Navarro, J. A., Hervás, M., Bernhardt, R., Velázquez‐Campoy, A., Díaz-Quintana, A., & la Rosa, M. Á. D. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.034322 · Cited by 85

The control of apoptosis in lymphocyte selection

Strasser, A., & Bouillet, P. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00036.x · Cited by 83

Prostaglandin D2 and J2 induce apoptosis in human leukemia cells via activation of the caspase 3 cascade and production of reactive oxygen species

Chen, Y., Shen, S., & Tsai, S. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.10.016 · Cited by 80

Loss of Caspase-9 Reveals Its Essential Role for Caspase-2 Activation and Mitochondrial Membrane Depolarization

Samraj, A. K., Sohn, D., Schulze‐Osthoff, K., & Schmitz, I. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-04-0263 · Cited by 79

Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway

Scholz, C. W., Wieder, T., Stärck, L., Eßmann, F., Schulze‐Osthoff, K., Dörken, B., & Daniel, P. T. (2005) · Oncogene · doi:10.1038/sj.onc.1208233 · Cited by 79

Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion

Lindqvist, L., Frank, D. O., McArthur, K., Dite, T. A., Lazarou, M., Oakhill, J. S., Kile, B. T., & Vaux, D. L. (2017) · Cell Death and Differentiation · doi:10.1038/s41418-017-0017-z · Cited by 82

Defective core-apoptosis signalling in diffuse malignant pleural mesothelioma: opportunities for effective drug development

Fennell, D. A., & Rudd, R. (2004) · The Lancet Oncology · doi:10.1016/s1470-2045(04)01492-5 · Cited by 74

Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin.

Díaz, G. D., Li, Q., & Dashwood, R. H. (2003) · PubMed · Cited by 78

IFN-γ Acts Directly on Activated CD4+ T Cells during Mycobacterial Infection to Promote Apoptosis by Inducing Components of the Intracellular Apoptosis Machinery and by Inducing Extracellular Proapoptotic Signals

Li, X., McKinstry, K. K., Swain, S. L., & Dalton, D. K. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.939 · Cited by 77

MicroRNA-497 Induces Apoptosis and Suppresses Proliferation via the Bcl-2/Bax-Caspase9-Caspase3 Pathway and Cyclin D2 Protein in HUVECs

Wu, R., Tang, S. J., Wang, M., Xu, X., Chen, Y., & Wang, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167052 · Cited by 77

Interferon-α-induced apoptosis in U266 cells is associated with activation of the proapoptotic Bcl-2 family members Bak and Bax

Panaretakis, T., Tamm, K. P., Shoshan, M. C., & Grandér, D. (2003) · Oncogene · doi:10.1038/sj.onc.1206503 · Cited by 76

Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway

Chen, S., Xuan, J., Wan, L., Lin, H., Couch, L., Mei, N., Dobrovolsky, V. N., & Guo, L. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kft254 · Cited by 75

What have animal models taught us about the p53 pathway?

Lozano, G., & Zambetti, G. P. (2005) · The Journal of Pathology · doi:10.1002/path.1704 · Cited by 78

Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity

Li, J., Yin, H. L., & Yuan, J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200711082 · Cited by 75

Radiobiology of radioimmunotherapy: Targeting CD20 B-cell antigen in non-Hodgkin's lymphoma

Hernandez, M. C., & Knox, S. J. (2004) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2004.02.065 · Cited by 74

Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasisPreprint

Tuzlak, S., Kaufmann, T., & Villunger, A. (2016) · Genes & Development · doi:10.1101/gad.289298.116 · Cited by 73

Protective actions of ovarian hormones in the serotonin system of macaques

Bethea, C. L., Reddy, A. P., Tokuyama, Y., Henderson, J. A., & Lima, F. B. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.003 · Cited by 73

Mitochondrially Localized Active Caspase-9 and Caspase-3 Result Mostly from Translocation from the Cytosol and Partly from Caspase-mediated Activation in the Organelle

Chandra, D., & Tang, D. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300750200 · Cited by 73

Divergence from a Dedicated Cellular Suicide Mechanism: Exploring the Evolution of Cell Death

Yuan, J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.008 · Cited by 73

Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G

Mishra, R., & Simonson, M. S. (2005) · Cardiovascular Diabetology · doi:10.1186/1475-2840-4-2 · Cited by 73

Anticancer mechanism of Sinapic acid in PC-3 and LNCaP human prostate cancer cell lines

Güneş, C. E., Avcı, E., Vural, H. C., & Kurar, E. (2018) · Gene · doi:10.1016/j.gene.2018.05.049 · Cited by 74

Dimerization and Processing of Procaspase-9 by Redox Stress in Mitochondria

Katoh, I., Tomimori, Y., Ikawa, Y., & Kurata, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311819200 · Cited by 72

Apaf-1-independent programmed cell death in mouse development

Nagasaka, A., Kawane, K., Yoshida, H., & Nagata, S. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.186 · Cited by 71

What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain

Strasser, A., Puthalakath, H., O’Reilly, L. A., & Bouillet, P. (2007) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100141 · Cited by 72

Induced Inhibition of Ischemic/Hypoxic Injury by APIP, a Novel Apaf-1-interacting Protein

Cho, D., Hong, Y., Lee, H., Woo, H., Pyo, J.-O., Mak, T. W., & Jung, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405747200 · Cited by 70

GDNF-deprived sympathetic neurons die via a novel nonmitochondrial pathway

Yu, L.-Y., Jokitalo, E., Sun, Y., Mehlen, P., Lindholm, D., Saarma, M., & Arumäe, U. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200305083 · Cited by 71

The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death

Mills, K., Daish, T., Harvey, K. F., Pfleger, C. M., Hariharan, I. K., & Kumar, S. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200512126 · Cited by 70

Role of Bim and other Bcl-2 Family Members in Autoimmune and Degenerative Diseases

Hughes, P., Bouillet, P., & Strasser, A. (2005) · KARGER eBooks · doi:10.1159/000090773 · Cited by 72

Apoptosome formation and caspase activation: is it different in the heart?

Czerski, L., & Núñez, G. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.04.016 · Cited by 70

Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent

Burek, M., Maddika, S., Burek, M., Daniel, P. T., Schulze‐Osthoff, K., & Łoś, M. (2005) · Oncogene · doi:10.1038/sj.onc.1209258 · Cited by 70

Stress-induced apoptosis: Toward a symmetry with receptor-mediated cell death

Fumarola, C., & Guidotti, G. (2004) · APOPTOSIS · doi:10.1023/b:appt.0000012124.30095.09 · Cited by 70

Negative selection of semimature CD4 + 8 - HSA + thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

Villunger, A., Marsden, V. S., Zhan, Y., Erlacher, M., Lew, A. M., Bouillet, P., Berzins, S. P., Godfrey, D. I., Heath, W. R., & Strasser, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305757101 · Cited by 69

The Marine Product Cephalostatin 1 Activates an Endoplasmic Reticulum Stress-specific and Apoptosome-independent Apoptotic Signaling Pathway

López-Antón, N., Rudy, A., Barth, N. D., Schmitz, L. M., Pettit, G. R., Schulze‐Osthoff, K., Dirsch, V. M., & Vollmar, A. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607904200 · Cited by 70

Wild-type α-synuclein interacts with pro-apoptotic proteins PKCδ and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death

Kaul, S., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.05.022 · Cited by 70

Transcriptional control of the core cell-death machinery

Kumar, S., & Cakouros, D. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.02.001 · Cited by 72

Heat Shock Induces Apoptosis Independently of Any Known Initiator Caspase-activating Complex

Milleron, R. S., & Bratton, S. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512754200 · Cited by 69

Caspase-3 is required in the apoptotic disintegration of the nuclear matrix

Kivinen, K., Kallajoki, M. A., & Taimen, P. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.08.006 · Cited by 69

Nucleocytoplasmic transport in apoptosis

Ferrando‐May, E. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401626 · Cited by 69

Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation

Scott, C. L., Schüler, M., Marsden, V. S., Egle, A., Pellegrini, M., Nešić, D., Gerondakis, S., Nutt, S. L., Green, D. R., & Strasser, A. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200310041 · Cited by 69

Epigallocatechin-3-gallate induces the apoptosis of hepatocellular carcinoma LM6 cells but not non-cancerous liver cells

Zhang, Y., Duan, W., Owusu, L., Wu, D., & Xin, Y. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1988 · Cited by 68

Bisphenol-A induces neurodegeneration through disturbance of intracellular calcium homeostasis in human embryonic stem cells-derived cortical neurons

Wang, H., Zhao, P., Huang, Q., Chi, Y., Dong, S., & Fan, J. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.04.099 · Cited by 69

Inhibition of acid‐sensing ion channels by amiloride protects rat articular chondrocytes from acid‐induced apoptosis via a mitochondrial‐mediated pathway

Rong, C., Chen, F., Jiang, S., Hu, W. M., Wu, F., Chen, T., & Yuan, F. (2011) · Cell Biology International · doi:10.1042/cbi20110432 · Cited by 66

Skin cancer chemopreventive agent, -santalol, induces apoptotic death of human epidermoid carcinoma A431 cells via caspase activation together with dissipation of mitochondrial membrane potential and cytochrome c release

Kaur, M. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh325 · Cited by 66

Components of the Cell Death Machine and Drug Sensitivity of the National Cancer Institute Cell Line Panel

Svingen, P. A., Loegering, D. A., Rodriquez, J., Meng, X. W., Mesner, P. W., Holbeck, S. L., Monks, A. P., Krajewski, S., Scudiero, D. A., Sausville, E. A., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0778-02 · Cited by 66

miR-187-5p/apaf-1 axis was involved in oxidative stress-mediated apoptosis caused by ammonia via mitochondrial pathway in chicken livers

Xu, Y., Li, Z., Zhang, S., Zhang, H., & Teng, X. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114869 · Cited by 65

The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias

Kamitsuji, Y., Kuroda, J., Kimura, S. H., Toyokuni, S., Watanabe, K., Ashihara, E., Tanaka, H., Yui, Y., Watanabe, M., Matsubara, H., et al. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.107 · Cited by 65

Biology of hypoxia.

Kiang, J. G., & Tsen, K. (2006) · PubMed · Cited by 65

Shooting at survivors: Bcl-2 family members as drug targets for cancer

Juin, P. P., Geneste, O., Raimbaud, E., & Hickman, J. A. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2003.10.010 · Cited by 64

Solamargine, a steroidal alkaloid glycoside, induces oncosis in human K562 leukemia and squamous cell carcinoma KB cells

Sun, L., Zhao, Y., Yuan, H., Li, X., Cheng, A., & Lou, H. (2010) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-010-1387-9 · Cited by 63

Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion

Si, L., Zheng, L., Xu, L., Yin, L., Han, X., Qi, Y., Xu, Y., Wang, C., & Peng, J. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.02.009 · Cited by 63

Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis

Sadasivam, S., Gupta, S., Radha, V., Batta, K., Kundu, T. K., & Swarup, G. (2004) · Oncogene · doi:10.1038/sj.onc.1208201 · Cited by 65

Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways

Hahn, M., Li, W., Yu, C., Rahmani, M., Dent, P., & Grant, S. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-04-0137 · Cited by 63

Resveratrol induces mitochondria-mediated, caspase-independent apoptosis in murine prostate cancer cells

Kumar, S., Eroğlu, E., Stokes, J. A., III, Scissum-Gunn, K. D., Saldanha, S. N., Singh, U. P., Manne, U., Ponnazhagan, S., & Mishra, M. K. (2017) · Oncotarget · doi:10.18632/oncotarget.14947 · Cited by 63

Exploiting death receptor signaling pathways for tumor therapy

Fulda, S., & Debatin, K. (2004) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2004.09.003 · Cited by 64

Mechanisms of postischemic cardiac death and protection following myocardial injury

Mastoor, Y., Murphy, E., & Román, B. (2025) · Journal of Clinical Investigation · doi:10.1172/jci184134 · Cited by 68

Mitochondrial Function in Apoptotic Neuronal Cell Death

Haeberlein, S. L. B. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000014823.74782.b7 · Cited by 61

Overexpression of miRNA-221 promotes cell proliferation by targeting the apoptotic protease activating factor-1 and indicates a poor prognosis in ovarian cancer

Li, J., Li, Q., Huang, H., Li, Y., Li, L., Hou, W., & You, Z. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.3898 · Cited by 60

The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm

Bender, L. M., Morgan, M. J., Thomas, L. R., Liu, Z., & Thorburn, A. M. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401578 · Cited by 60

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

van Delft, M. F., Chappaz, S., Khakham, Y., Bui, C. T., Debrincat, M. A., Lowes, K. N., Brouwer, J. M., Grohmann, C., Sharp, P. P., Dagley, L. F., et al. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0365-8 · Cited by 56

FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells

Pellegrini, M., Bath, S., Marsden, V. S., Huang, D. C. S., Metcalf, D., Harris, A. W., & Strasser, A. (2005) · Blood · doi:10.1182/blood-2005-01-0284 · Cited by 59

Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cells through the intrinsic pathway with involvement of NF-κB signalling and G0/G1 cell cycle arrest: A bioassay-guided approach

Arbab, I. A., Abdul, A. B., Sukari, M. A., Abdullah, R., Syam, S., Kamalıdehghan, B., Ibrahim, M. Y., Taha, M. M. E., Abdelwahab, S. İ., Ali, H. M., et al. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.11.020 · Cited by 58

Sinularin induces DNA damage, G2/M phase arrest, and apoptosis in human hepatocellular carcinoma cells

Chung, T.-W., Lin, S., Su, J., Chen, Y., Lin, C., & Chan, H. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-1583-9 · Cited by 58

The Bcl-2 protein family and its role in the development of neoplastic disease

Heiser, D., Labi, V., Erlacher, M., & Villunger, A. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.04.011 · Cited by 59

ARK, the Apaf-1 related killer in Drosophila, requires diverse domains for its apoptotic activity

Srivastava, M., Scherr, H., Lackey, M., Xu, D., Chen, Z., Lu, J. T., & Bergmann, A. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401931 · Cited by 58

A serine protease is involved in the initiation of DNA damage-induced apoptosis

de Bruin, E. C., Meersma, D., de Wilde, J., Otter, I., Schipper, E., Medema, J. P., & Peltenburg, L. T. C. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401296 · Cited by 58

The proteins and the mechanisms of apoptosis: a mini-review of the fundamentals.

Papaliagkas, V., Anogianaki, A., Anogianakis, G., & Ilonidis, G. C. (2007) · PubMed Central · Cited by 57

Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9

Fombonne, J., Bissey, P.-A., Guix, C., Sadoul, R., Thibert, C., & Mehlen, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200094109 · Cited by 56

Thy-1 interaction with Fas in lipid rafts regulates fibroblast apoptosis and lung injury resolution

Liu, X., Wong, S. S., Taype, C. A., Kim, J., Shentu, T., Espinoza, C. R., Finley, J. C., Bradley, J., Head, B. P., Patel, H. H., et al. (2017) · Laboratory Investigation · doi:10.1038/labinvest.2016.145 · Cited by 56

Pathways involved in sunburn cell formation: deregulation in skin cancer

Claerhout, S., Laethem, A. V., Agostinis, P., & Garmyn, M. (2005) · Photochemical & Photobiological Sciences · doi:10.1039/b504970a · Cited by 56

Caspase activation and apoptosis in response to proteasome inhibitors

Henderson, C. J., Aleo, E., Fontanini, A., Maestro, R., Paroni, G., & Brancolini, C. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401729 · Cited by 55

Induction of apoptosis by enediyne antibiotic calicheamicin ϑII proceeds through a caspase-mediated mitochondrial amplification loop in an entirely Bax-dependent manner

Prokop, A., Wrasidlo, W., Lode, H. N., Herold, R., Lang, F. J. W., Henze, G., Dörken, B., Wieder, T., & Daniel, P. T. (2003) · Oncogene · doi:10.1038/sj.onc.1207196 · Cited by 56

c-Myb Promotes the Survival of CD4+CD8+ Double-Positive Thymocytes through Upregulation of Bcl-xL

Yuan, J., Crittenden, R. B., & Bender, T. P. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902846 · Cited by 55

RIPK1–RIPK3–MLKL-Associated Necroptosis Drives Leishmania infantum Killing in Neutrophils

Barbosa, L. A., Fiuza, P. P., Borges, L. J., Rolim, F. A., Andrade, M. B., Luz, N. F., Carvalho, G. Q., Lima, J. B., de Almeida, R. P., Chan, F. K., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01818 · Cited by 56

Bcl-2–regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

Marsden, V. S., Ekert, P. G., van Delft, M. F., Vaux, D. L., Adams, J. M., & Strasser, A. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312030 · Cited by 100

Bcl-2 regulates amplification of caspase activation by cytochrome c

Cosulich, S. C., Savory, P., & Clarke, P. R. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80068-2 · Cited by 91

Broader role for Bcl-2

Buckland, J. (2002) · Nature reviews. Immunology · doi:10.1038/nri940

Bcl-2 Finds a New Way to Save Cells

(2002) · Science Signaling · doi:10.1126/scisignal.1542002tw373

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

Kluck, R. M., Bossy‐Wetzel, E., Green, D. R., & Newmeyer, D. D. (1997) · Science · doi:10.1126/science.275.5303.1132 · Cited by 4,715