The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
The inflammatory reflex
Abstract
Inflammation is a local, protective response to microbial invasion or injury. It must be fine-tuned and regulated precisely, because deficiencies or excesses of the inflammatory response cause morbidity and shorten lifespan. The discovery that cholinergic neurons inhibit acute inflammation has qualitatively expanded our understanding of how the nervous system modulates immune responses. The nervous system reflexively regulates the inflammatory response in real time, just as it controls heart rate and other vital functions. The opportunity now exists to apply this insight to the treatment of inflammation through selective and reversible 'hard-wired' neural systems.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Similarly, early life stressful experiences might reduce inhibitory cholinergic neurotransmission (25), favoring inflammation persistence (26).”
From Childhood maltreatment predicts adult inflammation in a life-course study (2007) · cites this paper as [26]
In the citing paper
“For example, in response to pathogens and other injurious stimuli, tumor-necrosis factor-alpha (TNF-α), a cytokine, is produced by activated macrophages, dendritic cells, and other cells in the mucosa (3, 65).”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [65]
In the citing paper
“In addition, the autonomic nervous system regulates peripheral cytokine production. Parasympathetic nerves directly affect the immune system, while sympathetic nerves affect the immune system through NA secretion from the peripheral sympathetic ganglia. The vagus nucleus, which is located in the pons, inhibits immune functions and cytokine production through the secretion of Ach from the vagus ner”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [8]
In the citing paper
“The efferent arm of the inflammatory reflex, now termed the cholinergic antiinflammatory pathway (14), is a highly robust mechanism for cytokine control.”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [14]
Citations
Cites
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211
Self-citationHMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386
Self-citationShock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Self-citationAnti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448 · cited 1×
“Inflammation mediated by TNF Tumour-necrosis factor (TNF), a cytokine with a relative molecular mass of 17,000 ( M r 17K), is produced by activated macrophages in response to pathogens and other injurious stimuli, and is a necessary and sufficient mediator of local and systemic inflammatio”
BackgroundSelf-citationRole of Transcriptional Activation of IκBα in Mediation of Immunosuppression by Glucocorticoids
Scheinman, R. I., Cogswell, P. C., Lofquist, A. K., & Baldwin, A. S. (1995) · Science · doi:10.1126/science.270.5234.283 · Cited by 1,676
Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones
Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986) · Science · doi:10.1126/science.3014662 · Cited by 1,519
Andersson, U., Wang, H., Palmblad, K., Aveberger, A.-C., Bloom, O., Erlandsson-Harris, H., Janson, A., Kokkola, R., Zhang, M., Yang, H., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.565 · Cited by 1,401
Self-citationFunctional and chemical anatomy of the afferent vagal system
Berthoud, H.-R., & Neuhuber, W. L. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00215-0 · Cited by 1,280
Neuroendocrine Regulation of Immunity
Webster, J. I., Tonelli, L., & Sternberg, E. M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.082401.104914 · Cited by 957
Deactivation of macrophages by transforming growth factor-β
Tsunawaki, S., Sporn, M. B., Ding, A. H., & Nathan, C. (1988) · Nature · doi:10.1038/334260a0 · Cited by 862
Research works printed but not linked: 3
- Metal'nikov, S. a. V. C. Role des reflexes conditionnels dans l'immunite. Ann. Inst. Pasteur 40, 893–900 (1926).
- Ader R. & Cohen, N. in Psychoneuroimmunology (eds Ader R., Felten, D. L. & Cohen, N) 3–34 (Academic, San Diego, 2001).
- Zachariae, R. in Psychoneuroimmunology (eds Ader R., Felten, D. L. & Cohen, N.) 133–160 (Academic, San Diego, 2001).
Cited by
Sorted by citations
Items 701–800 of 1,014
Folino, F., Buja, G., Zanotto, G., Marras, E., Allocca, G., Vaccari, D., GASPARINI, G., Bertaglia, E., Zoppo, F., Calzolari, V., et al. (2017) · The Lancet Planetary Health · doi:10.1016/s2542-5196(17)30020-7 · Cited by 71
Cognition-Enhancing Vagus Nerve Stimulation Alters the Epigenetic Landscape
Sanders, T. H., Weiss, J. B., Hogewood, L., Chen, L., Paton, C., McMahan, R. L., & Sweatt, J. D. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2407-18.2019 · Cited by 71
Closed-Loop Implantable Therapeutic Neuromodulation Systems Based on Neurochemical Monitoring
Mirza, K. B., Golden, C. T., Nikolić, K., & Toumazou, C. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00808 · Cited by 71
Role of Infection in the Pathogenesis of Alzheimerʼs Disease
Holmes, C., & Cotterell, D. (2009) · CNS Drugs · doi:10.2165/11310910-000000000-00000 · Cited by 71
Modulation of inflammatory response via α2-adrenoceptor blockade in acute murine colitis
Bai, A., Lü, N., Guo, Y., Chen, J., & Liu, Z. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.03894.x · Cited by 71
Sympathetic activation and inflammatory response in patients with subarachnoid haemorrhage
Naredi, S., Lambert, G. W., Friberg, P., Zäll, S., Edén, E., Rydenhag, B., Tylman, M., & Bengtsson, A. (2006) · Intensive Care Medicine · doi:10.1007/s00134-006-0408-y · Cited by 71
COVID-19 and the nicotinic cholinergic system
Farsalinos, K. E., Angelopoulou, A., Alexandris, N., & Poulas, K. A. (2020) · European Respiratory Journal · doi:10.1183/13993003.01589-2020 · Cited by 71
Vagus Nerve Stimulation in Rodent Models: An Overview of Technical Considerations
Noller, C. M., Levine, Y. A., Urakov, T. M., Aronson, J. P., & Nash, M. S. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00911 · Cited by 70
Potential Role of Autonomic Dysfunction in Covid-19 Morbidity and Mortality
Río, R. D., Marcus, N. J., & Inestrosa, N. C. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.561749 · Cited by 70
Keever, K. R., Cui, K., Casteel, J. L., Singh, S., Hoover, D. B., Williams, D. L., Pavlov, V. A., & Yakubenko, V. P. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-023-03001-7 · Cited by 70
Quílez, M. E., López‐Aguilar, J., & Blanch, L. L. (2011) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e32834ef3ea · Cited by 70
Leptin in Anorexia and Cachexia Syndrome
Engineer, D. R., & Garcia, J. M. (2012) · International Journal of Peptides · doi:10.1155/2012/287457 · Cited by 70
Inflammation at the Intersection of Behavior and Somatic Symptoms
Irwin, M. R. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2011.05.005 · Cited by 70
Gianaros, P. J., Salomon, K., Zhou, F., Owens, J. F., Edmundowicz, D., Kuller, L. H., & Matthews, K. A. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000170335.92770.7a · Cited by 70
Morandi, A., Hughes, C. G., Girard, T. D., McAuley, D. F., Ely, E. W., & Pandharipande, P. P. (2011) · CHEST Journal · doi:10.1378/chest.10-3065 · Cited by 70
Inflammation-induced pain sensitization in men and women
Wegner, A., Elsenbruch, S., Rebernik, L., Roderigo, T., Engelbrecht, E., Jäger, M., Engler, H., Schedlowski, M., & Benson, S. (2015) · Pain · doi:10.1097/j.pain.0000000000000256 · Cited by 70
Woodhead, J. L., Yang, K., Oldach, D., MacLauchlin, C., FERNANDES, P. B., Watkins, P. B., Siler, S. Q., & Howell, B. A. (2019) · Pharmaceutical Research · doi:10.1007/s11095-019-2582-y · Cited by 70
Relationship between stress, inflammation and metabolism
Seematter, G., Binnert, C., Martin, J., & Tappy, L. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200403000-00011 · Cited by 70
Diamond, B., Huerta, P. T., Tracey, K., & Volpe, B. T. (2011) · BioEssays · doi:10.1002/bies.201100042 · Cited by 69
Self-citationNocebo and the contribution of psychosocial factors to the generation of pain
Benedetti, F., Frisaldi, E., Barbiani, D., Camerone, E. M., & Shaibani, A. I. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02104-x · Cited by 69
Li, X., Li, H., Cai, D., Li, P., Jin, J., Jiang, X., Li, Z., Tian, L., Chen, G., Sun, J., et al. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111944 · Cited by 69
Pan, Y., Yu, Z., Yuan, Y., Han, J., Wang, Z., Chen, H., Wang, S., Wang, Z., Hu, H., Zhou, L., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.630038 · Cited by 69
Microbiota-gut-brain axis in the Alzheimer's disease pathology - an overview
Giridharan, V. V., Quevedo, C. E. B. D., & Petronilho, F. C. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.05.003 · Cited by 69
van der Kleij, H. P. M., O’Mahony, C., Shanahan, F., O’Mahony, L., & Bienenstock, J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90434.2008 · Cited by 69
Ebbinghaus, M., Gajda, M. R., Boettger, M. K., Schaible, H., & Bräuer, R. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2011.150318 · Cited by 69
Impact of heart rate variability, a marker for cardiac health, on lupus disease activity
Thanou, A., Stavrakis, S., DYER, J. W., Munroe, M. E., James, J. A., & Merrill, J. T. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-1087-x · Cited by 69
Fang, J.-F., Fang, J.-Q., Shao, X.-M., Du, J.-Y., Liang, Y., Wang, W., & Liu, Z. (2017) · Scientific Reports · doi:10.1038/srep39801 · Cited by 69
Meroni, E., Stakenborg, N., Viola, M. F., & Boeckxstaens, G. E. (2018) · Acta Physiologica · doi:10.1111/apha.13163 · Cited by 69
Neuroscientific therapies for atrial fibrillation
Hanna, P., Buch, E. F., Stavrakis, S., Meyer, C. G., Tompkins, J. D., Ardell, J. L., & Shivkumar, K. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab172 · Cited by 68
Overcoming Cancer Resistance: Strategies and Modalities for Effective Treatment
Koirala, M., & DiPaola, M. (2024) · Biomedicines · doi:10.3390/biomedicines12081801 · Cited by 68
Experimental Therapeutic Strategies for Severe Sepsis
Parrish, W. R., Gallowitsch‐Puerta, M., Czura, C. J., & Tracey, K. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1418.011 · Cited by 68
Self-citationLazzerini, P. E., Acampa, M., Capecchi, P. L., Hammoud, M., Maffei, S., Bisogno, S., Barreca, C., Galeazzi, M., & Pasini, F. L. (2013) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2013.02.009 · Cited by 68
Standardization of methods to record Vagus nerve activity in mice
Silverman, H. A., Stiegler, A., Tsaava, T., Newman, J. E., Steinberg, B. E., Battinelli, E., Robbiati, S. F., Bouton, C. E., Huerta, P. T., Chavan, S. S., et al. (2018) · Bioelectronic Medicine · doi:10.1186/s42234-018-0002-y · Cited by 68
Self-citationMicrobiota impacts on chronic inflammation and metabolic syndrome - related cognitive dysfunction
Arnoriaga‐Rodríguez, M., & Fernández‐Real, J. M. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09537-5 · Cited by 68
Disrupted brain–immune system–joint communication during experimental arthritis
del Rey, A., Wolff, C., Wildmann, J., Randolf, A., Hahnel, A., Besedovsky, H. O., & Straub, R. H. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23869 · Cited by 68
Giebelen, I. A. J., van Westerloo, D. J., LaRosa, G. J., de Vos, A. F., & van der Poll, T. (2007) · Shock · doi:10.1097/01.shk.0000245016.78493.bb · Cited by 68
The inflammatory reflex – Introduction
Andersson, J. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01440.x · Cited by 68
A Neurovisceral Integration Model of Health Disparities in Aging
Anderson, N. B., Bulatao, R. A. B., & Cohen, B. (2004) · Cited by 68
Kurita, A., Takase, B., Shinagawa, N., Kodani, E., Okada, K., Iwahara, S.-I., Kusama, Y., & Atarashi, H. (2011) · International Heart Journal · doi:10.1536/ihj.52.299 · Cited by 67
Wu, Z., Zhang, X., Cai, T., Li, Y., Guo, X., Zhao, X., Wu, D., Li, Z., & Zhang, L. (2023) · Brain stimulation · doi:10.1016/j.brs.2023.02.008 · Cited by 67
The cholinergic anti-inflammatory pathway inhibits inflammation without lymphocyte relay
Simon, T., Kirk, J., Doležalová, N., Guyot, M., Panzolini, C., Bondue, A., Lavergne, J., Hugues, S., Hypolite, N., Saeb‐Parsy, K., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1125492 · Cited by 67
Effects of acute and chronic sleep deprivation on cardiovascular regulation
Tobaldini, E. (2015) · ARCHIVES ITALIENNES DE BIOLOGIE · doi:10.12871/000298292014235 · Cited by 67
Vagal Stimulation in Heart Failure
Ferrari, G. M. D. (2014) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-014-9540-1 · Cited by 67
Gidron, Y., Kupper, N. H. M., Kwaijtaal, M., Winter, J. B., & Denollet, J. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.10.009 · Cited by 67
Zhou, Y., Zuo, X., Li, Y., Wang, Y., Zhao, H., & Xiao, X. (2010) · Rheumatology International · doi:10.1007/s00296-010-1549-4 · Cited by 67
Hiramoto, T., Chida, Y., Sonoda, J., Yoshihara, K., Sudo, N., & Kubo, C. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.005 · Cited by 67
From CNI-1493 to the immunological homunculus: physiology of the inflammatory reflex
Oke, S. L., & Tracey, K. J. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0607363 · Cited by 67
Self-citationSocial network diversity and white matter microstructural integrity in humans
Molesworth, T., Sheu, L. K., Cohen, S., Gianaros, P. J., & Verstynen, T. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv001 · Cited by 67
Electroacupuncture therapy in inflammation regulation: current perspectives
Park, J.-Y., & Namgung, U. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s141198 · Cited by 67
Martelli, D., Farmer, D., McKinley, M. J., Yao, S. T., & McAllen, R. M. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00298.2018 · Cited by 67
Naz, S., Garcı́a, A., Rusak, M., & Barbas, C. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-6882-5 · Cited by 66
Nicotine and the nicotinic cholinergic system in COVID‐19
Tizabi, Y., Getachew, B., Copeland, R., & Aschner, M. (2020) · FEBS Journal · doi:10.1111/febs.15521 · Cited by 66
Ludwig, M., Wienke, C., Betts, M. J., Zaehle, T., & Hämmerer, D. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102900 · Cited by 66
THE PROTECTIVE EFFECT OF THE CHOLINERGIC ANTI-INFLAMMATORY PATHWAY AGAINST SEPTIC SHOCK IN RATS
Song, X., Li, J.-G., Wang, Y., Hu, Z., Zhou, Q., Du, Z., & Jia, B. (2008) · Shock · doi:10.1097/shk.0b013e31816d5e49 · Cited by 66
Behavioural conditioning as the mediator of placebo responses in the immune system
Vits, S., Cesko, E., Enck, P., Hillen, U., Schadendorf, D., & Schedlowski, M. (2011) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0392 · Cited by 66
Wojna, V., Robles, L., Skolasky, R. L., Mayo, R., Selnes, O. A., de la Torre, T., Maldonado, E., Nath, A., Meléndez, L. M., & Lasalde‐Dominicci, J. A. (2007) · Journal of NeuroVirology · doi:10.1080/13550280701620747 · Cited by 66
Femur Shaft Fracture Fixation in Head-Injured Patients: When Is the Right Time?
Flierl, M. A., Stoneback, J. W., Beauchamp, K. M., Hak, D. J., Morgan, S. J., Smith, W. R., & Stahel, P. F. (2010) · Journal of Orthopaedic Trauma · doi:10.1097/bot.0b013e3181b6bdfc · Cited by 66
McLachlan, E. M., & Hu, P. (2013) · Autonomic Neuroscience · doi:10.1016/j.autneu.2013.12.009 · Cited by 66
Schmidt, H., Hoyer, D., Hennen, R., Heinroth, K. M., Rauchhaus, M., Prondzinsky, R., Hottenrott, K., Buerke, M., Müller‐Werdan, U., & Werdan, K. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181653263 · Cited by 66
Ardesch, J. J., Buschman, H. P. J., van der Burgh, P. H., Wagener-Schimmel, L. J. J. C., van der Aa, H. E., & Hageman, G. (2007) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2007.07.024 · Cited by 66
Role of the Cholinergic Antiinflammatory Pathway in Murine Autoimmune Myocarditis
Leib, C., Göser, S., Lüthje, D., Öttl, R., Tretter, T., Lasitschka, F., Zittrich, S., Pfitzer, G., Katus, H. A., & Kaya, Z. (2011) · Circulation Research · doi:10.1161/circresaha.111.245563 · Cited by 66
Gnatek, Y., Zimmerman, G., Goll, Y., Najami, N., Soreq, H., & Friedman, A. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00066 · Cited by 66
Tracey, K. J. (2016) · Cell · doi:10.1016/j.cell.2016.01.018 · Cited by 66
Self-citationNeuronal control of experimental colitis occurs via sympathetic intestinal innervation
Willemze, R. A., Welting, O., van Hamersveld, H. P., Meijer, S. L., Folgering, J. H. A., Darwinkel, H., Witherington, J. J., Sridhar, A., Vervoordeldonk, M. J., Seppen, J., et al. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13163 · Cited by 66
Yeboah, M. M., Xue, X., Javdan, M., Susin, M., & Metz, C. N. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90255.2008 · Cited by 66
González‐Clemente, J. M., Vilardell, C. P., Broch, M., Megía, A., Caixàs, A., Giménez‐Palop, O., Richart, C., Simón, I., Martínez-Riquelme, A., Arroyo, J., et al. (2007) · European Journal of Endocrinology · doi:10.1530/eje-07-0090 · Cited by 66
Scientific and Clinical Challenges in Sepsis
Ulloa, L., Brunner, M., Ramos, L., & Deitch, E. A. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788453248 · Cited by 66
Epigenetic targets for reversing immune defects caused by alcohol exposure
Curtis, B. J. (2013) · Alcohol research · doi:10.35946/arcr.v35.1.11 · Cited by 65
Deutschman, C. S., Raj, N. R., McGuire, E. O., & Kelz, M. B. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31828e9843 · Cited by 65
da Silva, M. D., Guginski, G., Werner, M. F. D. P., Baggio, C. H., Marcon, R., & Santos, A. R. S. (2010) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/neq036 · Cited by 65
Mkrtchian, S., Kåhlin, J., Ebberyd, A., González, C., Sánchez, D., Balbir, A., Kostuk, E. W., Shirahata, M., Fagerlund, M. J., & Eriksson, L. I. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.231084 · Cited by 65
Octopaminergic Signaling Mediates Neural Regulation of Innate Immunity in Caenorhabditis elegans
Sellegounder, D., Yuan, C.-H., Wibisono, P., Liu, Y., & Sun, J. (2018) · mBio · doi:10.1128/mbio.01645-18 · Cited by 65
Chaudhry, S. R., Lendvai, I. S., Muhammad, S., Westhofen, P., Kruppenbacher, J. P., Scheef, L., Boecker, H., Scheele, D., Hurlemann, R., & Kinfe, T. M. (2019) · Brain stimulation · doi:10.1016/j.brs.2019.01.008 · Cited by 65
Tsaava, T., Datta-Chaudhuri, T., Addorisio, M. E., Battinelli, E., Silverman, H. A., Newman, J. E., Imperato, G. H., Bouton, C. E., Tracey, K. J., Chavan, S. S., et al. (2020) · Bioelectronic Medicine · doi:10.1186/s42234-020-00042-8 · Cited by 65
Self-citationInflammation as a link between brain injury and heart damage: the model of subarachnoid hemorrhage.
Mashaly, H. A., & Provencio, J. J. (2008) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.75.suppl_2.s26 · Cited by 65
Gans, R. O. B. (2006) · Medical Clinics of North America · doi:10.1016/j.mcna.2006.05.002 · Cited by 64
Autonomic dysfunctions in patients with inflammatory bowel disease in clinical remission
Sharma, P., Makharia, G. K., Ahuja, V., Dwivedi, S. N., & Deepak, K. K. (2009) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0424-6 · Cited by 64
Farsalinos, K. E., Bagos, P. G., Giannouchos, T. V., NIAURA, R. S., Barbouni, A., & Poulas, K. A. (2021) · Harm Reduction Journal · doi:10.1186/s12954-020-00437-5 · Cited by 64
Fischer, L., Barop, H., Ludin, S. M., & Schaible, H. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102903 · Cited by 64
Ionescu, C. E., Popescu, C. C., Agache, M., Dinache, G., & Codreanu, C. (2022) · Medicina · doi:10.3390/medicina58111637 · Cited by 64
Mosili, P., Mkhize, B. C., Sibiya, N. H., Ngubane, P. S., & Khathi, A. (2024) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2022-003218 · Cited by 64
Grisaru, D., Pick, M., Perry, C., Sklan, E. H., Almog, R., Goldberg, I., Naparstek, E., Lessing, J. B., Soreq, H., & Deutsch, V. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.1.27 · Cited by 64
Association between resting heart rate and arterial stiffness in Korean adults
Park, B., Lee, H.-R., Shim, J., Lee, J., Jung, D., & Lee, Y. (2010) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2010.03.004 · Cited by 64
von Känel, R., Carney, R. M., Zhao, S., & Whooley, M. A. (2010) · Clinical Research in Cardiology · doi:10.1007/s00392-010-0236-5 · Cited by 64
Yu, P. Y., Jin, H. W., Zhang, J.-Y., Wang, G.-F., Li, J.-R., Zhu, Z., Tian, Y., Wu, S., Xu, W., Zhang, J., et al. (2011) · Inflammation · doi:10.1007/s10753-011-9400-y · Cited by 64
Schwacha, M. G., McGwin, G., Hutchinson, C. B., Cross, J. M., MacLennan, P. A., & Rue, L. W. (2006) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2006.01.001 · Cited by 64
Kosek, E., & Kadetoff, D. (2010) · Journal of Rehabilitation Medicine · doi:10.2340/16501977-0597 · Cited by 64
Kong, W., Kang, K., Gao, Y., Liu, H., Meng, X., Yang, S.-L., Yu, K., & Zhao, M. (2017) · Europe PMC (PubMed Central) · Cited by 64
Innes, K. E., Vincent, H. K., & Taylor, A. G. (2007) · PubMed · Cited by 64
Neuromodulation, Specialized Proresolving Mediators, and Resolution of Pain
Tao, X., Lee, M. S., Donnelly, C. R., & Ji, R. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00892-9 · Cited by 63
Bonaz, B. L., Sinniger, V., & Sonia Pellissier, A. (2020) · Bioelectronic Medicine · doi:10.1186/s42234-020-00051-7 · Cited by 64
Neurotoxicity evoked by organophosphates and available countermeasures
Pulkrabkova, L., Svobodová, B., Konecny, J., Kobrlová, T., Múčková, Ľ., Janousek, J., Pejchal, J., Korábečný, J., & Soukup, O. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03397-w · Cited by 63
Neuroinflammatory and Immunological Aspects of Fibromyalgia
Findeisen, K. E., Guymer, E. K., & Littlejohn, G. O. (2025) · Brain Sciences · doi:10.3390/brainsci15020206 · Cited by 63
Li, W., & Olshansky, B. (2010) · Heart Failure Reviews · doi:10.1007/s10741-010-9184-4 · Cited by 63
Kox, M., Vrouwenvelder, M. Q., Pompe, J. C., van der Hoeven, J. G., Pickkers, P., & Hoedemaekers, C. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2011.2035 · Cited by 63
Serhan, C. N., de la Rosa, X., & Jouvene, C. C. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12871 · Cited by 63
Emerging Frontier of Peripheral Nerve and Organ Interfaces
Shahriari, D., Rosenfeld, D., & Anikeeva, P. (2020) · Neuron · doi:10.1016/j.neuron.2020.09.025 · Cited by 63
Fat meets the cholinergic antiinflammatory pathway
Tracey, K. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051760 · Cited by 63
Self-citationBioelectronic medicine: updates, challenges and paths forward
Pavlov, V. A., & Tracey, K. J. (2019) · Bioelectronic Medicine · doi:10.1186/s42234-019-0018-y · Cited by 63
Self-citationNeuromechanism of acupuncture regulating gastrointestinal motility
Yu, Z. H. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i23.3182 · Cited by 62
Metadata
- Authors
- Tracey, K. J.
- Affiliations
- Northwell Health (US)
- Corresponding author
- Tracey, Kevin J.
- ORCID
- Tracey, Kevin J.
- Venue
- Nature
- Published
- 2002-12
- Volume
- 420
- Issue
- 6917
- Pages
- 853-859
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1995525413
- Cited by
- 3,728
- References
- 79
- Citations by year
- 2026: 264 · 2025: 197 · 2024: 177 · 2023: 172 · 2022: 208 · 2021: 204 · 2020: 179 · 2019: 180 · 2018: 160 · 2017: 150 · 2016: 161 · 2015: 150 · 2014: 162 · 2013: 171 · 2012: 157
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- cholinergic anti-inflammatory pathway, cholinergic neurons, neuroimmune regulation, acute inflammation, inflammation treatment
- MeSH terms
- Animals, Antibodies, Monoclonal, Humans, Inflammation, Nervous System Physiological Phenomena, Reflex, Tumor Necrosis Factor-alpha, Vagus Nerve
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
