The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
The inflammatory reflex
Abstract
Inflammation is a local, protective response to microbial invasion or injury. It must be fine-tuned and regulated precisely, because deficiencies or excesses of the inflammatory response cause morbidity and shorten lifespan. The discovery that cholinergic neurons inhibit acute inflammation has qualitatively expanded our understanding of how the nervous system modulates immune responses. The nervous system reflexively regulates the inflammatory response in real time, just as it controls heart rate and other vital functions. The opportunity now exists to apply this insight to the treatment of inflammation through selective and reversible 'hard-wired' neural systems.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Similarly, early life stressful experiences might reduce inhibitory cholinergic neurotransmission (25), favoring inflammation persistence (26).”
From Childhood maltreatment predicts adult inflammation in a life-course study (2007) · cites this paper as [26]
In the citing paper
“For example, in response to pathogens and other injurious stimuli, tumor-necrosis factor-alpha (TNF-α), a cytokine, is produced by activated macrophages, dendritic cells, and other cells in the mucosa (3, 65).”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [65]
In the citing paper
“In addition, the autonomic nervous system regulates peripheral cytokine production. Parasympathetic nerves directly affect the immune system, while sympathetic nerves affect the immune system through NA secretion from the peripheral sympathetic ganglia. The vagus nucleus, which is located in the pons, inhibits immune functions and cytokine production through the secretion of Ach from the vagus ner”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [8]
In the citing paper
“The efferent arm of the inflammatory reflex, now termed the cholinergic antiinflammatory pathway (14), is a highly robust mechanism for cytokine control.”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [14]
Citations
Cites
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211
Self-citationHMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386
Self-citationShock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Self-citationAnti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448 · cited 1×
“Inflammation mediated by TNF Tumour-necrosis factor (TNF), a cytokine with a relative molecular mass of 17,000 ( M r 17K), is produced by activated macrophages in response to pathogens and other injurious stimuli, and is a necessary and sufficient mediator of local and systemic inflammatio”
BackgroundSelf-citationRole of Transcriptional Activation of IκBα in Mediation of Immunosuppression by Glucocorticoids
Scheinman, R. I., Cogswell, P. C., Lofquist, A. K., & Baldwin, A. S. (1995) · Science · doi:10.1126/science.270.5234.283 · Cited by 1,676
Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones
Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986) · Science · doi:10.1126/science.3014662 · Cited by 1,519
Andersson, U., Wang, H., Palmblad, K., Aveberger, A.-C., Bloom, O., Erlandsson-Harris, H., Janson, A., Kokkola, R., Zhang, M., Yang, H., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.565 · Cited by 1,401
Self-citationFunctional and chemical anatomy of the afferent vagal system
Berthoud, H.-R., & Neuhuber, W. L. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00215-0 · Cited by 1,280
Neuroendocrine Regulation of Immunity
Webster, J. I., Tonelli, L., & Sternberg, E. M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.082401.104914 · Cited by 957
Deactivation of macrophages by transforming growth factor-β
Tsunawaki, S., Sporn, M. B., Ding, A. H., & Nathan, C. (1988) · Nature · doi:10.1038/334260a0 · Cited by 862
Research works printed but not linked: 3
- Metal'nikov, S. a. V. C. Role des reflexes conditionnels dans l'immunite. Ann. Inst. Pasteur 40, 893–900 (1926).
- Ader R. & Cohen, N. in Psychoneuroimmunology (eds Ader R., Felten, D. L. & Cohen, N) 3–34 (Academic, San Diego, 2001).
- Zachariae, R. in Psychoneuroimmunology (eds Ader R., Felten, D. L. & Cohen, N.) 133–160 (Academic, San Diego, 2001).
Cited by
Sorted by citations
Items 501–600 of 1,014
The Effects of Inflammation, Infection and Antibiotics on the Microbiota-Gut-Brain Axis
Berčík, P., & Collins, S. M. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_13 · Cited by 98
The systemic inflammatory response syndrome
Weigand, M. A., Hörner, C., Bardenheuer, H. J., & Bouchon, A. (2004) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2003.12.005 · Cited by 98
Dusi, V., Ghidoni, A., Ravera, A., Ferrari, G. M. D., & Calvillo, L. (2016) · Mediators of Inflammation · doi:10.1155/2016/5902947 · Cited by 98
Inflammation and cardiorespiratory control: the role of the vagus nerve.
Thayer, J. F., Loerbroks, A., & Sternberg, E. M. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.05.016 · Cited by 97
Parkinson's disease and periodontitis – the missing link? A review
Kaur, T., Uppoor, A. S., & Naik, D. G. (2015) · Gerodontology · doi:10.1111/ger.12188 · Cited by 97
Ghrelin inhibits sympathetic nervous activity in sepsis
Wu, R., Zhou, M., Das, P., Dong, W., Ji, Y., Yang, D., Miksa, M., Zhang, F., Ravikumar, T. S., & Wang, P. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00098.2007 · Cited by 97
Han, B., Li, X., & Hao, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.002 · Cited by 97
B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis
Schloss, M. J., Hulsmans, M., Rohde, D., Lee, I., Sévère, N., Foy, B. H., Pulous, F. E., Zhang, S., Kokkaliaris, K. D., Frodermann, V., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01165-7 · Cited by 97
Lanza, G. A., Sgueglia, G. A., Cianflone, D., Rebuzzi, A. G., Angeloni, G., Sestito, A., Infusino, F., Crea, F., & Maseri, A. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.01.029 · Cited by 97
Yuhki, K., Kojima, F., Kashiwagi, H., Kawabe, J.-I., Fujino, T., Narumiya, S., & Ushikubi, F. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.09.004 · Cited by 97
New Insights in (Inter)Cellular Mechanisms by Heart Failure with Preserved Ejection Fraction
Tschöpe, C., & Linthout, S. V. (2014) · Current Heart Failure Reports · doi:10.1007/s11897-014-0219-3 · Cited by 97
Immune-To-Brain Signaling: How Important are the Blood–Brain Barrier-independent Pathways?
Quan, N. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8026-z · Cited by 97
Mazzeo, A. T., Micalizzi, A., Mascia, L., Scicolone, A., & Siracusano, L. (2014) · British Journal of Anaesthesia · doi:10.1093/bja/aeu046 · Cited by 97
Neural inhibition of inflammation: the cholinergic anti-inflammatory pathway
Czura, C. J., Friedman, S. G., & Tracey, K. J. (2003) · Journal of Endotoxin Research · doi:10.1179/096805103225002755 · Cited by 97
Self-citationImmune Responses in Parkinson’s Disease: Interplay between Central and Peripheral Immune Systems
Su, X., & Federoff, H. J. (2014) · BioMed Research International · doi:10.1155/2014/275178 · Cited by 96
Interventions to promote cardiometabolic health and slow cardiovascular ageing
Fontana, L. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0026-8 · Cited by 96
The Role of α7nAChR-Mediated Cholinergic Anti-inflammatory Pathway in Immune Cells
Wu, Y., Wang, L., Ji, C.-F., Gu, S., Yin, Q., & Zuo, J. (2021) · Inflammation · doi:10.1007/s10753-020-01396-6 · Cited by 99
Higher Vagal Activity as Related to Survival in Patients With Advanced Breast Cancer
Giese‐Davis, J., Wilhelm, F. H., Tamagawa, R., Palesh, O. G., Neri, E., Taylor, C. B., KRAEMER, H. C., & Spiegel, D. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000167 · Cited by 96
Injury research in the genomic era
Cobb, J. P., & O’Keefe, G. E. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16460-x · Cited by 96
Inflammatory markers and heart rate variability in women with coronary heart disease
Janszky, I., Ericson, M. O., Lekander, M., Blom, M., Buhlin, K., Georgiades, A., & Ahnve, S. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01403.x · Cited by 96
The renaissance of corticotropin therapy in proteinuric nephropathies
Gong, R. (2011) · Nature Reviews Nephrology · doi:10.1038/nrneph.2011.190 · Cited by 95
Hintsanen, M., Elovainio, M. J., Puttonen, S., Mika Kivimaki, B., Koskinen, T., Raitakari, O. T., & Keltikangas‐Järvinen, L. (2007) · International Journal of Behavioral Medicine · doi:10.1007/bf03002994 · Cited by 95
Depressive Symptoms Predict Mucosal Wound Healing
Bosch, J. A., Engeland, C. G., Cacioppo, J. T., & Marucha, P. T. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318148c682 · Cited by 95
Kalb, A., von Haefen, C., Sifringer, M., Tegethoff, A., Paeschke, N., Kostova, M. H., Feldheiser, A., & Spies, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062679 · Cited by 94
Sense and Immunity: Context-Dependent Neuro-Immune Interplay
Foster, S. L., Seehus, C. R., Woolf, C. J., & Talbot, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01463 · Cited by 94
Neuronal GPCR NPR-8 regulates C. elegans defense against pathogen infection
Sellegounder, D., Liu, Y., Wibisono, P., Chen, C.-H., Leap, D. J., & Sun, J. (2019) · Science Advances · doi:10.1126/sciadv.aaw4717 · Cited by 94
Vagus Nerve Stimulation as a Potential Therapy in Early Alzheimer’s Disease: A Review
Vargas‐Caballero, M., Warming, H., Walker, R., Holmes, C., Cruickshank, G. S., & Patel, B. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.866434 · Cited by 94
Egli, S., Pfister, M., Ludin, S. M., de la Vega, K. P., Busato, A. R., & Fischer, L. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0735-z · Cited by 94
Wheat Gluten Causes Dendritic Cell Maturation and Chemokine Secretion
Nikulina, M., Habich, C., Flohé, S. B., Scott, F. W., & Kolb, H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1925 · Cited by 94
Role of the nervous system in cancer metastasis
Li, S., Sun, Y., & GAO, D. (2013) · Oncology Letters · doi:10.3892/ol.2013.1168 · Cited by 94
Systematic Review of Pharmacological Properties of the Oligodendrocyte Lineage
Marinelli, C., Bertalot, T., Zusso, M., Skaper, S. D., & Giusti, P. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00027 · Cited by 94
Mechanisms of the placebo response
Benedetti, F., & Amanzio, M. (2013) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2013.01.006 · Cited by 93
Addorisio, M. E., Imperato, G. H., de Vos, A. F., Forti, S., Goldstein, R. S., Pavlov, V. A., van der Poll, T., Yang, H., Diamond, B., Tracey, K. J., et al. (2019) · Bioelectronic Medicine · doi:10.1186/s42234-019-0020-4 · Cited by 93
Self-citationLinking mechanisms of periodontitis to Alzheimer's disease
Sadrameli, M., Bathini, P., & Alberi, L. A. (2020) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000797 · Cited by 93
Injurious mechanical ventilation affects neuronal activation in ventilated rats
Quílez, M. E., Fuster, G., Villar, J., Flores, C., Martı́, O., Blanch, L. L., & López‐Aguilar, J. (2011) · Critical Care · doi:10.1186/cc10230 · Cited by 93
Bansal, V., Costantini, T. W., Ryu, S. Y., Peterson, C. Y., Loomis, W. H., Putnam, J., Elicieri, B. P., Baird, A., & Coimbra, R. S. M. (2010) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3181d87373 · Cited by 93
Sominsky, L., Fuller, E. A., Bondarenko, E., Ong, L. K., Averell, L., Nalivaiko, E., Dunkley, P. R., Dickson, P. W., & Hodgson, D. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057700 · Cited by 93
Benefit Finding and Physical Health: Positive Psychological Changes and Enhanced Allostasis
Bower, J. E., Low, C. A., Moskowitz, J. T., Sepah, S., & Epel, E. S. (2007) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2007.00038.x · Cited by 93
Zafar, M. U., Paz-Yepes, M., Shimbo, D., Vilahur, G., Burg, M. M., Chaplin, W. F., Fuster, V., Davidson, K. W., & Badimón, J. J. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehp602 · Cited by 93
Polycaprolactone Thin-Film Micro- and Nanoporous Cell-Encapsulation Devices
Nyitray, C. E., Chang, R., Faleo, G., Lance, K. D., Bernards, D. A., Tang, Q., & Desai, T. A. (2015) · ACS Nano · doi:10.1021/acsnano.5b00679 · Cited by 93
A potential interaction between the SARS-CoV-2 spike protein and nicotinic acetylcholine receptors
Oliveira, A. S. F., Ibarra, A. Á., Bermúdez, I., Casalino, L., Gaieb, Z., Shoemark, D. K., Gallagher, T. C., Sessions, R. B., Amaro, R. E., & Mulholland, A. J. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2021.01.037 · Cited by 92
Wu, R., Dong, W., Ji, Y., Zhou, M., Marini, C. P., Ravikumar, T. S., & Wang, P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002026 · Cited by 92
Mannelli, L. D. C., Pacini, A., Matera, C., Zanardelli, M., Mello, T., Amici, M. D., Dallanoce, C., & Ghelardini, C. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.10.034 · Cited by 92
Neuronal regulation of tendon homoeostasis
Ackermann, P. W. (2013) · International Journal of Experimental Pathology · doi:10.1111/iep.12028 · Cited by 91
Herdt, V. D., Bogaert, S., Bracke, K. R., Raedt, R., Vos, M. D., Vonck, K. E. J., & Boon, P. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.06.008 · Cited by 91
Pizzi, C., Manzoli, L., Mancini, S., Bedetti, G., Fontana, F., & Costa, G. M. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.04.038 · Cited by 91
Cailotto, C., Costes, L. M. M., van der Vliet, J., van Bree, S. H. W., van Heerikhuize, J. J., Buijs, R. M., & Boeckxstaens, G. E. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01824.x · Cited by 91
Hickman, R. J., Khambaty, T., & Stewart, J. C. (2014) · Journal of Behavioral Medicine · doi:10.1007/s10865-013-9510-0 · Cited by 90
Indo, Y. (2012) · Clinical Genetics · doi:10.1111/j.1399-0004.2012.01943.x · Cited by 90
Georgakopoulos, D., Little, W. C., Abraham, W. T., Weaver, F. A., & Zile, M. R. (2010) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2010.09.004 · Cited by 90
Toohey, K. L., Pumpa, K. L., McKune, A. J., Cooke, J., Welvaert, M., Northey, J. M., Quinlan, C., & Semple, S. (2020) · BMC Cancer · doi:10.1186/s12885-020-07295-1 · Cited by 90
Neuroinflammation, Stem Cells, and Stroke
Anthony, S., Cabantan, D., Monsour, M., & Borlongan, C. V. (2022) · Stroke · doi:10.1161/strokeaha.121.036948 · Cited by 93
Liu, F., Wu, J., Gong, L.-J., Yang, H.-S., & Chen, H. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1490300 · Cited by 90
It takes nerve to dampen inflammation
Metz, C. N., & Tracey, K. J. (2005) · Nature Immunology · doi:10.1038/ni0805-756 · Cited by 90
Self-citationElevated S100B levels do not correlate with the severity of encephalopathy during sepsis
Piazza, O., Russo, E., Cotena, S., Esposito, G., & Tufano, R. (2007) · British Journal of Anaesthesia · doi:10.1093/bja/aem201 · Cited by 90
Norms of vagal nerve activity, indexed by Heart Rate Variability, in cancer patients
Couck, M., & Gidron, Y. (2013) · Cancer Epidemiology · doi:10.1016/j.canep.2013.04.016 · Cited by 90
Brüünsgaard, H. (2006) · PubMed · Cited by 90
ENDOTOXIN IMPAIRS THE HUMAN PACEMAKER CURRENT I f
Zorn‐Pauly, K., Pelzmann, B., Lang, P., Mächler, H., Schmidt, H., Ebelt, H., Werdan, K., Koidl, B., & Müller‐Werdan, U. (2007) · Shock · doi:10.1097/shk.0b013e31812386bf · Cited by 90
Neuroimmune crosstalk in the pathophysiology of hypertension
Calvillo, L., Gironacci, M. M., Crotti, L., Meroni, P. L., & Parati, G. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0178-1 · Cited by 89
Pavlovian Conditioning of Immunological and Neuroendocrine Functions
Hadamitzky, M., Lückemann, L., Pacheco‐López, G., & Schedlowski, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00033.2018 · Cited by 89
Sepsis-associated encephalopathy: From pathophysiology to clinical management
Hong, Y., Chen, P., Gao, J., Lin, Y., Chen, L., & Shang, X. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110800 · Cited by 94
Factor Structure Underlying Components of Allostatic Load
McCaffery, J. M., Marsland, A. L., Strohacker, K. A., Muldoon, M. F., & Manuck, S. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047246 · Cited by 89
Cellular Organization of Neuroimmune Interactions in the Gastrointestinal Tract
Margolis, K. G., Gershon, M. D., & Bogunovic, M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.05.003 · Cited by 89
Consolim‐Colombo, F. M., Sangaleti, C. T., Costa, F. O., de Morais, T. L., Lopes, H. F., Motta, J. M. E., Irigoyen, M. C., Bortolotto, L. A., Rochitte, C. E., Harris, Y., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.93340 · Cited by 89
Self-citationEnteric Glia Cells Attenuate Cytomix-Induced Intestinal Epithelial Barrier Breakdown
Cheadle, G. A., Costantini, T. W., Lopez, N., Bansal, V., Eliceiri, B. P., & Coimbra, R. S. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069042 · Cited by 88
The potential of dandelion in the fight against gastrointestinal diseases: A review
Li, Y., Chen, Y.-L., & Sun‐Waterhouse, D. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115272 · Cited by 88
Arrhythmic risk in rheumatoid arthritis: the driving role of systemic inflammation
Lazzerini, P. E., Capecchi, P. L., Acampa, M., Galeazzi, M., & Pasini, F. L. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.05.007 · Cited by 88
The Role of the Vagus Nerve in Cancer Prognosis: A Systematic and a Comprehensive Review
Couck, M., Caers, R., Spiegel, D., & Gidron, Y. (2018) · Journal of Oncology · doi:10.1155/2018/1236787 · Cited by 87
Qureshi, F., Leaphart, C. L., Çetin, S., Li, J., Grishin, A., Watkins, S. C., Ford, H. R., & Hackam, D. J. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.01.052 · Cited by 87
Huston, J. M. (2012) · Surgical Infections · doi:10.1089/sur.2012.126 · Cited by 87
Bansal, V., Ryu, S. Y., Lopez, N., Allexan, S. S., Krzyżaniak, M., Eliceiri, B. P., Baird, A., & Coimbra, R. S. M. (2011) · Inflammation · doi:10.1007/s10753-011-9307-7 · Cited by 87
Papaioannou, V. E., Pneumatikos, I. A., & Maglaveras, N. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00174 · Cited by 87
Heuschkel, K., & Kuypers, K. P. C. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00224 · Cited by 86
Hallman, D., Jørgensen, M. B., & Holtermann, A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177042 · Cited by 85
Ongnok, B., Khuanjing, T., Chunchai, T., Pantiya, P., Kerdphoo, S., Arunsak, B., Nawara, W., Jaiwongkam, T., Apaijai, N., Chattipakorn, N., et al. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01092-9 · Cited by 86
Zhu, X., Huang, J.-Y., Dong, W., Tang, H.-D., Xu, S., Wu, Q., Zhang, H., Cheng, P., Jin, Y., Zhu, M., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-023-01561-8 · Cited by 88
Chronic Pain and Heart Rate Variability in a Cross-Sectional Occupational Sample
Koenig, J., Loerbroks, A., Jarczok, M. N., Fischer, J. E., & Thayer, J. F. (2015) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000242 · Cited by 86
The Duplicated α7 Subunits Assemble and Form Functional Nicotinic Receptors with the Full-length α7
Wang, Y., Xiao, C., Indersmitten, T., Freedman, R., Leonard, S. S., & Lester, H. A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.582858 · Cited by 86
von Känel, R., Hari, R., Schmid, J. P., Wiedemar, L., Guler, E., Barth, J., Saner, H. E., Schnyder, U., & Begré, S. (2011) · Journal of Cardiology · doi:10.1016/j.jjcc.2011.02.007 · Cited by 86
Brack, K. E., Winter, J., & Ng, G. A. (2012) · Heart Failure Reviews · doi:10.1007/s10741-012-9314-2 · Cited by 86
Positive Affect and Immune Function
Marsland, A. L., Pressman, S. D., & Cohen, S. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50042-3 · Cited by 86
Neuroimmune Interactions in the Gut and Their Significance for Intestinal Immunity
Brinkman, D. J., ten Hove, A. S., Vervoordeldonk, M. J., Luyer, M. D. P., & de Jonge, W. J. (2019) · Cells · doi:10.3390/cells8070670 · Cited by 85
Kageyama‐Yahara, N., Suehiro, Y., Yamamoto, T., & Kadowaki, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.004 · Cited by 85
Targeting neural reflex circuits in immunity to treat kidney disease
Okusa, M. D., Rosin, D. L., & Tracey, K. J. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.132 · Cited by 85
Self-citationPavlov, V. A., Chavan, S. S., & Tracey, K. J. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a034140 · Cited by 85
Self-citationKimura, K., Tanida, M., Nagata, N., Inaba, Y., Watanabe, H., Nagashimada, M., Ota, T., Asahara, S.-I., Kido, Y., Matsumoto, M., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.032 · Cited by 84
VAN WESTERLOO, D. J., GIEBELEN, I. A. J., MEIJERS, J. C. M., DAALHUISEN, J., DE VOS, A. F., LEVI, M., & VAN DER POLL, T. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.02112.x · Cited by 84
Julio-Pieper, M., Bravo, J. A., Aliaga, E., & Gotteland, M. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12950 · Cited by 84
The neurological manifestations of acute liver failure
Shawcross, D. L., & Wendon, J. A. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.10.006 · Cited by 84
Does stress exacerbate liver diseases?
Chida, Y., Sudo, N., & Kubo, C. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04110.x · Cited by 84
van Maanen, M. A., Stoof, S. P., van der Zanden, E. P., de Jonge, W. J., Janssen, R. A. J., Fischer, D. F., Vandeghinste, N., Brys, R., Vervoordeldonk, M. J., & Tak, P. P. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24470 · Cited by 84
Depression and heart disease: What do we know, and where are we headed?
Pozuelo, L., Zhang, J., Franco, K. S. N., Tesar, G., Penn, M. S., & Jiang, W. (2009) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.75a.08011 · Cited by 84
Radek, K. A., Elias, P. M., Taupenot, L., Mahata, S. K., O’Connor, D. T., & Gallo, R. L. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.03.009 · Cited by 84
Hu, P. J., Pittet, J., Kerby, J. D., Bosarge, P. L., & Wagener, B. M. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00485.2016 · Cited by 84
Corcoran, C., Connor, T. J., O’Keane, V., & Garland, M. R. (2005) · Neuroimmunomodulation · doi:10.1159/000087109 · Cited by 83
Xie, Y., Zhao, Q. Y., Li, H. Y., Zhou, X., Liu, Y., & Zhang, H. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.08.005 · Cited by 83
Ma, J., Chen, Q., Li, J., Zhao, H., Mi, E., Chen, Y., Yi, B., Ning, J., Ma, D., Lu, K., et al. (2018) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000003820 · Cited by 83
Lee, J., Kim, D. W., Chun, S., Song, J. H., Yoo, E.-S., Kim, J. K., & Pang, C. (2020) · Advanced Materials Technologies · doi:10.1002/admt.202000073 · Cited by 83
Metabolic syndrome, physical activity and cardiac autonomic function
Soares‐Miranda, L., SANDERCOCK, G. R. H., Vale, S. M. C. G., Santos, R., Abreu, S., Moreira, C. M. M., & Mota, J. A. P. S. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2281 · Cited by 83
Freitas, K., Ghosh, S., Carroll, F. I., Lichtman, A. H., & Damaj, M. I. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.08.022 · Cited by 83
Metadata
- Authors
- Tracey, K. J.
- Affiliations
- Northwell Health (US)
- Corresponding author
- Tracey, Kevin J.
- ORCID
- Tracey, Kevin J.
- Venue
- Nature
- Published
- 2002-12
- Volume
- 420
- Issue
- 6917
- Pages
- 853-859
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1995525413
- Cited by
- 3,728
- References
- 79
- Citations by year
- 2026: 264 · 2025: 197 · 2024: 177 · 2023: 172 · 2022: 208 · 2021: 204 · 2020: 179 · 2019: 180 · 2018: 160 · 2017: 150 · 2016: 161 · 2015: 150 · 2014: 162 · 2013: 171 · 2012: 157
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- cholinergic anti-inflammatory pathway, cholinergic neurons, neuroimmune regulation, acute inflammation, inflammation treatment
- MeSH terms
- Animals, Antibodies, Monoclonal, Humans, Inflammation, Nervous System Physiological Phenomena, Reflex, Tumor Necrosis Factor-alpha, Vagus Nerve
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
