α7 nicotinic acetylcholine receptors in the hippocampal circuit: taming complexity

The cholinergic hypothesis of geriatric memory dysfunction

Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545 · see citing works

Exercise training increases size of hippocampus and improves memory

Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855 · see citing works

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627 · see citing works

Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation

Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., et al. (2003) · Nature · doi:10.1038/nature01339 · Cited by 3,228 · see citing works

An <i>in vivo</i> correlate of exercise-induced neurogenesis in the adult dentate gyrus

Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., Sloan, R., Gage, F. H., Brown, T. R., & Small, S. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611721104 · Cited by 1,353 · see citing works

Reflex control of immunity

Tracey, K. J. (2009) · Nature Reviews Immunology · doi:10.1038/nri2566 · Cited by 1,154 · see citing works

Spike Timing-Dependent Plasticity of Neural Circuits

Dan, Y., & Poo, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.007 · Cited by 1,029 · see citing works

Clinical trials of new drugs for Alzheimer disease

Huang, L.-K., Chao, S.-P., & Hu, C.-J. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-019-0609-7 · Cited by 702 · see citing works

A Quarter Century of APOE and Alzheimer’s Disease: Progress to Date and the Path Forward

Belloy, M. E., Napolioni, V., & Greicius, M. D. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.056 · Cited by 570 · see citing works

Cholinesterase inhibitors for patients with Alzheimer's disease: systematic review of randomised clinical trials

Kaduszkiewicz, H., Zimmermann, T., Beck-Bornholdt, H.-P., & van den Bussche, H. (2005) · BMJ · doi:10.1136/bmj.331.7512.321 · Cited by 522 · see citing works

Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories

Hainmueller, T., & Bartos, M. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0260-z · Cited by 474 · see citing works

It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood

PICCIOTTO, M., ADDY, N., MINEUR, Y., & BRUNZELL, D. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.12.005 · Cited by 451 · see citing works

Association of Promoter Variants in the α7 Nicotinic Acetylcholine Receptor Subunit Gene With an Inhibitory Deficit Found in Schizophrenia

Leonard, S. S., Gault, J., Hopkins, J., Logel, J., Vianzon, R., Short, M., Drebing, C. J., Berger, R., Venn, D., Sirota, P., et al. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.12.1085 · Cited by 443 · see citing works

Timing and Location of Nicotinic Activity Enhances or Depresses Hippocampal Synaptic Plasticity

Ji, D., Lape, R., & Dani, J. A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00332-4 · Cited by 419 · see citing works

An optimized acetylcholine sensor for monitoring in vivo cholinergic activity

Jing, M., Li, Y., Zeng, J., Huang, P., Skirzewski, M., Kljakic, O., Peng, W., Qian, T., Tan, K., Zou, J., et al. (2020) · Nature Methods · doi:10.1038/s41592-020-0953-2 · Cited by 408 · see citing works

Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial.

ten Brinke, L. F., Bolandzadeh, N., Nagamatsu, L. S., Hsu, C. L., Davis, J. C., Miran-Khan, K., & Liu-Ambrose, T. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2013-093184 · Cited by 380 · see citing works

Revisiting the Cholinergic Hypothesis in Alzheimer's Disease: Emerging Evidence from Translational and Clinical Research

Hampel, H. J., Mesulam, M. M., Cuello, A. C., Khachaturian, A. S., Vergallo, A., Farlow, M. R., Snyder, P. J., Giacobini, E., & Khachaturian, Z. S. (2019) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2018.43 · Cited by 369 · see citing works

Ultrastructural Distribution of the α7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus

Fabian‐Fine, R., Skehel, P., Errington, M. L., Davies, H. A., Sher, E., Stewart, M. G., & Fine, A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-07993.2001 · Cited by 361 · see citing works

OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons

Leão, R. N., Mikulovic, S., Leão, K. E., Munguba, H., Gezelius, H., Enjin, A., Patra, K., Eriksson, A., Loew, L. M., Tort, A. B. L., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3235 · Cited by 359 · see citing works

Rediscovering area CA2: unique properties and functions

Dudek, S. M., Alexander, G. M., & Farris, S. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2015.22 · Cited by 329 · see citing works

Structure and gating mechanism of the α7 nicotinic acetylcholine receptor

Noviello, C., Gharpure, A., Mukhtasimova, N., Cabuco, R., Baxter, L., Borek, D., Sine, S. M., & Hibbs, R. E. (2021) · Cell · doi:10.1016/j.cell.2021.02.049 · Cited by 303 · see citing works

Timing-Dependent Septal Cholinergic Induction of Dynamic Hippocampal Synaptic Plasticity

Gu, Z., & Yakel, J. L. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.026 · Cited by 286 · see citing works

Diversity of native nicotinic receptor subtypes in mammalian brain

Zoli, M., Pistillo, F., & Gotti, C. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.003 · Cited by 277 · see citing works

alpha-Bungarotoxin-sensitive hippocampal nicotinic receptor channel has a high calcium permeability

Castro, N. G., & Albuquerque, E. X. (1995) · Biophysical Journal · doi:10.1016/s0006-3495(95)80213-4 · Cited by 273 · see citing works

Functional nicotinic ACh receptors on interneurones in the rat hippocampus

Jones, S., & Yakel, J. L. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.603bd.x · Cited by 271 · see citing works

The touchscreen cognitive testing method for rodents: How to get the best out of your rat

Bussey, T. J., Padain, T. L., Skillings, E. A., Winters, B. D., Morton, A. J., & Saksida, L. M. (2008) · Learning &amp; Memory · doi:10.1101/lm.987808 · Cited by 255 · see citing works

Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness

Papouin, T., Dunphy, J. M., Tolman, M., Dineley, K. T., & Haydon, P. G. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.021 · Cited by 243 · see citing works

Microglial α7 nicotinic acetylcholine receptors drive a phospholipase C/IP 3 pathway and modulate the cell activation toward a neuroprotective role

Suzuki, T., Hide, I., Matsubara, A., Hama, C., Harada, K., Miyano, K., Andrä, M., Matsubayashi, H., Sakai, N., Kohsaka, S., et al. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20850 · Cited by 241 · see citing works

Nicotinic Acetylcholine Receptor α7 and α4β2 Subtypes Differentially Control GABAergic Input to CA1 Neurons in Rat Hippocampus

Alkondon, M., & Albuquerque, E. X. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.6.3043 · Cited by 240 · see citing works

Exercise and Hippocampal Memory Systems

Voss, M. W., Soto, C., Yoo, S., Sodoma, M., Vivar, C., & van Praag, H. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.01.006 · Cited by 235 · see citing works

Inhibition and Disinhibition of Pyramidal Neurons by Activation of Nicotinic Receptors on Hippocampal Interneurons

Ji, D., & Dani, J. A. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.5.2682 · Cited by 231 · see citing works

Nicotine Improves Sustained Attention in Mice: Evidence for Involvement of the α7 Nicotinic Acetylcholine Receptor

Young, J. W., Finlayson, K., Spratt, C., Marston, H. M., Crawford, N., Kelly, J. S., & Sharkey, J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300393 · Cited by 219 · see citing works

Aging Decreases Oxidative Metabolism and the Release and Synthesis of Acetylcholine

Gibson, G. E., & Peterson, C. M. (1981) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1981.tb04484.x · Cited by 219 · see citing works

Nicotinic Modulation of Glutamate and GABA Synaptic Transmission in Hippocampal Neurons

RADCLIFFE, K. A., FISHER, J. L., GRAY, R., & DANI, J. A. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11332.x · Cited by 205 · see citing works

Genetic Correlation of Inhibitory Gating of Hippocampal Auditory Evoked Response and α-Bungarotoxin-Binding Nicotinic Cholinergic Receptors in Inbred Mouse Strains

Stevens, K. E. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00178-g · Cited by 203 · see citing works

Functional and molecular characterization of neuronal nicotinic ACh receptors in rat CA1 hippocampal neurons

Sudweeks, S. N., & Yakel, J. L. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00515.x · Cited by 197 · see citing works

Activation of the Macrophage α7 Nicotinic Acetylcholine Receptor and Control of Inflammation

Báez-Pagán, C. A., Delgado‐Vélez, M., & Lasalde‐Dominicci, J. A. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9601-5 · Cited by 193 · see citing works

The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function

Sinkus, M. L., Graw, S. L., Freedman, R., Ross, R. G., Lester, H. A., & Leonard, S. S. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.02.006 · Cited by 186 · see citing works

Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity

Halder, N., & Lal, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.660342 · Cited by 186 · see citing works

Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days

Derbyshire, E. J., & Obeid, R. (2020) · Nutrients · doi:10.3390/nu12061731 · Cited by 185 · see citing works

Beyond the Channel: Metabotropic Signaling by Nicotinic Receptors

Kabbani, N., & Nichols, R. A. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.01.002 · Cited by 169 · see citing works

Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO

Gu, S., Matta, J. A., Lord, B., Harrington, A., Sutton, S. W., Davini, W. B., & Bredt, D. S. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.018 · Cited by 156 · see citing works

The genetics of sensory gating deficits in schizophrenia

Freedman, R., Olincy, A., Ross, R. G., Waldo, M. C., Stevens, K. E., Adler, L. E., & Leonard, S. (2003) · Current Psychiatry Reports · doi:10.1007/s11920-003-0032-2 · Cited by 153 · see citing works

The fate of the brain cholinergic neurons in neurodegenerative diseases

Pepeu, G., & Giovannini, M. G. (2017) · Brain Research · doi:10.1016/j.brainres.2017.06.023 · Cited by 144 · see citing works

Relationship of Cigarette Smoking and Time of Quitting with Incident Dementia and Cognitive Decline

Deal, J. A., Power, M. C., Palta, P., Alonso, A., Schneider, A. L. C., Perryman, K., Bandeen‐Roche, K., & Sharrett, A. R. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16228 · Cited by 134 · see citing works

Assessment of Total Choline Intakes in the United States

Wallace, T. C., & Fulgoni, V. L. I. (2016) · Journal of the American College of Nutrition · doi:10.1080/07315724.2015.1080127 · Cited by 130 · see citing works

Nicotinic Acetylcholine Receptors at Glutamate Synapses Facilitate Long-Term Depression or Potentiation

Ge, S., & Dani, J. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0542-05.2005 · Cited by 125 · see citing works

Nicotine and vascular dysfunction

Whitehead, A., Erwin, A. P., & Yue, X. (2021) · Acta Physiologica · doi:10.1111/apha.13631 · Cited by 125 · see citing works

Functional Mapping and Ca2+Regulation of Nicotinic Acetylcholine Receptor Channels in Rat Hippocampal CA1 Neurons

Khiroug, L. S., Giniatullin, R. A., Klein, R. C., Fayuk, D. A., & Yakel, J. L. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-27-09024.2003 · Cited by 124 · see citing works

Astrocyte Intermediaries of Septal Cholinergic Modulation in the Hippocampus

Pabst, M., Braganza, O., Dannenberg, H., Hu, W., Pothmann, L., Rosen, J., Mody, I., van Loo, K., Deisseroth, K., Becker, A. J., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.003 · Cited by 123 · see citing works

Nicotinic acetylcholine receptors: Conventional and unconventional ligands and signaling

Papke, R. L., & Lindstrom, J. M. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108021 · Cited by 123 · see citing works

The human clinical phenotypes of altered CHRNA7 copy number

Gillentine, M. A., & Schaaf, C. P. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.06.012 · Cited by 122 · see citing works

Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease.

Counts, S., He, B., Che, S.-L., Ikonomovic, M., DeKosky, S., Ginsberg, S. D., & Mufson, E. (2007) · Archives of Neurology · doi:10.1001/archneur.64.12.1771 · Cited by 115 · see citing works

Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor

Mikulovic, S., Restrepo, C. E., Siwani, S., Bauer, P., Pupe, S., Tort, A. B. L., Kullander, K., & Leão, R. N. (2018) · Nature Communications · doi:10.1038/s41467-018-05907-w · Cited by 114 · see citing works

Immunologic Role of the Cholinergic Anti‐Inflammatory Pathway and the Nicotinic Acetylcholine α7 Receptor

Gallowitsch‐Puerta, M., & Tracey, K. J. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1358.024 · Cited by 111 · see citing works

Basal forebrain cholinergic system in the dementias: Vulnerability, resilience, and resistance

Geula, C., Dunlop, S. R., Ayala, I., Kawles, A. S., Flanagan, M. E., Gefen, T., & Mesulam, M. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15471 · Cited by 102 · see citing works

Neuromodulatory Action of Picomolar Extracellular Aβ42 Oligomers on Presynaptic and Postsynaptic Mechanisms Underlying Synaptic Function and Memory

Gulisano, W., Melone, M., Ripoli, C., Tropea, M. R., Li Puma, D. D., Giunta, S., Cocco, S., Marcotulli, D., Origlia, N., Palmeri, A., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0163-19.2019 · Cited by 100 · see citing works

Heteromeric α7β2 Nicotinic Acetylcholine Receptors in the Brain

Wu, J., Liu, Q., Tang, P. S., Mikkelsen, J. D., Shen, J., Whiteaker, P., & Yakel, J. L. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.03.005 · Cited by 98 · see citing works

Physiological Concentrations of Amyloid Beta Regulate Recycling of Synaptic Vesicles via Alpha7 Acetylcholine Receptor and CDK5/Calcineurin Signaling

Lazarevic, V., Fieńko, S., Andres‐Alonso, M., Anni, D., Ivanova, D., Montenegro‐Venegas, C., Gundelfinger, E. D., Cousin, M. A., & Fejtová, A. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00221 · Cited by 97 · see citing works

Progress in nicotinic receptor structural biology

Gharpure, A., Noviello, C., & Hibbs, R. E. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108086 · Cited by 97 · see citing works

Nicotinic acetylcholine receptors in human genetic disease

Schaaf, C. P. (2014) · Genetics in Medicine · doi:10.1038/gim.2014.9 · Cited by 96 · see citing works

Therapeutic Targeting of α7 Nicotinic Acetylcholine Receptors

Papke, R. L., & Horenstein, N. A. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000097 · Cited by 90 · see citing works

Alcohol and Dementia – What is the Link? A Systematic Review

Wiegmann, C., Mick, I., Brandl, E. J., Heinz, A., & Gutwinski, S. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s198772 · Cited by 86 · see citing works

α7 nicotinic acetylcholine receptors as therapeutic targets in schizophrenia: Update on animal and clinical studies and strategies for the future

Terry, A. V., & Callahan, P. M. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108053 · Cited by 86 · see citing works

The effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus

Cheng, Q., & Yakel, J. L. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.015 · Cited by 85 · see citing works

Contribution of cholinergic interneurons to striatal pathophysiology in Parkinson's disease

Ztaou, S., & Amalric, M. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.02.019 · Cited by 85 · see citing works

The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery

Papke, R. L., Dwoskin, L. P., & Crooks, P. A. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04355.x · Cited by 83 · see citing works

Cholinergic Coordination of Presynaptic and Postsynaptic Activity Induces Timing-Dependent Hippocampal Synaptic Plasticity

Gu, Z., Lamb, P. W., & Yakel, J. L. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2129-12.2012 · Cited by 80 · see citing works

Nicotinic Receptors on Local Circuit Neurons in Dentate Gyrus: A Potential Role in Regulation of Granule Cell Excitability

Frazier, C. J., Strowbridge, B. W., & Papke, R. L. (2003) · Journal of Neurophysiology · doi:10.1152/jn.01036.2002 · Cited by 80 · see citing works

Sleep loss drives acetylcholine- and somatostatin interneuron–mediated gating of hippocampal activity to inhibit memory consolidation

Delorme, J. E., Wang, L., Kuhn, F. R., Kodoth, V., Ma, J., Martinez, J. D., Raven, F., Toth, B. A., Balendran, V., Vega-Medina, A., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2019318118 · Cited by 77 · see citing works

Nicotinic acetylcholine receptor redux: Discovery of accessories opens therapeutic vistas

Matta, J. A., Gu, S., Davini, W. B., & Bredt, D. S. (2021) · Science · doi:10.1126/science.abg6539 · Cited by 75 · see citing works

Diverse Spatiotemporal Scales of Cholinergic Signaling in the Neocortex

Disney, A. A., & Higley, M. J. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1306-19.2019 · Cited by 71 · see citing works

A G protein‐coupled α7 nicotinic receptor regulates signaling and TNF‐α release in microglia

King, J. R., Gillevet, T., & Kabbani, N. (2017) · FEBS Open Bio · doi:10.1002/2211-5463.12270 · Cited by 68 · see citing works

The Firing of Theta State-Related Septal Cholinergic Neurons Disrupt Hippocampal Ripple Oscillations via Muscarinic Receptors

Ma, X., Zhang, Y., Wang, L., Li, N., Barkai, E., Zhang, X., Lin, L., & Xu, J. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1568-19.2020 · Cited by 68 · see citing works

Presynaptic α7 Nicotinic Acetylcholine Receptors Enhance Hippocampal Mossy Fiber Glutamatergic Transmission via PKA Activation

Cheng, Q., & Yakel, J. L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2973-13.2014 · Cited by 66 · see citing works

Anxiolytic profile of pregabalin on elicited hippocampal theta oscillation

Siok, C. J., Taylor, C. P., & Hajós, M. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.09.013 · Cited by 62 · see citing works

Septal cholinergic neurons gate hippocampal output to entorhinal cortex via oriens lacunosum moleculare interneurons

Haam, J., Zhou, J., Cui, G., & Yakel, J. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1712538115 · Cited by 62 · see citing works

Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors

Shivange, A. V., Borden, P. M., Muthusamy, A. K., Nichols, A. L., Bera, K., Bao, H., Bishara, I., Jeon, J., Mulcahy, M. J., Cohen, B. N., et al. (2019) · The Journal of General Physiology · doi:10.1085/jgp.201812201 · Cited by 62 · see citing works

Cholinergic Signaling, Neural Excitability, and Epilepsy

Wang, Y., Tan, B., Wang, Y., & Chen, Z. (2021) · Molecules · doi:10.3390/molecules26082258 · Cited by 60 · see citing works

Molecular Modulation of Human α7 Nicotinic Receptor by Amyloid-β Peptides

Lasala, M., Fabiani, C., Corradi, J., Antollini, S. S., & Bouzat, C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00037 · Cited by 58 · see citing works

Chrna7 deficient mice manifest no consistent neuropsychiatric and behavioral phenotypes

Yin, J., Chen, W., Yang, H., Xue, M., & Schaaf, C. P. (2017) · Scientific Reports · doi:10.1038/srep39941 · Cited by 57 · see citing works

Hippocampus and Entorhinal Cortex Recruit Cholinergic and NMDA Receptors Separately to Generate Hippocampal Theta Oscillations

Gu, Z., Alexander, G. M., Dudek, S. M., & Yakel, J. L. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.080 · Cited by 57 · see citing works

OLMα2 Cells Bidirectionally Modulate Learning

Siwani, S., França, A. S. C., Mikulovic, S., Reis, A., Hilscher, M. M., Edwards, S. J., Leão, R. N., Tort, A. B. L., & Kullander, K. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.022 · Cited by 57 · see citing works

Regulation of the activity of hippocampal stratum oriens interneurons by α7 nicotinic acetylcholine receptors

Buhler, A. V., & Dunwiddie, T. V. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00257-3 · Cited by 54 · see citing works

Neurobiological Determinants of Tobacco Smoking in Schizophrenia

Lucatch, A. M., Lowe, D. J. E., Clark, R. C., Kozak, K., & George, T. P. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00672 · Cited by 53 · see citing works

Cardiorespiratory fitness is associated with enhanced hippocampal functional connectivity in healthy young adults

Stillman, C. M., Uyar, F., Huang, H., Grove, G., Watt, J. C., Wollam, M. E., & Erickson, K. I. (2018) · Hippocampus · doi:10.1002/hipo.22827 · Cited by 52 · see citing works

Nanosensors for the Chemical Imaging of Acetylcholine Using Magnetic Resonance Imaging

Luo, Y., Kim, E. H., Flask, C. A., & Clark, H. A. (2018) · ACS Nano · doi:10.1021/acsnano.8b01640 · Cited by 51 · see citing works

DENDRITIC SPINE ALTERATIONS IN THE HIPPOCAMPUS AND PARIETAL CORTEX OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR KNOCKOUT MICE

Morley, B., & Mervis, R. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.025 · Cited by 50 · see citing works

Distribution of α7 Nicotinic Acetylcholine Receptor Subunit mRNA in the Developing Mouse

Broide, R. S., Winzer‐Serhan, U. H., Chen, Y., & Leslie, F. M. (2019) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2019.00076 · Cited by 50 · see citing works

A silent agonist of α7 nicotinic acetylcholine receptors modulates inflammation ex vivo and attenuates EAE

Godin, J., Roy, P., Quadri, M., Bağdaş, D., Toma, W. B., Narendrula-Kotha, R., Kishta, O. A., Damaj, M. I., Horenstein, N. A., Papke, R. L., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.12.014 · Cited by 49 · see citing works

Changes in cholinergic activity in human hippocampus following chronic alcohol abuse

Nordberg, A. K., Larsson, C. U., Perdahl, E., & Winblad, B. G. (1983) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(83)90206-x · Cited by 48 · see citing works

Synaptic muscarinic response types in hippocampal CA1 interneurons depend on different levels of presynaptic activity and different muscarinic receptor subtypes

Bell, L. A., Bell, K. A., & McQuiston, A. R. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.026 · Cited by 48 · see citing works

Tropisetron sensitizes &agr;7 containing nicotinic receptors to low levels of acetylcholine in vitro and improves memory‐related task performance in young and aged animals

Callahan, P., Bertrand, D., Bertrand, S., Plagenhoef, M. R., & Terry, A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.02.025 · Cited by 48 · see citing works

Implications of Oligomeric Amyloid-Beta (oAβ 42 ) Signaling through α7β2-Nicotinic Acetylcholine Receptors (nAChRs) on Basal Forebrain Cholinergic Neuronal Intrinsic Excitability and Cognitive Decline

George, A. A., Vieira, J. M., Xavier-Jackson, C., Gee, M. T., Cirrito, J. R., Bimonte‐Nelson, H. A., Picciotto, M. R., Lukas, R. J., & Whiteaker, P. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0876-20.2020 · Cited by 46 · see citing works

Biomolecular archaeology reveals ancient origins of indigenous tobacco smoking in North American Plateau

Tushingham, S., Snyder, C. M., Brownstein, K. J., Damitio, W. J., & Gang, D. R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1813796115 · Cited by 45 · see citing works

Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model

Newcombe, J., Chatzidaki, A., Sheppard, T. D., Topf, M., & Millar, N. S. (2017) · Molecular Pharmacology · doi:10.1124/mol.117.110551 · Cited by 43 · see citing works

Hippocampal Interneuronal α7 nAChRs Modulate Theta Oscillations in Freely Moving Mice

Gu, Z., Smith, K. G., Alexander, G. M., Guerreiro, I. C., Dudek, S. M., Gutkin, B. S., Jensen, P., & Yakel, J. L. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107740 · Cited by 42 · see citing works

High Availability of the α7-Nicotinic Acetylcholine Receptor in Brains of Individuals with Mild Cognitive Impairment: A Pilot Study Using 18F-ASEM PET

Coughlin, J. M., Rubin, L. H., Du, Y., Rowe, S. P., Crawford, J. L., Rosenthal, H. B., Frey, S. M., Marshall, E. S., Shinehouse, L. K., Chen, A. R., et al. (2019) · Journal of Nuclear Medicine · doi:10.2967/jnumed.119.230979 · Cited by 39 · see citing works

Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer’s disease-like pathology

Tropea, M. R., Puma, D. D. L., Melone, M., Gulisano, W., Arancio, O., Grassi, C., Conti, F., & Puzzo, D. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102154 · Cited by 39 · see citing works

Quantitative assessment of oligomeric amyloid β peptide binding to α7 nicotinic receptor

Cecon, E., Dam, J., Luka, M., Gautier, C., Chollet, A., Delagrange, P., Danober, L., & Jockers, R. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14688 · Cited by 38 · see citing works

New frontiers in translational research: Touchscreens, open science, and the mouse translational research accelerator platform

Sullivan, J. A., Dumont, J. R., Memar, S., Skirzewski, M., Wan, J., Mofrad, M. H., Ansari, H. Z., Li, Y., Muller, L., Prado, V. F., et al. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12705 · Cited by 38 · see citing works

The distribution of the alpha7 nicotinic acetylcholine receptor in healthy aging: An in vivo positron emission tomography study with [18F]ASEM

Coughlin, J. M., Du, Y., Rosenthal, H. B., Slania, S., Koo, S. M., Park, A., Solomon, G., Vranešić, M., Antonsdottir, I. M., Speck, C. L., et al. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.10.009 · Cited by 37 · see citing works

Sensory perception drives food avoidance through excitatory basal forebrain circuits

Patel, J. M., Swanson, J., Ung, K., Herman, A. M., Hanson, E., Ortiz‐Guzman, J., Selever, J., Tong, Q., & Arenkiel, B. R. (2019) · eLife · doi:10.7554/elife.44548 · Cited by 34 · see citing works

Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors

Lewis, A. S., Pittenger, S. T., Mineur, Y. S., Stout, D., Smith, P. H., & Picciotto, M. R. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.276 · Cited by 32 · see citing works

Antagonizing α7 nicotinic receptors with methyllycaconitine (MLA) potentiates receptor activity and memory acquisition

van Goethem, N. P., Paes, D., Puzzo, D., Fedele, E., Rebosio, C., Gulisano, W., Palmeri, A., Wennogle, L. P., Peng, Y., Bertrand, D., et al. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.06.003 · Cited by 30 · see citing works

Cholinergic Receptors and Addiction

Papke, R. L., Brunzell, D. H., & Biasi, M. D. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_139 · Cited by 30 · see citing works

α7-nAChR agonist enhances neural plasticity in the hippocampus via a GABAergic circuit

Townsend, M., Whyment, A. D., Walczak, J., Jeggo, R., van den Top, M., Flood, D. G., Leventhal, L., Patzke, H., & Koenig, G. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00243.2016 · Cited by 29 · see citing works

Unbalanced Regulation of α7 nAChRs by Ly6h and NACHO Contributes to Neurotoxicity in Alzheimer's Disease

Wu, M., Liu, C. Z., Barrall, E. A., Rissman, R. A., & Joiner, W. J. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0494-21.2021 · Cited by 28 · see citing works

Hippocampal network dynamics in response to α7 nACh receptors activation in amyloid-β overproducing transgenic mice

Stoiljković, M., Kelley, C., Hajos, G. P., Nagy, D., Koenig, G., Leventhal, L., & Hajós, M. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.05.021 · Cited by 27 · see citing works

Selective activation of α7 nicotinic acetylcholine receptors augments hippocampal oscillations

Stoiljković, M., Kelley, C., Nagy, D., Leventhal, L., & Hajós, M. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.010 · Cited by 27 · see citing works

A watershed moment for protein structure prediction

AlQuraishi, M. (2020) · Nature · doi:10.1038/d41586-019-03951-0 · Cited by 27 · see citing works

An Evolving Therapeutic Rationale for Targeting the α7 Nicotinic Acetylcholine Receptor in Autism Spectrum Disorder

Deutsch, S. I., & Burket, J. A. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_136 · Cited by 27 · see citing works

The mechanisms shaping CA2 pyramidal neuron action potential bursting induced by muscarinic acetylcholine receptor activation

Robert, V., Therreau, L., Davatolhagh, M. F., Bernardo-Garcia, F. J., Clements, K. N., Chevaleyre, V., & Piskorowski, R. A. (2020) · The Journal of General Physiology · doi:10.1085/jgp.201912462 · Cited by 25 · see citing works

Facilitation of spatial working memory performance following intra-prefrontal cortical administration of the adrenergic alpha1 agonist phenylephrine

Hvoslef‐Eide, M., Oomen, C. A., Fisher, B. M., Heath, C. J., Robbins, T. W., Saksida, L. M., & Bussey, T. J. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4038-3 · Cited by 24 · see citing works

Stress Regulation of Sustained Attention and the Cholinergic Attention System

Eck, S. R., Xu, S., Telenson, A. M., Duggan, M. R., Cole, R. D., Wicks, B., Bergmann, J., Lefebo, H., Shore, M. E., Shepard, K. A., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.04.013 · Cited by 24 · see citing works

Lateral Mobility of Presynaptic α7-Containing Nicotinic Receptors and Its Relevance for Glutamate Release

Gómez‐Varela, D., & Berg, D. K. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1482-13.2013 · Cited by 23 · see citing works

Prenatal Nicotine Exposure in Rodents: Why Are There So Many Variations in Behavioral Outcomes?

Polli, F. S., & Kohlmeier, K. A. (2019) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntz196 · Cited by 23 · see citing works

JAK2/STAT3 Pathway is Required for α7nAChR-Dependent Expression of POMC and AGRP Neuropeptides in Male Mice

de Souza, C. M., do Amaral, C. L., Souza, S. C., de Souza, A. C. P., Martins, Í. D. C. A., Contieri, L. S., Milanski, M., Torsoni, A. S., Ignácio-Souza, L. M., & Torsoni, M. A. (2019) · Cellular Physiology and Biochemistry · doi:10.33594/000000166 · Cited by 23 · see citing works

Mecp2Deletion from Cholinergic Neurons Selectively Impairs Recognition Memory and Disrupts Cholinergic Modulation of the Perirhinal Cortex

Ballinger, E. C., Schaaf, C. P., Patel, A. J., Maio, A. D., Tao, H., Talmage, D. A., Zoghbi, H. Y., & Role, L. W. (2019) · eNeuro · doi:10.1523/eneuro.0134-19.2019 · Cited by 22 · see citing works

Independent and Combined Effects of Nicotine or Chronic Tobacco Smoking and HIV on the Brain: A Review of Preclinical and Clinical Studies

Chang, L., Liang, H., Kandel, S. R., & He, J. J. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-020-09963-2 · Cited by 22 · see citing works

Genetic knockout of the α7 nicotinic acetylcholine receptor gene alters hippocampal long-term potentiation in a background strain-dependent manner

Freund, R. K., Graw, S. L., Choo, K. S., Stevens, K. E., Leonard, S. S., & Dell’Acqua, M. L. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.05.043 · Cited by 21 · see citing works

One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia

Xia, L., Liu, L., Hong, X., Wang, D., Wei, G., Wang, J., Zhou, H., Xu, H., Tian, Y., Dai, Q., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0685-0 · Cited by 21 · see citing works

Effects of transdermal nicotine delivery on cognitive outcomes: A meta‐analysis

Majdi, A., Sadigh‐Eteghad, S., & GJEDDE, A. H. (2021) · Acta Neurologica Scandinavica · doi:10.1111/ane.13436 · Cited by 19 · see citing works

Loss of α7 nicotinic acetylcholine receptors in GABAergic neurons causes sex-dependent decreases in radial glia-like cell quantity and impairments in cognitive and social behavior

Nacer, S. A., Letsinger, A. C., Otto, S., DeFilipp, J. S., Nikolova, V. D., Riddick, N. V., Stevanovic, K. D., Cushman, J. D., & Yakel, J. L. (2021) · Brain Structure and Function · doi:10.1007/s00429-020-02179-3 · Cited by 17 · see citing works

Ethanol-Induced Motor Impairment Mediated by Inhibition of 7 Nicotinic Receptors

McDaid, J., Abburi, C., Wolfman, S. L., Gallagher, K. R., & McGehee, D. S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0154-16.2016 · Cited by 16 · see citing works

Peri-adolescent alcohol consumption increases sensitivity and dopaminergic response to nicotine during adulthood in female alcohol-preferring (P) rats: Alterations to α7 nicotinic acetylcholine receptor expression

Waeiss, R. A., Knight, C. P., Carvajal, G. B., Bell, R. L., Engleman, E. A., McBride, W. J., Hauser, S. R., & Rodd, Z. A. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112190 · Cited by 16 · see citing works

Postsynaptic nicotinic acetylcholine receptors facilitate excitation of developing CA1 pyramidal neurons

Chung, B. Y. T., Bignell, W., Jacklin, D. L., Winters, B. D., & Bailey, C. D. C. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00370.2016 · Cited by 15 · see citing works

NS6740, an α7 nicotinic acetylcholine receptor silent agonist, disrupts hippocampal synaptic plasticity

Papke, R. L., Peng, C., Kumar, A., & Stokes, C. A. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.04.025 · Cited by 14 · see citing works

Synergy of Glutamatergic and Cholinergic Modulation Induces Plateau Potentials in Hippocampal OLM Interneurons

Hagger‐Vaughan, N., & Storm, J. F. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00508 · Cited by 14 · see citing works

<i>CHRNA7</i> Deletions are Enriched in Risperidone-Treated Children and Adolescents

Gillentine, M. A., White, J. J., Grochowski, C. M., Lupski, J. R., Schaaf, C. P., & Calarge, C. A. (2017) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2017.0068 · Cited by 11 · see citing works

Wheel running during chronic nicotine exposure is protective against mecamylamine‐precipitated withdrawal and up‐regulates hippocampal α7 nACh receptors in mice

Keyworth, H. L., Georgiou, P., Zanos, P., Rueda, A. V. L., Chen, Y., Kitchen, I., Camarini, R., Cropley, M., & Bailey, A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14068 · Cited by 11 · see citing works

Activation of nicotinic acetylcholine receptors induces potentiation and synchronization within in vitro hippocampal networks

Djemil, S., Chen, X., Zhang, Z., Lee, J., Rauf, M., Pak, D. T. S., & Dzakpasu, R. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14938 · Cited by 11 · see citing works

Differential signalling induced by α7 nicotinic acetylcholine receptors in hippocampal dentate gyrus in vitro and in vivo

Cheng, Q., Lamb, P. W., Stevanovic, K. D., Bernstein, B. J., Fry, S. A., Cushman, J. D., & Yakel, J. L. (2021) · The Journal of Physiology · doi:10.1113/jp280505 · Cited by 11 · see citing works

Development of hippocampal α7 nicotinic receptors in C3H and DBA/2 congenic mice

Adams, C. E., Yonchek, J. C., & Stitzel, J. A. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.113 · Cited by 8 · see citing works

3D-Printed Capacitive Sensor Objects for Object Recognition Assays

Spry, K. P., Fry, S. A., DeFilipp, J. S., Drye, S. G., Stevanovic, K. D., Hunnicutt, J., Bernstein, B. J., Thompson, E. E., & Cushman, J. D. (2021) · eNeuro · doi:10.1523/eneuro.0310-20.2020 · Cited by 4 · see citing works

Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies.

Zhang, J., Zhang, Y., Wang, J., Xia, Y., Zhang, J., & Chen, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01911-3 · Cited by 1,138 · see citing works

Amyloid β-based therapy for Alzheimer’s disease: Challenges, successes and future

Zhang, Y., Chen, H., Li, R., Sterling, K., & Song, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01484-7 · Cited by 988 · see citing works

The role of astrocytic α7 nicotinic acetylcholine receptors in Alzheimer disease

Fontana, I. C., Kumar, A., & Nordberg, A. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00792-4 · Cited by 86 · see citing works

Physiological Roles of β-amyloid in Regulating Synaptic Function: Implications for AD Pathophysiology

Cai, W., Li, L., Sang, S., Pan, X., & Zhong, C. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-022-00985-9 · Cited by 83 · see citing works

Noradrenergic and cholinergic systems take centre stage in neuropsychiatric diseases of ageing

Orlando, I. F., Shine, J. M., Robbins, T. W., Rowe, J. B., & O’Callaghan, C. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105167 · Cited by 77 · see citing works

Nicotinic acetylcholine receptors and epilepsy

Becchetti, A., Grandi, L. C., Cerina, M., & Amadeo, A. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106698 · Cited by 53 · see citing works

Effect and mechanism of acupuncture on Alzheimer’s disease: A review

Wu, L., Dong, Y., Zhu, C., & Chen, Y. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1035376 · Cited by 33 · see citing works

Cholinergic Regulation of Hippocampal Theta Rhythm

Gu, Z., & Yakel, J. L. (2022) · Biomedicines · doi:10.3390/biomedicines10040745 · Cited by 31 · see citing works

Navigating the dementia landscape: Biomarkers and emerging therapies

Maheshwari, S., Singh, A., Ansari, V. A., Mahmood, T., Wasim, R., Akhtar, J., & Verma, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102193 · Cited by 30 · see citing works

Neuroimmune Regulation in Sepsis-Associated Encephalopathy: The Interaction Between the Brain and Peripheral Immunity

Liu, Y., Yu, Y., Liu, J., Liu, W., Cao, Y., Yan, R., & Yao, Y. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.892480 · Cited by 30 · see citing works

Calcium signaling hypothesis: A non-negligible pathogenesis in Alzheimer’s disease

Wang, M., Zhang, H., Liang, J., Huang, J., Wu, T., & Chen, N. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.01.007 · Cited by 25 · see citing works

α7 nicotinic acetylcholine receptor in memory processing

Pastor, V. E., & Medina, J. H. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15913 · Cited by 21 · see citing works

The Role of α7-Nicotinic Acetylcholine Receptors in the Pathophysiology and Treatment of Parkinson’s Disease

Nebrisi, E. E., Lozon, Y., & Öz, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073210 · Cited by 20 · see citing works

Therapeutic Targeting of the α7 Nicotinic Receptor: Challenges and Prospects for Cognitive Improvement in Alzheimer's and Schizophrenia

Magnussen, J. H. (2025) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.70061 · Cited by 21 · see citing works

Activation of nicotinic acetylcholine receptor α7 subunit limits Zika viral infection via promoting autophagy and ferroptosis

Zhao, C., Chen, J., Liu, Z., Liang, H., Chen, X., Cheng, L., Xie, S., Lin, Z., Wu, R., Zhao, Q., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.05.037 · Cited by 19 · see citing works

Alterations in Neuronal Nicotinic Acetylcholine Receptors in the Pathogenesis of Various Cognitive Impairments

Guan, Z. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70069 · Cited by 14 · see citing works

Structural Elucidation of Ivermectin Binding to α7nAChR and the Induced Channel Desensitization

Bondarenko, V., Chen, Q., Singewald, K., Haloi, N., Tillman, T. S., Howard, R. J., Lindahl, E. R., Xu, Y., & Tang, P. S. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00783 · Cited by 14 · see citing works

α7 nicotinic acetylcholine receptors induce long‐term synaptic enhancement in the dorsal but not ventral hippocampus

Tsotsokou, G., Kouri, V., & Papatheodoropoulos, C. (2024) · Synapse · doi:10.1002/syn.22285 · Cited by 12 · see citing works

Neuronal and Glial α7 Nicotinic Acetylcholine Receptors: Role in Alzheimer’s Disease Pathophysiology

Rennie, K. (2025) · Life · doi:10.3390/life15071032 · Cited by 11 · see citing works

Subcortical glutamatergic inputs exhibit a Hebbian form of long-term potentiation in the dentate gyrus

Hirai, H., Sakaba, T., & Hashimotodani, Y. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111871 · Cited by 11 · see citing works

SARS-CoV-2 Spike Protein Downregulates Cell Surface α7nAChR through a Helical Motif in the Spike Neck

Tillman, T. S., Chen, Q., Bondarenko, V., Coleman, J. A., Xu, Y., & Tang, P. S. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00610 · Cited by 12 · see citing works

The Role of Alpha-7 Nicotinic Acetylcholine Receptors in Pain: Potential Therapeutic Implications

Yu, T., Sun, Y., Jiang, X., Tao, J., & Zhang, Y. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22666240528161117 · Cited by 8 · see citing works

Delayed Magnetic Resonance Imaging of Alzheimer’s Disease by Using Poly(2-(methacryloyloxy)ethyl phosphorylcholine)-Functionalized Nanoprobes

Li, W., Zhang, X., Liu, C., Ma, Y., Jiang, Y., Zhang, N., & Hou, Y. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c17432 · Cited by 8 · see citing works

Targeting Neuronal Alpha7 Nicotinic Acetylcholine Receptor Upregulation in Age-Related Neurological Disorders

Abraham, S. M., Suresh, S., & Komal, P. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01586-6 · Cited by 7 · see citing works

Selective α3β4 Nicotinic Acetylcholine Receptor Ligand as a Potential Tracer for Drug Addiction

Kanasuwan, A., Deuther‐Conrad, W., Chongruchiroj, S., Sarasamkan, J., Chotipanich, C., Vajragupta, O., & Arunrungvichian, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043614 · Cited by 6 · see citing works

Competitive Antagonism of Xylazine on α7 Nicotinic Acetylcholine Receptors and Reversal by Curcuminoids

Chen, Q., Xu, Y., & Tang, P. S. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00784 · Cited by 6 · see citing works

Ameliorative Processes of Beta-Carotene in Streptozotocin-Induced Diabetic Vascular Dementia in Rats

Lim, K. G., & Muthuraman, A. (2022) · Processes · doi:10.3390/pr10071324 · Cited by 6 · see citing works

Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity

Letsinger, A. C., Ward, J. M., Fannin, R. D., Mahapatra, D., Bridge, M. F., Sills, R. C., Gerrish, K., & Yakel, J. L. (2023) · Scientific Reports · doi:10.1038/s41598-023-29118-6 · Cited by 6 · see citing works

An Acetylcholine Electrochemical Biosensor Based on Bi-Enzyme Functionalized Nanofiber Composites

Jing, C., Kuang, Y., Gu, X., Xu, M., Wu, Y.-K., & Wang, X. (2023) · Journal of The Electrochemical Society · doi:10.1149/1945-7111/ace8bf · Cited by 6 · see citing works

Structure and function of the blood–brain barrier in perioperative neurocognitive disorders

Su, Y., Chen, Y., Zheng, B., Huang, Y., Liao, Z., Zheng, X., & Gao, F. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1690354 · Cited by 5 · see citing works

Nicotinic acetylcholine receptors-targeting drug discovery

Zhang, D., Zheng, H., Cui, K., Li, Y., Liu, C., Mao, J., Zheng, J., & Wan, Y. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118679 · Cited by 5 · see citing works

Huperzine A attenuates epileptic seizures via enhancing dCA1-projecting septal cholinergic transmission

Wang, Y., Hu, K.-Y., Zhang, Q., Song, Y., Li, L.-J., Wang, F., Tian, G., Fei, F., Xu, C., Fang, J.-J., et al. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01522-w · Cited by 5 · see citing works

A trans-synaptic IgLON adhesion molecular complex directly contacts and clusters a nicotinic receptor

Mialon, M., Patrash, L., Granger, L., Weinreb, A., Özkan, E., Bessereau, J., & Pinan‐Lucarré, B. (2026) · Nature Communications · doi:10.1038/s41467-025-68141-1 · Cited by 5 · see citing works

Single-cell quantitative expression of nicotinic acetylcholine receptor mRNA in rat hippocampal interneurons

Jackson, D. C., Burgon, R. M., Thompson, S., & Sudweeks, S. N. (2024) · PLoS ONE · doi:10.1371/journal.pone.0301592 · Cited by 5 · see citing works

The efficacy of an allosteric modulator of the alpha 7 nicotinic acetylcholine receptor in a murine model of stroke

Hernandez, K., Jones, N., & Ortega, S. B. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1525975 · Cited by 5 · see citing works

Functional deletion of α7 nicotinic acetylcholine receptor impairs Ca2+-dependent glutamatergic synaptic transmission by affecting both presynaptic and postsynaptic protein expression and function

Cannata, B., Sposito, L., Albini, M., Aceto, G., Puliatti, G., Lazzarino, G., Ripoli, C., Tropea, M. R., Puzzo, D., Piacentini, R., et al. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1662171 · Cited by 4 · see citing works

Unconventional PDZ Recognition Revealed in α7 nAChR-PICK1 Complexes

Bondarenko, V., Chen, Q., Tillman, T. S., Xu, Y., & Tang, P. S. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00138 · Cited by 4 · see citing works

Neuroimmune interactions in inflammatory bowel disease: Role of intestinal macrophages and the cholinergic pathway

Zheng, L., & Duan, S.-L. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i44.109440 · Cited by 4 · see citing works

Re-Addressing Dementia by Network Medicine and Mechanism-Based Molecular Endotypes

Pachado, M. P., Casas, A. I., Elbatreek, M. H., Nogales, C., Güney, E., Espay, A. J., & Schmidt, H. H. H. W. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230694 · Cited by 4 · see citing works

Pharmaceutical-mediated neuroimmune modulation in psychiatric/psychological adverse events

Marques, S. I., Sá, S. I., Carmo, H., Carvalho, F. D., & Silva, J. P. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111114 · Cited by 5 · see citing works

Evaluation of [125I]α-Bungarotoxin Binding to α7 Nicotinic Acetylcholinergic Receptors in Hippocampus–Subiculum of Postmortem Human Alzheimer’s Disease Brain

Ngo, A., Karim, F., Keerthisinghe, O. V., Danh, T. B., Liang, C., & Mukherjee, J. (2025) · Receptors · doi:10.3390/receptors4010007 · Cited by 4 · see citing works

Unraveling the molecular interactions between α7 nicotinic receptor and a RIC3 variant associated with backward speech

Pradhan, A., Mounford, H., Peixinho, J., Rea, E., Epeslidou, E., Scott, J. S., Cull, J., Maxwell, S., Webster, R. G., Beeson, D., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05149-8 · Cited by 4 · see citing works

Efficacy and safety of an alpha 7-nicotinic acetylcholine receptor agonist, VQW-765, in subjects with performance anxiety: randomised, double-blind, placebo-controlled trial

He, Y., Polymeropoulos, C. M., Mohrman, M. A., Truslow, S. O., Xiao, C., Wu, Y., Birznieks, G., & Polymeropoulos, M. H. (2025) · The British Journal of Psychiatry · doi:10.1192/bjp.2025.84 · Cited by 5 · see citing works

Ameliorative effect of palonosetron against binge alcohol-induced neurodamage via targeting miR-155/AKT/mTOR/AMPK-mediated autophagic pathway

Saad, M. A. E., Sayed, R. H., El-Sahar, A. E., Sayed, N. H., Kortam, M. A., & Fathy, N. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110525 · Cited by 3 · see citing works

Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only

Letsinger, A. C., Nacer, S. A., Stevanovic, K. D., Larson, G. J., DeFilipp, J. S., Cushman, J. D., & Yakel, J. L. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1244118 · Cited by 3 · see citing works

GRP94 mediates blood-brain barrier permeation and substantia nigra-specific drug distribution in Parkinson’s disease

Lv, Z., Zeng, Y., Lv, T., Liu, Q., & Han, L. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.114585 · Cited by 3 · see citing works

AAV.PHP.eB-based strategies for precise modulation of α7 nicotinic acetylcholine receptor in neurons and astrocytes in the adult mouse brain

Puliatti, G., Renna, P., Battistoni, M., Piacentini, R., Ripoli, C., & Grassi, C. (2026) · Scientific Reports · doi:10.1038/s41598-026-46279-2 · Cited by 2 · see citing works

Vitamin B12 supplementation improved memory impairment following nicotine withdrawal in adolescent male rats: The role of oxidative stress, inflammatory, BDNF, GFAP, and AChE activity

Rezavanimehr, M. M., Kakhki, S., Pahlavani, H., Khosropour, M., Khatibi, S. R., & Beheshti, F. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115180 · Cited by 2 · see citing works

The relationship between α4β2-nicotinic acetylcholine receptor availability and brain arousal regulation as assessed by 2-[18F]F-A85380 PET and EEG following nicotine cessation in male individuals with nicotine dependence

Huang, J., Meyer, P., Guerrero, I. B., Becker, G., Rullmann, M., Mauche, N., Sattler, B., Hesse, S., Zientek, F., Hegerl, U., et al. (2025) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2025.112035 · Cited by 2 · see citing works

Galantamine as add-on therapy to escitalopram: enhancing antidepressant therapeutic potential via. Targeting α7nAChR/BDNF/KYN signalling

Bajaj, S., & Radhakrishnan, M. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06841-8 · Cited by 1 · see citing works

Assessment of [125I]a-Bungarotoxin Binding to a7 Nicotinic Acetylcholinergic Receptors in Hippocampus-Subiculum of Postmortem Human Parkinson’s Disease Brain

Karim, F., Ngo, A., Tucker, T. E., Coronel, A. D. L., & Mukherjee, J. (2025) · Biomolecules · doi:10.3390/biom15121686 · Cited by 1 · see citing works

LvID-BDP: A Conotoxin-Based Fluorescent Probe for Visualizing α7 nAChR Expression in Intestinal Inflammation

Tan, Y., Ma, T., Li, S., Xu, C., Han, Y., zhangsun, D., Zhu, X., & Luo, S. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03269 · Cited by 1 · see citing works

Dual strategies for neural injury repair: Targeted modulation of reactive astrocytes and functional astrocyte transplantation

Cai, Z., Zhou, X., Teng, T., Li, H., Chen, T., Dai, S., & Zhang, K. (2026) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-01020 · Cited by 1 · see citing works

Microglial Adaptations to Chronic Nicotine in the Cerebellum: Proteomic Evidence for Neuroimmune Vulnerability

Nusir, A., Anthony, S. M., Zhou, W., & Kabbani, N. (2026) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5c01027 · Cited by 1 · see citing works

An Optonanobody for Reversible Photoactivation of Recombinant and Native α7 Nicotinic Receptors

Vangelatou, M., Stenbolt, K., Bay, S., Medjebeur, K., Aymé, G., Lafaye, P. J., Blondel, A., Peverini, L., Mourot, A., & Corringer, P. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6c00285 · Cited by 1 · see citing works

Nicotinic Receptors of the Neuronal and Non-neuronal Cholinergic Systems as Therapeutic Targets: Opportunities and Limitations

Wonnacott, S. (2024) · Springer eBooks · doi:10.1007/978-3-031-52197-3_12

Electroacupuncture Alleviates Neuroinflammation and Memory Dysfunction by Regulating Hippocampal Microglial α7nAChR in LPS-Induced Systemic Inflammation in MicePreprint

Yu, X., Cheng, X., Lan, Y., Huang, Q., Chen, H., Pang, L., Fu, J., Zeng, W., & Wang, Z. (2024) · Research Square · doi:10.21203/rs.3.rs-4480515/v1

Gut Akkermansia muciniphila ameliorates HIV-1 gp120-induced age-dependent neuronal pyroptosis by regulating α7nAChR

Gao, X., Luo, J., Zou, J., Gong, Z., Li, Y., Lun, J., Zhou, B., Chen, J., Wang, Z., & Cao, H. (2025) · Food Science and Human Wellness · doi:10.26599/fshw.2025.9250580

Curcumin Derivatives as Allosteric Modulator of α7-nAChR: Functional and Molecular Docking Insights

Nebrisi, E. E., Ghattas, M. A., Atatreh, N., Hasan, S., & Oz, M. (2025) · Medical Principles and Practice · doi:10.1159/000548995

Physostigmine modulates hippocampal GABAergic neurotransmission via α7 nicotinic acetylcholine receptors

Hernández-Abrego, A., Vázquez-Gómez, E., Mejía-Piedras, J., & García‐Colunga, J. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110736

Alpha-7 nicotinic acetylcholine receptor: targeting the interplay between inflammation, renin-angiotensin aldosterone system, and nervous system for the novel treatment of heart failure

Swiderski, J., Gadanec, L. K., Hearth, S., Rowlands, B. D., Murphy, A. J., Apostolopoulos, V., & Zulli, A. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1756039

Fast analysis and engineering of protein function by microbe-independent deep assembly and screening

Wu, Y., Wang, P., Liu, L. X., Song, D., Qin, Q., Gao, C., Hageman, M., Kirkland, T. A., Su, Y., & Lin, M. Z. (2026) · Molecular Systems Biology · doi:10.1038/s44320-026-00210-z

Prenatal Exposure to Neonicotinoid Insecticides and Neurological and Cognitive Development in Preschool Children: Evidence from a Birth Cohort in Guangxi, China

Liang, Q., Li, H., Zhou, L., Mu, C., Lin, M., Liao, Q., Liu, S., Qiu, X., Huang, D., Pan, D., et al. (2026) · Toxics · doi:10.3390/toxics14050445

Lovastatin Potentiates the Function of α7-Nicotinic Acetylcholine Receptors

Isaev, D. S., Yang, K. S., & Oz, M. (2026) · Pharmaceuticals · doi:10.3390/ph19060849

From Genes to Behavior: Mouse Models of the Cholinergic System

Lamprou, E., Kolydas, N., & Konsolaki, E. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1015550

Treatment Using Anti-Amyloid Antibodies for Alzheimer’s Disease

Chatterjee, S., Gayen, S., & Roy, S. (2026) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9798898815646126010012

Advances in Tricyclic Compounds for the Treatment of Alzheimer's Disease

Shi, Y., 廖心丹, & Yu, G. (2026) · ChemMedChem · doi:10.1002/cmdc.70384 · Cited by 1 · see citing works

Nicotine in Neurodegenerative and Neuropsychiatric Disorders: Mechanisms and Clinical Evidence

Bjørklund, G., Gurgas, L., & Hangan, T. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04845-0

Molecular mechanisms of nicotinic acetylcholine receptors in mood dysregulation

Murthy, M. K., & Samal, D. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111880

Herbal bioactives with neuroactive potential

Youssef, I. M., & El-Hack, M. E. A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45446-2.00009-0

Adult-onset hippocampal α7 nicotinic acetylcholine receptor loss rapidly drives Alzheimer-like neuropathology in mice

Li, J., Liu, G.-L., Wang, X.-T., Song, Z., Chen, H., Hou, H.-W., & Hu, Q.-Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1929468

Advances in Targeting Central Cholinergic Dysfunction for Neurodegenerative Diseases: From Pharmacotherapy to Neuromodulation

Lei, L., Hu, X., Lu, R., Yang, J., & Meng, Q. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.71151

Dynamic contributions of astrocytes in Alzheimer’s disease

Guo, F., Li, T., & He, X. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.116032

Neuroinflammation in Alzheimer’s disease: pathogenic signaling, biomarkers, and emerging therapeutic interventions

Poonam, Rana, R., Thakur, M., Sharma, A., Pannu, S., Sharma, S., Naman, S., Rani, S., Devi, D., Kumar, V., et al. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1908830

The role of alpha3beta4 nicotinic receptors in cocaine-induced reward acquisition and behavioral sensitization

Khroyan, T. V., Toll, L., Polgar, W. E., Yasuda, D. M., & Zaveri, N. T. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.02.298

Impaired Hippocampal Theta Oscillations in the Mice Null Alpha7 Nicotinic Acetylcholine Receptors

Jin, Y., Quan-xi, S., Shen, J., Marks, M. J., & Wu, J. (2013) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12138 · Cited by 4 · see citing works

The α7-nACh nicotinic receptor and its role in memory and selected diseases of the central nervous system

Baranowska, U., & Rj, W. (2017) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.5604/01.3001.0010.3844 · Cited by 19 · see citing works

The effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus

Cheng, Q., & Yakel, J. L. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.015 · Cited by 85 · see citing works

The nicotinic acetylcholine receptor subtypes and their function in the hippocampus and cerebral cortex

Alkondon, M., & Albuquerque, E. X. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)45007-3 · Cited by 197 · see citing works