Cited by 74Gut microbiota and healthBlood Pressure and Hypertension StudiesHeart Rate Variability and Autonomic Control

Gut–Brain Axis in Regulation of Blood Pressure

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Yang, Tao, Zubcevic, Jasenka·2017·Frontiers in Physiology

Abstract

Hypertension (HTN) is an escalating health issue worldwide. It is estimated that 1.56 billion people will suffer from high blood pressure (BP) by 2025. Recent studies reported an association between gut dysbiosis and HTN, thus proposing interesting avenues for novel treatments of this condition. The sympathetic nervous system (SNS) and the immune system (IS) play a recognized role in the onset and progression of HTN, while reciprocal communication between gut microbiota and the brain can regulate BP by modulating the interplay between the IS and SNS. This review presents the current state of the science implicating brain-gut connection in HTN, highlighting potential pathways of their interaction in control of BP.

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Authors
Yang, T., & Zubcevic, J.
Affiliations
University of Florida (US)
Corresponding author
Zubcevic, Jasenka
Venue
Frontiers in Physiology
Published
2017-10-25
Volume
8
Pages
845-845
ISSN
1664-042X (ISSN-L)
OpenAlex
W2767024108
Cited by
74
References
164
Citations by year
2026: 6 · 2025: 11 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 10 · 2020: 10 · 2019: 5 · 2018: 7
FWCI
0.56
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Physiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
American Heart Association (14SDG18300010)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
gut-brain axis, hypertension, blood pressure regulation, gut dysbiosis, gut microbiota, sympathetic nervous system, immune system, neuroimmune interactions

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