Gut–Brain Axis in Regulation of Blood Pressure
Open accessAbstract
Hypertension (HTN) is an escalating health issue worldwide. It is estimated that 1.56 billion people will suffer from high blood pressure (BP) by 2025. Recent studies reported an association between gut dysbiosis and HTN, thus proposing interesting avenues for novel treatments of this condition. The sympathetic nervous system (SNS) and the immune system (IS) play a recognized role in the onset and progression of HTN, while reciprocal communication between gut microbiota and the brain can regulate BP by modulating the interplay between the IS and SNS. This review presents the current state of the science implicating brain-gut connection in HTN, highlighting potential pathways of their interaction in control of BP.
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The sympathetic nervous system directly innervates primary (bone marrow) and secondary (spleen) immune organs.
“The SNS directly innervates both primary (bone marrow) and secondary (spleen) immune organs80.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [80]
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- Authors
- Yang, T., & Zubcevic, J.
- Affiliations
- University of Florida (US)
- Corresponding author
- Zubcevic, Jasenka
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2017-10-25
- Volume
- 8
- Pages
- 845-845
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC5661004
- OpenAlex
- W2767024108
- Cited by
- 74
- References
- 164
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 10 · 2020: 10 · 2019: 5 · 2018: 7
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- American Heart Association (14SDG18300010)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- gut-brain axis, hypertension, blood pressure regulation, gut dysbiosis, gut microbiota, sympathetic nervous system, immune system, neuroimmune interactions
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