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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Open accessAbstract
A central issue in stem cell biology is to understand the mechanisms that regulate the self-renewal of haematopoietic stem cells (HSCs), which are required for haematopoiesis to persist for the lifetime of the animal. We found that adult and fetal mouse and adult human HSCs express the proto-oncogene Bmi-1. The number of HSCs in the fetal liver of Bmi-1-/- mice was normal. In postnatal Bmi-1-/- mice, the number of HSCs was markedly reduced. Transplanted fetal liver and bone marrow cells obtained from Bmi-1-/- mice were able to contribute only transiently to haematopoiesis. There was no detectable self-renewal of adult HSCs, indicating a cell autonomous defect in Bmi-1-/- mice. A gene expression analysis revealed that the expression of stem cell associated genes, cell survival genes, transcription factors, and genes modulating proliferation including p16Ink4a and p19Arf was altered in bone marrow cells of the Bmi-1-/- mice. Expression of p16Ink4a and p19Arf in normal HSCs resulted in proliferative arrest and p53-dependent cell death, respectively. Our results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs.
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“Upregulation of p16 and Arf has been implicated in mediating the induction of cellular senescence in a variety of cells including HSCs.”
From Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner (2014) · cites this paper as [15]
In the citing paper
“However, it appears that p16, but not Arf, plays an important role in mediating induction of Bmi1−/− HSC senescence, whereas Arf mainly promotes HSC apoptosis.15”
From Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner (2014) · cites this paper as [15]
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“For example, increased expression of p16 and Arf was found in HSCs from Bmi1−/− mice.15”
From Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner (2014) · cites this paper as [15]
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“ROS plays an important role in mediating induction of HSC senescence under various pathological conditions, such as mutation of ATM and various Fanconi anemia genes; deletion of Bmi1, FoxOs, Mdm2, and Tsc1; and aging.15,19,20,35-38”
From Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner (2014) · cites this paper as [15]
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Cites
Production of high-titer helper-free retroviruses by transient transfection.
Pear, W. S., Nolan, G. P., Scott, M. L., & Baltimore, D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8392 · Cited by 2,267
"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells
Ramalho‐Santos, M., Yoon, S., Matsuzaki, Y., Mulligan, R. C., & Melton, D. A. (2002) · Science · doi:10.1126/science.1072530 · Cited by 1,711
Zhang, Y., Xiong, Y., & Yarbrough, W. G. (1998) · Cell · doi:10.1016/s0092-8674(00)81401-4 · Cited by 1,626
Jacobs, J. J. L., Kieboom, K., Marino, S., DePinho, R. A., & van Lohuizen, M. (1999) · Nature · doi:10.1038/16476 · Cited by 1,580
Ouelle, D. E., Zindy, F., Ashmun, R. A., & Sherr, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90214-7 · Cited by 1,485
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.
Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452
Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1
Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339
Kiyono, T., Foster, S. A., Koop, J. I., McDougall, J. K., Galloway, D. A., & Klingelhutz, A. J. (1998) · Nature · doi:10.1038/23962 · Cited by 1,206 · cited 1×
“Analysis of genes expressed in HSCs identified Bmi-1 , a member of the Polycomb Group ( PcG ) family linked to malignant transformation, lymphocyte development, neurological development and senescence of fibroblast”
BackgroundMorrison, S. J., & Weissman, I. L. (1994) · Immunity · doi:10.1016/1074-7613(94)90037-x · Cited by 1,116
Self-citationNucleolar Arf sequesters Mdm2 and activates p53
Weber, J. D., Taylor, L. J., Roussel, M. F., Sherr, C. J., & Bar-Sagi, D. (1999) · Nature Cell Biology · doi:10.1038/8991 · Cited by 940
Flagged first, then by citations
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Items 501–600 of 1,002
Chromatin state maps: new technologies, new insights
Mendenhall, E. M., & Bernstein, B. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.01.010 · Cited by 89
Dirks, P. B. (2007) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.2017 · Cited by 87
Hematopoietic Stem Cells and the Aging Hematopoietic System
Gazit, R., Weissman, I. L., & Rossi, D. J. (2008) · Seminars in Hematology · doi:10.1053/j.seminhematol.2008.07.010 · Cited by 84
Self-citationKranc, K. R., Bamforth, S. D., Bragança, J., Norbury, C. J., van Lohuizen, M., & Bhattacharya, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7658-7666.2003 · Cited by 85
MLL-AF9– and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C
Zhu, N., Chen, M., Eng, R., DeJong, J., Sinha, A. U., Rahnamay, N. F., Koche, R. P., Al‐Shahrour, F., Minehart, J. C., Chen, C.-W. D., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci82978 · Cited by 87
The Bone Marrow Microenvironment as Niche Retreats for Hematopoietic and Leukemic Stem Cells
Nwajei, F., & Konopleva, M. Y. (2013) · Advances in Hematology · doi:10.1155/2013/953982 · Cited by 87
Polycomb complexes PRC1 and their function in hematopoiesis
Vidal, M., & Starowicz, K. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2016.12.006 · Cited by 90
USP22 Acts as an Oncogene by the Activation of BMI-1-Mediated INK4a/ARF Pathway and Akt Pathway
Liu, Y., Jiang, S., Yang, Y., Xu, H., Liu, J.-L., & Wang, X. (2011) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-011-9287-0 · Cited by 85
Kimura, Y., Ding, B., Imai, N., Nolan, D. J., Butler, J. M., & Rafii, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026918 · Cited by 87
Hoffmann, M. J., Engers, R., Florl, A. R., Otte, A. P., Müller, M., & Schulz, W. A. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.9.4542 · Cited by 85
Plant and animal stem cells: conceptually similar, molecularly distinct?
Sablowski, R. W. M. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.09.011 · Cited by 86
Epigenetics in the hematologic malignancies
Fong, C. Y., Morison, J., & Dawson, M. A. (2014) · Haematologica · doi:10.3324/haematol.2013.092007 · Cited by 87
He, S., Iwashita, T., Buchstaller, J., Molofsky, A. V., Thomas, D. G., & Morrison, S. J. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.01.020 · Cited by 84
Self-citationEnhancing Chemotherapy Response with Bmi-1 Silencing in Ovarian Cancer
Wang, E., Bhattacharyya, S., Szabolcs, A., Rodriguez‐Aguayo, C., Jennings, N. B., Lopez‐Berestein, G., Mukherjee, P., Sood, A. K., & Bhattacharya, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017918 · Cited by 85
Tanno, T., Lim, Y., Wang, Q., Chesi, M., Bergsagel, P. L., Matthews, G., Johnstone, R. W., Ghosh, N., Borrello, I., Huff, C. A., et al. (2013) · Blood · doi:10.1182/blood-2013-08-524025 · Cited by 82
Xiang, J., Wu, D.-C., Chen, Y., & Paulson, R. F. (2015) · Blood · doi:10.1182/blood-2014-07-591453 · Cited by 92
BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells
Rizo, A., Horton, S. J., Olthof, S. G. M., Dontje, B., Ausema, A., van Os, R. P., van den Boom, V., Vellenga, E., de Haan, G., & Schuringa, J. J. (2010) · Blood · doi:10.1182/blood-2010-02-270660 · Cited by 85
Converging pathways in leukemogenesis and stem cell self-renewal
Moore, M. A. S. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2005.04.011 · Cited by 84
Targeting cancer stem cells in squamous cell carcinoma
Chen, D., & Wang, C. (2019) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbz016 · Cited by 83
BMI-1 Is Highly Expressed in M0-Subtype Acute Myeloid Leukemia
Sawa, M., Yamamoto, K., Yokozawa, T., Kiyoi, H., Hishida, A., Kajiguchi, T., Seto, M., Kohno, A., Kitamura, K., Itoh, Y., et al. (2005) · International Journal of Hematology · doi:10.1532/ijh97.05013 · Cited by 81
Stem cells of the adult cornea: From cytometric markers to therapeutic applications
Takács, L., Tóth, E., Berta, A., & Vereb, G. (2008) · Cytometry Part A · doi:10.1002/cyto.a.20671 · Cited by 81
Rodriguez, D. A., Ramkairsingh, M., Lin, X., Kapoor, A., Major, P. P., & Tang, D. (2019) · Cancers · doi:10.3390/cancers11071028 · Cited by 82
Suh, H. N., & Han, H. J. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22697 · Cited by 80
Cancer stem cells with genetic instability: the best vehicle with the best engine for cancer
Lagasse, E. (2007) · Gene Therapy · doi:10.1038/sj.gt.3303068 · Cited by 80
Cui, H., Ma, J., Ding, J., Li, T., Alam, G. N., & Ding, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604009200 · Cited by 81
Cancer stem cells hypothesis and stem cells in head and neck cancers
Mannelli, G., & Gallo, O. (2011) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2011.11.007 · Cited by 80
Loss of the human polycomb group protein BMI1 promotes cancer-specific cell death
LIU, L.-M., Andrews, L. G., & Tollefsbol, T. O. (2006) · Oncogene · doi:10.1038/sj.onc.1209454 · Cited by 82
Neoplastic stem cells: A novel therapeutic target in clinical oncology
Schulenburg, A., Ulrich-Pur, H., Thurnher, D., Erović, B. M., Florian, S., Sperr, W. R., Kalhs, P., Marian, B., Wrba, F., Zielinski, C. C., et al. (2006) · Cancer · doi:10.1002/cncr.22277 · Cited by 81
Huang, R., Cheung, N. V., Vider, J., Cheung, I. Y., Gerald, W. L., Tickoo, S. K., Holland, E. C., & Blasberg, R. G. (2011) · The FASEB Journal · doi:10.1096/fj.11-185033 · Cited by 82
HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis
Bagger, F. O., Rapin, N., Theilgaard‐Mönch, K., Kaczkowski, B., Thorén, L., Jendholm, J., Winther, O., & Porse, B. T. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1021 · Cited by 81
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury.
Shao, L., Wang, Y., Chang, J., Luo, Y., Meng, A., & Zhou, D. (2013) · PubMed · doi:10.3978/j.issn.2218-676x.2013.07.03 · Cited by 87
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Motoda, L., Osato, M., Yamashita, N., Jacob, B., Chen, L. Q., Yanagida, M., Ida, H., Wee, H., Sun, A. X., Taniuchi, I., et al. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0061 · Cited by 80
Lin, S.-P., Lee, Y., Wang, J.-Y., Miller, S. A., Chiou, S., Hung, M., & Hung, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049605 · Cited by 80
Lee, J., & Zhou, P. (2010) · Genes & Cancer · doi:10.1177/1947601910382899 · Cited by 79
Zhang, S., Ge, J., Sun, A., Xu, D., Qian, J., Lin, J., Zhao, Y., Hu, H., Li, Y., Wang, K., et al. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20949 · Cited by 83
Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches
Zhang, L., Mack, R. M., Breslin, P., & Zhang, J. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00994-z · Cited by 80
Cbx4 regulates the proliferation of thymic epithelial cells and thymus function
Liu, B., Liu, Y.-F., Du, Y., Mardaryev, A. N., Yang, W., Chen, H., Xu, Z.-M., Xu, C., Zhang, X., Botchkarev, V. A., et al. (2013) · Development · doi:10.1242/dev.085035 · Cited by 78
Hock, H. R., & Orkin, S. H. (2005) · Current Opinion in Hematology · doi:10.1097/01.moh.0000190111.85284.8f · Cited by 78
Design principle of gene expression used by human stem cells: implication for pluripotency
Golan‐Mashiach, M., Dazard, J.-E., Gerecht, S., Amariglio, N., Fisher, T., Jacob‐Hirsch, J., Bielorai, B., Osenberg, S., Barad, O., Getz, G. A., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-2417fje · Cited by 81
Stem cells in tissues, organoids, and cancers
Wang, X. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03199-x · Cited by 80
Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms
Geng, Z., & Gao, Z. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228594 · Cited by 88
Metabolic regulation of stem cell function
Burgess, R., Agathocleous, M., & Morrison, S. J. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12247 · Cited by 81
Self-citationRunx1 Loss Minimally Impacts Long-Term Hematopoietic Stem Cells
Cai, X., Gaudet, J., Mangan, J. K., Chen, M. J., Obaldia, M. E. D., Oo, Z. M., Ernst, P., & Speck, N. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028430 · Cited by 82
Stem cells, mitochondria and aging
Ahlqvist, K. J., Suomalainen, A., & Hämäläinen, R. H. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.014 · Cited by 77
Li, J., Bench, A. J., Vassiliou, G. S., Fourouclas, N., Ferguson‐Smith, A. C., & Green, A. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308195101 · Cited by 77
Hierarchical organization of fetal and adult hematopoietic stem cells
Babovic, S., & Eaves, C. J. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.08.005 · Cited by 81
Kim, J., Kang, Y., Park, G., Kim, M., Park, Y.-O., Kim, H., Leem, S., Chu, I., Lee, J.-S., Jho, E., et al. (2009) · Stem Cells · doi:10.1002/stem.52 · Cited by 77
Nitric Oxide Is a Regulator of Hematopoietic Stem Cell Activity
Michurina, T. V., Krasnov, P. A., Balazs, A. B., Nakaya, N., Vasilieva, T. V., Ba, K., Khrushchov, N. G., Mulligan, R. C., & Enikolopov, G. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.05.030 · Cited by 75
Transcription Factor Oct1 Is a Somatic and Cancer Stem Cell Determinant
Maddox, J., Shakya, A., South, S., Shelton, D. N., Andersen, J. N., Chidester, S., Kang, J., Gligorich, K. M., Jones, D. A., Spangrude, G. J., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003048 · Cited by 77
Genetic programs regulating HSC specification, maintenance and expansion
Lessard, J. A., Faubert, A., & Sauvageau, G. (2004) · Oncogene · doi:10.1038/sj.onc.1207940 · Cited by 76
Luo, Y., Li, L., Zou, P., Wang, J., Shao, L., Zhou, D., & Liu, L. (2013) · Transplantation · doi:10.1097/tp.0b013e3182a7fcf8 · Cited by 76
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Qian, Z., Chen, L., Fernald, A. A., Williams, B. O., & Beau, M. M. L. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080578 · Cited by 81
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Zhang, H., Peng, C., Hu, Y., Li, H., Sheng, Z., Chen, Y., Sullivan, C., Černý, J., Hutchinson, L., Higgins, A. W., et al. (2012) · Nature Genetics · doi:10.1038/ng.2350 · Cited by 77
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Oh, M., & Nor, J. E. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00367 · Cited by 75
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Smad7 promotes self-renewal of hematopoietic stem cells
Blank, U., Karlsson, G., Moody, J. L., Utsugisawa, T., Magnusson, M., Singbrant, S., Larsson, J., & Karlsson, S. (2006) · Blood · doi:10.1182/blood-2006-02-005611 · Cited by 77
Schneider, T. E., Barland, C. O., Alex, A. M., Mancianti, M., Lü, Y., Cleaver, J. E., Lawrence, H. J., & Ghadially, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2034935100 · Cited by 80
Gieni, R. S., & Hendzel, M. J. (2009) · Biochemistry and Cell Biology · doi:10.1139/o09-057 · Cited by 76
Cherry, C., & Matunis, E. L. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.04.018 · Cited by 77
VEGFA activates an epigenetic pathway upregulating ovarian cancer‐initiating cells
Jang, K., Kim, M., Gilbert, C. A., Simpkins, F. A., Ince, T. A., & Slingerland, J. M. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201606840 · Cited by 75
Bellantuono, I. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2003.10.008 · Cited by 77
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Su, J., Xu, X., Huang, Q., Lu, M., Li, D., Xue, F., Fang, Y., Ren, J., & Wu, Y. (2011) · Archives of Medical Research · doi:10.1016/j.arcmed.2011.01.007 · Cited by 73
Hematopoietic stem cell ageing is uncoupled from p16INK4A-mediated senescence
Attema, J. L., Pronk, C. J. H., Norddahl, G. L., Nygren, J. M., & Bryder, D. (2009) · Oncogene · doi:10.1038/onc.2009.94 · Cited by 72
Expression patterns of USP22 and potential targets BMI-1, PTEN, p-AKT in non-small-cell lung cancer
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Walkley, C. R., & Orkin, S. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603389103 · Cited by 71
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Lu, X., Sun, S., Qi, J., Li, W., Liu, L.-M., Zhang, Y., Chen, Y., Zhang, S., Wang, L., Miao, D., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9686-8 · Cited by 71
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García-Olmo, D. C., Ruiz-Piqueras, R., & García‐Olmo, D. (2004) · PubMed · doi:10.14670/hh-19.575 · Cited by 71
Yang, D., Cui, B., Sun, L., Zheng, H., Huang, Q., Tong, J., & Zhang, Q.-F. (2011) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-011-9229-x · Cited by 71
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Nakada, D., Levi, B. P., & Morrison, S. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.011 · Cited by 78
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Tabor, M. H., Clay, M. R., Owen, J. H. J., Bradford, C. R., Carey, T. E., Wolf, G. T., & Prince, M. E. P. (2010) · The Laryngoscope · doi:10.1002/lary.21032 · Cited by 70
Alajez, N. M., Shi, W., Hui, A. B., Yue, S., Ng, R., Lo, K. W., Bastianutto, C., O’Sullivan, B., Gullane, P., & Liu, F. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.85 · Cited by 70
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Bello, B. C., Holbro, N., & Reichert, H. (2007) · Development · doi:10.1242/dev.02793 · Cited by 74
Uchida, N., Dykstra, B. J., Lyons, K. J., Leung, F. Y. K., Kristiansen, M., & Eaves, C. J. (2004) · Blood · doi:10.1182/blood-2003-11-3989 · Cited by 71
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Wang, Y., Liu, Y., Tang, F., Bernot, K. M., Schore, R., Marcucci, G., Caligiuri, M. A., Zheng, P., & Liu, Y. (2014) · Blood · doi:10.1182/blood-2013-12-544221 · Cited by 69
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Metadata
- Authors
- Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F.
- Affiliations
- University of Michigan (US)
- Howard Hughes Medical Institute (US)
- Stanford Medicine (US)
- Corresponding author
- Clarke, Michael F.
- ORCID
- Venue
- Nature
- Published
- 2003-04-20
- Volume
- 423
- Issue
- 6937
- Pages
- 302-305
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2021050536
- Cited by
- 1,871
- References
- 31
- Citations by year
- 2026: 16 · 2025: 19 · 2024: 15 · 2023: 29 · 2022: 50 · 2021: 48 · 2020: 45 · 2019: 51 · 2018: 52 · 2017: 68 · 2016: 79 · 2015: 81 · 2014: 97 · 2013: 100 · 2012: 127
- FWCI
- 55.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- University of Michigan
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- BMI1, hematopoietic stem cells, self-renewal, stem cell maintenance, p16INK4a, p19ARF, p53-dependent cell death, growth arrest, cell survival genes, hematopoiesis, bone marrow
- MeSH terms
- Proto-Oncogene Mas, Animals, Bone Marrow Cells, Cell Division, Gene Expression Regulation, Hematopoietic Stem Cells, Humans, Liver, Models, Biological, Nuclear Proteins, Proto-Oncogene Proteins, Repressor Proteins, RNA, Messenger, Bone Marrow Transplantation, Gene Deletion, Hematopoietic Stem Cell Transplantation, Cyclin-Dependent Kinase Inhibitor p16, Tumor Suppressor Protein p14ARF, Mice, Polycomb Repressive Complex 1
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