Cited by 1,871Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchBlood disorders and treatments

The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.

Open access

Park, In-kyung, Qian, Dalong, Kiel, Mark, Becker, Michael W., Pihalja, Michael, Weissman, Irving L., Morrison, Sean J., Clarke, Michael F.·2003·Nature

DOI 10.1038/nature01587

Open this paper in CoChat — free account Open PDF

Abstract

A central issue in stem cell biology is to understand the mechanisms that regulate the self-renewal of haematopoietic stem cells (HSCs), which are required for haematopoiesis to persist for the lifetime of the animal. We found that adult and fetal mouse and adult human HSCs express the proto-oncogene Bmi-1. The number of HSCs in the fetal liver of Bmi-1-/- mice was normal. In postnatal Bmi-1-/- mice, the number of HSCs was markedly reduced. Transplanted fetal liver and bone marrow cells obtained from Bmi-1-/- mice were able to contribute only transiently to haematopoiesis. There was no detectable self-renewal of adult HSCs, indicating a cell autonomous defect in Bmi-1-/- mice. A gene expression analysis revealed that the expression of stem cell associated genes, cell survival genes, transcription factors, and genes modulating proliferation including p16Ink4a and p19Arf was altered in bone marrow cells of the Bmi-1-/- mice. Expression of p16Ink4a and p19Arf in normal HSCs resulted in proliferative arrest and p53-dependent cell death, respectively. Our results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature01587

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Production of high-titer helper-free retroviruses by transient transfection.
Pear, W. S., Nolan, G. P., Scott, M. L., & Baltimore, D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8392 · Cited by 2,267
"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells
Ramalho‐Santos, M., Yoon, S., Matsuzaki, Y., Mulligan, R. C., & Melton, D. A. (2002) · Science · doi:10.1126/science.1072530 · Cited by 1,711
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
Zhang, Y., Xiong, Y., & Yarbrough, W. G. (1998) · Cell · doi:10.1016/s0092-8674(00)81401-4 · Cited by 1,626
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
Jacobs, J. J. L., Kieboom, K., Marino, S., DePinho, R. A., & van Lohuizen, M. (1999) · Nature · doi:10.1038/16476 · Cited by 1,580
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
Ouelle, D. E., Zindy, F., Ashmun, R. A., & Sherr, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90214-7 · Cited by 1,485
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.
Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452
Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1
Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
Kiyono, T., Foster, S. A., Koop, J. I., McDougall, J. K., Galloway, D. A., & Klingelhutz, A. J. (1998) · Nature · doi:10.1038/23962 · Cited by 1,206 · cited 1×
“Analysis of genes expressed in HSCs identified Bmi-1 , a member of the Polycomb Group ( PcG ) family linked to malignant transformation, lymphocyte development, neurological development and senescence of fibroblast”
Background
The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype
Morrison, S. J., & Weissman, I. L. (1994) · Immunity · doi:10.1016/1074-7613(94)90037-x · Cited by 1,116
Self-citation
Nucleolar Arf sequesters Mdm2 and activates p53
Weber, J. D., Taylor, L. J., Roussel, M. F., Sherr, C. J., & Bar-Sagi, D. (1999) · Nature Cell Biology · doi:10.1038/8991 · Cited by 940

Show all 31 references

Sorted by citations

Items 301–400 of 1,002

C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence
Ye, M., Zhang, H., Amabile, G., Yang, H. H., Staber, P. B., Zhang, P., Levantini, E., Alberich-Jordà, M., Zhang, J., Kawasaki, A., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2698 · Cited by 149
Therapeutic Implications of the Cancer Stem Cell Hypothesis
Diehn, M., Cho, R. W., & Clarke, M. F. (2009) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2008.11.002 · Cited by 145
Self-citation
MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway
Wang, D., Zhang, Z., O’Loughlin, E., Wang, L., Fan, X., Lai, E. C., & Yi, R. (2013) · Nature Cell Biology · doi:10.1038/ncb2827 · Cited by 145
Cellular memory and dynamic regulation of polycomb group proteins
Bantignies, F., & Cavalli, G. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.04.003 · Cited by 142
Immunological Tolerance During Fetal Development
Mold, J. E., & McCune, J. M. (2012) · Advances in immunology · doi:10.1016/b978-0-12-394299-9.00003-5 · Cited by 141
Effects of hypoxia on expression of a panel of stem cell and chemoresistance markers in glioblastoma-derived spheroids
Kolenda, J., Jensen, S. S., Aaberg-Jessen, C., Christensen, K., Andersen, C., Brünner, N., & Kristensen, B. W. (2011) · Journal of Neuro-Oncology · doi:10.1007/s11060-010-0357-8 · Cited by 144
Inhibition of Histone Deacetylase Impacts Cancer Stem Cells and Induces Epithelial-Mesenchyme Transition of Head and Neck Cancer
Giudice, F. S., Júnior, D. D. S. P., Nor, J. E., SQUARIZE, C. H., & CASTILHO, R. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058672 · Cited by 140
Bmi-1 Is Essential for the Tumorigenicity of Neuroblastoma Cells
Cui, H., Hu, B., Li, T., Ma, J., Alam, G. N., Gunning, W. T., & Ding, H. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060754 · Cited by 140
In Search of Adrenocortical Stem and Progenitor Cells
Kim, A. C., Barlaskar, F. M., Heaton, J. H., Else, T., Kelly, V. R., Krill, K. T., Scheys, J. O., Simon, D. P., Trovato, A., Yang, W., et al. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0039 · Cited by 136
Tumor Suppressor p16INK4A Regulates Polycomb-mediated DNA Hypermethylation in Human Mammary Epithelial Cells
Reynolds, P. A., Sigaroudinia, M., Zardo, G., Wilson, M. B., Benton, G. M., Miller, C. J., Hong, C., Fridlyand, J., Costello, J., & Tlsty, T. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604175200 · Cited by 137
Stem Cell Review Series: Role of neurogenesis in age‐related memory disorders
Drapeau, E., & Abrous, D. N. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00369.x · Cited by 148
BMI1 as a novel target for drug discovery in cancer
Cao, L., Bombard, J., Cintron, K., Sheedy, J., Weetall, M. L., & Davis, T. W. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23234 · Cited by 137
MicroRNA‐200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells
Lo, W., Yu, C., Chiou, G., Chen, Y., Huang, P., Chien, C., Tseng, L., Chu, P., Lu, K., Chang, K., et al. (2010) · The Journal of Pathology · doi:10.1002/path.2826 · Cited by 136
Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition
Sun, W. S., Qiao, W., Zhou, B., Hu, Z., Yan, Q., Wu, J., Wang, R., Zhang, Q., & Miao, D. (2018) · Metabolism · doi:10.1016/j.metabol.2018.06.006 · Cited by 135
Stem cells in the etiology and treatment of cancer
Zhang, M., & Rosen, J. M. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.12.008 · Cited by 135
Usp16 contributes to somatic stem-cell defects in Down’s syndrome
Adorno, M., Sikandar, S., Mitra, S. S., Kuo, A., Nicolis di Robilant, B., Haro-Acosta, V., Ouadah, Y., Quarta, M., Rodriguez, J., Qian, D., et al. (2013) · Nature · doi:10.1038/nature12530 · Cited by 134
Self-citation
The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia
Mohty, M., Yong, A. S. M., Szydlo, R., Apperley, J. F., & Melo, J. V. (2007) · Blood · doi:10.1182/blood-2006-12-065599 · Cited by 138
Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease
Cianflone, E., Torella, M., Biamonte, F., Angelis, A. D., Urbanek, K., Costanzo, F. S., Rota, M., Ellison, G. M., & Torella, D. (2020) · Cells · doi:10.3390/cells9061558 · Cited by 137
Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells
Yang, J., Chai, L., Liu, F., Fink, L. M., Lin, P., Silberstein, L. E., Amin, H. M., Ward, D. C., & Ma, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704001104 · Cited by 135
Cancer initiation and progression: Involvement of stem cells and the microenvironment
Tysnes, B. B., & BJERKVIG, R. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2007.01.001 · Cited by 138
Polycomb group complexes – many combinations, many functions
Kerppola, T. K. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.10.001 · Cited by 136
Hemopoietic Stem Cells with Higher Hemopoietic Potential Reside at the Bone Marrow Endosteum
Haylock, D. N., Williams, B., Johnston, H. M., Liu, M. C. P., Rutherford, K. E., Whitty, G. A., Simmons, P. J., Bertoncello, I., & Nilsson, S. K. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0528 · Cited by 132
CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes
Dik, W. A., Brahim, W., Braun, C., Asnafi, V., Dastugue, N., Bernard, O., van Dongen, J. J. M., Langerak, A. W., Macintyre, E. A., & Delabesse, É. (2005) · Leukemia · doi:10.1038/sj.leu.2403891 · Cited by 138
The expression profile of purified Drosophila germline stem cells
Kai, T., Williams, D., & Spradling, A. C. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.04.018 · Cited by 134
SALL4 is a key regulator of survival and apoptosis in human leukemic cells
Yang, J., Chai, L., Gao, C., Fowles, T. C., Alipio, Z., Dang, H., Xu, D., Fink, L. M., Ward, D. C., & Ma, Y. (2008) · Blood · doi:10.1182/blood-2007-11-126326 · Cited by 132
Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and after Transplantation
Pontiggia, L., Biedermann, T., Meuli, M., Widmer, D., Sophie Böttcher-haberzeth, A., Schiestl, C. M., Schneider, J. J., Braziulis, E., Montaño, I., Meuli‐Simmen, C., et al. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.254 · Cited by 131
Stem Cell Self-Renewal and Cancer Cell Proliferation Are Regulated by Common Networks That Balance the Activation of Proto-oncogenes and Tumor SuppressorsPreprint
Pardal, R., Molofsky, A. V., He, S., & Morrison, S. J. (2005) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2005.70.057 · Cited by 133
Self-citation
Endothelial Cell-Secreted EGF Induces Epithelial to Mesenchymal Transition and Endows Head and Neck Cancer Cells with Stem-like Phenotype
Zhang, Z., Dong, Z., Lauxen, I. S., Filho, M. S., & Nor, J. E. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2032 · Cited by 132
Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences
Vincenz, C., & Kerppola, T. K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805317105 · Cited by 138
Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells
Janković, V., Ciarrocchi, A., Boccuni, P., DeBlasio, T., Benezra, R., & Nimer, S. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607894104 · Cited by 133
Polycomb Repressive Complex 2 (PRC2) Restricts Hematopoietic Stem Cell Activity
Majewski, I. J., Blewitt, M. E., de Graaf, C. A., McManus, E. J., Bahlo, M., Hilton, A. A., Hyland, C. D., Smyth, G. K., Corbin, J. E., Metcalf, D., et al. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060093 · Cited by 135
Cancer stem cells: the theory and perspectives in cancer therapy
Gil, J., Stembalska, A., Pesz, K. A., & Sasiadek, M. M. (2008) · Journal of Applied Genetics · doi:10.1007/bf03195612 · Cited by 129
Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis
Mihara, K., Chowdhury, M., Nakaju, N., Hidani, S., Ihara, A., Hyodo, H., Yasunaga, S., Takihara, Y., & Kimura, A. (2005) · Blood · doi:10.1182/blood-2005-06-2393 · Cited by 132
Epigenetic regulation of aging stem cells
Pollina, E. A., & Brunet, A. (2011) · Oncogene · doi:10.1038/onc.2011.45 · Cited by 111
Bmi1 Regulates Stem Cells and Proliferation and Differentiation of Committed Cells in Mammary Epithelium
Pietersen, A. M., Evers, B., Prasad, A. A., Tanger, E., Cornelissen‐Steijger, P., Jonkers, J., & van Lohuizen, M. (2008) · Current Biology · doi:10.1016/j.cub.2008.06.070 · Cited by 134
Limbal Epithelial Side-Population Cells Have Stem Cell–Like Properties, Including Quiescent State
Umemoto, T., Yamato, M., Nishida, K., Yang, J., Tano, Y., & Okano, T. (2005) · Stem Cells · doi:10.1634/stemcells.2005-0064 · Cited by 127
Stem Cells in Mammary Development and Carcinogenesis: Implications for Prevention and Treatment
Dontu, G., Liu, S., & Wicha, M. S. (2005) · Stem Cell Reviews and Reports · doi:10.1385/scr:1:3:207 · Cited by 126
Emerging Roles for Polycomb-Group Proteins in Stem Cells and Cancer
Chan, H. L., & Morey, L. (2019) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2019.04.005 · Cited by 131
Bmi-1: At the crossroads of physiological and pathological biology
Bhattacharya, R., Mustafi, S. B., Street, M., Dey, A., & Dwivedi, S. K. D. (2015) · Genes & Diseases · doi:10.1016/j.gendis.2015.04.001 · Cited by 132
Mechanisms controlling pathogenesis and survival of leukemic stem cells
Jordan, C. T., & Guzmán, M. L. (2004) · Oncogene · doi:10.1038/sj.onc.1207935 · Cited by 129
NOV (CCN3) Functions as a Regulator of Human Hematopoietic Stem or Progenitor Cells
Gupta, R., Hong, D., Iborra, F. J., Sarno, S. M., & Enver, T. (2007) · Science · doi:10.1126/science.1136031 · Cited by 128
The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformationPreprint
Boukarabila, H., Saurin, A. J., Batsché, É., Mossadegh‐Keller, N., van Lohuizen, M., Otte, A. P., Pradel, J., Muchardt, C., Sieweke, M. H., & Duprez, E. (2009) · Genes & Development · doi:10.1101/gad.512009 · Cited by 138
Cancer stem cell biology: from leukemia to solid tumors
Jordan, C. T. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.09.002 · Cited by 127
Selective Targeting of Cancer Stem Cells
Körkaya, H., & Wicha, M. S. (2007) · BioDrugs · doi:10.2165/00063030-200721050-00002 · Cited by 126
The BAF53a subunit of SWI/SNF-like BAF complexes is essential for hemopoietic stem cell function
Krasteva, V., Buscarlet, M., Diaz‐Tellez, A., Bernard, M.-A., Crabtree, G. R., & Lessard, J. A. (2012) · Blood · doi:10.1182/blood-2012-04-427047 · Cited by 126
Role of Hedgehog Signaling in Ovarian Cancer
Bhattacharya, R., Kwon, J., Ali, B., Wang, E., Patra, S., Shridhar, V., & Mukherjee, P. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1414 · Cited by 124
p16INK4a Prevents Centrosome Dysfunction and Genomic Instability in Primary Cells
McDermott, K. M., Zhang, J., Holst, C. R., Kozakiewicz, B. K., Singla, V., & Tlsty, T. D. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040051 · Cited by 124
Deletion of Shp2 in the Brain Leads to Defective Proliferation and Differentiation in Neural Stem Cells and Early Postnatal Lethality
Ke, Y., Zhang, E. E., Hagihara, K., Wu, D., Pang, Y., Klein, R., Curran, T., Ranscht, B., & Feng, G. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01225-07 · Cited by 125
Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells
Yu, C., Lo, W., Chen, Y., Huang, P., Hsu, H., Tseng, L., Hung, S., Kao, S., Chang, C., & Chiou, S. H. (2010) · Journal of Oncology · doi:10.1155/2011/609259 · Cited by 124
The Histone Demethylase KDM5b/JARID1b Plays a Role in Cell Fate Decisions by Blocking Terminal Differentiation
Dey, B. K., Stalker, L., Schnerch, A., Bhatia, M., Taylor-Papidimitriou, J., & Wynder, C. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00128-08 · Cited by 122
The Promyelocytic Leukemia Zinc Finger Protein: Two Decades of Molecular Oncology
Suliman, B. A., Xu, D., & Williams, B. R. G. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00074 · Cited by 126
Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells
Bardot, E., Valdés, V. J., Zhang, J., Perdigoto, C. N., Nicolis, S. K., Hearn, S., Silva, J. M., & Ezhkova, E. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.110 · Cited by 126
Advances in the 5q− syndrome
Boultwood, J., Pellagatti, A., McKenzie, A. N. J., & Wainscoat, J. S. (2010) · Blood · doi:10.1182/blood-2010-04-273771 · Cited by 126
Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side
Prieto-Bermejo, R., Romo-González, M., Pérez‐Fernández, A., Ijurko, C., & Hernández‐Hernández, Á. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0797-0 · Cited by 126
Differential m6A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function
Yin, R., Chang, J.-W., Li, Y., Gao, Z., Qiu, Q., Wang, Q., Han, G., Chai, J., Feng, M., Wang, P., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.09.014 · Cited by 123
Is there more to BARD1 than BRCA1?
Irminger‐Finger, I., & Jefford, C. E. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1878 · Cited by 123
Phase I and Pharmacokinetic Study of Bortezomib in Combination with Idarubicin and Cytarabine in Patients with Acute Myelogenous Leukemia
Attar, E. C., DeAngelo, D. J., Supko, J. G., D’Amato, F., Zahrieh, D., Sirulnik, A., Wadleigh, M., Ballen, K. K., McAfee, S., Miller, K. B., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4626 · Cited by 121
A set of miRNAs that involve in the pathways of drug resistance and leukemic stem-cell differentiation is associated with the risk of relapse and glucocorticoid response in childhood ALL
Han, B., Feng, D.-D., Li, Z.-G., Luo, X.-Q., Zhang, H., Li, X.-J., Zhang, X., Zheng, L., Zeng, C., Lin, K.-Y., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr428 · Cited by 121
Bmi1 Loss Produces an Increase in Astroglial Cells and a Decrease in Neural Stem Cell Population and Proliferation
Zencak, D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3452-04.2005 · Cited by 122
Reprogramming fibroblasts into induced pluripotent stem cells with Bmi1
Moon, J.-H., Heo, J. S., Kim, J. S., Jun, E. K., Lee, J. H., Kim, A., Kim, J., Whang, K. Y., Kang, Y., Yeo, S., et al. (2011) · Cell Research · doi:10.1038/cr.2011.107 · Cited by 120
Head neck squamous cell carcinoma c‐Met+ cells display cancer stem cell properties and are responsible for cisplatin‐resistance and metastasis
Sun, S., & Wang, Z. (2011) · International Journal of Cancer · doi:10.1002/ijc.25927 · Cited by 125
A Limited Role for p21Cip1/Waf1 in Maintaining Normal Hematopoietic Stem Cell Functioning
van Os, R. P., Kamminga, L. M., Ausema, A., Bystrykh, L. V., Draijer, D. P., van Pelt, K., Dontje, B., & de Haan, G. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0631 · Cited by 118
Contribution of Polycomb Homologues Bmi-1 and Mel-18 to Medulloblastoma Pathogenesis
Wiederschain, D., Chen, L., Johnson, B. V., Bettano, K. A., Jackson, D., Taraszka, J. A., Wang, Y., Jones, M. D., Morrissey, M., Deeds, J. D., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02244-06 · Cited by 121
Cell cycle inhibitors in normal and tumor stem cells.
Cheng, T. (2004) · Oncogene · doi:10.1038/sj.onc.1207945 · Cited by 117
Contributions of DNA Damage to Alzheimer’s Disease
Lin, X., Kapoor, A., Gu, Y., Chow, M. J., Peng, J., Zhao, K., & Tang, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051666 · Cited by 117
5-Fluorouracil Chemotherapy of Gastric Cancer Generates Residual Cells with Properties of Cancer Stem Cells
Xu, Z., Tang, J., Xie, H., Du, Y., Huang, L., Yu, P., & Cheng, X. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.10248 · Cited by 121
Cancer Treatment-Induced Accelerated Aging in Cancer Survivors: Biology and Assessment
Wang, S., Prizment, A. E., Thyagarajan, B., & Blaes, A. H. (2021) · Cancers · doi:10.3390/cancers13030427 · Cited by 118
Inhibition of tumorigenicity and enhancement of radiochemosensitivity in head and neck squamous cell cancer-derived ALDH1-positive cells by knockdown of Bmi-1
Chen, Y., Chang, C.-J., Hsu, H., Chen, Y., Tai, L.-K., Tseng, L., Chiou, G., Chang, S., Kao, S., Chiou, S., et al. (2009) · Oral Oncology · doi:10.1016/j.oraloncology.2009.11.007 · Cited by 115
Chromatin Regulator PRC2 Is a Key Regulator of Epigenetic Plasticity in Glioblastoma
Natsume, A., Ito, M., Katsushima, K., Ohka, F., Hatanaka, A., Shinjo, K., Sato, S., Takahashi, S., Ishikawa, Y., Takeuchi, I., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0109 · Cited by 123
Senescence-Associated MCP-1 Secretion Is Dependent on a Decline in BMI1 in Human Mesenchymal Stromal Cells
Jin, H. J., Lee, H. J., Heo, J., Lim, J., Kim, M., Kim, M. K., Nam, H. Y., Hong, G. H., Cho, Y. S., Choi, S. J., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6359 · Cited by 115
Sox17 expression confers self-renewal potential and fetal stem cell characteristics upon adult hematopoietic progenitorsPreprint
He, S., Kim, I., Lim, M. S., & Morrison, S. J. (2011) · Genes & Development · doi:10.1101/gad.2052911 · Cited by 125
Self-citation
Maintenance of gene expression patterns
Brock, H. W., & Fisher, C. L. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20298 · Cited by 115
Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications
Wang, W. T., Qin, J., Voruganti, S., Nag, S. A., Zhou, J., & Zhang, R. (2015) · Medicinal Research Reviews · doi:10.1002/med.21358 · Cited by 118
Cancer stem cells and “stemness” genes in neuro-oncology
Nicolis, S. K. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.08.022 · Cited by 113
Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies
Warr, M. R., Pietras, E. M., & Passegué, E. (2011) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.145 · Cited by 112
Notch Signaling Is Required to Maintain All Neural Stem Cell Populations – Irrespective of Spatial or Temporal Niche
Alexson, T. O., Hitoshi, S., Coles, B. L. K., Bernstein, A., & van der Kooy, D. (2006) · Developmental Neuroscience · doi:10.1159/000090751 · Cited by 111
Brain Tumor Stem Cells
Nakano, I., & Kornblum, H. I. (2006) · Pediatric Research · doi:10.1203/01.pdr.0000203568.63482.f9 · Cited by 111
Molecular Mechanisms of Germline Stem Cell Regulation
Wong, M. D., Jin, Z., & Xie, T. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.073003.105855 · Cited by 111
The Contributions of Prostate Cancer Stem Cells in Prostate Cancer Initiation and Metastasis
Mei, W., Lin, X., Kapoor, A., Gu, Y. J., Zhao, K., & Tang, D. (2019) · Cancers · doi:10.3390/cancers11040434 · Cited by 110
Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells
Warner, J. K., Wang, J. C. Y., Takenaka, K., Doulatov, S. R., McKenzie, J. L., Harrington, L. A., & Dick, J. E. (2005) · Leukemia · doi:10.1038/sj.leu.2403917 · Cited by 118
Differential Gene Expression Profiling of Human Umbilical Cord Blood–Derived Mesenchymal Stem Cells by DNA Microarray
Jeong, J. A., Hong, S. H., Gang, E. J., Ahn, C., Hwang, S. H., Yang, I. H., Han, H. J., & Kim, H. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0304 · Cited by 109
Hematopoietic stem cells: generation and self-renewal
Huang, X., Cho, S., & Spangrude, G. J. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402225 · Cited by 116
Beyond transcription factors: how oncogenic signalling reshapes the epigenetic landscape
Liu, F., Wang, L., Perna, F., & Nimer, S. D. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.41 · Cited by 109
Defining Aggressive Prostate Cancer Using a 12-Gene Model
Bismar, T. A., Demichelis, F., Riva, A., Kim, R., Varambally, S., He, L., Kutok, J. L., Aster, J. C., Tang, J., Kuefer, R., et al. (2006) · Neoplasia · doi:10.1593/neo.05664 · Cited by 106
Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration
Chung, Y.-J., Park, B.-B., Kang, Y.-J., Kim, T.-M., Eaves, C. J., & Oh, I.-H. (2006) · Blood · doi:10.1182/blood-2006-01-010199 · Cited by 107
Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance
Singh, S. K., Williams, C. A., Klarmann, K. D., Burkett, S. S., Keller, J. R., & Oberdoerffer, P. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121608 · Cited by 107
Signaling pathways in self-renewing hematopoietic and leukemic stem cells: do all stem cells need a niche?
Rizo, A., Vellenga, E., de Haan, G., & Schuringa, J. J. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl175 · Cited by 114
NVP-LDE-225 (Erismodegib) inhibits epithelial–mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2Rγ null mice by regulating Bmi-1 and microRNA-128
Nanta, R., Kumar, D., Meeker, D. G., Rodova, M., Veldhuizen, P. J. V., Shankar, S., & Srivastava, R. K. (2013) · Oncogenesis · doi:10.1038/oncsis.2013.5 · Cited by 110
Bmi1 Enhances Tumorigenicity and Cancer Stem Cell Function in Pancreatic Adenocarcinoma
Proctor, E., Waghray, M., Lee, C. J., Heidt, D. G., Yalamanchili, M., Li, C., Bednar, F., & Simeone, D. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055820 · Cited by 111
Metastasis-related miRNAs, active players in breast cancer invasion, and metastasis
Shi, M., Liu, D., Duan, H., Shen, B., & Guo, N. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9265-9 · Cited by 108
Cited2 Is an Essential Regulator of Adult Hematopoietic Stem Cells
Kranc, K. R., Schepers, H., Rodrigues, N. P., Bamforth, S. D., Villadsen, E., Ferry, H., Bouriez‐Jones, T., Sigvardsson, M., Bhattacharya, S., Jacobsen, S. E. W., et al. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.11.001 · Cited by 109
Long-term maintenance of human hematopoietic stem/progenitor cells by expression of BMI1
Rizo, A., Dontje, B., Vellenga, E., de Haan, G., & Schuringa, J. J. (2007) · Blood · doi:10.1182/blood-2007-08-106666 · Cited by 113
Consistent expression of the stem cell renewal factor BMI‐1 in primary and metastatic melanoma
Mihic‐Probst, D., Kuster, A., Kilgus, S., Bode‐Lesniewska, B., Ingold‐Heppner, B., Leung, C., Storz, M., Seifert, B., Marino, S., Schraml, P., et al. (2007) · International Journal of Cancer · doi:10.1002/ijc.22891 · Cited by 106
Cancer stem cells: the lessons from pre‐cancerous stem cells
Gao, J. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00170.x · Cited by 106
Aberrant cytokine signaling in leukemia
Etten, R. A. V. (2007) · Oncogene · doi:10.1038/sj.onc.1210758 · Cited by 108
Bmi‐1‐Green Fluorescent Protein‐Knock‐In Mice Reveal the Dynamic Regulation of Bmi‐1 Expression in Normal and Leukemic Hematopoietic Cells
Hosen, N., Yamane, T., Muijtjens, M., Pham, K., Clarke, M. F., & Weissman, I. L. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0229 · Cited by 106
Self-citation
ABC transporter expression in hematopoietic stem cells and the role in AML drug resistance
de Jonge-Peeters, S. D. P. W. M., Kuipers, F., de Vries, E. G. E., & Vellenga, E. (2007) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2007.02.003 · Cited by 107
Single-Cell Analysis of Proxy Reporter Allele-Marked Epithelial Cells Establishes Intestinal Stem Cell Hierarchy
Li, N., Yousefi, M., Nakauka‐Ddamba, A., Jain, R., Tobias, J. W., Epstein, J. A., Jensen, S. T., & Lengner, C. J. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.09.011 · Cited by 108
CBX7 regulates stem cell-like properties of gastric cancer cells via p16 and AKT-NF-κB-miR-21 pathways
Ni, S.-J., Zhao, L.-Q., Wang, X. F., Wu, Z.-H., Hua, R., Wan, C., Zhang, J., Zhang, X.-W., Huang, M., Gan, L., et al. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0562-z · Cited by 105
Self-renewal writ in blood
Dick, J. E. (2003) · Nature · doi:10.1038/423231a · Cited by 107

Authors: Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F.
Affiliations: University of Michigan (US)
Howard Hughes Medical Institute (US)
Stanford Medicine (US)
Corresponding author: Clarke, Michael F.
ORCID: Park, In-kyung
Qian, Dalong
Kiel, Mark
Becker, Michael W.
Weissman, Irving L.
Morrison, Sean J.
Clarke, Michael F.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2003-04-20
Volume: 423
Issue: 6937
Pages: 302-305
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature01587
OpenAlex: W2021050536
Cited by: 1,871
References: 31
Citations by year: 2026: 16 · 2025: 19 · 2024: 15 · 2023: 29 · 2022: 50 · 2021: 48 · 2020: 45 · 2019: 51 · 2018: 52 · 2017: 68 · 2016: 79 · 2015: 81 · 2014: 97 · 2013: 100 · 2012: 127
FWCI: 55.81
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Deep Blue (University of Michigan) (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: University of Michigan
National Institutes of Health
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Hematology › Blood disorders and treatments
Keywords: BMI1, hematopoietic stem cells, self-renewal, stem cell maintenance, p16INK4a, p19ARF, p53-dependent cell death, growth arrest, cell survival genes, hematopoiesis, bone marrow
MeSH terms: Proto-Oncogene Mas, Animals, Bone Marrow Cells, Cell Division, Gene Expression Regulation, Hematopoietic Stem Cells, Humans, Liver, Models, Biological, Nuclear Proteins, Proto-Oncogene Proteins, Repressor Proteins, RNA, Messenger, Bone Marrow Transplantation, Gene Deletion, Hematopoietic Stem Cell Transplantation, Cyclin-Dependent Kinase Inhibitor p16, Tumor Suppressor Protein p14ARF, Mice, Polycomb Repressive Complex 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks