Wnt proteins are lipid-modified and can act as stem cell growth factors

Large-scale analysis of the yeast proteome by multidimensional protein identification technology

Washburn, M. P., Wolters, D. A., & Yates, J. R. (2001) · Nature Biotechnology · doi:10.1038/85686 · Cited by 4,768

Phase separation of integral membrane proteins in Triton X-114 solution.

Bordier, C. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69848-0 · Cited by 3,324

Wnt signaling and cancer

Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183

Wnt signaling: a common theme in animal development

Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567

A role for Wnt signalling in self-renewal of haematopoietic stem cells

Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A.-P., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01014-0 · Cited by 2,030

DTASelect and Contrast: Tools for Assembling and Comparing Protein Identifications from Shotgun Proteomics

Tabb, D. L., McDonald, W. H., & Yates, J. R. (2002) · Journal of Proteome Research · doi:10.1021/pr015504q · Cited by 1,369

Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog

Pepinsky, R. B., Zeng, C., Wen, D., Rayhorn, P., Baker, D. P., Williams, K. P., Bixler, S. A., Ambrose, C. M., Garber, E. A., Miatkowski, K., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.14037 · Cited by 754

Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos

Rocheleau, C. E., Downs, W. D., Lin, R., Wittmann, C., Bei, Y., Cha, Y.-H., Ali, M., Priess, J. R., & Mello, C. C. (1997) · Cell · doi:10.1016/s0092-8674(00)80531-0 · Cited by 660

Shotgun identification of protein modifications from protein complexes and lens tissue

MacCoss, M. J., McDonald, W. H., Saraf, A., Sadygov, R. G., Clark, J., Tasto, J. J., Gould, K. L., Wolters, D. A., Washburn, M. P., Weiss, A., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122231399 · Cited by 593

Three decades of Wnts: a personal perspective on how a scientific field developed

Nusse, R., & VARMUS, H. E. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.146 · Cited by 427

Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response

Gerdes, J. M., Liu, Y., Zaghloul, N. A., Leitch, C. C., Lawson, S. S., Kato, M., Beachy, P. A., Beales, P. L., DeMartino, G. N., Fisher, S., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.12 · Cited by 399

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

Janda, C. Y., Dang, L. T., You, C., Chang, J., de Lau, W., Zhong, Z. A., Yan, K. S., Marecic, O., Siepe, D., Li, X., et al. (2017) · Nature · doi:10.1038/nature22306 · Cited by 403

Hematopoietic stem cell fate is established by the Notch-Runx pathway

Burns, C. E., Traver, D., Mayhall, E., Shepard, J. L., & Zon, L. I. (2005) · Genes & Development · doi:10.1101/gad.1337005 · Cited by 401

Transitions between epithelial and mesenchymal states in development and disease

Baum, B., Settleman, J. E., & Quinlan, M. P. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.02.001 · Cited by 398

Kinetics of Morphogen Gradient Formation

Kicheva, A., Pantazis, P., Bollenbach, T., Kalaidzidis, Y. L., Bittig, T., Jülicher, F., & González‐Gaitán, M. (2007) · Science · doi:10.1126/science.1135774 · Cited by 397

Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture

Zeng, Y. A., & Nusse, R. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.020 · Cited by 407

Wnt Proteins Prevent Apoptosis of Both Uncommitted Osteoblast Progenitors and Differentiated Osteoblasts by β-Catenin-dependent and -independent Signaling Cascades Involving Src/ERK and Phosphatidylinositol 3-Kinase/AKT

Almeida, M., Li, H., Bellido, T., Manolagas, S. C., & Kousteni, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502168200 · Cited by 403

Hematopoietic stem cell and multilineage defects generated by constitutive β-catenin activation

Scheller, M., Huelsken, J., Rosenbauer, F., Taketo, M. M., Birchmeier, W., Tenen, D. G., & Leutz, A. (2006) · Nature Immunology · doi:10.1038/ni1387 · Cited by 409

Wnt signaling in myogenesis

von Maltzahn, J., Chang, N. C., Bentzinger, C. F., & Rudnicki, M. A. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.07.008 · Cited by 408

Defining the impact of β-catenin/Tcf transactivation on epithelial stem cellsPreprint

Lowry, W. E., Blanpain, C., Nowak, J. A., Guasch, G., Lewis, L. E., & Fuchs, E. V. (2005) · Genes & Development · doi:10.1101/gad.1324905 · Cited by 402

Long-lived intestinal tuft cells serve as colon cancer–initiating cells

Westphalen, C. B., Asfaha, S., Hayakawa, Y., Takemoto, Y., Lukin, D. J., Nuber, A. H., Brandtner, A. K., Setlik, W., Remotti, H. E., Muley, A., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci73434 · Cited by 400

Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis

Turashvili, G., Bouchal, J., Baumforth, K. R. N., Wei, W., Dziechciarková, M., Ehrmann, J., Klein, J., Fridman, E., Škarda, J., Srovnal, J., et al. (2007) · BMC Cancer · doi:10.1186/1471-2407-7-55 · Cited by 385

A Wnt Survival Guide: From Flies to Human Disease

Chien, A. J., Conrad, W. H., & Moon, R. T. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.445 · Cited by 382

Wnt10b Inhibits Development of White and Brown Adipose Tissues

Longo, K. A., Hahn, W. S., Kang, S., Gerin, I., Chiang, S.-H., Lucas, P. C., Opp, M. R., & MacDougald, O. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402937200 · Cited by 372

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.Preprint

Chen, M.-H., Li, Y.-J., Kawakami, T., Xu, S.-M., & Chuang, P.-T. (2004) · Genes & Development · doi:10.1101/gad.1185804 · Cited by 407

Seeing is believing

Berthiaume, L. G. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1414 · Cited by 367

Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells

Zhang, C. C., Kaba, M., Ge, G., Xie, K. T., Tong, W., Hug, C., & Lodish, H. F. (2006) · Nature Medicine · doi:10.1038/nm1342 · Cited by 372

Wnt signals across the plasma membrane to activate the β-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP

Cong, F., Schweizer, L., & Varmus, H. (2004) · Development · doi:10.1242/dev.01318 · Cited by 317

Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease

Hu, L., Chen, W., Qian, A., & Li, Y.-P. (2024) · Bone Research · doi:10.1038/s41413-024-00342-8 · Cited by 359

Wnts as ligands: processing, secretion and reception

Mikels, A. J., & Nusse, R. (2006) · Oncogene · doi:10.1038/sj.onc.1210053 · Cited by 370

Gene Profile of Electroconvulsive Seizures: Induction of Neurotrophic and Angiogenic Factors

Newton, S. S., Collier, E. F., Hunsberger, J. G., Adams, D., Terwilliger, R. Z., Selvanayagam, E., & Duman, R. S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10841.2003 · Cited by 360

β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis

Cobas, M., Wilson, A., Ernst, B., Mancini, S. J. C., MacDonald, H. R., Kemler, R., & Radtke, F. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031615 · Cited by 358

Signaling pathways governing stem-cell fate

Blank, U., Karlsson, G., & Karlsson, S. (2007) · Blood · doi:10.1182/blood-2007-07-075168 · Cited by 369

Wnt ProteinsPreprint

Willert, K., & Nusse, R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007864 · Cited by 370

Hematopoiesis

Jagannathan‐Bogdan, M., & Zon, L. I. (2013) · Development · doi:10.1242/dev.083147 · Cited by 394

A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis

Gujral, T. S., Chan, M., Peshkin, L., Sorger, P. K., Kirschner, M. W., & MacBeath, G. (2014) · Cell · doi:10.1016/j.cell.2014.10.032 · Cited by 357

WNT Signaling in Cardiac and Vascular Disease

Foulquier, S., Daskalopoulos, E. P., Lluri, G., Hermans, K. C. M., Deb, A., & Blankesteijn, W. M. (2017) · Pharmacological Reviews · doi:10.1124/pr.117.013896 · Cited by 350

Expression Profiling and Functional Analysis of Wnt Signaling Mechanisms in Mesenchymal Stem Cells

Etheridge, S. L., Spencer, G. J., Heath, D. J., & Genever, P. G. (2004) · Stem Cells · doi:10.1634/stemcells.22-5-849 · Cited by 353

Wnt signaling regulates pancreatic β cell proliferation

Rulifson, I. C., Karnik, S. K., Heiser, P. W., ten Berge, D., Chen, H., Gu, X., Taketo, M. M., Nusse, R., Hebrok, M., & Kim, S. K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701509104 · Cited by 351

Side population cells in human cancers

Wu, C., & Alman, B. A. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.048 · Cited by 349

Identification of multipotent mammary stem cells by protein C receptor expression

Wang, D., Cai, C., Dong, X., Yu, Q. C., Zhang, X.-O., Yang, L. C., & Zeng, Y. A. (2014) · Nature · doi:10.1038/nature13851 · Cited by 346

Defining the Role of Wnt/β‐Catenin Signaling in the Survival, Proliferation, and Self‐Renewal of Human Embryonic Stem Cells

Dravid, G. G., Ye, Z., Hammond, H., Chen, G., Pyle, A. D., Donovan, P. J., Yu, X., & Cheng, L. (2005) · Stem Cells · doi:10.1634/stemcells.2005-0034 · Cited by 343

An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/ wingless signaling pathway

Gonsalves, F. C., Klein, K., Carson, B. B., Katz, S., Ekas, L. A., Evans, S., Nagourney, R., Cardozo, T., Brown, A. M. C., & DasGupta, R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017496108 · Cited by 337

Activation of β-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters

Li, J., & Zhou, B. P. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-49 · Cited by 345

Hematopoietic Stem and Progenitor Cells: Clinical and Preclinical Regeneration of the Hematolymphoid System

Shizuru, J. A., Negrin, R. S., & Weissman, I. L. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.54.101601.152334 · Cited by 349

Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals

Loh, K. M., van Amerongen, R., & Nusse, R. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.08.011 · Cited by 335

Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface

Nusse, R. (2003) · Development · doi:10.1242/dev.00821 · Cited by 334

Wnt signalling in osteoblasts regulates expression of the receptor activator of NFκB ligand and inhibits osteoclastogenesis in vitro

Spencer, G. J., Utting, J. C., Etheridge, S. L., Arnett, T. R., & Genever, P. G. (2006) · Journal of Cell Science · doi:10.1242/jcs.02883 · Cited by 341

Wnt-mediated self-renewal of neural stem/progenitor cells

Kalani, M. Y. S., Cheshier, S. H., Cord, B. J., Bababeygy, S. R., Vogel, H. S., Weissman, I. L., Palmer, T. D., & Nusse, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808616105 · Cited by 345

Diverse mechanisms regulate stem cell self-renewal

Molofsky, A. V., Pardal, R., & Morrison, S. J. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.09.004 · Cited by 344

Gone with the Wnts: β-Catenin, T-Cell Factor, Forkhead Box O, and Oxidative Stress in Age-Dependent Diseases of Bone, Lipid, and Glucose Metabolism

Manolagas, S. C., & Almeida, M. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0259 · Cited by 333

WNT signalling and haematopoiesis: a WNT–WNT situation

Staal, F. J. T., & Clevers, H. C. (2005) · Nature reviews. Immunology · doi:10.1038/nri1529 · Cited by 335

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

Man, S. M., Zhu, Q., Zhu, L., Liu, Z., Karki, R., Malik, A., Sharma, D., Li, L., Malireddi, R. K. S., Gurung, P., et al. (2015) · Cell · doi:10.1016/j.cell.2015.06.001 · Cited by 338

Transcription factor Gfi1 regulates self‐renewal and engraftment of hematopoietic stem cells

Zeng, H., Yücel, R., Kosan, C., Klein‐Hitpaß, L., & Möröy, T. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600419 · Cited by 346

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation

Brandenberger, R., Wei, H., Zhang, S., Lei, S., Murage, J., Fisk, G. J., Li, Y., Xu, C., Fang, R. H., Guegler, K., et al. (2004) · Nature Biotechnology · doi:10.1038/nbt971 · Cited by 336

The Retromer Complex Influences Wnt Secretion by Recycling Wntless from Endosomes to the Trans-Golgi Network

Belenkaya, T. Y., Wu, Y., Tang, X., Zhou, B., Cheng, L., Sharma, Y. V., Yan, D., Selva, E. M., & Lin, X. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.12.003 · Cited by 327

Canonical Wnt Signaling Regulates Hematopoiesis in a Dosage-Dependent Fashion

Luis, T. C., Naber, B. A. E., Roozen, P. P. C., Brugman, M. H., de Haas, E. F. E., Ghazvini, M., Fibbe, W. E., van Dongen, J. J. M., Fodde, R., & Staal, F. J. T. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.07.017 · Cited by 330

Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling

Spiegel, A., Shivtiel, S., Kalinkovich, A., Ludin, A., Netzer, N., Goichberg, P., Azaria, Y., Resnick, I. B., Hardan, I., Ben‐Hur, H., et al. (2007) · Nature Immunology · doi:10.1038/ni1509 · Cited by 330

Novel Lipid Modifications of Secreted Protein Signals

Mann, R. K., & Beachy, P. A. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073933 · Cited by 334

Wnt5a: its signalling, functions and implication in diseases

Kikuchi, A., Yamamoto, H., Sato, A., & Matsumoto, S. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02294.x · Cited by 322

Repression of Nanog Gene Transcription by Tcf3 Limits Embryonic Stem Cell Self-Renewal

Pereira, L., Yi, F., & Merrill, B. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00368-06 · Cited by 328

Wnt/β-catenin signalling: from plasma membrane to nucleus

Kim, W., Kim, M., & Jho, E. (2013) · Biochemical Journal · doi:10.1042/bj20121284 · Cited by 320

EphB Receptors Coordinate Migration and Proliferation in the Intestinal Stem Cell Niche

Holmberg, J., Genander, M., Halford, M. M., Annerén, C., Sondell, M., Chumley, M. J., Silvany, R. E., Henkemeyer, M. J., & Frisén, J. (2006) · Cell · doi:10.1016/j.cell.2006.04.030 · Cited by 313

Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation

Nemeth, M. J., Topol, L. Z., Anderson, S. M., Yang, Y., & Bodine, D. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704747104 · Cited by 316

Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency

Miyabayashi, T., Teo, J.-L., Yamamoto, M., McMillan, M., Nguyen, C., & Kahn, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701331104 · Cited by 310

Redox mechanisms switch on hypoxia-dependent epithelial–mesenchymal transition in cancer cells

Cannito, S., Novo, E., Compagnone, A., di Bonzo, L. V., Busletta, C., Zamara, E., Paternostro, C., Povero, D., Bandino, A., Bozzo, F., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn216 · Cited by 319

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

Derksen, P. W. B., Tjin, E. P. M., Meijer, H. P., Klok, M. D., MacGillavry, H. D., van Oers, M. H. J., Lokhorst, H. M., Bloem, A. C., Clevers, H. C., Nusse, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305855101 · Cited by 309

Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development

ten Berge, D., Brugmann, S. A., Helms, J. A., & Nusse, R. (2008) · Development · doi:10.1242/dev.023176 · Cited by 301

A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro

Habib, S. J., Chen, B., Tsai, F., Anastassiadis, K., Meyer, T., Betzig, E., & Nusse, R. (2013) · Science · doi:10.1126/science.1231077 · Cited by 304

Wnt Signaling from Development to Disease: Insights from Model SystemsPreprint

Cadigan, K. M., & Peifer, M. A. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002881 · Cited by 312

Orphan nuclear receptor TLX activates Wnt/β-catenin signalling to stimulate neural stem cell proliferation and self-renewal

Qu, Q., Sun, G., Li, W., Su, Y., Ye, P., Zhao, C., Yu, R. T., Gage, F. H., Evans, R. M., & Shi, Y. (2009) · Nature Cell Biology · doi:10.1038/ncb2001 · Cited by 306

Role of Glycosaminoglycans in Cellular Communication

Linhardt, R. J., & Toida, T. (2004) · Accounts of Chemical Research · doi:10.1021/ar030138x · Cited by 303

Wnt signaling in triple-negative breast cancer

Pohl, S., Brook, N., Agostino, M., Arfuso, F., Kumar, A. P., & Dharmarajan, A. (2017) · Oncogenesis · doi:10.1038/oncsis.2017.14 · Cited by 305

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells

Majeti, R., Becker, M. W., Tian, Q., Lee, T.-L. M., Yan, X., Liu, R., Chiang, J.-H., Hood, L., Clarke, M. F., & Weissman, I. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900089106 · Cited by 281

Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea

Chai, R., Kuo, B., Wang, T., Liaw, E. J., Xia, A., Jan, T. A., Liu, Z., Taketo, M. M., Oghalai, J. S., Nusse, R., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202774109 · Cited by 292

The fat side of prostate cancer

Zadra, G., Photopoulos, C., & Loda, M. F. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.03.010 · Cited by 301

Wnt–Ryk signalling mediates medial–lateral retinotectal topographic mapping

Schmitt, A. M., Shi, J., Wolf, A. M., Lu, C.-C., King, L. A., & Zou, Y. (2006) · Nature · doi:10.1038/nature04334 · Cited by 292

Hepatocellular Carcinoma: Molecular Pathways and New Therapeutic Targets

Roberts, L. R., & Gores, G. J. (2005) · Seminars in Liver Disease · doi:10.1055/s-2005-871200 · Cited by 293

Wnt/Notch signalling and information processing during development

Hayward, P. C., Kalmár, T., & Arias, A. M. (2008) · Development · doi:10.1242/dev.000505 · Cited by 299

Mouse Cristin/R-spondin Family Proteins Are Novel Ligands for the Frizzled 8 and LRP6 Receptors and Activate β-Catenin-dependent Gene Expression

Nam, J., Turcotte, T. J., Smith, P. F., Choi, S., & Yoon, J. K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508324200 · Cited by 288

Tcf3 Governs Stem Cell Features and Represses Cell Fate Determination in Skin

Nguyen, H., Rendl, M., & Fuchs, E. V. (2006) · Cell · doi:10.1016/j.cell.2006.07.036 · Cited by 287

WNT/β-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells

Hao, J., Li, T.-G., Qi, X., Zhao, D., & Zhao, G.-Q. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.11.011 · Cited by 295

Medulloblastoma in childhood: new biological advances

Crawford, J. R., MacDonald, T. J., & Packer, R. J. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70289-2 · Cited by 285

Multiplicity of the interactions of Wnt proteins and their receptors

Kikuchi, A., Yamamoto, H., & Kishida, S. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.11.001 · Cited by 289

Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury

Saha, S., Aranda, E., Hayakawa, Y., Bhanja, P., Atay, S., Brodin, N. P., Li, J., Asfaha, S., Liu, L., Tailor, Y. H., et al. (2016) · Nature Communications · doi:10.1038/ncomms13096 · Cited by 284

In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein

Krošl, J., Austin, P., Beslu, N., KROON, E. J., Humphries, R. K., & Sauvageau, G. (2003) · Nature Medicine · doi:10.1038/nm951 · Cited by 283

Hyperoxia, Endothelial Progenitor Cell Mobilization, and Diabetic Wound Healing

Liu, Z., & Velazquez, O. C. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2121 · Cited by 287

Deficiency of PORCN, a regulator of Wnt signaling, is associated with focal dermal hypoplasia

Grzeschik, K., Bornholdt, D., Oeffner, F., König, A., Boente, M. D. C., Enders, H., Fritz, B., Hertl, M., Grasshoff, U., Höfling, K., et al. (2007) · Nature Genetics · doi:10.1038/ng2052 · Cited by 289

The Intestinal Stem Cell Niche: Homeostasis and Adaptations

Santos, A. J. M., Lo, Y., Mah, A. T., & Kuo, C. J. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.08.001 · Cited by 290

ThreeDrosophilaEXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans

Takei, Y., Ozawa, Y., Sato, M., Watanabe, A., & Tabata, T. (2003) · Development · doi:10.1242/dev.00913 · Cited by 279

Identification and isolation of hematopoietic stem cells

Wognum, A. W., Eaves, A. C., & Thomas, T. E. (2003) · Archives of Medical Research · doi:10.1016/j.arcmed.2003.09.008 · Cited by 281

Wingless secretion promotes and requires retromer-dependent cycling of Wntless

Port, F., Kuster, M., Herr, P., Furger, E., Bänziger, C., Hausmann, G., & Basler, K. (2008) · Nature Cell Biology · doi:10.1038/ncb1687 · Cited by 278

Asymmetric Homotypic Interactions of the Atypical Cadherin Flamingo Mediate Intercellular Polarity Signaling

Chen, W.-S., Antic, D., Matis, M., Logan, C. Y., Povelones, M., Anderson, G. A., Nusse, R., & Axelrod, J. D. (2008) · Cell · doi:10.1016/j.cell.2008.04.048 · Cited by 269

Non-hematopoietic bone marrow stem cells: Molecular control of expansion and differentiation

Gregory, C. A., Prockop, D. J., & Spees, J. L. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.03.018 · Cited by 270

Subcellular spatial regulation of canonical Wnt signalling at the primary cilium

Lancaster, M. A., Schroth, J., & Gleeson, J. G. (2011) · Nature Cell Biology · doi:10.1038/ncb2259 · Cited by 267

Wnt Proteins Promote Bone Regeneration

Minear, S. C., Leucht, P., Jiang, J., Liu, B., Zeng, A., Fuerer, C., Nusse, R., & Helms, J. A. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000231 · Cited by 271

Tissue Engineering and Regenerative Medicine: Recent Innovations and the Transition to Translation

Fisher, M. B., & Mauck, R. L. (2012) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2012.0723 · Cited by 267

New Insights into the Mechanism of Wnt Signaling Pathway Activation

Kikuchi, A., Yamamoto, H., Sato, A., & Matsumoto, S. (2011) · International review of cytology · doi:10.1016/b978-0-12-386035-4.00002-1 · Cited by 275

Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance

Mohammed, M. K., Shao, C. C., Wang, J., Wei, Q., Wang, X. W., Collier, Z. J., Tang, S., Liu, H., Zhang, F., Huang, J., et al. (2016) · Genes & Diseases · doi:10.1016/j.gendis.2015.12.004 · Cited by 266

WNT Signaling in Lung Disease

Königshoff, M., & Eickelberg, O. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0485tr · Cited by 262

The Frizzled family of unconventional G-protein-coupled receptors

Schulte, G., & Bryja, V. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.09.001 · Cited by 253

The nature of stem cells: state rather than entity

Zipori, D. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1475 · Cited by 271

Wnt Signaling Requires Retromer-Dependent Recycling of MIG-14/Wntless in Wnt-Producing Cells

Yang, P., Lorenowicz, M. J., Macůrková, M., Coudreuse, D. Y. M., Betist, M. C., & Korswagen, H. C. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.12.004 · Cited by 259

A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro

Schlaermann, P., Toelle, B., Berger, H., Schmidt, S. C., Glanemann, M., Ordemann, J., Bartfeld, S., Mollenkopf, H., & Meyer, T. F. (2014) · Gut · doi:10.1136/gutjnl-2014-307949 · Cited by 264

Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention

McCubrey, J. A., Steelman, L. S., Bertrand, F. E., Davis, N. M., Abrams, S. L., Montalto, G., D’Assoro, A. B., Libra, M., Nicoletti, F., Maestro, R., et al. (2013) · Leukemia · doi:10.1038/leu.2013.184 · Cited by 265

A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo

Prakash, N., Brodski, C., Naserke, T., Puelles, E., Gogoi, R., Hall, A. C., Panhuysen, M., Echevarrı́a, D., Sussel, L., Weisenhorn, D. M. V., et al. (2005) · Development · doi:10.1242/dev.02181 · Cited by 254

Protein lipidation

Nadolski, M. J., & Linder, M. E. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.06056.x · Cited by 254

Targeting the Wnt pathway in human cancers: Therapeutic targeting with a focus on OMP-54F28

Le, P. N., McDermott, J. D., & Jimeno, A. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.08.005 · Cited by 257

Stable expansion of high‐grade serous ovarian cancer organoids requires a low‐Wnt environment

Hoffmann, K., Berger, H., Kulbe, H., Thillainadarasan, S., Mollenkopf, H., Żemojtel, T., TAUBE, E. T., Darb‐Esfahani, S., Mangler, M., Sehouli, J., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019104013 · Cited by 252

A little fat ... could go a long way

Bussell, K. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1139

Sticky Proteins for Stem Cells

Kolter, T. (2003) · ChemBioChem · doi:10.1002/cbic.200300733 · Cited by 1

Constructing cellular niche properties by localized presentation of Wnt proteins on synthetic surfaces

Lowndes, M., Junyent, S., & Habib, S. J. (2017) · Nature Protocols · doi:10.1038/nprot.2017.061 · Cited by 28

Making, Exporting, and Modulating Wnts

Langton, P. F., Kakugawa, S., & Vincent, J. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.05.011 · Cited by 98

A truncated Wnt7a retains full biological activity in skeletal muscle

von Maltzahn, J., Zinoviev, R. I., Chang, N. C., Bentzinger, C. F., & Rudnicki, M. A. (2013) · Nature Communications · doi:10.1038/ncomms3869 · Cited by 49