Cited by 224Chromosomal and Genetic VariationsDNA Repair MechanismsCRISPR and Genetic Engineering

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Transposition of hAT elements links transposable elements and V(D)J recombination

Zhou, Liqin, Mitra, Rupak, Atkinson, Peter W., Burgess Hickman, Alison, Dyda, Fred, Craig, Nancy L.·2004·Nature

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Abstract

Transposons are DNA sequences that encode functions that promote their movement to new locations in the genome. If unregulated, such movement could potentially insert additional DNA into genes, thereby disrupting gene expression and compromising an organism's viability. Transposable elements are classified by their transposition mechanisms and by the transposases that mediate their movement. The mechanism of movement of the eukaryotic hAT superfamily elements was previously unknown, but the divergent sequence of hAT transposases from other elements suggested that these elements might use a distinct mechanism. Here we have analysed transposition of the insect hAT element Hermes in vitro. Like other transposons, Hermes excises from DNA via double-strand breaks between the donor-site DNA and the transposon ends, and the newly exposed transposon ends join to the target DNA. Interestingly, the ends of the donor double-strand breaks form hairpin intermediates, as observed during V(D)J recombination, the process which underlies the combinatorial formation of antigen receptor genes. Significant similarities exist in the catalytic amino acids of Hermes transposase, the V(D)J recombinase RAG, and retroviral integrase superfamily transposases, thereby linking the movement of transposable elements and V(D)J recombination.

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Authors: Zhou, L., Mitra, R., Atkinson, P. W., Burgess Hickman, A., Dyda, F., & Craig, N. L.
Affiliations: Howard Hughes Medical Institute (US)
University of California, Riverside (US)
National Institutes of Health (US)
Corresponding author: Craig, Nancy L.
ORCID: Zhou, Liqin
Atkinson, Peter W.
Dyda, Fred
Craig, Nancy L.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2004-12
Volume: 432
Issue: 7020
Pages: 995-1001
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature03157
OpenAlex: W2071441005
Cited by: 224
References: 50
Citations by year: 2026: 2 · 2025: 5 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 6 · 2015: 23 · 2014: 15 · 2013: 11 · 2012: 19
FWCI: 20.37
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Howard Hughes Medical Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
Keywords: hAT transposons, transposition mechanism, V(D)J recombination, DNA double-strand breaks, transposon excision
MeSH terms: Animals, Base Sequence, Binding Sites, DNA, DNA Transposable Elements, Drosophila melanogaster, Nucleic Acid Conformation, Recombination, Genetic, Substrate Specificity, Gene Rearrangement, B-Lymphocyte, Homeodomain Proteins, Transposases

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Transposition of hAT elements links transposable elements and V(D)J recombination

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